Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0003 Transporter Info
Gene Name	ABCB1
Transporter Name	P-glycoprotein 1
Gene ID	5243
UniProt ID	P08183

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Cyanotoxin
cylindrospermopsin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cylindrospermopsin results in increased expression of ABCB1 protein			[485]
Regulation Mechanism				Transcription Factor Info
Biotoxin
Digitoxin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Digitoxin			[500]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Digitoxin inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[411]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Cyclosporine	69 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the transportation of Calcein AM by ABCB1 (Ki = 1.8 microM)			[1]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	CEM/VLB100 drug-resistant cells-MDR1
DT Modulation2	Cyclosporine inhibits the transportation of Calcein AM by ABCB1 (IC50 = 3.41 microM)			[2]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	CEM/VLB100 drug-resistant cells-MDR1
DT Modulation3	Cyclosporine inhibits the transportation of Calcein AM by ABCB1 (IC50 = 1.7 microM)			[3]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation4	Cyclosporine inhibits the transportation of Calcein AM by ABCB1 (Ki = 4.66 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation5	Cyclosporine inhibits the transportation of Calcein AM by ABCB1 (IC50 = 0.8 microM)			[5]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation6	Cyclosporine inhibits the transportation of Colchicine by ABCB1 (IC50 = 1.36 microM)			[6]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation7	Cyclosporine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 1.4 microM)			[3]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation8	Cyclosporine inhibits the transportation of Digoxin by ABCB1 (Ki = 0.46 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation9	Cyclosporine inhibits the transportation of Digoxin by ABCB1 (IC50 = 1.3 microM)			[8]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation10	Cyclosporine inhibits the transportation of Digoxin by ABCB1 (Ki = 0.35 +/- 0.04 microM)			[9]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation11	Cyclosporine inhibits the transportation of Digoxin by ABCB1 (IC50 = 1.6 microM)			[6]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation12	Cyclosporine inhibits the transportation of Doxorubicin by ABCB1 (IC50 = 3.66 microM)			[10]
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation13	Cyclosporine inhibits the transportation of Fluo-3-AM by ABCB1 (IC50 = 2.4 microM)			[3]
Affected Drug/Substrate	Fluo-3-AM	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation14	Cyclosporine inhibits the transportation of LDS-751 by ABCB1 (IC50 = 1.8 microM)			[3]
Affected Drug/Substrate	LDS-751	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation15	Cyclosporine inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 1.4 microM)			[11]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation16	Cyclosporine inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 1.7 microM)			[3]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation17	Cyclosporine inhibits the transportation of Tetramethylrosamine by ABCB1 (IC50 = 2.1 microM)			[3]
Affected Drug/Substrate	Tetramethylrosamine	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation18	Cyclosporine inhibits the transportation of Verapamil by ABCB1 (Ki = 0.02 microM)			[12]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MDR1
DT Modulation19	Cyclosporine inhibits the transportation of Vinblastine by ABCB1 (Ki = 1.3 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation20	Cyclosporine inhibits the transportation of Vinblastine by ABCB1 (IC50 = 6.18 microM)			[6]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation21	Cyclosporine inhibits the transportation of Calcein AM by ABCB1			[13], [14]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Doxorubicin resistant A2780adr cell lines-MDR1
DT Modulation22	Cyclosporine inhibits the transportation of Colchicine by ABCB1			[15]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Human T-cell line (CEM)/Tumour cell line-MDR1
DT Modulation23	Cyclosporine inhibits the transportation of Doxorubicin by ABCB1			[16]
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
DT Modulation24	Cyclosporine inhibits the transportation of Imatinib by ABCB1			[17]
Affected Drug/Substrate	Imatinib	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation25	Cyclosporine inhibits the transportation of Indinavir by ABCB1			[18]
Affected Drug/Substrate	Indinavir	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation26	Cyclosporine inhibits the transportation of Propranolol by ABCB1			[19]
Affected Drug/Substrate	Propranolol	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation27	Cyclosporine inhibits the transportation of Rhodamine 123 by ABCB1			[20]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human ileocecal adenocarcinoma cell lines (HCT-8)-MDR1
DT Modulation28	Cyclosporine inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
DT Modulation29	Cyclosporine inhibits the transportation of Saquinavir by ABCB1			[20]
Affected Drug/Substrate	Saquinavir	Modulation Type	Inhibition
Cell System	Human ileocecal adenocarcinoma cell lines (HCT-8)-MDR1
DT Modulation30	Cyclosporine inhibits the transportation of Saquinavir by ABCB1			[22]
Affected Drug/Substrate	Saquinavir	Modulation Type	Inhibition
Cell System	LLC-PK1 porcine kidney epithelial (LLC-GA5-COL150) cells-MDR1
DT Modulation31	Cyclosporine inhibits the transportation of JC-1 by ABCB1			[23]
Affected Drug/Substrate	JC-1	Modulation Type	Inhibition
DT Modulation32	Cyclosporine inhibits the transportation of Vinblastine by ABCB1			[24]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
DT Modulation33	Cyclosporine inhibits the activity of ABCB1			[25]
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation34	Cyclosporine induces the activity of ABCB1			[26], [27]
Verapamil	97 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the transportation of Colchicine by ABCB1 (IC50 = 17.3 microM)			[6]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Verapamil inhibits the transportation of Digoxin by ABCB1 (Ki = 15.1 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
DT Modulation3	Verapamil inhibits the transportation of Digoxin by ABCB1 (Ki = 8.11 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation4	Verapamil inhibits the transportation of Digoxin by ABCB1 (IC50 = 10.7 microM)			[6]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation5	Verapamil inhibits the transportation of Fexofenadine by ABCB1 (IC50 = 8.44 microM)			[28]
Affected Drug/Substrate	Fexofenadine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation6	Verapamil inhibits the transportation of Irinotecan by ABCB1 (Ki = 29 microM)			[29]
Affected Drug/Substrate	Irinotecan	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation7	Verapamil inhibits the transportation of Paclitaxel by ABCB1 (IC50 = 4.78 microM)			[30]
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
Cell System	Human uterine cancer cells (MES-SA/Dx5)
DT Modulation8	Verapamil inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 4.2 microM)			[11]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation9	Verapamil inhibits the transportation of Vinblastine by ABCB1 (IC50 = 33.5 microM)			[6]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation10	Verapamil inhibits the transportation of Vincristine by ABCB1 (IC50 = 0.2 microM)			[31]
Affected Drug/Substrate	Vincristine	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
DT Modulation11	Verapamil inhibits the transportation of Paclitaxel by ABCB1 (IC50 = 2.21 microM)			[30]
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
DT Modulation12	Verapamil inhibits the transportation of Calcein by ABCB1			[32]
Affected Drug/Substrate	Calcein	Modulation Type	Inhibition
Cell System	Adriamycin-Resistant Human Ovarian Cancer A2780 cells-MDR1
DT Modulation13	Verapamil inhibits the transportation of Calcein AM by ABCB1			[33]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Human colon cancer cell lines (HCT-15)-MDR1
DT Modulation14	Verapamil inhibits the transportation of Daunomycin by ABCB1			[34]
Affected Drug/Substrate	Daunomycin	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
DT Modulation15	Verapamil inhibits the transportation of Digoxin by ABCB1			[35]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation16	Verapamil inhibits the transportation of Rhodamine 123 by ABCB1			[36]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
DT Modulation17	Verapamil inhibits the transportation of Adriamycin by ABCB1			[37], [38], [39]
Affected Drug/Substrate	Adriamycin	Modulation Type	Inhibition
DT Modulation18	Verapamil inhibits the transportation of Doxorubicin by ABCB1			[40], [39]
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
DT Modulation19	Verapamil inhibits the activity of ABCB1			[41], [40]
Quinine	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of Colchicine by ABCB1 (IC50 = 51.7 microM)			[6]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Quinine inhibits the transportation of Digoxin by ABCB1 (Ki = 8.59 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
DT Modulation3	Quinine inhibits the transportation of Digoxin by ABCB1 (Ki = 3.23 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation4	Quinine inhibits the transportation of Digoxin by ABCB1 (IC50 = 9.52 microM)			[49]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation5	Quinine inhibits the transportation of Digoxin by ABCB1 (IC50 = 22.4 microM)			[50]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation6	Quinine inhibits the transportation of Digoxin by ABCB1 (IC50 = 9.4 microM)			[50]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation7	Quinine inhibits the transportation of Digoxin by ABCB1 (IC50 = 14.9 microM)			[6]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation8	Quinine inhibits the transportation of Vinblastine by ABCB1 (IC50 = 22.9 microM)			[6]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation9	Quinine inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Troleandomycin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troleandomycin inhibits the transportation of Calcein AM by ABCB1 (Ki = 483.3 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Troleandomycin inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 68.3 microM)			[3]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation3	Troleandomycin inhibits the transportation of LDS-751 by ABCB1 (IC50 = 78.2 microM)			[3]
Affected Drug/Substrate	LDS-751	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation4	Troleandomycin inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 86.3 microM)			[3]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation5	Troleandomycin inhibits the transportation of Vinblastine by ABCB1 (Ki = 87.64 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Lovastatin	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lovastatin inhibits the transportation of Calcein AM by ABCB1 (IC50 = 10 +/- 4 microM)			[53]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
DT Modulation2	Lovastatin inhibits the transportation of LDS-751 by ABCB1 (IC50 = 32.7 microM)			[3]
Affected Drug/Substrate	LDS-751	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation3	Lovastatin inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 114.4 microM)			[3]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation4	Lovastatin inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 26 microM)			[54]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
DT Modulation5	Lovastatin inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 67 microM)			[54]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
DT Modulation6	Lovastatin inhibits the transportation of Digoxin by ABCB1			[57]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Vinblastine	36 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vinblastine inhibits the transportation of Calcein AM by ABCB1 (IC50 = 29 microM)			[53]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
DT Modulation2	Vinblastine inhibits the transportation of Colchicine by ABCB1 (IC50 = 30.1 microM)			[6]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation3	Vinblastine inhibits the transportation of Digoxin by ABCB1 (IC50 = 17.8 microM)			[6]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation4	Vinblastine inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 18 microM)			[11]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation5	Vinblastine inhibits the transportation of Vinblastine by ABCB1 (IC50 = 89.7 microM)			[6]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation6	Vinblastine inhibits the transportation of Rhodamine 123 by ABCB1			[36]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
Ketoconazole	33 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the transportation of Colchicine by ABCB1 (IC50 = 5.49 microM)			[6]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Ketoconazole inhibits the transportation of Digoxin by ABCB1 (IC50 = 1.34 microM)			[50]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation3	Ketoconazole inhibits the transportation of Digoxin by ABCB1 (IC50 = 3.07 microM)			[6]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation4	Ketoconazole inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 5.6 microM)			[11]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation5	Ketoconazole inhibits the transportation of Vinblastine by ABCB1 (IC50 = 6.34 microM)			[6]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation6	Ketoconazole inhibits the activity of ABCB1			[58]
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Progesterone	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 96.2 microM)			[3]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation2	Progesterone inhibits the transportation of LDS-751 by ABCB1 (IC50 = 88.1 microM)			[3]
Affected Drug/Substrate	LDS-751	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation3	Progesterone inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 192.2 microM)			[3]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation4	Progesterone inhibits the transportation of Calcein AM by ABCB1			[55]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
DT Modulation5	Progesterone inhibits the transportation of Cortisol by ABCB1			[56]
Affected Drug/Substrate	Cortisol	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation6	Progesterone inhibits the transportation of Vinblastine by ABCB1			[24]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Etoposide	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etoposide inhibits the transportation of Calcein AM by ABCB1 (IC50 = 50 microM)			[5]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Etoposide inhibits the transportation of Digoxin by ABCB1 (Ki = 768 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
DT Modulation3	Etoposide inhibits the transportation of Taxol by ABCB1 (Ki = 276 microM)			[25]
Affected Drug/Substrate	Taxol	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation4	Etoposide inhibits the transportation of Rhodamine 123 by ABCB1			[5]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation5	Etoposide induces the activity of ABCB1			[69]
Reserpine	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Reserpine inhibits the transportation of Digoxin by ABCB1 (Ki = 1.38 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Reserpine inhibits the transportation of Rhodamine 123 by ABCB1			[60], [61]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-MDR1
DT Modulation3	Reserpine induces the activity of ABCB1			[66]
Cell System	Human colon carcinoma cell lines (LS174T)-MDR1
DT Modulation4	Reserpine inhibits the activity of ABCB1			[70], [71]
Miconazole	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Miconazole inhibits the transportation of Calcein AM by ABCB1 (Ki = 55.5 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Miconazole inhibits the transportation of Calcein AM by ABCB1 (IC50 = 3.5 microM)			[5]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation3	Miconazole inhibits the transportation of Vinblastine by ABCB1 (Ki = 26.36 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation4	Miconazole inhibits the transportation of Rhodamine 123 by ABCB1			[5]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Trifluoperazine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trifluoperazine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 7.2 microM)			[3]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation2	Trifluoperazine inhibits the transportation of LDS-751 by ABCB1 (IC50 = 6.3 microM)			[3]
Affected Drug/Substrate	LDS-751	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation3	Trifluoperazine inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 10.9 microM)			[3]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation4	Trifluoperazine inhibits the activity of ABCB1			[77]
Ritonavir	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the transportation of Digoxin by ABCB1 (IC50 = 3.8 microM)			[8]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Ritonavir inhibits the transportation of Digoxin by ABCB1 (IC50 = 28.2 microM)			[50]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation3	Ritonavir inhibits the transportation of Digoxin by ABCB1 (IC50 = 5 microM)			[73]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation4	Ritonavir induces the activity of ABCB1			[76]
Erythromycin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin inhibits the transportation of Digoxin by ABCB1 (IC50 = 10 microM)			[4]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Erythromycin inhibits the transportation of Digoxin by ABCB1 (IC50 = 22.7 microM)			[72]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation3	Erythromycin inhibits the transportation of Ximelagatran by ABCB1 (IC50 = 119 microM)			[74]
Affected Drug/Substrate	Ximelagatran	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation4	Erythromycin induces the activity of ABCB1			[75]
Bromocriptine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromocriptine inhibits the transportation of Calcein AM by ABCB1 (Ki = 2.81 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Bromocriptine inhibits the transportation of Vinblastine by ABCB1 (Ki = 3.96 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation3	Bromocriptine inhibits the activity of ABCB1			[86]
Nifedipine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 113 microM)			[78]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation2	Nifedipine inhibits the transportation of Digoxin by ABCB1 (IC50 = 472 microM)			[80]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation3	Nifedipine induces the activity of ABCB1			[66]
Cell System	Human colon carcinoma cell lines (LS174T)-MDR1
Amiodarone	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiodarone inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 22.5 microM)			[79]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Amiodarone inhibits the transportation of Digoxin by ABCB1 (IC50 = 45.6 microM)			[79]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation3	Amiodarone inhibits the transportation of Digoxin by ABCB1 (IC50 = 5.48 microM)			[49]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Felodipine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Felodipine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 26.3 microM)			[3]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation2	Felodipine inhibits the transportation of LDS-751 by ABCB1 (IC50 = 32.3 microM)			[3]
Affected Drug/Substrate	LDS-751	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation3	Felodipine inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 > 60 microM)			[3]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
Fluphenazine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluphenazine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 6.5 microM)			[3]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation2	Fluphenazine inhibits the transportation of LDS-751 by ABCB1 (IC50 = 5.7 microM)			[3]
Affected Drug/Substrate	LDS-751	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation3	Fluphenazine inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 10.4 microM)			[3]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
Dipyridamole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the transportation of Digoxin by ABCB1 (IC50 = 40 microM)			[49]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Dipyridamole inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
DT Modulation3	Dipyridamole inhibits the activity of ABCB1			[87]
Quercetin	24 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the transportation of Ritonavir by ABCB1 (IC50 = 26.4 microM)			[81]
Affected Drug/Substrate	Ritonavir	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-MDR1
DT Modulation2	Quercetin inhibits the transportation of Rhodamine 123 by ABCB1			[82]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Model organism in vivo (rat)
DT Modulation3	Quercetin induces the transportation of Ritonavir by ABCB1			[81]
Affected Drug/Substrate	Ritonavir	Modulation Type	Inducer
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Dihydroergocristine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydroergocristine inhibits the transportation of Calcein AM by ABCB1 (Ki = 511 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Dihydroergocristine inhibits the transportation of Vinblastine by ABCB1 (Ki = 16 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Dihydroergotamine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydroergotamine inhibits the transportation of Calcein AM by ABCB1 (Ki > 1000 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Dihydroergotamine inhibits the transportation of Vinblastine by ABCB1 (Ki = 119.94 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Ergonovine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ergonovine inhibits the transportation of Calcein AM by ABCB1 (Ki = 115.5 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Ergonovine inhibits the transportation of Vinblastine by ABCB1 (Ki > 100 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Ergotamine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ergotamine inhibits the transportation of Calcein AM by ABCB1 (Ki = 98.9 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Ergotamine inhibits the transportation of Vinblastine by ABCB1 (Ki = 14.25 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Fluconazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluconazole inhibits the transportation of Calcein AM by ABCB1 (Ki > 1000 microM)			[4]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Fluconazole inhibits the transportation of Vinblastine by ABCB1 (Ki > 400 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Hydrocortisone	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrocortisone inhibits the transportation of Calcein AM by ABCB1 (IC50 = 50 microM)			[5]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Hydrocortisone inhibits the transportation of Rhodamine 123 by ABCB1			[5]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Morphine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Morphine inhibits the transportation of Calcein AM by ABCB1 (IC50 = 50 microM)			[5]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Morphine inhibits the transportation of Rhodamine 123 by ABCB1			[5]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Pimozide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pimozide inhibits the transportation of Calcein AM by ABCB1 (IC50 = 2.9 microM)			[5]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Pimozide inhibits the transportation of Rhodamine 123 by ABCB1			[5]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Amlodipine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amlodipine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 22 microM)			[88]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Amlodipine inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Azelastine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azelastine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 16 microM)			[79]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Azelastine inhibits the transportation of Digoxin by ABCB1 (IC50 = 30 microM)			[79]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Nitrendipine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitrendipine inhibits the transportation of Digoxin by ABCB1 (IC50 = 68.2 microM)			[80]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation2	Nitrendipine inhibits the transportation of Calcein AM by ABCB1			[93]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Itraconazole	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the transportation of Digoxin by ABCB1 (IC50 = 0.95 microM)			[50]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Itraconazole inhibits the transportation of Digoxin by ABCB1 (IC50 = 2 microM)			[73]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nefazodone inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 4.7 microM)			[90]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Paclitaxel	59 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 54 microM)			[11]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
Tamoxifen	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 7.1 microM)			[11]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
DT Modulation2	Tamoxifen induces the activity of ABCB1			[111]
Rifampicin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampicin inhibits the transportation of Azidopine by ABCB1			[91]
Affected Drug/Substrate	Azidopine	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
DT Modulation2	Rifampicin induces the activity of ABCB1			[66]
Cell System	Human colon carcinoma cell lines (LS174T)-MDR1
Haloperidol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Haloperidol inhibits the transportation of Calcein AM by ABCB1			[92]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Haloperidol inhibits the transportation of Calcein AM by ABCB1			[55]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Amprenavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amprenavir inhibits the transportation of Calcein AM by ABCB1			[94]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Amprenavir induces the activity of ABCB1			[104]
Indinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indinavir inhibits the transportation of Calcein AM by ABCB1			[94]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Pyronaridine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyronaridine inhibits the transportation of doxorubicin by ABCB1			[95]
Affected Drug/Substrate	doxorubicin	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)/ADR
DT Modulation2	Pyronaridine inhibits the transportation of Rhodamine 123 by ABCB1			[95]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Carbamazepine	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine induces the transportation of Fexofenadine by ABCB1			[96]
Affected Drug/Substrate	Fexofenadine	Modulation Type	Inducer
Cell System	Twelve healthy Japanese volunteers
DT Modulation2	Carbamazepine induces the activity of ABCB1			[114]
Apatinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apatinib inhibits the transportation of Adriamycin by ABCB1			[38]
Affected Drug/Substrate	Adriamycin	Modulation Type	Inhibition
DT Modulation2	Apatinib inhibits the transportation of Rhodamine 123 by ABCB1			[38]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Venlafaxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Venlafaxine inhibits the transportation of Calcein by ABCB1			[101]
Affected Drug/Substrate	Calcein	Modulation Type	Inhibition
Telaprevir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telaprevir inhibits the transportation of Calcein by ABCB1			[102]
Affected Drug/Substrate	Calcein	Modulation Type	Inhibition
DT Modulation2	Telaprevir inhibits the activity of ABCB1			[106]
Cobicistat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cobicistat inhibits the transportation of Dabigatran by ABCB1			[103]
Affected Drug/Substrate	Dabigatran	Modulation Type	Inhibition
DT Modulation2	Cobicistat inhibits the activity of ABCB1			[116]
Nelfinavir	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nelfinavir induces the activity of ABCB1			[104]
Biricodar	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Biricodar inhibits the activity of ABCB1			[105]
DT Modulation2	Biricodar modulates the activity of ABCB1			[107]
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the activity of ABCB1			[108]
Atorvastatin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the activity of ABCB1			[109]
DT Modulation2	Atorvastatin modulates the activity of ABCB1			[109]
DT Modulation3	ABCB1 alternative form affects the reaction CYP3A4 polymorphism affects the susceptibility to Atorvastatin			[389]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein results in increased transport of Atorvastatin			[390]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 protein results in increased transport of Atorvastatin analog			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Atorvastatin analog inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Atorvastatin analog results in decreased activity of ABCB1 protein			[53]
Regulation Mechanism				Transcription Factor Info
Arsenic Trioxide	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic trioxide inhibits the activity of ABCB1			[110]
Doxorubicin	113 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin induces the activity of ABCB1			[112], [113]
DT Modulation2	Doxorubicin inhibits the activity of ABCB1			[112], [113]
Cytarabine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cytarabine induces the activity of ABCB1			[115]
Simvastatin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the transportation of Calcein AM by ABCB1 (IC50 = 10 +/- 8 microM)			[53]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
Desloratadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desloratadine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 43 microM)			[118]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	NIH-3T3-G185-MDR1
Omeprazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the transportation of Digoxin by ABCB1 (IC50 = 17.7 microM)			[119]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Pantoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pantoprazole inhibits the transportation of Digoxin by ABCB1 (IC50 = 17.9 microM)			[119]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Alfentanil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alfentanil inhibits the transportation of Digoxin by ABCB1 (IC50 = 112 microM)			[120]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Fentanyl	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fentanyl inhibits the transportation of Digoxin by ABCB1 (IC50 = 6.5 microM)			[120]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Sufentanil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sufentanil inhibits the transportation of Digoxin by ABCB1 (IC50 = 4.5 microM)			[120]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Nisoldipine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nisoldipine inhibits the transportation of Digoxin by ABCB1 (IC50 = 44.1 microM)			[80]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Azithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azithromycin inhibits the transportation of Digoxin by ABCB1 (IC50 = 21.8 microM)			[72]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Clarithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clarithromycin inhibits the transportation of Digoxin by ABCB1 (IC50 = 4.1 microM)			[72]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Telithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telithromycin inhibits the transportation of Digoxin by ABCB1 (IC50 = 1.8 microM)			[72]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Atovaquone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atovaquone inhibits the transportation of N-methyl quinidine by ABCB1 (IC50 = 6.8 microM)			[121]
Affected Drug/Substrate	N-methyl quinidine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MDR1
Metoprolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metoprolol inhibits the transportation of Verapamil by ABCB1 (Ki = 200 microM)			[125]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Erlotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erlotinib inhibits the transportation of Vincristine by ABCB1 (IC50 = 2 microM)			[31]
Affected Drug/Substrate	Vincristine	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
Paroxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paroxetine inhibits the transportation of Calcein by ABCB1 (IC50 = 29.8 microM)			[101]
Affected Drug/Substrate	Calcein	Modulation Type	Inhibition
Sertraline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sertraline inhibits the transportation of Calcein by ABCB1 (IC50 = 31.8 microM)			[101]
Affected Drug/Substrate	Calcein	Modulation Type	Inhibition
Loratadine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loratadine inhibits the transportation of Daunorubicin by ABCB1 (IC50 = 11.4 microM)			[118]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
KB-2796	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lomerizine inhibits the transportation of Calcein by ABCB1			[130]
Affected Drug/Substrate	Calcein	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
Chlorprothixene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorprothixene inhibits the transportation of Calcein AM by ABCB1			[92]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Clomipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clomipramine inhibits the transportation of Calcein AM by ABCB1			[92]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Maprotiline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Maprotiline inhibits the transportation of Calcein AM by ABCB1			[92]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Mebendazole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mebendazole inhibits the transportation of Calcein AM by ABCB1			[93]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Benzocaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzocaine inhibits the transportation of Calcein AM by ABCB1			[55]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Prednisone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prednisone inhibits the transportation of Calcein AM by ABCB1			[55]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Tetracaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetracaine inhibits the transportation of Calcein AM by ABCB1			[55]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Trimipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trimipramine inhibits the transportation of Calcein AM by ABCB1			[55]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Lopinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lopinavir inhibits the transportation of Calcein AM by ABCB1			[94]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Glyburide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glibenclamide inhibits the transportation of Colchicine by ABCB1			[15]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Human T-cell line (CEM)/Tumour cell line-MDR1
Doxazosin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxazosin inhibits the transportation of Digoxin by ABCB1			[131]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine inhibits the transportation of Digoxin by ABCB1			[57]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Chlorzoxazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorzoxazone inhibits the transportation of Digoxin by ABCB1			[57]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Dolutegravir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dolutegravir inhibits the transportation of Digoxin by ABCB1			[132]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Capsaicin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Capsaicin inhibits the transportation of Fexofenadine by ABCB1			[133]
Affected Drug/Substrate	Fexofenadine	Modulation Type	Inhibition
Cell System	Model organism in vivo (rat)
Bepridil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bepridil inhibits the transportation of Rhodamine 123 by ABCB1			[134]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Chlorpropamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpropamide inhibits the transportation of Rhodamine 123 by ABCB1			[134]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Prochlorperazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prochlorperazine inhibits the transportation of Rhodamine 123 by ABCB1			[134]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Promethazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Promethazine inhibits the transportation of Rhodamine 123 by ABCB1			[134]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Protriptyline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Protriptyline inhibits the transportation of Rhodamine 123 by ABCB1			[134]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Aprindine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aprindine inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Aripiprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aripiprazole inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Loperamide	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loperamide inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Repaglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Repaglinide inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Ziprasidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ziprasidone inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Reboxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Reboxetine inhibits the transportation of Calcein by ABCB1			[101]
Affected Drug/Substrate	Calcein	Modulation Type	Inhibition
Fluvoxamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvoxamine inhibits the transportation of Calcein AM by ABCB1			[101]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Sesquiterpene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sesquiterpene inhibits the transportation of Colchicine by ABCB1			[149]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Simeprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simeprevir inhibits the transportation of Digoxin by ABCB1			[150]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Carvedilol	15 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carvedilol inhibits the transportation of Doxorubicin by ABCB1			[151]
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Dronedarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dronedarone inhibits the transportation of Edoxaban by ABCB1			[152]
Affected Drug/Substrate	Edoxaban	Modulation Type	Inhibition
Crizotinib	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Crizotinib inhibits the transportation of Rhodamine 123 by ABCB1			[153]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Vandetanib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vandetanib inhibits the transportation of Rhodamine 123 by ABCB1			[154]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Estramustine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estramustine inhibits the transportation of Vinblastine by ABCB1			[155]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Caspofungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caspofungin inhibits the transportation of Vinblastine by ABCB1			[156]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Buspirone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Buspirone inhibits the activity of ABCB1			[92]
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Clotrimazole	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clotrimazole induces the activity of ABCB1			[66]
Cell System	Human colon carcinoma cell lines (LS174T)-MDR1
Dexamethasone	12 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone induces the activity of ABCB1			[66]
Cell System	Human colon carcinoma cell lines (LS174T)-MDR1
Digoxin	81 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Digoxin induces the activity of ABCB1			[161], [162]
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Liothyronine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Liothyronine induces the activity of ABCB1			[163]
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Calcitriol	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the activity of ABCB1			[164]
Cell System	Human embryonic kidney 293 cells (HEK293)-MDR1
Bexarotene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bexarotene induces the activity of ABCB1			[165]
Cell System	Human BBB model derived from hematopoietic stem cells
Decitabine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine restores drug sensitivity by depressing ABCB1 activity through MAPK signaling pathway			[172]
Cell System	K562/ADR cells and MCF-7/ADR cells
Dihydromyricetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydromyricetin inhibits the transporation of adriamycin by ABCB1 through ERK/Akt signaling pathways (IC50 = 0.172 microM)			[173]
Affected Drug/Substrate	Adriamycin	Modulation Type	Inhibition
Cell System	Human myelogenous leukemia cell line (K562)
Imatinib Mesylate	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imatinib Mesylate inhibits the expression of ABCB1			[174]
Regulation Mechanism	via the inhibition of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Doxycycline	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxycycline inhibits the expression of ABCB1			[175]
Regulation Mechanism	via enhancement of Interferon regulatory factor 1 (IRF1)			Transcription Factor Info
Cell System	Human gastric adenocarcinoma cells (MKN45)
Spironolactone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone increases the expression of ABCB1			[178]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Estrone	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone increases the expression of ABCB1			[177]
Regulation Mechanism	via enhancement of Estrogen receptor (ESR1)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS180)
Flutamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flutamide increases the expression of ABCB1			[180]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS180)
Cyclophosphamide	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclophosphamide increases the expression of ABCB1			[180]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS180)
Hydrogen Peroxide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide increases the expression of ABCB1			[181]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (Caco-2)
Methotrexate	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of ABCB1			[182]
Regulation Mechanism	via enhancement of Transcription factor SOX-2 (SOX2)			Transcription Factor Info
Cell System	Human osteosarcoma cells (U-2OS)
Rifampin	19 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of ABCB1			[183]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS180)
Midostaurin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midostaurin inhibits the activity of ABCB1			[184]
Carmustine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carmustine increases the expression of ABCB1			[186]
Chlorambucil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorambucil increases the expression of ABCB1			[186]
Levonorgestrel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levonorgestrel increases the expression of ABCB1			[177]
Thalidomide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thalidomide inhibits the expression of ABCB1			[190]
Cepharanthine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cepharanthine inhibits the activity of ABCB1			[191]
Disulfiram	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram inhibits the activity of ABCB1			[192]
Ursodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ursodeoxycholic Acid increases the expression of ABCB1			[193]
Chlorpromazine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine inhibits the activity of ABCB1			[194]
Clozapine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine inhibits the activity of ABCB1			[194]
Olanzapine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olanzapine inhibits the activity of ABCB1			[194]
Quetiapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quetiapine inhibits the activity of ABCB1			[194]
Diethylstilbestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol inhibits the expression of ABCB1			[195]
Raloxifene Hydrochloride	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride inhibits the expression of ABCB1			[196]
Clopidogrel	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clopidogrel inhibits the expression of ABCB1			[197]
Venlafaxine Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Venlafaxine Hydrochloride increases the expression of ABCB1			[198]
Mitomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitomycin increases the expression of ABCB1			[199]
Gabapentin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gabapentin inhibits the activity of ABCB1			[200]
Lamotrigine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lamotrigine inhibits the activity of ABCB1			[200]
Levetiracetam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levetiracetam inhibits the activity of ABCB1			[200]
Methylprednisolone	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methylprednisolone increases the expression of ABCB1			[201]
Ciclesonide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ciclesonide increases the expression of ABCB1			[202]
Lindane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lindane increases the expression of ABCB1			[124]
Fulvestrant	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fulvestrant increases the expression of ABCB1			[203]
Estradiol	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of ABCB1			[204]
Ivermectin	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the activity of ABCB1			[205]
Abemaciclib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Abemaciclib inhibits the activity of ABCB1			[206]
Deoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deoxycholic acid increases the expression of ABCB1			[207]
Bosentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bosentan inhibits the expression of ABCB1			[208]
Macitentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Macitentan inhibits the expression of ABCB1			[208]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane increases the expression of ABCB1			[209]
Methoxsalen	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methoxsalen inhibits the activity of ABCB1			[210]
Pioglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pioglitazone increases the expression of ABCB1			[211]
Tolbutamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolbutamide inhibits the activity of ABCB1			[212]
Titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Titanium dioxide increases the expression of ABCB1			[213]
Gemcitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemcitabine inhibits the expression of ABCB1			[214]
Mitotane	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitotane inhibits the activity of ABCB1			[215]
Ethinyl Estradiol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol increases the expression of ABCB1			[203]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of ABCB1			[216]
Romidepsin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Romidepsin increases the expression of ABCB1			[217]
Risperidone	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Risperidone inhibits the activity of ABCB1			[218]
Chloroquine	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the expression of ABCB1			[219]
Dacomitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dacomitinib inhibits the activity of ABCB1			[220]
Aldosterone	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aldosterone induces the activity of ABCB1			[56], [26]
Midazolam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midazolam induces the activity of ABCB1			[75]
Phenobarbital	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital induces the activity of ABCB1			[75]
Sirolimus	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sirolimus induces the activity of ABCB1			[75]
Tacrolimus	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tacrolimus induces the activity of ABCB1			[75]
Saquinavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Saquinavir induces the activity of ABCB1			[104], [221]
Trazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trazodone induces the activity of ABCB1			[90]
Phenytoin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenytoin induces the activity of ABCB1			[222]
Brilinta	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Brilinta inhibits the activity of ABCB1			[223]
Canagliflozin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Canagliflozin inhibits the activity of ABCB1			[223]
Fidaxomicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fidaxomicin inhibits the activity of ABCB1			[223]
Fluoxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluoxetine inhibits the activity of ABCB1			[223]
Mirabegron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mirabegron inhibits the activity of ABCB1			[223]
Rifaximin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifaximin inhibits the activity of ABCB1			[223]
Suvorexant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Suvorexant inhibits the activity of ABCB1			[223]
Tolvaptan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolvaptan inhibits the activity of ABCB1			[223]
Vemurafenib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vemurafenib inhibits the activity of ABCB1			[223]
Fosphenytoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fosphenytoin induces the activity of ABCB1			[224]
Donepezil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Donepezil inhibits the activity of ABCB1			[225]
Docetaxel	21 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Docetaxel induces the activity of ABCB1			[226]
Tretinoin	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin induces the activity of ABCB1			[227], [228]
Cisplatin	28 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin induces the activity of ABCB1			[229], [230]
Chenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic acid induces the activity of ABCB1			[193]
Vincristine	21 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine induces the activity of ABCB1			[231], [232]
Dinoprostone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dinoprostone induces the activity of ABCB1			[233]
Celecoxib	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the activity of ABCB1			[233], [234]
Metformin	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the activity of ABCB1			[235]
DT Modulation2	Metformin inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Metformin inhibits the reaction RELA protein results in increased expression of ABCB1 mRNA			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Metformin inhibits the reaction TNF protein results in increased expression of ABCB1 mRNA			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Metformin inhibits the reaction TNF protein results in increased expression of ABCB1 protein			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Metformin results in decreased expression of ABCB1 mRNA			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Metformin results in decreased expression of ABCB1 protein			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	PRKAA1 protein affects the reaction Metformin results in decreased expression of ABCB1 protein			[235]
Regulation Mechanism				Transcription Factor Info
Fluorouracil	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorouracil induces the activity of ABCB1			[236]
Ouabain	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ouabain induces the activity of ABCB1			[237], [238]
Epirubicin	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epirubicin induces the activity of ABCB1			[239], [240]
Probenecid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the activity of ABCB1			[241], [242]
Mitoxantrone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitoxantrone induces the activity of ABCB1			[243]
Daunorubicin	90 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daunorubicin induces the activity of ABCB1			[244]
Budesonide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide induces the activity of ABCB1			[245]
Oxycodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxycodone induces the activity of ABCB1			[246]
Valproic Acid	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid induces the activity of ABCB1			[247]
Diltiazem	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diltiazem inhibits the activity of ABCB1			[248]
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac induces the activity of ABCB1			[249]
Fenbufen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenbufen induces the activity of ABCB1			[249]
Acetylcysteine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine induces the activity of ABCB1			[250]
Floxacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flucloxacillin induces the activity of ABCB1			[251]
Acetaminophen	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen induces the activity of ABCB1			[252]
DT Modulation2	ABCB1 protein affects the susceptibility to Acetaminophen			[358]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased transport of Acetaminophen			[358]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Acetaminophen promotes the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[359]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Acetaminophen results in increased activity of ABCB1 protein			[358]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Acetaminophen results in increased expression of ABCB1 mRNA			[360]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Acetaminophen results in increased expression of ABCB1 protein			[358]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Verapamil inhibits the reaction Acetaminophen results in increased activity of ABCB1 protein			[358]
Regulation Mechanism				Transcription Factor Info
Hydroxyurea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydroxyurea induces the activity of ABCB1			[253]
Dimethyl Sulfoxide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dimethyl sulfoxide induces the activity of ABCB1			[254]
Vincamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincamine inhibits the activity of ABCB1			[255]
Rescinnamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rescinnamine induces the activity of ABCB1			[256]
Yohimbine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Yohimbine induces the activity of ABCB1			[256]
Dactinomycin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin induces the activity of ABCB1			[257]
Insulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Insulin inhibits the activity of ABCB1			[258]
Artemisinin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Artemisinin induces the activity of ABCB1			[259]
Vismodegib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vismodegib inhibits the activity of ABCB1			[260]
Conivaptan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Conivaptan inhibits the activity of ABCB1			[116]
Daclatasvir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daclatasvir inhibits the activity of ABCB1			[116]
Eliglustat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eliglustat inhibits the activity of ABCB1			[116]
Everolimus	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Everolimus inhibits the activity of ABCB1			[116]
Flibanserin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flibanserin inhibits the activity of ABCB1			[116]
Fosamprenavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fosamprenavir induces the activity of ABCB1			[116]
Ivacaftor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivacaftor inhibits the activity of ABCB1			[116]
Lapatinib	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lapatinib inhibits the activity of ABCB1			[116]
Ledipasvir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ledipasvir inhibits the activity of ABCB1			[116]
Pibrentasvir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pibrentasvir inhibits the activity of ABCB1			[116]
Posaconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Posaconazole inhibits the activity of ABCB1			[116]
Rolapitant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rolapitant inhibits the activity of ABCB1			[116]
Ticagrelor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ticagrelor inhibits the activity of ABCB1			[116]
Velpatasvir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Velpatasvir inhibits the activity of ABCB1			[116]
Captopril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Captopril inhibits the activity of ABCB1			[116]
Etravirine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etravirine inhibits the activity of ABCB1			[116]
Isradipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isradipine inhibits the activity of ABCB1			[116]
Lomitapide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lomitapide inhibits the activity of ABCB1			[116]
Naproxen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen inhibits the activity of ABCB1			[116]
Nilotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nilotinib inhibits the activity of ABCB1			[116]
Propafenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propafenone inhibits the activity of ABCB1			[116]
Ranolazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranolazine inhibits the activity of ABCB1			[116]
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the activity of ABCB1			[116]
Glecaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glecaprevir inhibits the activity of ABCB1			[261]
Vancomycin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vancomycin inhibits the activity of ABCB1			[262]
Eetuximab	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eetuximab induces the activity of ABCB1			[263]
Oxytetracycline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxytetracycline induces the activity of ABCB1			[264]
Micafungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Micafungin inhibits the activity of ABCB1			[265]
Betamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Betamethasone induces the activity of ABCB1			[266]
Bortezomib	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bortezomib inhibits the expression of ABCB1			[267]
Regulation Mechanism	via the inhibition of Transcription factor p65 (RELA)			Transcription Factor Info
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	Human chronic myeloid leukemia cells (K-562)
Pentoxifylline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pentoxifylline inhibits the expression of ABCB1			[268]
Regulation Mechanism	via the inhibition of Transcription factor p65 (RELA)			Transcription Factor Info
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Cell System	Human breast cancer cells (MDA-MB-231); human breast cancer cells (MDA-MB-231)
Ifosfamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ifosfamide increases the expression of ABCB1			[180]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inducer
Cell System	Human colon adenocarcinoma cells (LS180)
Topotecan	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Topotecan inhibits the expression of ABCB1			[269]
Regulation Mechanism	via the inhibition of Hypoxia-inducible factor 1-alpha (HIF1A)			Transcription Factor Info
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
Cell System	Human ovarian serous adenocarcinoma cells (Caov-3)
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the expression of ABCB1			[270]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
Cell System	Human ovarian endometrioid adenocarcinoma cells (A2780)
Aspirin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin results in increased activity of ABCB1 protein			[385]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Aspirin results in increased expression of ABCB1 mRNA			[386]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aspirin results in increased expression of ABCB1 protein			[386]
Regulation Mechanism				Transcription Factor Info
Drug Marketed but not Approved by US FDA
Formononetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formononetin increases the expression of ABCB1			[176]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	C57BL/6 mice
Estriol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estriol increases the expression of ABCB1			[177]
Regulation Mechanism	via enhancement of Estrogen receptor (ESR1)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS180)
Ginkgolide A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgolide A increases the expression of ABCB1			[179]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Demecolcine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Demecolcine increases the activity of ABCB1			[185]
Tocotrienol beta	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tocotrienol beta increases the expression of ABCB1			[187]
Tocotrienol delta	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tocotrienol delta increases the expression of ABCB1			[187]
Rotenone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone affects the activity of ABCB1			[189]
Drug in Phase 2/3 Trial
Silibinin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silibinin inhibits the transportation of Ritonavir by ABCB1			[81]
Affected Drug/Substrate	Ritonavir	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-MDR1
Butyric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyric Acid increases the expression of ABCB1			[188]
Drug in Phase 3 Trial
Curcumin	20 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin inhibits the transportation of Rhodamine 123 by ABCB1			[136]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Multidrug resistance human gastric carcinoma cell line (SGC7901/VCR)-MDR1
Istradefylline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Istradefylline inhibits the transportation of Atorvastatin by ABCB1			[157]
Affected Drug/Substrate	Atorvastatin	Modulation Type	Inhibition
Glycyrrhizin (high concentration)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhizin (high concentration) inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oltipraz increases the expression of ABCB1			[286]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulforafan inhibits the expression of ABCB1			[272]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan increases the expression of ABCB1			[318]
Afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Afimoxifene increases the expression of ABCB1			[330]
Asunaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asunaprevir inhibits the activity of ABCB1			[223]
Elobixibat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Elobixibat inhibits the activity of ABCB1			[223]
Trabectedin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trabectedin inhibits the activity of ABCB1			[336]
Isavuconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isavuconazole inhibits the activity of ABCB1			[116]
DT Modulation1	Resveratrol inhibits the expression of ABCB1			[688]
Regulation Mechanism	via the inhibition of Transcription factor p65 (RELA)			Transcription Factor Info
Affected Drug/Substrate	Oxaliplatin	Modulation Type	Inhibition
Cell System	Human colon carcinoma cells (HCT 116)
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate inhibits the expression of ABCB1			[685]
Regulation Mechanism	via enhancement of Transcription factor p65 (RELA)			Transcription Factor Info
Affected Drug/Substrate	5-fluorouracil	Modulation Type	Inhibition
Cell System	Human colon carcinoma cells (HCT-116)
Drug in Phase 2 Trial
DT Modulation1	Genistein induces the activity of ABCB1			[100]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MDR1
Icaritin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Icaritin inhibits the activity of ABCB1			[58]
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Ursolic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ursolic acid increases the expression of ABCB1			[274]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS180)
Colforsin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin increases the expression of ABCB1			[281]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of ABCB1			[300]
Camptothecin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Camptothecin inhibits the expression of ABCB1			[317]
Ethanol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol increases the expression of ABCB1			[329]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of ABCB1			[333]
Drug in Phase 1 Trial
Naringenin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringenin inhibits the transportation of Talinolol by ABCB1 (IC50 = 2409 microM)			[63]
Affected Drug/Substrate	Talinolol	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Naringenin inhibits the transportation of Rhodamine 123 by ABCB1			[82]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Model organism in vivo (rat)
Butyrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyrate increases the expression of ABCB1			[275]
Regulation Mechanism	via enhancement of Signal transducer and activator of transcription 3 (STAT3)			Transcription Factor Info
Cell System	Human lung adenocarcinoma cells (A549)
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of ABCB1			[278]
CCRIS-9277	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CCRIS-9277 inhibits the activity of ABCB1			[282]
LY-294002	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LY-294002 inhibits the expression of ABCB1			[304]
HSDB-3466	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	HSDB-3466 inhibits the activity of ABCB1			[210]
Luteolin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Luteolin inhibits the expression of ABCB1			[327]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of ABCB1			[334]
Tetrandrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrandrine inhibits the expression of ABCB1			[689]
Regulation Mechanism	via the inhibition of Nuclear factor NF-kappa-B p105 subunit (NFKB1)			Transcription Factor Info
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
Cell System	Human osteosarcoma cells (U-2OS)
SR-12813	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SR-12813 increases the expression of ABCB1			[654]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inducer
Cell System	Human breast adenocarcinoma cells (MDA-MB-231)
NS-398	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NS-398 increases the expression of ABCB1			[690]
Regulation Mechanism	via enhancement of Transcription factor Jun (JUN)			Transcription Factor Info
Affected Drug/Substrate	Vincristine	Modulation Type	Inducer
Cell System	Human colorectal cancer cells (HCT8)
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of ABCB1			[309]
Epinephrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epinephrine induces the activity of ABCB1			[335]
Dioscin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dioscin inhibits the expression of ABCB1			[686]
Regulation Mechanism	via enhancement of Nuclear factor NF-kappa-B p105 subunit (NFKB1)			Transcription Factor Info
Affected Drug/Substrate	Adriamycin	Modulation Type	Inhibition
Cell System	Human invasive breast carcinoma of no special type cells (MCF-7)
Discontinued Drug
Valspodar	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valspodar inhibits the transportation of Digoxin by ABCB1 (IC50 = 0.11 microM)			[8]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Valspodar inhibits the transportation of Digoxin by ABCB1 (IC50 = 0.0222 microM)			[42]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation3	Valspodar inhibits the transportation of Doxorubicin by ABCB1 (IC50 = 0.291 microM)			[10]
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation4	Valspodar inhibits the transportation of Vinblastine by ABCB1 (IC50 = 1.06 microM)			[10]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MDR1
DT Modulation5	Valspodar inhibits the transportation of Calcein AM by ABCB1 (Ki = 1.3 microM)			[1]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
DT Modulation6	Valspodar inhibits the transportation of Verapamil by ABCB1 (Ki = 0.134 microM)			[43]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
DT Modulation7	Valspodar inhibits the transportation of Cyclosporin A by ABCB1			[44]
Affected Drug/Substrate	Cyclosporine A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation8	Valspodar inhibits the transportation of Indinavir by ABCB1			[45]
Affected Drug/Substrate	Indinavir	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation9	Valspodar inhibits the transportation of Iodoaryl-azidoprazosin by ABCB1			[46]
Affected Drug/Substrate	Iodoaryl-azidoprazosin	Modulation Type	Inhibition
Cell System	CEM/VLB100 drug-resistant cells-MDR1
DT Modulation10	Valspodar inhibits the transportation of mitoxantrone by ABCB1			[47]
Affected Drug/Substrate	mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-MDR1
DT Modulation11	Valspodar inhibits the transportation of Nelfinavir by ABCB1			[45]
Affected Drug/Substrate	Nelfinavir	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation12	Valspodar inhibits the transportation of Saquinavir by ABCB1			[45]
Affected Drug/Substrate	Saquinavir	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation13	Valspodar inhibits the transportation of Calcein AM by ABCB1			[48]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Elacridar	53 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Elacridar inhibits the transportation of Colchicine by ABCB1 (IC50 = 0.027 microM)			[6]
Affected Drug/Substrate	Colchicine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Elacridar inhibits the transportation of Digoxin by ABCB1 (Ki = 0.44 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MDR1
DT Modulation3	Elacridar inhibits the transportation of Digoxin by ABCB1 (Ki = 0.39 microM)			[7]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation4	Elacridar inhibits the transportation of Digoxin by ABCB1 (IC50 = 0.18 microM)			[50]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation5	Elacridar inhibits the transportation of Digoxin by ABCB1 (IC50 = 0.055 microM)			[6]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation6	Elacridar inhibits the transportation of Vinblastine by ABCB1 (IC50 = 0.043 microM)			[6]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation7	Elacridar inhibits the transportation of Quinine by ABCB1			[51]
Affected Drug/Substrate	Quinine	Modulation Type	Inhibition
Cell System	LLC-PK1 porcine kidney epithelial (LLC-GA5-COL150) cells-MDR1
DT Modulation8	Elacridar inhibits the transportation of Mitoxantrone by ABCB1			[52]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Tariquidar	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tariquidar inhibits the transportation of Rhodamine 123 by ABCB1			[97]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Tariquidar inhibits the activity of ABCB1			[117]
Brecanavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Brecanavir inhibits the transportation of Calcein AM by ABCB1			[94]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
Miltirone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Miltirone inhibits the transportation of Doxorubicin by ABCB1			[135]
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Cell System	Human hepatoma HepaRG cells-MDR1
Epothilone D	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epothilone D inhibits the transportation of Calcein AM by ABCB1			[158]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Investigative Drug
Hyperforin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hyperforin inhibits the transportation of Ritonavir by ABCB1			[81]
Affected Drug/Substrate	Ritonavir	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Hyperforin induces the activity of ABCB1			[85]
Cell System	Human gastrointestinal epithelial cell line (LS-180)-MDR1
Kaempferol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kaempferol inhibits the transportation of Ritonavir by ABCB1 (IC50 = 146.7 microM)			[81]
Affected Drug/Substrate	Ritonavir	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-MDR1
Naringin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringin inhibits the transportation of Talinolol by ABCB1 (IC50 = 236 microM)			[63]
Affected Drug/Substrate	Talinolol	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
2'-Hydroxychalcone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2'-Hydroxychalcone inhibits the transportation of Calcein AM by ABCB1			[138]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Doxorubicin resistant A2780adr cell lines-MDR1
Daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daidzein induces the transportation of Rhodamine 123 by ABCB1			[145]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inducer
Cell System	Human colon carcinoma LS-180 cells (LS-180V)-MDR1
Corticosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Corticosterone induces the activity of ABCB1			[66]
Cell System	Human colon carcinoma cell lines (LS174T)-MDR1
Chlorogenic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorogenic acid inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Manganese	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Manganese increases the activity of ABCB1			[279]
N-ethylmaleimide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-ethylmaleimide inhibits the activity of ABCB1			[279]
Methoxyamphetamine beta	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methoxyamphetamine beta inhibits the activity of ABCB1			[282]
Chloropyrifos oxon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloropyrifos oxon increases the expression of ABCB1			[284]
PB28	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PB28 inhibits the expression of ABCB1			[287]
Lithocholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lithocholic Acid increases the expression of ABCB1			[293]
Phloxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phloxine inhibits the activity of ABCB1			[296]
Glucose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glucose inhibits the expression of ABCB1			[301]
Methylenedioxyamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methylenedioxyamphetamine increases the activity of ABCB1			[303]
3,3',4,5'-tetrahydroxystilbene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,3',4,5'-tetrahydroxystilbene increases the expression of ABCB1			[321]
27-hydroxycholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	27-hydroxycholesterol increases the expression of ABCB1			[326]
Patented Pharmaceutical Agent
Geneticin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Geneticin inhibits the expression of ABCB1			[295]
HSDB-595	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	HSDB-595 increases the expression of ABCB1			[302]
K-7174	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	K-7174 increases the expression of ABCB1			[306]
Ro-21-5104	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ro-21-5104 increases the expression of ABCB1			[307]
BMS 536924	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	BMS 536924 inhibits the expression of ABCB1			[312]
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK-J4 increases the expression of ABCB1			[316]
GW-7647	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW-7647 increases the expression of ABCB1			[322]
Drug Withdrawn
Astemizole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Astemizole inhibits the transportation of Digoxin by ABCB1 (IC50 = 2.73 microM)			[50]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MDR1
DT Modulation2	Astemizole inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Roxithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Roxithromycin inhibits the transportation of Digoxin by ABCB1 (IC50 = 15.4 microM)			[72]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Alprenolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alprenolol inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Sertindole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sertindole inhibits the transportation of Rhodamine 123 by ABCB1			[21]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Mouse T-lymphoma L5178-MDR1
Retigabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ezogabine inhibits the transportation of Digoxin by ABCB1			[159]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Flupenthixol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flupenthixol inhibits the activity of ABCB1			[280]
Terfenadine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Terfenadine inhibits the activity of ABCB1			[280]
Nimesulide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nimesulide inhibits the expression of ABCB1			[299]
Quinidine	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinidine inhibits the activity of ABCB1			[116]
Natural Product
Piperine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piperine inhibits the transportation of Cyclosporine A by ABCB1 (IC50 = 74.1 microM)			[59]
Affected Drug/Substrate	Cyclosporine A	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Piperine inhibits the transportation of Digoxin by ABCB1 (IC50 = 15.5 microM)			[59]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation3	Piperine increases the expression of ABCB1			[64]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Affected Drug/Substrate	Diltiazem	Modulation Type	Inducer
Cell System	Human colon adenocarcinoma cells (Caco-2)
DT Modulation4	Piperine inhibits the transportation of Fexofenadine by ABCB1			[65]
Affected Drug/Substrate	Fexofenadine	Modulation Type	Inhibition
Cell System	Model organism in vivo (rat)
DT Modulation5	Piperine induces the activity of ABCB1			[68]
Cell System	Multiple cell lines of human
DT Modulation1	3-methylquercetin promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased abundance of Quercetin			[461]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in decreased susceptibility to Doxorubicin inhibits the reaction Quercetin results in increased cleavage of PARP1 protein			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Genistein promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	morin promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Quercetin co-treated with Doxorubicin results in decreased expression of ABCB1 protein			[532]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Quercetin inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Quercetin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Quercetin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Quercetin inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Quercetin inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[543]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Quercetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Quercetin results in decreased expression of ABCB1			[633]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Quercetin results in decreased expression of ABCB1 mRNA			[634]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Quercetin results in decreased expression of ABCB1 protein			[634]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Quercetin results in increased expression of ABCB1 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Quercetin results in increased expression of ABCB1 protein			[421]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	VDR promotes the reaction Quercetin results in increased expression of ABCB1 mRNA			[421]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Verapamil inhibits the reaction ABCB1 protein results in decreased abundance of Quercetin			[461]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Verapamil promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
SGX301	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hypericin inhibits the transportation of Ritonavir by ABCB1 (IC50 = 247 microM)			[81]
Affected Drug/Substrate	Ritonavir	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-MDR1
DT Modulation2	Hypericin induces the activity of ABCB1			[85]
Cell System	Human gastrointestinal epithelial cell line (LS-180)-MDR1
Garlic extract	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Garlic extract induces the transportation of Rhodamine 123 by ABCB1			[83]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inducer
Cell System	Model organism in vivo (rat)
DT Modulation2	Garlic extract induces the transportation of Saquinavir by ABCB1			[84]
Affected Drug/Substrate	Saquinavir	Modulation Type	Inducer
Cell System	Healthy people
St Johns wort extract	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	St Johns wort extract inhibits the transportation of Digoxin by ABCB1 (IC50 = 15.4 microM)			[89]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	St Johns wort extract increases the expression of ABCB1			[98]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Sprague-Dawley rats
Gingerol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gingerol inhibits the transportation of Daunorubicin by ABCB1			[99]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	Multiple drug-resistant human KB carcinoma cell line (KB-C2)-MDR1
DT Modulation2	Gingerol inhibits the transportation of Rhodamine 123 by ABCB1			[99]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Multiple drug-resistant human KB carcinoma cell line (KB-C2)-MDR1
Genistein	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein induces the transportation of Sorafenib by increasing ABCB1 expression at translational and transcriptional levels			[100]
Affected Drug/Substrate	Sorafenib	Modulation Type	Inducer
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MDR1
Ginkgo biloba extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgo biloba extract inhibits the transportation of Digoxin by ABCB1 (IC50 = 23.6 microM)			[89]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Acetochlor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetochlor inhibits the transportation of Paclitaxel by ABCB1 (IC50 = 25 microM)			[122]
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
Alachlor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alachlor inhibits the transportation of Paclitaxel by ABCB1 (IC50 = 25 microM)			[122]
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
Cigarette smoke condensate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 224.3 microM)			[123]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human hepatoma HepaRG cells-MDR1
Chlordecone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlordecone inhibits the transportation of Rhodamine 123 by ABCB1 (IC50 = 138.8 microM)			[124]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-MDR1
Allicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Allicin inhibits the transportation of Ritonavir by ABCB1 (IC50 = 119.1 microM)			[81]
Affected Drug/Substrate	Ritonavir	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-MDR1
6,7-dihydroxybergamottin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6,7-dihydroxybergamottin inhibits the transportation of Talinolol by ABCB1 (IC50 = 34 microM)			[63]
Affected Drug/Substrate	Talinolol	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
6,7-epoxybergamottin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6,7-epoxybergamottin inhibits the transportation of Talinolol by ABCB1 (IC50 = 0.7 microM)			[63]
Affected Drug/Substrate	Talinolol	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Endosulfan	20 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the transportation of Verapamil by ABCB1 (IC50 = 1.5 microM)			[126]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Phosalone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phosalone inhibits the transportation of Verapamil by ABCB1 (IC50 = 1.5 microM)			[126]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Propiconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propiconazole inhibits the transportation of Verapamil by ABCB1 (IC50 = 1.5 microM)			[126]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
Pyrethroids	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrethroids inhibits the transportation of Verapamil by ABCB1 (IC50 = 65.5 microM)			[127]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MDR1
Tetramethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethrin inhibits the transportation of Verapamil by ABCB1 (IC50 = 100 microM)			[127]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MDR1
Diazinon	21 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon inhibits the transportation of Verapamil by ABCB1 (IC50 = 58.4 microM)			[129]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	NIH 3T3 cells-MDR1
DT Modulation1	ABCB1 affects the susceptibility to Curcumin			[466]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to Curcumin			[467]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Calcitriol co-treated with Curcumin inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Calcitriol inhibits the reaction Curcumin co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Curcumin analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Curcumin analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Vinblastine			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Curcumin analog results in decreased expression of ABCB1 protein			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Curcumin co-treated with Calcitriol inhibits the reaction Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Curcumin co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Curcumin inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Curcumin inhibits the reaction ABCB1 protein results in decreased susceptibility to Vinblastine			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Curcumin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[469]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Curcumin inhibits the reaction Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Curcumin inhibits the reaction Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Curcumin inhibits the reaction Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Curcumin inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Curcumin results in decreased expression of ABCB1 mRNA			[470]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein			[471]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	sulfinosine co-treated with Curcumin results in decreased expression of ABCB1 mRNA			[472]
Regulation Mechanism				Transcription Factor Info
Hypericum perforatum	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hypericum perforatum induces the transportation of Amitriptyline by ABCB1			[137]
Affected Drug/Substrate	Amitriptyline	Modulation Type	Inducer
Cell System	Depression patients
Glabridin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glabridin inhibits the transportation of Daunorubicin by ABCB1			[139]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	Multiple drug-resistant human KB carcinoma cell line (KB-C2)-MDR1
Glycyrrhetinic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhetinic acid inhibits the transportation of Daunorubicin by ABCB1			[139]
Affected Drug/Substrate	Daunorubicin	Modulation Type	Inhibition
Cell System	Multiple drug-resistant human KB carcinoma cell line (KB-C2)-MDR1
Echinacea purpurea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Echinacea purpurea inhibits the transportation of Digoxin by ABCB1			[140]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Echinacea extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Echinacea extract inhibits the transportation of Digoxin by ABCB1			[140]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Fructose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fructose inhibits the transportation of Digoxin by decreasing the expression and activity of the ABCB1			[141]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Model organism in vivo (Male Sprague-Dawley rats)
(-)Epicatechin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(-)Epicatechin induces the transportation of LDS-751 by ABCB1			[142]
Affected Drug/Substrate	LDS-751	Modulation Type	Inducer
Cell System	NIH-3T3-G185-MDR1
Chloroacetanilides	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroacetanilides inhibits the transportation of Paclitaxel by ABCB1			[122]
Affected Drug/Substrate	Paclitaxel	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-MDR1
Q-100154	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginsenoside Rg3 inhibits the transportation of Rhodamine 123 by ABCB1 in a competitive manner			[144]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Multidrug-resistant human fibroblast carcinoma cell line (KBV20C)-MDR1
Sesamin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sesamin inhibits the transportation of Rhodamine 123 by significantly increasing the mRNA expression of ABCB1			[145]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human colon carcinoma LS-180 cells (LS-180V)-MDR1
Schisandra chinensis extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Schisandra chinensis extract inhibits the transportation of Talinolol by ABCB1			[146]
Affected Drug/Substrate	Talinolol	Modulation Type	Inhibition
Cell System	Healthy people
Xanthohumol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Xanthohumol inhibits the transportation of Tetraethylammonium by ABCB1			[147]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2); LLC-PK1 vesicles
Fangchinoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fangchinoline inhibits the transportation of Verapamil by ABCB1			[148]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human colon adenocarcinoma cell line (HCT15)-MDR1
Tetrandine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrandine inhibits the transportation of Verapamil by ABCB1			[148]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human colon adenocarcinoma cell line (HCT15)-MDR1
Ginseng extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginseng extracts inhibits the transportation of Verapamil by ABCB1			[160]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Acteoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acteoside inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Agnuside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Agnuside inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Catechin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Catechin inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Negundoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Negundoside induces the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Oleanolic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oleanolic acid induces the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Picroside-I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Picroside-I induces the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Picroside-II	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Picroside-II inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Piperine (high concentration)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piperine (high concentration) inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Santonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Santonin inhibits the activity of ABCB1			[166]
Cell System	Model organism in vivo (rat)
Echinacea pallida roots extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Echinacea pallida roots extract inhibits the activity of ABCB1			[167]
Cell System	Human proximal tubule HK-2 cell line (HK-2)-MDR1
Nobiletin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nobiletin inhibits the activity of ABCB1			[168]
Cell System	Model organism in vivo (rat)
Rutin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rutin inhibits the activity of ABCB1			[168]
Cell System	Model organism in vivo (rat)
Tangeretin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tangeretin inhibits the activity of ABCB1			[168]
Cell System	Model organism in vivo (rat)
Protopanaxatriol ginsenoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Protopanaxatriol ginsenoside inhibits the activity of ABCB1			[169]
Cell System	Doxorubicin-resistant Acute myelogenous leukemia cell line (AML-2/D100)-MDR1
Cyanidin-3-rutinoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyanidin-3-rutinoside inhibits the activity of ABCB1			[170]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Delphinidin-3-Glucoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Delphinidin-3-Glucoside inhibits the activity of ABCB1			[170]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Malvidin-3-galactoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Malvidin-3-galactoside inhibits the activity of ABCB1			[170]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Malvidin-3-glucoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Malvidin-3-glucoside inhibits the activity of ABCB1			[170]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Pelargonidin-3,5-diglucoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pelargonidin-3,5-diglucoside inhibits the activity of ABCB1			[170]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Tetrahydrocurcumin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrahydrocurcumin inhibits the activity of ABCB1			[171]
Cell System	Multidrug-resistant subclone KB-V-1 cells
Ginkgolide B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgolide B increases the expression of ABCB1			[272]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human umbilical vein endothelial cells (HUVECs)
Tamarixetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamarixetin increases the expression of ABCB1			[273]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS180)
6-bromoindirubin-3'-oxime	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-bromoindirubin-3'-oxime increases the expression of ABCB1			[289]
Bergamottin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bergamottin increases the expression of ABCB1			[291]
Chrysin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chrysin inhibits the activity of ABCB1			[297]
Gallic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gallic Acid inhibits the expression of ABCB1			[298]
Mangiferin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mangiferin increases the expression of ABCB1			[298]
Notoginsenoside R1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Notoginsenoside R1 increases the expression of ABCB1			[308]
Clove Oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clove Oil increases the expression of ABCB1			[319]
Lemongrass oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lemongrass oil increases the expression of ABCB1			[319]
Peppermint oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Peppermint oil increases the expression of ABCB1			[319]
Flavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flavone inhibits the expression of ABCB1			[327]
Thapsigargin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thapsigargin inhibits the expression of ABCB1			[328]
Resveratrol	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lipopolysaccharides co-treated with Resveratrol results in decreased expression of ABCB1 mRNA			[638]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	methoxy poly(ethylene glycol-co-epsilon-caprolactone) co-treated with tocophersolan co-treated with Resveratrol results in decreased expression of ABCB1 protein			[639]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Resveratrol co-treated with Doxorubicin results in decreased expression of ABCB1 mRNA			[545]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Resveratrol co-treated with Doxorubicin results in decreased expression of ABCB1 mRNA which results in increased uptake of Doxorubicin			[545]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Resveratrol inhibits the reaction Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of CTNNB1 protein which results in increased expression of ABCB1 mRNA			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Resveratrol inhibits the reaction Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of CTNNB1 protein which results in increased expression of ABCB1 protein			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Resveratrol inhibits the reaction Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of RELA protein which results in increased expression of ABCB1 mRNA			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Resveratrol inhibits the reaction Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of RELA protein which results in increased expression of ABCB1 protein			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Resveratrol inhibits the reaction Rifampin results in increased expression of ABCB1 protein			[312]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Resveratrol results in increased expression of ABCB1 mRNA			[566]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Resveratrol results in increased expression of ABCB1 protein			[566]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Resveratrol results in increased susceptibility to Doxorubicin which results in decreased expression of ABCB1 mRNA			[546]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Resveratrol results in increased susceptibility to Doxorubicin which results in decreased expression of ABCB1 protein			[546]
Regulation Mechanism				Transcription Factor Info
Rhein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rhein inhibits the expression of ABCB1			[687]
Regulation Mechanism	via the inhibition of Signal transducer and activator of transcription 3 (STAT3)			Transcription Factor Info
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Cell System	Human cervical epithelioid carcinoma cells (HeLaS3)
Plant Extract
Mangifera indica extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mangifera indica extract inhibits the expression of ABCB1			[298]
Basil oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Basil oil increases the expression of ABCB1			[319]
Caraway oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caraway oil increases the expression of ABCB1			[319]
Cinnamon oil, bark	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cinnamon oil, bark increases the expression of ABCB1			[319]
Coriander oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coriander oil increases the expression of ABCB1			[319]
Juniper berry oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Juniper berry oil increases the expression of ABCB1			[319]
Plant Extracts	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts inhibits the activity of ABCB1			[167]
Dietary Constituent
Grapefruit juice	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Grapefruit juice inhibits the transportation of Digoxin by ABCB1			[62]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation2	Grapefruit juice peel inhibits the transportation of Digoxin by ABCB1			[62]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation3	Grapefruit juices induces the transportation of Fexofenadine by ABCB1			[62]
Affected Drug/Substrate	Fexofenadine	Modulation Type	Inducer
Cell System	Transfected cell lines-MDR1
DT Modulation4	Grapefruit juices inhibits the transportation of Talinolol by ABCB1			[63]
Affected Drug/Substrate	Talinolol	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
DT Modulation5	Grapefruit juice induces the activity of ABCB1			[67]
Cell System	Madin darby canine kidney strain cell line (MDCK)-MDR1
Calcium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcium deficiency inhibits the reaction ABCB1 protein results in increased export of Xanthenes			[422]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Calcium inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
o,p'-dichlorodiphenyltrichloroethane (DDT)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	O,p'-DDT inhibits the transportation of Verapamil by ABCB1 (IC50 = 7.8 microM)			[128]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MDR1
p,p'-dichlorodiphenyltrichloroethane (DDT)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p,p'-DDT inhibits the transportation of Verapamil by ABCB1 (IC50 = 3.8 microM)			[128]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MDR1
p,p'-tetrachlorodiphenylethane (DDD)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p,p'-DDD inhibits the transportation of Verapamil by ABCB1 (IC50 = 10.7 microM)			[128]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MDR1
p,p'-dichlorodiphenyldichloroethane (DDE)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p,p'-DDE inhibits the transportation of Verapamil by ABCB1			[128]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MDR1
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of ABCB1			[271]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Killifish renal proximal tubule cells
Dichlorodiphenyl Dichloroethylene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene inhibits the expression of ABCB1			[285]
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A inhibits the activity of ABCB1			[305]
Lead	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene polymorphism affects the abundance of Lead			[582]
Regulation Mechanism				Transcription Factor Info
Mercury	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene SNP affects the susceptibility to and affects the abundance of Mercury			[584]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene SNP affects the susceptibility to Mercury which affects the abundance of Mercury			[585]
Regulation Mechanism				Transcription Factor Info
Pharmaceutical excipient
PEG 300	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PEG 300 inhibits the transportation of Ranitidine by ABCB1			[143]
Affected Drug/Substrate	Ranitidine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
PEG 400	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PEG 400 inhibits the transportation of Ranitidine by ABCB1			[143]
Affected Drug/Substrate	Ranitidine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MDR1
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of ABCB1			[313]
DT Modulation2	Aflatoxin B1 results in decreased methylation of ABCB1 gene			[313]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of ABCB1 intron			[368]
Regulation Mechanism				Transcription Factor Info
fumonisin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fumonisin B1 inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[328]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Indole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indole increases the expression of ABCB1			[276]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human Caucasian colon adenocarcinoma cells (LS180)
Chlorpyrifos	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos increases the expression of ABCB1			[277]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Rainbow trout intestine isolates
Cycloheximide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cycloheximide increases the expression of ABCB1			[256]
Sarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sarin inhibits the expression of ABCB1			[294]
Avermectin B1a	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Avermectin B1a inhibits the activity of ABCB1			[205]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of ABCB1			[314]
Sinensetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sinensetin inhibits the activity of ABCB1			[320]
Okadaic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid increases the expression of ABCB1			[323]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrylamide increases the expression of ABCB1			[325]
Morin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Morin increases the activity of ABCB1			[327]
Carcinogen
2-acetylaminofluorene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-acetylaminofluorene inhibits the expression of ABCB1			[26]
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of ABCB1			[332]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the susceptibility to Arsenic			[377]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased export of Arsenic			[378]
Regulation Mechanism				Transcription Factor Info
Benzene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 affects the susceptibility to Benzene			[396]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzene results in increased expression of ABCB1 mRNA			[397]
Regulation Mechanism				Transcription Factor Info
Cadmium	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein inhibits the reaction Cadmium results in increased abundance of Ceramides			[413]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to Cadmium			[413]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cadmium inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
Nickel	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nickel results in decreased expression of ABCB1 mRNA			[602]
Regulation Mechanism				Transcription Factor Info
Fungicide
Triadimefon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triadimefon increases the expression of ABCB1			[292]
Pesticide/Insecticide
DT Modulation1	Chlorpyrifos binds to ABCB1 protein			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Chlorpyrifos inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
Fenvalerate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenvalerate inhibits the activity of ABCB1			[129]
Dieldrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dieldrin increases the expression of ABCB1			[124]
Heptachlor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Heptachlor increases the expression of ABCB1			[124]
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of ABCB1			[315]
DDT	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DDT metabolite results in decreased activity of ABCB1 protein			[128]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	DDT results in increased expression of ABCB1 mRNA			[285]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
DT Modulation1	ABCB1 protein results in decreased susceptibility to Endosulfan			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased export of Endosulfan			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Diazinon promotes the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Diazinon promotes the reaction Endosulfan results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Endosulfan binds to ABCB1 protein			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Endosulfan co-treated with Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Endosulfan co-treated with Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Endosulfan inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Endosulfan inhibits the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Endosulfan inhibits the reaction phosalone results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Endosulfan metabolite results in decreased activity of ABCB1 protein			[128]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Endosulfan promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Endosulfan promotes the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Endosulfan results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	phosalone inhibits the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	phosalone inhibits the reaction Endosulfan results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	propiconazole promotes the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	propiconazole promotes the reaction Endosulfan results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
Isosafrole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isosafrole increases the expression of ABCB1			[75]
Diethylhexyl Phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of ABCB1			[288]
Lithium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lithium Chloride increases the expression of ABCB1			[289]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the activity of ABCB1			[305]
Chlordan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlordan increases the expression of ABCB1			[124]
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde increases the expression of ABCB1			[310]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of ABCB1			[311]
2-methylindole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methylindole increases the expression of ABCB1			[324]
3-methylquercetin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-methylquercetin inhibits the expression of ABCB1			[327]
Herbicide
metolachlor	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	metolachlor increases the activity of ABCB1			[122]
Glyphosate	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
Paraquat	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the reaction Doxorubicin results in decreased susceptibility to Paraquat			[521]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased export of and results in decreased susceptibility to Paraquat			[620]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Doxorubicin results in increased expression of ABCB1 protein which results in decreased susceptibility to Paraquat			[521]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	valspodar inhibits the reaction ABCB1 protein results in increased export of Paraquat			[620]
Regulation Mechanism				Transcription Factor Info
Peptide
Carbon Tetrachloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbon Tetrachloride increases the expression of ABCB1			[283]
Chemical Compound
DT Modulation1	ABCB1 protein affects the export of Cyclosporine			[475]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the susceptibility to Cyclosporine			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the transport of Cyclosporine			[476]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein polymorphism affects the susceptibility to Cyclosporine			[477]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 protein results in increased transport of Cyclosporine			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Cyclosporine affects the expression of ABCB1 mRNA			[478]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Cyclosporine binds to and results in decreased activity of ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Cyclosporine binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Cyclosporine co-treated with Raloxifene Hydrochloride results in decreased expression of ABCB1 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Cyclosporine co-treated with Raloxifene Hydrochloride results in decreased expression of ABCB1 protein			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Cyclosporine inhibits the reaction ABCB1 protein affects the export of calcein AM			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Cyclosporine inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Cyclosporine inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Cyclosporine inhibits the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Cyclosporine inhibits the reaction ABCB1 protein results in increased chemical synthesis of globotriaosylceramide			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Cyclosporine inhibits the reaction ABCB1 protein results in increased chemical synthesis of Glucosylceramides			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Cyclosporine inhibits the reaction ABCB1 protein results in increased chemical synthesis of Lactosylceramides			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Cyclosporine inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[481]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Cyclosporine inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Cyclosporine inhibits the reaction ABCB1 protein results in increased export of Fluorescent Dyes			[123]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Cyclosporine inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Cyclosporine inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Cyclosporine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Cyclosporine results in decreased activity of ABCB1 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Cyclosporine results in decreased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of benzoylaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of benzoylhypaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of benzoylmesaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of hypaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of mesaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Cyclosporine results in decreased activity of ABCB1 protein which results in increased susceptibility to Paclitaxel			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Cyclosporine results in decreased expression of ABCB1 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Cyclosporine results in decreased expression of ABCB1 protein			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Cyclosporine results in increased expression of ABCB1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Plant Extracts affects the reaction ABCB1 protein results in increased transport of Cyclosporine			[484]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased transport of Verapamil			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Colchicine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclosporine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Demecolcine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Diazinon promotes the reaction Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Diazinon promotes the reaction Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Endosulfan co-treated with Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Endosulfan co-treated with Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Glycyrrhetinic Acid inhibits the reaction Verapamil results in increased activity of ABCB1 protein			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	phosalone co-treated with Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	phosalone co-treated with Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	propiconazole promotes the reaction Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	propiconazole promotes the reaction Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Verapamil affects the reaction ABCB1 protein results in increased export of Tacrolimus			[660]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Verapamil binds to and affects the activity of ABCB1 protein			[365]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Verapamil binds to and results in decreased activity of ABCB1 protein			[505]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Verapamil binds to and results in decreased activity of ABCB1 protein inhibits the reaction sodium arsenite promotes the reaction ABCB1 protein results in increased secretion of calcein AM			[417]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Verapamil binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Verapamil binds to and results in decreased activity of ABCB1 protein which results in decreased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide			[540]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Verapamil co-treated with kaempferol results in decreased expression of ABCB1 mRNA			[214]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Verapamil co-treated with kaempferol results in decreased expression of ABCB1 protein			[214]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Verapamil inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCB1 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Verapamil inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Verapamil inhibits the reaction ABCB1 protein affects the transport of traumatic acid			[598]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Verapamil inhibits the reaction ABCB1 protein affects the uptake of Vinblastine			[678]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Verapamil inhibits the reaction ABCB1 protein results in decreased abundance of Quercetin			[461]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Verapamil inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Verapamil inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Verapamil inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Verapamil inhibits the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[359]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Verapamil inhibits the reaction ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Verapamil inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[402]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Verapamil inhibits the reaction ABCB1 protein results in increased export of Fluorescent Dyes			[365]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Verapamil inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Verapamil inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[640]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	Verapamil inhibits the reaction ABCB1 protein results in increased transport of cyazofamid			[473]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[505]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Doxorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Verapamil inhibits the reaction ABCB1 protein results in increased transport of huperzine A			[549]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Verapamil inhibits the reaction ABCB1 protein results in increased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide			[540]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Paclitaxel			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Verapamil inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[556]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Sulpiride			[657]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Vinblastine			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	Verapamil inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Verapamil inhibits the reaction Acetaminophen results in increased activity of ABCB1 protein			[358]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Verapamil inhibits the reaction Doxorubicin results in increased activity of ABCB1 protein			[359]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Verapamil inhibits the reaction Methoxsalen results in decreased activity of ABCB1 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Verapamil inhibits the reaction Methoxsalen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Verapamil inhibits the reaction tangeretin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	Verapamil inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Verapamil promotes the reaction ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate			[355]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Verapamil promotes the reaction galangin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	Verapamil promotes the reaction kaempferol results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation58	Verapamil promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation59	Verapamil promotes the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation60	Verapamil promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation61	Verapamil results in decreased activity of ABCB1 protein			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation62	Verapamil results in decreased activity of ABCB1 protein which results in decreased export of calcein AM			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation63	Verapamil results in decreased activity of ABCB1 protein which results in decreased export of Rhodamine 123			[536]
Regulation Mechanism				Transcription Factor Info
DT Modulation64	Verapamil results in decreased activity of ABCB1 protein which results in decreased export of Topotecan			[297]
Regulation Mechanism				Transcription Factor Info
DT Modulation65	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of benzoylaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation66	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of benzoylhypaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation67	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of benzoylmesaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation68	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of Digoxin			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation69	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of hypaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation70	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of mesaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation71	Verapamil results in decreased activity of ABCB1 protein which results in increased susceptibility to Doxorubicin			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation72	Verapamil results in decreased activity of ABCB1 protein which results in increased susceptibility to Paclitaxel			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation73	Verapamil results in decreased activity of ABCB1 protein which results in increased uptake of fluorexon			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation74	Verapamil results in decreased expression of ABCB1 protein			[201]
Regulation Mechanism				Transcription Factor Info
DT Modulation75	Verapamil results in increased activity of ABCB1 protein			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation76	Verapamil results in increased expression of ABCB1 mRNA			[631]
Regulation Mechanism				Transcription Factor Info
DT Modulation77	Vinblastine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation78	yu ping feng san inhibits the reaction Verapamil results in increased activity of ABCB1 protein			[679]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the uptake of Quinine analog			[635]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	3-methylquercetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5,7-dimethoxyflavone inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	5-hydroxyflavone inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	baicalein inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	baicalein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	biochanin A inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	biochanin A promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	daidzein inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Elacridar binds to and results in decreased activity of ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Elacridar binds to and results in decreased activity of ABCB1 protein which results in decreased export of amprenavir			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Elacridar binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Elacridar binds to and results in decreased activity of ABCB1 protein which results in decreased export of Vinblastine			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Elacridar inhibits the reaction ABCB1 protein affects the transport of 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine			[548]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Elacridar inhibits the reaction ABCB1 protein results in increased export of Estriol			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Elacridar inhibits the reaction ABCB1 protein results in increased export of Estrone			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Aldosterone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Beclomethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Dexamethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Fluticasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Hydrocortisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Methylprednisolone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Prednisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Elacridar inhibits the reaction ABCB1 protein results in increased transport of huperzine A			[549]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Elacridar inhibits the reaction ABCB1 protein results in increased transport of Quinacrine			[550]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Elacridar results in decreased activity of ABCB1 protein			[551]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Elacridar results in decreased activity of ABCB1 protein which results in increased uptake of Digoxin			[506]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Elacridar results in decreased export of ABCB1 protein results in increased transport of Ethinyl Estradiol			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	flavone promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	formononetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	galangin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	glycitein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	glycitein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	isovitexin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	kaempferide inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	naringenin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	naringenin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	naringin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Quercetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	quercitrin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Rutin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Silybin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	tangeretin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	taxifolin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Troleandomycin inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Troleandomycin inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased transport of Lovastatin			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased transport of Lovastatin analog			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Lovastatin analog inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Lovastatin analog results in decreased activity of ABCB1 protein			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the uptake of Vinblastine			[678]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to Vinblastine			[591]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein results in increased transport of Vinblastine			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Amiodarone inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Vinblastine			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Vinblastine which results in decreased susceptibility to Vinblastine			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Clotrimazole inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	cnidiadin inhibits the reaction ABCB1 protein results in increased export of Vinblastine			[680]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Curcumin analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Vinblastine			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Curcumin inhibits the reaction ABCB1 protein results in decreased susceptibility to Vinblastine			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Cyclosporine inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Diazinon affects the reaction ABCB1 protein results in increased transport of Vinblastine			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Elacridar binds to and results in decreased activity of ABCB1 protein which results in decreased export of Vinblastine			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Erythromycin inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Glycyrrhetinic Acid affects the activity of ABCB1 protein which affects the susceptibility to Vinblastine			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Ketoconazole inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Miconazole inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	NR1I2 protein promotes the reaction Vinblastine results in increased expression of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Reserpine inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Sesquiterpenes analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Vinblastine			[149]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	sodium arsenite results in increased expression of ABCB1 protein which results in decreased susceptibility to Vinblastine			[278]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Troleandomycin inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Verapamil inhibits the reaction ABCB1 protein affects the uptake of Vinblastine			[678]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Vinblastine			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Vinblastine binds to ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Vinblastine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Vinblastine results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Vinblastine results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Vinblastine results in increased expression of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased transport of Ketoconazole			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ketoconazole binds to and results in decreased activity of ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoconazole binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ketoconazole inhibits the reaction 3,3'-diindolylmethane results in increased expression of ABCB1 mRNA			[347]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Ketoconazole inhibits the reaction ABCB1 protein affects the transport of Digoxin			[503]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Ketoconazole inhibits the reaction ABCB1 protein results in increased chemical synthesis of globotriaosylceramide			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Ketoconazole inhibits the reaction ABCB1 protein results in increased chemical synthesis of Glucosylceramides			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Ketoconazole inhibits the reaction ABCB1 protein results in increased chemical synthesis of Lactosylceramides			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Ketoconazole inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Ketoconazole inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Ketoconazole inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[502]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Ketoconazole inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Ketoconazole inhibits the reaction Ethanol results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Ketoconazole inhibits the reaction Hydrogen Peroxide affects the expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction piperine results in increased expression of ABCB1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction piperine results in increased expression of ABCB1 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction Rifampin results in increased expression of ABCB1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction Rifampin results in increased expression of ABCB1 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Ketoconazole inhibits the reaction Paclitaxel results in increased expression of ABCB1 mRNA			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Ketoconazole inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Ketoconazole inhibits the reaction Rifampin results in increased expression of ABCB1 mRNA			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Ketoconazole inhibits the reaction Rifampin results in increased expression of ABCB1 protein			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Ketoconazole inhibits the reaction Spironolactone results in increased expression of ABCB1 protein			[178]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Ketoconazole inhibits the reaction titanium dioxide results in increased expression of ABCB1 mRNA			[213]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Ketoconazole results in decreased activity of ABCB1 protein			[391]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Ketoconazole results in decreased activity of ABCB1 protein which results in increased uptake of Digoxin			[506]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Ketoconazole results in decreased expression of ABCB1 mRNA			[502]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dactinomycin inhibits the reaction Progesterone results in increased expression of ABCB1 mRNA			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dactinomycin inhibits the reaction Progesterone results in increased expression of ABCB1 protein			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Progesterone results in increased expression of ABCB1 mRNA			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Progesterone results in increased expression of ABCB1 protein			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 exon polymorphism affects the susceptibility to Etoposide			[558]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Celecoxib results in decreased expression of ABCB1 which results in increased susceptibility to Etoposide			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Etoposide results in increased expression of ABCB1 mRNA			[334]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Etoposide results in increased expression of ABCB1 protein			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of CTNNB1 protein which results in increased expression of ABCB1 protein inhibits the reaction Etoposide results in increased activity of CASP3 protein			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of RELA protein which results in increased expression of ABCB1 protein inhibits the reaction Etoposide results in increased activity of CASP3 protein			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cycloheximide promotes the reaction Reserpine results in increased expression of ABCB1 mRNA			[256]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Reserpine inhibits the reaction ABCB1 protein affects the export of calcein AM			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Reserpine inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Reserpine inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Reserpine results in decreased activity of ABCB1 protein			[637]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Reserpine results in increased expression of ABCB1 mRNA			[256]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Reserpine results in increased expression of ABCB1 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Miconazole inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Miconazole inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Trifluoperazine results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	hyperforin inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	hypericin inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	kaempferol inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Quercetin inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Erythromycin inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Erythromycin inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[556]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nifedipine results in increased expression of ABCB1 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Amiodarone inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Amiodarone inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Amiodarone inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Amiodarone results in decreased activity of ABCB1 protein			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased secretion of Hydrocortisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Hydrocortisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Hydrocortisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 affects the metabolism of Morphine			[594]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the transport of Itraconazole			[577]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Itraconazole affects the activity of ABCB1 protein			[475]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Itraconazole inhibits the reaction ABCB1 protein affects the transport of Digoxin			[503]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Itraconazole promotes the reaction ABCB1 gene SNP affects the susceptibility to fexofenadine			[564]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Itraconazole results in decreased activity of ABCB1 protein			[577]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	6-OH-BDE-47 inhibits the reaction ABCB1 protein results in increased export of Paclitaxel			[612]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene polymorphism affects the metabolism of Paclitaxel			[613]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 gene SNP affects the susceptibility to Paclitaxel			[614]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 mRNA results in decreased susceptibility to Paclitaxel			[615]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 mRNA results in increased susceptibility to Paclitaxel			[512]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 protein affects the reaction acetochlor results in increased susceptibility to Paclitaxel			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCB1 protein affects the reaction alachlor results in increased susceptibility to Paclitaxel			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB1 protein affects the reaction metolachlor results in increased susceptibility to Paclitaxel			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCB1 protein affects the susceptibility to Paclitaxel			[606]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	ABCB1 protein results in decreased susceptibility to Paclitaxel			[616]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	ABCB1 protein results in decreased uptake of Paclitaxel			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	ABCB1 protein results in increased export of and affects the susceptibility to Paclitaxel			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	ABCB1 protein results in increased export of Paclitaxel			[612]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	ABCB1 protein results in increased transport of Paclitaxel			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Calcitriol co-treated with Curcumin inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Calcitriol inhibits the reaction Curcumin co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Calcitriol inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Paclitaxel			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Paclitaxel which results in decreased susceptibility to Paclitaxel			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	CEP 33779 inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	cinchonine analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	cinchonine inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Crizotinib inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Curcumin analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Curcumin co-treated with Calcitriol inhibits the reaction Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Curcumin co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Curcumin inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[468]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Curcumin inhibits the reaction Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Curcumin inhibits the reaction Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Curcumin inhibits the reaction Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Curcumin inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	CXCL8 results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Paclitaxel			[450]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	CXCL8 results in increased expression of ABCB1 protein which results in decreased susceptibility to Paclitaxel			[450]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Cyclosporine results in decreased activity of ABCB1 protein which results in increased susceptibility to Paclitaxel			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	HIF1A protein affects the reaction Paclitaxel co-treated with IL6 protein results in increased expression of ABCB1 protein			[531]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	Ketoconazole inhibits the reaction Paclitaxel results in increased expression of ABCB1 mRNA			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Ketoconazole inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	NR1I2 protein promotes the reaction Paclitaxel results in increased expression of and results in increased activity of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Paclitaxel co-treated with IL6 protein results in increased expression of ABCB1 protein			[531]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Paclitaxel results in increased activity of ABCB1 protein			[617]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Paclitaxel results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Paclitaxel results in increased expression of ABCB1 mRNA			[449]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Paclitaxel results in increased expression of ABCB1 protein			[449]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Cisplatin			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Doxorubicin			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Fluorouracil			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Vincristine			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Paclitaxel results in increased expression of and binds to and results in increased activity of ABCB1 protein			[338]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	pinostrobin inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	propiconazole inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[556]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Quinidine inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	tectochrysin inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	valspodar results in decreased activity of ABCB1 protein which results in increased susceptibility to Paclitaxel			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Verapamil inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Paclitaxel			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation58	Verapamil results in decreased activity of ABCB1 protein which results in increased susceptibility to Paclitaxel			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Celecoxib results in decreased expression of ABCB1 which results in increased susceptibility to Tamoxifen			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NR1I2 protein promotes the reaction Tamoxifen results in increased expression of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tamoxifen inhibits the reaction Estradiol results in decreased expression of ABCB1 protein			[195]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tamoxifen results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tamoxifen results in increased expression of ABCB1 protein			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Haloperidol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[537]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Haloperidol results in decreased activity of ABCB1 protein			[194]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Haloperidol results in decreased expression of ABCB1 mRNA			[537]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene polymorphism affects the susceptibility to Carbamazepine			[424]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the susceptibility to Carbamazepine			[425]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the transport of Carbamazepine			[426]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Carbamazepine results in decreased activity of ABCB1 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Carbamazepine results in increased expression of ABCB1 mRNA			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Carbamazepine results in increased expression of ABCB1 protein			[427]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fulvestrant inhibits the reaction Genistein results in increased expression of ABCB1 protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Genistein promotes the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Genistein promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Genistein results in decreased expression of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Genistein results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Genistein results in increased expression of ABCB1 mRNA			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Genistein results in increased expression of ABCB1 protein			[566]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Genistein results in increased expression of and results in increased activity of ABCB1 protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene SNP affects the susceptibility to Nelfinavir			[601]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 intron SNP affects the susceptibility to Nelfinavir			[601]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the transport of Nelfinavir			[601]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Arsenic Trioxide results in decreased expression of ABCB1 mRNA			[379]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Arsenic Trioxide results in decreased expression of ABCB1 protein			[380]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Arsenic Trioxide results in increased expression of ABCB1 mRNA			[381]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Arsenic Trioxide results in increased expression of ABCB1 protein			[382]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-(1-hydroxy-4-oxocyclohexa-2,5-dienyl)pyran-4-one results in increased susceptibility to Doxorubicin which results in decreased expression of ABCB1 protein			[518]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 affects the susceptibility to Doxorubicin			[490]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 mRNA results in decreased susceptibility to Doxorubicin			[519]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 mRNA results in increased susceptibility to Doxorubicin			[512]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 promoter modified form results in decreased susceptibility to Doxorubicin			[520]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCB1 protein affects the reaction Doxorubicin results in decreased susceptibility to Paraquat			[521]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB1 protein affects the susceptibility to Doxorubicin			[522]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCB1 protein affects the transport of Doxorubicin			[523]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	ABCB1 protein inhibits the reaction germacrone results in increased susceptibility to Doxorubicin			[524]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	ABCB1 protein inhibits the reaction Ursolic Acid results in increased susceptibility to Doxorubicin			[525]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	ABCB1 protein results in decreased abundance of Doxorubicin			[526]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	ABCB1 protein results in decreased export of Doxorubicin			[218]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	ABCB1 protein results in decreased secretion of Doxorubicin			[527]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	ABCB1 protein results in decreased susceptibility to Doxorubicin			[528]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	ABCB1 protein results in decreased susceptibility to Doxorubicin affects the reaction 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	ABCB1 protein results in decreased susceptibility to Doxorubicin affects the reaction eriodictyol inhibits the reaction Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	ABCB1 protein results in decreased susceptibility to Doxorubicin inhibits the reaction Quercetin results in increased cleavage of PARP1 protein			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	ABCB1 protein results in decreased uptake of Doxorubicin			[359]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	ABCB1 protein results in increased export of and results in decreased susceptibility to Doxorubicin			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	ABCB1 protein results in increased export of Doxorubicin			[461]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	ABCB1 protein results in increased transport of and affects the susceptibility to Doxorubicin			[529]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	ABCB1 protein results in increased transport of Doxorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	ABCB1 protein results in increased uptake of Doxorubicin			[467]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	ABCB1 results in decreased susceptibility to Doxorubicin			[530]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	abemaciclib inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Acetaminophen promotes the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[359]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Acetylcysteine affects the reaction gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of CASP7 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Acetylcysteine affects the reaction gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of PARP1 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Beclomethasone inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	betulin inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[402]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Bortezomib co-treated with Doxorubicin results in decreased expression of ABCB1 protein			[268]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Doxorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Doxorubicin which results in decreased susceptibility to Doxorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Carvedilol results in decreased activity of ABCB1 protein which results in increased susceptibility to Doxorubicin			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	CEP 33779 inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	CEP 33779 inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Chlorpyrifos inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	CJX1, amlodipine derivative inhibits the reaction ABCB1 protein results in decreased secretion of Doxorubicin			[527]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Clotrimazole inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Crizotinib inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Cycloserine inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[328]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Cyclosporine inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Cyclosporine inhibits the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	desisobutyrylciclesonide inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	Digoxin results in increased expression of ABCB1 which results in decreased susceptibility to Doxorubicin			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	Doxorubicin co-treated with IL6 protein results in increased expression of ABCB1 protein			[531]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Doxorubicin inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[402]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Doxorubicin results in decreased expression of ABCB1 protein			[532]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Doxorubicin results in increased activity of ABCB1 protein			[533]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Doxorubicin results in increased expression of ABCB1			[534]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Doxorubicin results in increased expression of ABCB1 mRNA			[535]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	Doxorubicin results in increased expression of ABCB1 protein			[533]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Doxorubicin results in increased expression of ABCB1 protein which results in decreased susceptibility to Paraquat			[521]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Endosulfan inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	eriodictyol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation58	Flupenthixol analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation59	fumonisin B1 inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[328]
Regulation Mechanism				Transcription Factor Info
DT Modulation60	gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation61	gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of CASP7 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation62	gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of PARP1 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation63	germacrone inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[524]
Regulation Mechanism				Transcription Factor Info
DT Modulation64	germacrone inhibits the reaction Doxorubicin results in increased expression of ABCB1 protein			[524]
Regulation Mechanism				Transcription Factor Info
DT Modulation65	Glutathione inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation66	GSK 1363089 inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[536]
Regulation Mechanism				Transcription Factor Info
DT Modulation67	Haloperidol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[537]
Regulation Mechanism				Transcription Factor Info
DT Modulation68	HIF1A protein affects the reaction Doxorubicin co-treated with IL6 protein results in increased expression of ABCB1 protein			[531]
Regulation Mechanism				Transcription Factor Info
DT Modulation69	Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of CTNNB1 protein which results in increased expression of ABCB1 protein inhibits the reaction Doxorubicin results in increased activity of CASP3 protein			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation70	Hyaluronic Acid binds to CD44 protein which results in increased expression of and results in increased activity of EP300 protein which results in increased acetylation of and results in increased activity of RELA protein which results in increased expression of ABCB1 protein inhibits the reaction Doxorubicin results in increased activity of CASP3 protein			[538]
Regulation Mechanism				Transcription Factor Info
DT Modulation71	hydramethylnon inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation72	Ivermectin inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation73	kaempferol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation74	Ketoconazole inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation75	Lapatinib inhibits the reaction ABCB1 protein results in increased export of and results in decreased susceptibility to Doxorubicin			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation76	Loperamide inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[539]
Regulation Mechanism				Transcription Factor Info
DT Modulation77	Meloxicam inhibits the reaction Doxorubicin results in increased activity of ABCB1 protein			[533]
Regulation Mechanism				Transcription Factor Info
DT Modulation78	Meloxicam inhibits the reaction Doxorubicin results in increased expression of ABCB1 protein			[533]
Regulation Mechanism				Transcription Factor Info
DT Modulation79	Metformin inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation80	Mometasone Furoate inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation81	N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[540]
Regulation Mechanism				Transcription Factor Info
DT Modulation82	Ouabain results in increased expression of ABCB1 which results in decreased susceptibility to Doxorubicin			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation83	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Doxorubicin			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation84	Paliperidone Palmitate inhibits the reaction ABCB1 protein results in decreased export of Doxorubicin			[218]
Regulation Mechanism				Transcription Factor Info
DT Modulation85	Parathion inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation86	Pentoxifylline co-treated with Doxorubicin results in decreased expression of ABCB1 protein			[268]
Regulation Mechanism				Transcription Factor Info
DT Modulation87	pluronic block copolymer p85 inhibits the reaction Doxorubicin results in increased expression of ABCB1 protein			[541]
Regulation Mechanism				Transcription Factor Info
DT Modulation88	psorospermin inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[542]
Regulation Mechanism				Transcription Factor Info
DT Modulation89	Quercetin co-treated with Doxorubicin results in decreased expression of ABCB1 protein			[532]
Regulation Mechanism				Transcription Factor Info
DT Modulation90	Quercetin inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation91	Quercetin inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[543]
Regulation Mechanism				Transcription Factor Info
DT Modulation92	RAB6C protein affects the expression of ABCB1 mRNA which affects the susceptibility to Doxorubicin			[544]
Regulation Mechanism				Transcription Factor Info
DT Modulation93	Resveratrol co-treated with Doxorubicin results in decreased expression of ABCB1 mRNA			[545]
Regulation Mechanism				Transcription Factor Info
DT Modulation94	Resveratrol co-treated with Doxorubicin results in decreased expression of ABCB1 mRNA which results in increased uptake of Doxorubicin			[545]
Regulation Mechanism				Transcription Factor Info
DT Modulation95	Resveratrol results in increased susceptibility to Doxorubicin which results in decreased expression of ABCB1 mRNA			[546]
Regulation Mechanism				Transcription Factor Info
DT Modulation96	Resveratrol results in increased susceptibility to Doxorubicin which results in decreased expression of ABCB1 protein			[546]
Regulation Mechanism				Transcription Factor Info
DT Modulation97	Rifampin binds to and results in increased activity of NR1I2 protein promotes the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation98	Risperidone inhibits the reaction ABCB1 protein results in decreased export of Doxorubicin			[218]
Regulation Mechanism				Transcription Factor Info
DT Modulation99	terameprocol inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[535]
Regulation Mechanism				Transcription Factor Info
DT Modulation100	Tretinoin co-treated with romidepsin results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation101	tryptoquivaline inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation102	valspodar inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation103	valspodar inhibits the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation104	valspodar inhibits the reaction Tretinoin co-treated with romidepsin results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation105	Verapamil inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation106	Verapamil inhibits the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[359]
Regulation Mechanism				Transcription Factor Info
DT Modulation107	Verapamil inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[402]
Regulation Mechanism				Transcription Factor Info
DT Modulation108	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Doxorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation109	Verapamil inhibits the reaction Doxorubicin results in increased activity of ABCB1 protein			[359]
Regulation Mechanism				Transcription Factor Info
DT Modulation110	Verapamil results in decreased activity of ABCB1 protein which results in increased susceptibility to Doxorubicin			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation111	withaferin A inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the susceptibility to Cytarabine			[486]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cytarabine results in increased expression of ABCB1			[487]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 alternative form affects the reaction CYP3A4 polymorphism affects the susceptibility to Simvastatin			[389]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 polymorphism affects the susceptibility to Simvastatin			[649]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased transport of Simvastatin			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Simvastatin analog inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Simvastatin analog results in decreased activity of ABCB1 protein			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Omeprazole promotes the reaction Cisplatin results in increased expression of ABCB1 protein			[452]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased transport of Fentanyl			[562]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tariquidar inhibits the reaction ABCB1 protein results in increased transport of Fentanyl			[562]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nisoldipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chlordecone results in decreased activity of ABCB1 protein			[124]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in decreased susceptibility to Diazinon			[499]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclosporine inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Deoxyglucose inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Diazinon affects the reaction ABCB1 protein results in increased transport of Digoxin			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Diazinon affects the reaction ABCB1 protein results in increased transport of Vinblastine			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Diazinon inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Diazinon promotes the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Diazinon promotes the reaction Endosulfan results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Diazinon promotes the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Diazinon promotes the reaction phosalone results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Diazinon promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Diazinon promotes the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Diazinon promotes the reaction Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Diazinon promotes the reaction Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Diazinon results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Diazinon results in increased activity of ABCB1 protein			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Diazinon results in increased expression of ABCB1 protein			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Sodium Azide inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	valspodar inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sertraline results in increased activity of ABCB1 protein			[303]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased export of Loratadine			[434]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mebendazole results in decreased expression of ABCB1 mRNA			[583]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mebendazole results in decreased expression of ABCB1 protein			[583]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased secretion of Prednisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Prednisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Prednisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Doxazosin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Capsaicin affects the reaction ABCB1 protein results in increased export of Digoxin			[423]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Capsaicin results in increased expression of ABCB1 mRNA			[423]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Capsaicin results in increased expression of ABCB1 protein			[423]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bepridil inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased transport of Loperamide			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Loperamide binds to ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Loperamide inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[539]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Loperamide results in decreased expression of ABCB1 mRNA			[539]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased transport of Carvedilol			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin which results in decreased susceptibility to Daunorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Doxorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Doxorubicin which results in decreased susceptibility to Doxorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Paclitaxel			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Paclitaxel which results in decreased susceptibility to Paclitaxel			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Vinblastine			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Vinblastine which results in decreased susceptibility to Vinblastine			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Carvedilol results in decreased activity of ABCB1 protein			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Carvedilol results in decreased activity of ABCB1 protein which results in increased susceptibility to Doxorubicin			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Carvedilol results in decreased activity of ABCB1 protein which results in increased uptake of fluorexon			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	valspodar inhibits the reaction ABCB1 protein results in increased transport of Carvedilol			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Crizotinib inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Crizotinib inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Crizotinib promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Crizotinib results in decreased activity of ABCB1 protein			[465]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clotrimazole binds to ABCB1 protein			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Clotrimazole inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Clotrimazole inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Clotrimazole inhibits the reaction ABCB1 protein results in increased secretion of Vinblastine			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Clotrimazole results in increased expression of ABCB1 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene polymorphism affects the reaction Dexamethasone results in decreased secretion of IFNG protein			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene polymorphism affects the reaction Dexamethasone results in decreased secretion of IL2 protein			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 gene polymorphism affects the reaction Dexamethasone results in decreased secretion of IL4 protein			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 gene polymorphism affects the reaction Dexamethasone results in decreased secretion of TNF protein			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 gene polymorphism affects the susceptibility to Dexamethasone			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 protein results in increased secretion of Dexamethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Dexamethasone results in decreased activity of ABCB1 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Dexamethasone results in increased expression of ABCB1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Dexamethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Tacrolimus results in decreased activity of ABCB1 protein which results in decreased export of Dexamethasone			[496]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Dexamethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	18alpha-glycyrrhetinic acid inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction Digoxin results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Digoxin results in increased expression of ABCB1 mRNA			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Digoxin results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 gene SNP affects the abundance of Digoxin			[501]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCB1 gene SNP affects the transport of Digoxin			[502]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB1 protein affects the transport of Digoxin			[503]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCB1 protein binds to and affects the metabolism of Digoxin			[504]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	ABCB1 protein results in decreased uptake of Digoxin			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	ABCB1 protein results in increased export of Digoxin			[423]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	ABCB1 protein results in increased transport of Digoxin			[505]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	abietic acid inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Amiodarone inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	azelastine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	benidipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Bepridil inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	beta-pinene inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Bisoprolol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Capsaicin affects the reaction ABCB1 protein results in increased export of Digoxin			[423]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	citronellal inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	citronellal results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[454]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	citronellol inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	citronellol results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[454]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	cucurbitacin I inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Curcumin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[469]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	cyazofamid affects the reaction ABCB1 protein results in increased uptake of Digoxin			[473]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Cyclosporine binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	dehydroandrographolide inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	desethylamiodarone inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	desmethylazelastine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Diazinon affects the reaction ABCB1 protein results in increased transport of Digoxin			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Digoxin binds to ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Digoxin inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[411]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Digoxin results in increased expression of ABCB1 mRNA			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	Digoxin results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Digoxin results in increased expression of ABCB1 which results in decreased susceptibility to Doxorubicin			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Diltiazem inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Doxazosin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	efonidipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Elacridar binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Elacridar results in decreased activity of ABCB1 protein which results in increased uptake of Digoxin			[506]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Emodin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Fusidic Acid inhibits the reaction ABCB1 protein results in increased export of Digoxin			[507]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	gamma-terpinene inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	gingerol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[469]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	ginsenoside F2 analog inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Glycyrrhetinic Acid inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein which results in increased uptake of Digoxin			[506]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Itraconazole inhibits the reaction ABCB1 protein affects the transport of Digoxin			[503]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Ketoconazole binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	Ketoconazole inhibits the reaction ABCB1 protein affects the transport of Digoxin			[503]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Ketoconazole inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[502]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Ketoconazole results in decreased activity of ABCB1 protein which results in increased uptake of Digoxin			[506]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	KN 93 inhibits the reaction Digoxin results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation58	manidipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation59	mepirodipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation60	Nicardipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation61	nilvadipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation62	Nisoldipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation63	nobiletin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation64	ophiobolin A inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation65	Plant Extracts results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[454]
Regulation Mechanism				Transcription Factor Info
DT Modulation66	Propranolol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation67	rhodioloside affects the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
DT Modulation68	Rifampin promotes the reaction ABCB1 protein results in increased transport of Digoxin			[502]
Regulation Mechanism				Transcription Factor Info
DT Modulation69	sciadopitysin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation70	sinensetin analog inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation71	sinensetin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation72	spinosad inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[419]
Regulation Mechanism				Transcription Factor Info
DT Modulation73	tangeretin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation74	terpinolene inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation75	valspodar inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation76	valspodar results in decreased activity of ABCB1 protein which results in decreased transport of Digoxin			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation77	Verapamil binds to and results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation78	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[505]
Regulation Mechanism				Transcription Factor Info
DT Modulation79	Verapamil inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation80	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of Digoxin			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Calcitriol co-treated with Curcumin inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Calcitriol inhibits the reaction Curcumin co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Calcitriol inhibits the reaction Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Calcitriol results in decreased activity of ABCB1 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Calcitriol results in increased expression of ABCB1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Calcitriol results in increased expression of ABCB1 protein			[421]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Curcumin co-treated with Calcitriol inhibits the reaction Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Curcumin inhibits the reaction Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 mRNA			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Curcumin inhibits the reaction Calcitriol co-treated with Paclitaxel results in increased expression of ABCB1 protein			[420]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	VDR protein promotes the reaction Calcitriol results in increased expression of ABCB1 mRNA			[293]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rutin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Decitabine affects the methylation of ABCB1 gene which affects the expression of ABCB1 mRNA			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Decitabine co-treated with trichostatin A affects the methylation of ABCB1 gene which affects the expression of ABCB1 mRNA			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Decitabine promotes the reaction trichostatin A results in increased expression of ABCB1 mRNA			[334]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Decitabine results in increased expression of ABCB1 mRNA			[334]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the susceptibility to Imatinib Mesylate			[569]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to Imatinib Mesylate			[492]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Imatinib Mesylate inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Imatinib Mesylate inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein which results in decreased export of Daunorubicin			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Imatinib Mesylate results in increased expression of and results in increased activity of ABCB1 protein			[570]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Doxycycline results in increased expression of ABCB1 protein			[547]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	MB protein inhibits the reaction Doxycycline results in increased expression of ABCB1 protein			[547]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased export of Estriol			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCB1 protein results in increased export of Estriol			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ketoconazole inhibits the reaction Spironolactone results in increased expression of ABCB1 protein			[178]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NR1I2 affects the reaction Spironolactone results in increased expression of ABCB1 protein			[178]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased export of Estrone			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCB1 protein results in increased export of Estrone			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Estrone results in increased expression of ABCB1 mRNA			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Estrone results in increased expression of ABCB1 protein			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Flutamide results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NR1I2 protein promotes the reaction Flutamide results in increased expression of and results in increased activity of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the susceptibility to Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil			[474]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the susceptibility to Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide			[474]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclophosphamide results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NR1I2 protein promotes the reaction Cyclophosphamide results in increased expression of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Glutathione inhibits the reaction Hydrogen Peroxide affects the expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ketoconazole inhibits the reaction Hydrogen Peroxide affects the expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene polymorphism affects the reaction Methotrexate results in decreased secretion of IFNG protein			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene polymorphism affects the reaction Methotrexate results in decreased secretion of IL2 protein			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 gene polymorphism affects the reaction Methotrexate results in decreased secretion of TNF protein			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 gene polymorphism affects the susceptibility to Methotrexate			[495]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 gene polymorphism affects the susceptibility to Methotrexate co-treated with Methylprednisolone			[586]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 gene SNP affects the susceptibility to Methotrexate			[587]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCB1 polymorphism results in increased susceptibility to Methotrexate			[588]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB1 protein affects the susceptibility to Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil			[474]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCB1 protein results in increased susceptibility to Methotrexate co-treated with Methylprednisolone			[586]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Vitamin B 12 inhibits the reaction Methotrexate results in increased expression of ABCB1 mRNA			[589]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Camptothecin inhibits the reaction Rifampin results in increased expression of ABCB1 mRNA			[317]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction Rifampin results in increased expression of ABCB1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction Rifampin results in increased expression of ABCB1 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ketoconazole inhibits the reaction Rifampin results in increased expression of ABCB1 mRNA			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Ketoconazole inhibits the reaction Rifampin results in increased expression of ABCB1 protein			[580]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	mulberroside A inhibits the reaction NR1I2 protein results in increased susceptibility to Rifampin which results in increased expression of ABCB1 mRNA			[596]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	mulberroside A inhibits the reaction NR1I2 protein results in increased susceptibility to Rifampin which results in increased expression of ABCB1 protein			[596]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	NR1I2 protein promotes the reaction Rifampin results in increased expression of ABCB1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	NR1I2 protein promotes the reaction Rifampin results in increased expression of ABCB1 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	NR1I2 protein results in increased susceptibility to Rifampin which results in increased expression of ABCB1 mRNA			[596]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	NR1I2 protein results in increased susceptibility to Rifampin which results in increased expression of ABCB1 protein			[596]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	pimecrolimus inhibits the reaction Rifampin results in increased expression of ABCB1 mRNA			[317]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Resveratrol inhibits the reaction Rifampin results in increased expression of ABCB1 protein			[312]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Rifampin affects the activity of ABCB1 protein			[475]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Rifampin binds to and results in increased activity of NR1I2 protein promotes the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Rifampin promotes the reaction ABCB1 protein results in increased transport of Digoxin			[502]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Rifampin promotes the reaction NR1I2 protein binds to ABCB1 promoter			[276]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Rifampin results in increased activity of NR1I2 protein which results in increased expression of ABCB1 protein			[641]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Demecolcine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Demecolcine results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	MGMT protein co-treated with ABCB1 protein results in decreased susceptibility to Carmustine			[429]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rotenone affects the activity of ABCB1 protein			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Thalidomide results in decreased activity of ABCB1 protein			[385]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Disulfiram affects the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Disulfiram inhibits the reaction 8-azidoadenosine 5'-triphosphate binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Disulfiram inhibits the reaction azidopine binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Disulfiram inhibits the reaction azidoprazosin binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Disulfiram metabolite results in decreased activity of ABCB1 protein			[192]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Disulfiram results in decreased activity of ABCB1 protein			[510]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chlorpromazine analog results in increased expression of ABCB1 mRNA			[436]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpromazine results in decreased activity of ABCB1 protein			[194]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clozapine results in decreased activity of ABCB1 protein			[194]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Olanzapine results in decreased activity of ABCB1 protein			[194]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the activity of Raloxifene Hydrochloride			[636]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine co-treated with Raloxifene Hydrochloride results in decreased expression of ABCB1 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclosporine co-treated with Raloxifene Hydrochloride results in decreased expression of ABCB1 protein			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene affects the reaction CYP2C19 gene affects the susceptibility to Clopidogrel			[455]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene affects the susceptibility to Clopidogrel			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 gene polymorphism affects the susceptibility to Clopidogrel			[456]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 gene SNP affects the susceptibility to Clopidogrel			[457]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 protein results in decreased uptake of Clopidogrel			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 protein results in increased secretion of Clopidogrel			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Clopidogrel results in decreased activity of ABCB1 protein			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Gabapentin results in decreased activity of ABCB1 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lamotrigine results in decreased activity of ABCB1 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Levetiracetam results in decreased activity of ABCB1 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene polymorphism affects the susceptibility to Methotrexate co-treated with Methylprednisolone			[586]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased secretion of Methylprednisolone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased susceptibility to Methotrexate co-treated with Methylprednisolone			[586]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Methylprednisolone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Methylprednisolone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fulvestrant inhibits the reaction Ethinyl Estradiol results in increased expression of ABCB1 protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fulvestrant inhibits the reaction Genistein results in increased expression of ABCB1 protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dactinomycin inhibits the reaction Estradiol results in increased expression of ABCB1 mRNA			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dactinomycin inhibits the reaction Estradiol results in increased expression of ABCB1 protein			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	EGF protein promotes the reaction Estradiol results in decreased expression of ABCB1 mRNA			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ESR1 protein affects the reaction Estradiol results in decreased expression of ABCB1 protein			[195]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Estradiol results in decreased expression of ABCB1 protein which results in increased uptake of and results in increased susceptibility to Vincristine			[195]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Estradiol results in increased expression of ABCB1 mRNA			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Estradiol results in increased expression of ABCB1 protein			[557]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Tamoxifen inhibits the reaction Estradiol results in decreased expression of ABCB1 protein			[195]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene polymorphism affects the abundance of Ivermectin			[578]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene polymorphism affects the susceptibility to Ivermectin			[579]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased transport of Ivermectin			[419]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ivermectin binds to ABCB1 protein			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Ivermectin inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Ivermectin inhibits the reaction ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Ivermectin results in decreased activity of ABCB1 protein			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	spinosad inhibits the reaction ABCB1 protein results in increased transport of Ivermectin			[419]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Methoxsalen results in decreased activity of ABCB1 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Methoxsalen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Methoxsalen results in increased expression of ABCB1 mRNA			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Verapamil inhibits the reaction Methoxsalen results in decreased activity of ABCB1 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Verapamil inhibits the reaction Methoxsalen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tolbutamide inhibits the reaction ABCB1 protein results in increased uptake of quinidinium			[212]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tolbutamide results in decreased activity of ABCB1 protein			[212]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mitotane inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[494]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mitotane results in decreased activity of ABCB1 protein			[592]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Mitotane results in increased expression of ABCB1 mRNA			[593]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased export of Ethinyl Estradiol			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar results in decreased export of ABCB1 protein results in increased transport of Ethinyl Estradiol			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ethinyl Estradiol results in increased expression of and results in increased activity of ABCB1 protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Fulvestrant inhibits the reaction Ethinyl Estradiol results in increased expression of ABCB1 protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene polymorphism affects the abundance of Risperidone			[618]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene polymorphism affects the susceptibility to Risperidone			[643]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the abundance of Risperidone			[618]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein affects the susceptibility to Risperidone			[643]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 protein results in increased susceptibility to Risperidone			[644]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 protein results in increased transport of Risperidone			[619]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Risperidone inhibits the reaction ABCB1 protein results in decreased export of Doxorubicin			[218]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Risperidone results in decreased activity of ABCB1 protein			[194]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bortezomib promotes the reaction Chloroquine results in decreased expression of ABCB1 mRNA			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bortezomib promotes the reaction Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chloroquine promotes the reaction Bortezomib results in decreased expression of ABCB1 mRNA			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chloroquine promotes the reaction Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chloroquine promotes the reaction Cisplatin results in decreased expression of ABCB1 mRNA			[435]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chloroquine promotes the reaction Cisplatin results in decreased expression of ABCB1 protein			[435]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased secretion of Aldosterone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Aldosterone results in increased expression of ABCB1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Aldosterone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Aldosterone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Midazolam results in increased expression of ABCB1 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenobarbital affects the expression of ABCB1 mRNA			[622]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Phenobarbital results in decreased activity of ABCB1 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Phenobarbital results in increased expression of ABCB1 mRNA			[286]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Phenobarbital results in increased expression of ABCB1 protein			[286]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the metabolism of Sirolimus			[650]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the transport of Sirolimus			[476]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene SNP results in increased susceptibility to Tacrolimus			[658]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the export of Tacrolimus			[659]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the susceptibility to Tacrolimus			[659]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein results in increased export of Tacrolimus			[660]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tacrolimus binds to ABCB1 protein inhibits the reaction azidoprazosin binds to ABCB1 protein			[393]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Tacrolimus results in decreased activity of ABCB1 protein			[496]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Tacrolimus results in decreased activity of ABCB1 protein which results in decreased export of Dexamethasone			[496]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Verapamil affects the reaction ABCB1 protein results in increased export of Tacrolimus			[660]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the export of Saquinavir			[551]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased export of Saquinavir			[648]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the abundance of Phenytoin			[623]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the susceptibility to Phenytoin			[425]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased metabolism of Phenytoin			[624]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Phenytoin results in decreased activity of ABCB1 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rifaximin results in increased expression of ABCB1 mRNA			[642]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene polymorphism affects the susceptibility to Docetaxel			[511]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 mRNA results in increased susceptibility to Docetaxel			[512]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the reaction EGFR protein results in decreased susceptibility to Docetaxel			[513]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein results in decreased susceptibility to Docetaxel			[514]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	cinchonine analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	cinchonine inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Docetaxel analog binds to ABCB1 protein			[338]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Docetaxel binds to ABCB1 protein			[338]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Docetaxel results in decreased expression of ABCB1 mRNA			[515]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Docetaxel results in decreased susceptibility to Docetaxel which results in increased expression of ABCB1 mRNA			[232]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Docetaxel results in decreased susceptibility to Docetaxel which results in increased expression of ABCB1 protein			[232]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Docetaxel results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Docetaxel results in increased expression of ABCB1 mRNA			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Docetaxel results in increased expression of ABCB1 protein			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Docetaxel results in increased expression of TP53 mRNA which results in decreased expression of ABCB1 mRNA			[515]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	NR1I2 protein promotes the reaction Docetaxel results in increased expression of and results in increased activity of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	pinostrobin inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Quinidine inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	tectochrysin inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	TP53 protein affects the reaction Docetaxel results in decreased expression of ABCB1 mRNA			[515]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	romidepsin promotes the reaction Tretinoin results in increased expression of ABCB1 mRNA			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of ABCB1 protein			[341]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tretinoin co-treated with romidepsin results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tretinoin co-treated with romidepsin results in increased expression of ABCB1 protein			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tretinoin promotes the reaction romidepsin results in increased acetylation of ABCB1 promoter			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Tretinoin results in increased acetylation of ABCB1 promoter			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Tretinoin results in increased expression of ABCB1 mRNA			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	valspodar inhibits the reaction Tretinoin co-treated with romidepsin results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 affects the reaction HIF1A affects the susceptibility to Cisplatin			[441]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 affects the susceptibility to Cisplatin			[442]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 gene polymorphism affects the susceptibility to Cisplatin			[443]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 gene SNP affects the susceptibility to Cisplatin co-treated with Fluorouracil			[444]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 protein inhibits the reaction Cisplatin results in decreased expression of BCL2 protein			[445]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 protein inhibits the reaction Cisplatin results in increased activity of and results in increased cleavage of CASP3 protein			[445]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCB1 protein inhibits the reaction Cisplatin results in increased activity of CASP9 protein			[445]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB1 protein promotes the reaction Cisplatin results in increased expression of TRP53 protein			[445]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCB1 protein results in decreased susceptibility to Cisplatin			[446]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Chloroquine promotes the reaction Cisplatin results in decreased expression of ABCB1 mRNA			[435]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Chloroquine promotes the reaction Cisplatin results in decreased expression of ABCB1 protein			[435]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Cisplatin promotes the reaction APEX1 protein modified form promotes the reaction YBX1 protein binds to EP300 protein which binds to ABCB1 promoter			[447]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Cisplatin results in decreased expression of ABCB1 mRNA			[435]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Cisplatin results in decreased expression of ABCB1 protein			[435]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Cisplatin results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 mRNA			[448]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Cisplatin results in increased acetylation of APEX1 protein promotes the reaction APEX1 protein modified form binds to ABCB1 promoter			[447]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Cisplatin results in increased acetylation of APEX1 protein promotes the reaction APEX1 protein modified form binds to ABCB1 promoter which results in increased expression of ABCB1 mRNA			[447]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Cisplatin results in increased expression of ABCB1 mRNA			[449]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Cisplatin results in increased expression of ABCB1 protein			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	CXCL8 results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Cisplatin			[450]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	CXCL8 results in increased expression of ABCB1 protein which results in decreased susceptibility to Cisplatin			[450]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	kang-lai-te inhibits the reaction Cisplatin results in increased expression of ABCB1 mRNA			[451]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	kang-lai-te inhibits the reaction Cisplatin results in increased expression of ABCB1 protein			[451]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Omeprazole promotes the reaction Cisplatin results in increased expression of ABCB1 protein			[452]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Cisplatin			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the susceptibility to Vincristine			[681]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the uptake of Vincristine			[635]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in decreased susceptibility to Vincristine			[682]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein results in decreased uptake of Vincristine			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 protein results in increased transport of Vincristine			[561]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	CEP 33779 inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Cyclosporine inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Estradiol results in decreased expression of ABCB1 protein which results in increased uptake of and results in increased susceptibility to Vincristine			[195]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Fenofibrate inhibits the reaction ABCB1 protein results in increased transport of Vincristine			[561]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Flupenthixol analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	MGMT protein co-treated with ABCB1 protein results in decreased susceptibility to Vincristine			[429]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	NR1I2 protein promotes the reaction Vincristine results in increased expression of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Vincristine			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	pinostrobin inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	tectochrysin inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Verapamil inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Vincristine results in decreased susceptibility to Vincristine which affects the expression of ABCB1 mRNA			[232]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Vincristine results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Vincristine results in increased expression of ABCB1 protein			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	zosuquidar trihydrochloride inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[682]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Celecoxib results in decreased expression of ABCB1 protein			[299]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Celecoxib results in decreased expression of ABCB1 which results in increased susceptibility to Etoposide			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Celecoxib results in decreased expression of ABCB1 which results in increased susceptibility to Tamoxifen			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Celecoxib results in increased expression of ABCB1 mRNA			[299]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Celecoxib results in increased methylation of ABCB1 promoter			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 gene SNP affects the susceptibility to Cisplatin co-treated with Fluorouracil			[444]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the susceptibility to Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil			[474]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the susceptibility to Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide			[474]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Fluorouracil results in decreased expression of ABCB1 mRNA			[565]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Fluorouracil results in increased expression of ABCB1 protein			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Paclitaxel results in increased expression of ABCB1 which results in decreased susceptibility to Fluorouracil			[453]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction Ouabain results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Ouabain results in increased expression of ABCB1 mRNA			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Ouabain results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	KN 93 inhibits the reaction Ouabain results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Ouabain results in increased expression of ABCB1 mRNA			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Ouabain results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Ouabain results in increased expression of ABCB1 which results in decreased susceptibility to Doxorubicin			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	3',4',7-trihydroxyisoflavone inhibits the reaction Epirubicin results in increased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the susceptibility to Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide			[474]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Epirubicin analog co-treated with chrysophsin analog results in increased expression of ABCB1 mRNA			[555]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Epirubicin analog results in increased expression of ABCB1 mRNA			[555]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Epirubicin co-treated with chrysophsin results in increased expression of ABCB1 mRNA			[555]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Epirubicin results in increased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	formononetin inhibits the reaction Epirubicin results in increased expression of ABCB1 mRNA			[362]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mitoxantrone results in increased expression of ABCB1 protein			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Daunorubicin results in increased expression of ABCB1 mRNA			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	5,7-dimethoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	5-hydroxyflavone inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	5-methoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	5-Methoxypsoralen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB1 affects the susceptibility to Daunorubicin			[490]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCB1 mutant form promotes the reaction Daunorubicin results in decreased expression of ABCB1 mRNA			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	ABCB1 mutant form promotes the reaction Daunorubicin results in decreased expression of ABCB1 protein			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	ABCB1 mutant form promotes the reaction Magnetite Nanoparticles results in increased susceptibility to Daunorubicin			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	ABCB1 mutant form results in increased susceptibility to Daunorubicin			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	ABCB1 protein affects the susceptibility to Daunorubicin			[492]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	ABCB1 protein results in decreased susceptibility to Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	ABCB1 protein results in decreased uptake of Daunorubicin			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	ABCB1 protein results in increased export of Daunorubicin			[481]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	ABCB1 protein results in increased import of Daunorubicin			[366]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Amiodarone inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	aurapten promotes the reaction ABCB1 protein results in increased import of Daunorubicin			[366]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	azelastine inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	baicalein inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	baicalein inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	biochanin A inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	biochanin A promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Carvedilol inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin which results in decreased susceptibility to Daunorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Cyclosporine inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[481]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles results in decreased expression of ABCB1 mRNA			[410]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Daunorubicin co-treated with bromotetrandrine results in decreased expression of ABCB1 mRNA			[410]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Daunorubicin promotes the reaction ABCB1 mutant form results in decreased expression of ABCB1 protein			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Daunorubicin promotes the reaction Magnetite Nanoparticles results in decreased expression of ABCB1 protein			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Daunorubicin results in decreased expression of ABCB1 mRNA			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Daunorubicin results in decreased expression of ABCB1 protein			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Daunorubicin results in increased expression of ABCB1 mRNA			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	desethylamiodarone inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	desmethylazelastine inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	dihydromyricetin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	enasidenib inhibits the reaction ABCB1 protein results in decreased susceptibility to Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	enasidenib inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	enasidenib inhibits the reaction ABCB1 protein results in increased export of Daunorubicin which results in increased susceptibility to Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	flavone inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	flavone promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	galangin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	ginkgolic acid affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	glabridin affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	glycitein inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	glycitein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Glycyrrhetinic Acid affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Imatinib Mesylate inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Imatinib Mesylate inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein which results in decreased export of Daunorubicin			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	isovitexin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	kaempferide inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	kaempferide inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	kaempferol inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation58	Luteolin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation59	Magnetite Nanoparticles promotes the reaction ABCB1 mutant form promotes the reaction Daunorubicin results in decreased expression of ABCB1 mRNA			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation60	Magnetite Nanoparticles promotes the reaction ABCB1 mutant form promotes the reaction Daunorubicin results in decreased expression of ABCB1 protein			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation61	Magnetite Nanoparticles promotes the reaction ABCB1 mutant form results in increased susceptibility to Daunorubicin			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation62	Magnetite Nanoparticles promotes the reaction Daunorubicin promotes the reaction ABCB1 mutant form results in decreased expression of ABCB1 protein			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation63	Magnetite Nanoparticles promotes the reaction Daunorubicin results in decreased expression of ABCB1 mRNA			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation64	Magnetite Nanoparticles promotes the reaction Daunorubicin results in decreased expression of ABCB1 protein			[491]
Regulation Mechanism				Transcription Factor Info
DT Modulation65	matairesinol affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation66	Methoxsalen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation67	Mitotane inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[494]
Regulation Mechanism				Transcription Factor Info
DT Modulation68	MLN 8237 affects the activity of ABCB1 protein which affects the export of Daunorubicin			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation69	naringenin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation70	naringenin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation71	nobiletin promotes the reaction ABCB1 protein results in increased import of Daunorubicin			[366]
Regulation Mechanism				Transcription Factor Info
DT Modulation72	phyllodulcin affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation73	puerarin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation74	Quercetin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation75	schaftoside inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation76	sesamin affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation77	Sesquiterpenes analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Daunorubicin			[149]
Regulation Mechanism				Transcription Factor Info
DT Modulation78	Silybin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation79	Silybin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation80	Sodium Azide co-treated with Iodoacetates inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[481]
Regulation Mechanism				Transcription Factor Info
DT Modulation81	tangeretin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation82	valspodar inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[494]
Regulation Mechanism				Transcription Factor Info
DT Modulation83	venetoclax inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation84	venetoclax inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein which results in decreased export of Daunorubicin			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation85	Verapamil inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation86	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation87	Verapamil inhibits the reaction Methoxsalen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation88	zosuquidar trihydrochloride inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation89	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased export of Daunorubicin			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Budesonide results in increased expression of ABCB1 protein			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the susceptibility to Valproic Acid			[425]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of ABCB1 mRNA			[673]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid results in decreased activity of ABCB1 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Valproic Acid results in decreased methylation of ABCB1 gene			[674]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Valproic Acid results in increased expression of ABCB1 mRNA			[675]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diltiazem inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Acetylcysteine affects the reaction gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of CASP7 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine affects the reaction gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of PARP1 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetylcysteine inhibits the reaction 3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Acetylcysteine inhibits the reaction formononetin results in increased expression of ABCB1 mRNA			[362]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dimethyl Sulfoxide affects the expression of ABCB1 mRNA			[254]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Yohimbine analog results in increased expression of ABCB1 mRNA			[256]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in decreased susceptibility to Dactinomycin			[488]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dactinomycin inhibits the reaction Estradiol results in increased expression of ABCB1 mRNA			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dactinomycin inhibits the reaction Estradiol results in increased expression of ABCB1 protein			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Dactinomycin inhibits the reaction Progesterone results in increased expression of ABCB1 mRNA			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Dactinomycin inhibits the reaction Progesterone results in increased expression of ABCB1 protein			[489]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Dactinomycin inhibits the reaction sodium arsenite results in increased expression of ABCB1 mRNA			[278]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 polymorphism affects the susceptibility to Everolimus			[559]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lapatinib inhibits the reaction ABCB1 protein results in increased export of and results in decreased susceptibility to Doxorubicin			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Lapatinib inhibits the reaction azidoprazosin binds to ABCB1 protein			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Lapatinib promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Naproxen affects the expression of ABCB1 mRNA			[600]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cilastatin inhibits the reaction Vancomycin results in decreased expression of and affects the localization of ABCB1 protein			[439]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Vancomycin results in decreased expression of and affects the localization of ABCB1 protein			[439]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ATP2A1 protein affects the reaction Bortezomib results in decreased expression of ABCB1			[408]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bortezomib co-treated with Doxorubicin results in decreased expression of ABCB1 protein			[268]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Bortezomib inhibits the reaction CERS2 protein affects the expression of ABCB1 protein			[328]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Bortezomib inhibits the reaction CERS6 protein affects the expression of ABCB1 protein			[328]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Bortezomib promotes the reaction Chloroquine results in decreased expression of ABCB1 mRNA			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Bortezomib promotes the reaction Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Bortezomib results in decreased activity of ABCB1 protein			[408]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Chloroquine promotes the reaction Bortezomib results in decreased expression of ABCB1 mRNA			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Chloroquine promotes the reaction Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein			[219]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pentoxifylline co-treated with Doxorubicin results in decreased expression of ABCB1 protein			[268]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ifosfamide results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NR1I2 protein promotes the reaction Ifosfamide results in increased expression of ABCB1 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	chrysin results in decreased activity of ABCB1 protein which results in decreased export of Topotecan			[297]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Verapamil results in decreased activity of ABCB1 protein which results in decreased export of Topotecan			[297]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Manganese results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Manganese results in increased activity of ABCB1 protein which results in increased hydrolysis of Adenosine Triphosphate			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cycloheximide promotes the reaction Reserpine results in increased expression of ABCB1 mRNA			[256]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Flupenthixol analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Flupenthixol analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Flupenthixol analog results in decreased activity of ABCB1 protein			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Flupenthixol analog results in decreased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the transport of Terfenadine			[391]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the transport of Terfenadine analog			[391]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Terfenadine results in decreased activity of ABCB1 protein			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Colforsin results in increased expression of ABCB1 mRNA			[281]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in increased expression of ABCB1 mRNA			[285]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diethylhexyl Phthalate promotes the reaction NR1I2 protein results in increased expression of ABCB1 mRNA			[288]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the reaction metolachlor results in increased susceptibility to Paclitaxel			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	metolachlor results in increased activity of ABCB1 protein			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	6-bromoindirubin-3'-oxime results in increased expression of and results in increased activity of ABCB1 protein			[289]
Regulation Mechanism				Transcription Factor Info
Naphthalene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naphthalene inhibits the activity of ABCB1			[290]
DT Modulation1	VDR protein promotes the reaction Lithocholic Acid results in increased expression of ABCB1 mRNA			[293]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Camptothecin inhibits the reaction Rifampin results in increased expression of ABCB1 mRNA			[317]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein results in increased transport of Okadaic Acid			[608]
Regulation Mechanism				Transcription Factor Info
7-methylindole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7-methylindole increases the expression of ABCB1			[324]
DT Modulation1	Luteolin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Luteolin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	3-methylquercetin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-methylquercetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-methylquercetin promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	3-methylquercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	3-methylquercetin results in increased expression of ABCB1 mRNA			[273]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 protein results in increased transport of 3-methylquercetin			[349]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction Thapsigargin results in decreased expression of ABCB1 protein			[328]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Glutathione inhibits the reaction Ethanol results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ketoconazole inhibits the reaction Ethanol results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
Gold	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gold increases the expression of ABCB1			[331]
DT Modulation1	Benzo(a)pyrene affects the methylation of ABCB1 5' UTR			[398]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB1 protein affects the transport of Quinidine			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased transport of Quinidine			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	methoxyfenozide inhibits the reaction ABCB1 protein results in increased transport of Quinidine			[590]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Quinidine binds to ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Quinidine inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Quinidine inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Quinidine results in decreased expression of ABCB1 protein			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	tebufenozide inhibits the reaction ABCB1 protein results in increased transport of Quinidine			[590]
Regulation Mechanism				Transcription Factor Info
10,11-dihydro-10-hydroxycarbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of 10,11-dihydro-10-hydroxycarbamazepine			[337]
Regulation Mechanism				Transcription Factor Info
10-deacetylpaclitaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	10-deacetylpaclitaxel binds to ABCB1 protein			[338]
Regulation Mechanism				Transcription Factor Info
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction TNF protein results in increased expression of ABCB1 mRNA			[339]
Regulation Mechanism				Transcription Factor Info
18alpha-glycyrrhetinic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	18alpha-glycyrrhetinic acid inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of ABCB1 protein			[341]
Regulation Mechanism				Transcription Factor Info
1-methylindole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-methylindole results in increased expression of ABCB1 mRNA			[324]
Regulation Mechanism				Transcription Factor Info
22,23-dihydroavermectin B(1)a	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	22,23-dihydroavermectin B(1)a results in decreased activity of ABCB1 protein			[342]
Regulation Mechanism				Transcription Factor Info
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction Digoxin results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction Ouabain results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 mRNA			[304]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 protein			[304]
Regulation Mechanism				Transcription Factor Info
2-Acetylaminofluorene	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-Acetylaminofluorene results in decreased expression of ABCB1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-Acetylaminofluorene results in increased activity of ABCB1 protein			[344]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	2-Acetylaminofluorene results in increased activity of AKT1 protein which results in increased expression of ABCB1 mRNA			[344]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	2-Acetylaminofluorene results in increased activity of RAC1 protein which results in increased expression of ABCB1 mRNA			[344]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	2-Acetylaminofluorene results in increased expression of ABCB1 mRNA			[344]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	RELA protein binds to NFKB1 protein affects the reaction 2-Acetylaminofluorene results in increased expression of ABCB1 mRNA			[344]
Regulation Mechanism				Transcription Factor Info
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[345]
Regulation Mechanism				Transcription Factor Info
2-phenylphenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-phenylphenol results in decreased expression of ABCB1 mRNA			[346]
Regulation Mechanism				Transcription Factor Info
3,3'-diindolylmethane	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,3'-diindolylmethane results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[347]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3,3'-diindolylmethane results in increased expression of ABCB1 mRNA			[347]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoconazole inhibits the reaction 3,3'-diindolylmethane results in increased expression of ABCB1 mRNA			[347]
Regulation Mechanism				Transcription Factor Info
3',4',7-trihydroxyisoflavone	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3',4',7-trihydroxyisoflavone inhibits the reaction Epirubicin results in increased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetylcysteine inhibits the reaction 3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ascorbic Acid inhibits the reaction 3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	CAT protein inhibits the reaction 3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
3,4-Methylenedioxyamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,4-Methylenedioxyamphetamine results in increased activity of ABCB1 protein			[303]
Regulation Mechanism				Transcription Factor Info
3,4-methylenedioxyethamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,4-methylenedioxyethamphetamine results in decreased activity of ABCB1 protein			[282]
Regulation Mechanism				Transcription Factor Info
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Digoxin results in increased expression of ABCB1 mRNA			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Digoxin results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Ouabain results in increased expression of ABCB1 mRNA			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction Ouabain results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
3-hydroxyflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-hydroxyflavone results in increased expression of ABCB1 mRNA			[273]
Regulation Mechanism				Transcription Factor Info
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
4-cumylphenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-cumylphenol results in increased expression of ABCB1 mRNA			[300]
Regulation Mechanism				Transcription Factor Info
4-iodo-2,5-dimethoxyphenylisopropylamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of ABCB1 protein			[303]
Regulation Mechanism				Transcription Factor Info
4-methoxyamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-methoxyamphetamine results in decreased activity of ABCB1 protein			[282]
Regulation Mechanism				Transcription Factor Info
4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Daunorubicin results in increased expression of ABCB1 mRNA			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to Doxorubicin affects the reaction 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA			[351]
Regulation Mechanism				Transcription Factor Info
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 protein			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA			[352]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of and results in decreased activity of ABCB1 protein			[352]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	diacetyldiphenylurea bisguanylhydrazone inhibits the reaction 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA			[352]
Regulation Mechanism				Transcription Factor Info
5,7-dimethoxyflavone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dimethoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5,7-dimethoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	5,7-dimethoxyflavone inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
5-hydroxyflavone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-hydroxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5-hydroxyflavone inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
5-methoxyflavone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-methoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5-methoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
5-Methoxypsoralen	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-Methoxypsoralen results in decreased activity of ABCB1 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5-Methoxypsoralen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	5-Methoxypsoralen results in increased expression of ABCB1 mRNA			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Verapamil inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCB1 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Verapamil inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCB1 protein which results in decreased export of and results in increased abundance of Daunorubicin			[210]
Regulation Mechanism				Transcription Factor Info
5-methylindole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-methylindole results in increased expression of ABCB1 mRNA			[324]
Regulation Mechanism				Transcription Factor Info
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide affects the expression of ABCB1 mRNA			[353]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide affects the expression of ABCB1 protein			[353]
Regulation Mechanism				Transcription Factor Info
8-azidoadenosine 5'-triphosphate	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-azidoadenosine 5'-triphosphate binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate			[355]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	beryllium fluoride promotes the reaction ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate			[355]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Disulfiram inhibits the reaction 8-azidoadenosine 5'-triphosphate binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	fluoroaluminum promotes the reaction ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate			[355]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Verapamil promotes the reaction ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate			[355]
Regulation Mechanism				Transcription Factor Info
abamectin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abamectin inhibits the reaction ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	abamectin results in decreased activity of ABCB1 protein			[205]
Regulation Mechanism				Transcription Factor Info
abemaciclib	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abemaciclib inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	abemaciclib inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	abemaciclib results in decreased activity of ABCB1 protein			[206]
Regulation Mechanism				Transcription Factor Info
abietic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abietic acid inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
Acenocoumarol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene polymorphism affects the susceptibility to Acenocoumarol			[357]
Regulation Mechanism				Transcription Factor Info
acetochlor	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the reaction acetochlor results in increased susceptibility to Paclitaxel			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	acetochlor results in increased activity of ABCB1 protein			[122]
Regulation Mechanism				Transcription Factor Info
Aconitine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 affects the transport of Aconitine			[363]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 results in decreased susceptibility to Aconitine			[363]
Regulation Mechanism				Transcription Factor Info
Adenosine Triphosphate	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Adenosine Triphosphate binds to ABCB1 protein			[365]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	aurapten promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[366]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Cobalt results in increased activity of ABCB1 protein which results in increased hydrolysis of Adenosine Triphosphate			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Crizotinib promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Disulfiram affects the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Lapatinib promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Magnesium results in increased activity of ABCB1 protein which results in increased hydrolysis of Adenosine Triphosphate			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Manganese results in increased activity of ABCB1 protein which results in increased hydrolysis of Adenosine Triphosphate			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	nobiletin promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[366]
Regulation Mechanism				Transcription Factor Info
afimoxifene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to afimoxifene			[367]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	afimoxifene results in increased expression of ABCB1 protein			[330]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ALB protein co-treated with afimoxifene results in increased expression of ABCB1 protein			[330]
Regulation Mechanism				Transcription Factor Info
alachlor	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the reaction alachlor results in increased susceptibility to Paclitaxel			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	alachlor results in increased activity of ABCB1 protein			[122]
Regulation Mechanism				Transcription Factor Info
allyl sulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	allyl sulfide results in increased expression of ABCB1 mRNA			[302]
Regulation Mechanism				Transcription Factor Info
amorphigenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	amorphigenin affects the activity of ABCB1 protein			[189]
Regulation Mechanism				Transcription Factor Info
amprenavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of amprenavir			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	amprenavir binds to ABCB1 protein			[370]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Elacridar binds to and results in decreased activity of ABCB1 protein which results in decreased export of amprenavir			[370]
Regulation Mechanism				Transcription Factor Info
amyloid beta-protein (1-40)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	amyloid beta-protein (1-40) results in decreased expression of ABCB1 protein			[371]
Regulation Mechanism				Transcription Factor Info
AN 204	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AN 204 results in increased expression of ABCB1 mRNA			[372]
Regulation Mechanism				Transcription Factor Info
anandamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of anandamide			[373]
Regulation Mechanism				Transcription Factor Info
antibiotic G 418	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of antibiotic G 418			[295]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	antibiotic G 418 results in decreased expression of ABCB1 mRNA			[295]
Regulation Mechanism				Transcription Factor Info
antofine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	antofine results in decreased expression of ABCB1 mRNA			[374]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	antofine results in decreased expression of ABCB1 protein			[374]
Regulation Mechanism				Transcription Factor Info
apicidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to apicidin			[375]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of ABCB1 mRNA			[376]
Regulation Mechanism				Transcription Factor Info
artemisinin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	artemisinin results in decreased activity of ABCB1 protein			[259]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	artemisinin results in increased expression of ABCB1 mRNA			[259]
Regulation Mechanism				Transcription Factor Info
ar-turmerone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ar-turmerone results in increased expression of ABCB1 mRNA			[383]
Regulation Mechanism				Transcription Factor Info
Asbestos, Crocidolite	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in increased expression of ABCB1 protein			[384]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ferric nitrilotriacetate inhibits the reaction Asbestos, Crocidolite results in increased expression of ABCB1 protein			[384]
Regulation Mechanism				Transcription Factor Info
Ascorbic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid inhibits the reaction 3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA			[348]
Regulation Mechanism				Transcription Factor Info
Atazanavir Sulfate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Atazanavir Sulfate			[387]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
aurapten	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aurapten promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[366]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	aurapten promotes the reaction ABCB1 protein results in increased import of Daunorubicin			[366]
Regulation Mechanism				Transcription Factor Info
azacyclonol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the transport of azacyclonol			[391]
Regulation Mechanism				Transcription Factor Info
Azathioprine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene polymorphism affects the susceptibility to Azathioprine			[392]
Regulation Mechanism				Transcription Factor Info
azelastine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azelastine inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	azelastine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	azelastine results in decreased activity of ABCB1 protein			[79]
Regulation Mechanism				Transcription Factor Info
azidopine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azidopine binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Disulfiram inhibits the reaction azidopine binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
azidoprazosin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azidoprazosin binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Disulfiram inhibits the reaction azidoprazosin binds to ABCB1 protein			[354]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Lapatinib inhibits the reaction azidoprazosin binds to ABCB1 protein			[364]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tacrolimus binds to ABCB1 protein inhibits the reaction azidoprazosin binds to ABCB1 protein			[393]
Regulation Mechanism				Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in decreased expression of ABCB1 mRNA			[346]
Regulation Mechanism				Transcription Factor Info
baicalein	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	baicalein inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	baicalein inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	baicalein inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	baicalein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	baicalein results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	baicalein results in increased expression of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
Beclomethasone	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased secretion of Beclomethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Beclomethasone inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Beclomethasone inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Beclomethasone results in increased expression of ABCB1 mRNA			[395]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Beclomethasone results in increased expression of ABCB1 protein			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Beclomethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Beclomethasone			[202]
Regulation Mechanism				Transcription Factor Info
benidipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benidipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased expression of ABCB1 mRNA			[399]
Regulation Mechanism				Transcription Factor Info
benzo(k)fluoranthene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(k)fluoranthene results in increased expression of ABCB1 mRNA			[400]
Regulation Mechanism				Transcription Factor Info
benzoylaconine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of benzoylaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of benzoylaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of benzoylaconine			[401]
Regulation Mechanism				Transcription Factor Info
benzoylhypaconine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of benzoylhypaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of benzoylhypaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of benzoylhypaconine			[401]
Regulation Mechanism				Transcription Factor Info
benzoylmesaconine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of benzoylmesaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of benzoylmesaconine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of benzoylmesaconine			[401]
Regulation Mechanism				Transcription Factor Info
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction CERS6 protein affects the expression of ABCB1 protein			[328]
Regulation Mechanism				Transcription Factor Info
bergamottin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bergamottin results in increased expression of ABCB1 mRNA			[291]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bergamottin results in increased expression of ABCB1 protein			[291]
Regulation Mechanism				Transcription Factor Info
beryllium fluoride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beryllium fluoride promotes the reaction ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate			[355]
Regulation Mechanism				Transcription Factor Info
beta-pinene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-pinene inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
betulin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	betulin inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[402]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	betulin inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[402]
Regulation Mechanism				Transcription Factor Info
biochanin A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	biochanin A inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	biochanin A inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	biochanin A promotes the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	biochanin A promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
bisbenzimide ethoxide trihydrochloride	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abamectin inhibits the reaction ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	emamectin inhibits the reaction ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ivermectin inhibits the reaction ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased export of bisbenzimide ethoxide trihydrochloride			[403]
Regulation Mechanism				Transcription Factor Info
Bisoprolol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Bisoprolol			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bisoprolol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	valspodar inhibits the reaction ABCB1 protein results in increased transport of Bisoprolol			[404]
Regulation Mechanism				Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 promoter SNP affects the reaction bisphenol A results in increased expression of ABCB1 mRNA			[333]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A affects the expression of ABCB1 mRNA			[405]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in increased expression of ABCB1 mRNA			[300]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in increased methylation of ABCB1 gene			[406]
Regulation Mechanism				Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol AF results in increased expression of ABCB1 mRNA			[407]
Regulation Mechanism				Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of ABCB1 mRNA			[300]
Regulation Mechanism				Transcription Factor Info
bisphenol S	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 promoter SNP affects the reaction bisphenol S affects the expression of ABCB1 mRNA			[333]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol S affects the expression of ABCB1 mRNA			[333]
Regulation Mechanism				Transcription Factor Info
bromotetrandrine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bromotetrandrine results in decreased expression of ABCB1 protein			[409]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles results in decreased expression of ABCB1 mRNA			[410]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Daunorubicin co-treated with bromotetrandrine results in decreased expression of ABCB1 mRNA			[410]
Regulation Mechanism				Transcription Factor Info
bufalin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bufalin inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[411]
Regulation Mechanism				Transcription Factor Info
butylbenzyl phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butylbenzyl phthalate results in increased expression of ABCB1 protein			[412]
Regulation Mechanism				Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in increased expression of ABCB1 mRNA			[310]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased expression of ABCB1 mRNA			[278]
Regulation Mechanism				Transcription Factor Info
calcein AM	44 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[345]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the export of calcein AM			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the reaction Mifepristone results in decreased transport of calcein AM			[415]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein affects the reaction zosuquidar trihydrochloride results in decreased transport of calcein AM			[415]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB1 protein results in increased secretion of calcein AM			[417]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCB1 protein results in increased transport of calcein AM			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Atorvastatin analog inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	calcein AM results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	chlorpyrifos-methyl affects the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Cyclosporine inhibits the reaction ABCB1 protein affects the export of calcein AM			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	deoxynivalenol inhibits the reaction valspodar inhibits the reaction ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Diazinon inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Diazinon promotes the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Diazinon promotes the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Diazinon promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Diazinon promotes the reaction Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Endosulfan co-treated with Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Endosulfan inhibits the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Endosulfan promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	fenoxycarb inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	fenvalerate inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Lovastatin analog inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	phosalone co-treated with Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	phosalone inhibits the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	phosalone inhibits the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	pinostrobin results in decreased activity of ABCB1 protein which results in decreased export of calcein AM			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	propiconazole inhibits the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	propiconazole promotes the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	propiconazole promotes the reaction Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Reserpine inhibits the reaction ABCB1 protein affects the export of calcein AM			[414]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Simvastatin analog inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	sodium arsenite promotes the reaction ABCB1 protein results in increased secretion of calcein AM			[417]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	spinosad inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[419]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	tectochrysin results in decreased activity of ABCB1 protein which results in decreased export of calcein AM			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	valspodar inhibits the reaction ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Verapamil binds to and results in decreased activity of ABCB1 protein inhibits the reaction sodium arsenite promotes the reaction ABCB1 protein results in increased secretion of calcein AM			[417]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Verapamil inhibits the reaction ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Verapamil promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Verapamil results in decreased activity of ABCB1 protein which results in decreased export of calcein AM			[418]
Regulation Mechanism				Transcription Factor Info
cambinol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cambinol affects the expression of ABCB1 mRNA			[353]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	cambinol affects the expression of ABCB1 protein			[353]
Regulation Mechanism				Transcription Factor Info
cannogenin thevetoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cannogenin thevetoside inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[411]
Regulation Mechanism				Transcription Factor Info
Carboplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carboplatin results in decreased expression of ABCB1 mRNA			[428]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Carboplatin results in decreased expression of ABCB1 protein			[428]
Regulation Mechanism				Transcription Factor Info
CEP 33779	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the reaction CEP 33779 results in decreased phosphorylation of STAT3 protein			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	CEP 33779 inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	CEP 33779 inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	CEP 33779 inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	CEP 33779 inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	CEP 33779 inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	CEP 33779 results in decreased activity of ABCB1 protein			[432]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	CEP 33779 results in increased activity of ABCB1 protein			[431]
Regulation Mechanism				Transcription Factor Info
cepharanthine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cepharanthine results in decreased activity of ABCB1 protein			[191]
Regulation Mechanism				Transcription Factor Info
cerivastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the export of cerivastatin			[433]
Regulation Mechanism				Transcription Factor Info
Cetirizine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of Cetirizine			[434]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
Chloroform	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroform results in increased expression of ABCB1 mRNA			[283]
Regulation Mechanism				Transcription Factor Info
chlorpyrifos-methyl	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chlorpyrifos-methyl affects the activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	chlorpyrifos-methyl affects the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
chlortoluron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chlortoluron results in decreased expression of ABCB1 mRNA			[346]
Regulation Mechanism				Transcription Factor Info
chrysene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chrysene results in increased expression of ABCB1 mRNA			[400]
Regulation Mechanism				Transcription Factor Info
chrysin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chrysin affects the activity of ABCB1 protein			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	chrysin results in decreased activity of ABCB1 protein			[297]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	chrysin results in decreased activity of ABCB1 protein which results in decreased export of Topotecan			[297]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	chrysin results in increased expression of ABCB1 protein			[297]
Regulation Mechanism				Transcription Factor Info
ciclesonide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ciclesonide results in increased expression of ABCB1 protein			[202]
Regulation Mechanism				Transcription Factor Info
Cilastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cilastatin inhibits the reaction Vancomycin results in decreased expression of and affects the localization of ABCB1 protein			[439]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cilastatin results in increased expression of and affects the localization of ABCB1 protein			[439]
Regulation Mechanism				Transcription Factor Info
cinchonine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cinchonine analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	cinchonine analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	cinchonine analog results in decreased expression of ABCB1 protein			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	cinchonine inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	cinchonine inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[440]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	cinchonine results in decreased expression of ABCB1 protein			[440]
Regulation Mechanism				Transcription Factor Info
citronellal	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	citronellal inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	citronellal results in decreased activity of ABCB1 protein			[454]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	citronellal results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[454]
Regulation Mechanism				Transcription Factor Info
citronellol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	citronellol inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	citronellol results in decreased activity of ABCB1 protein			[454]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	citronellol results in decreased activity of ABCB1 protein which results in decreased export of Digoxin			[454]
Regulation Mechanism				Transcription Factor Info
Cobalt	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cobalt results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cobalt results in increased activity of ABCB1 protein which results in increased hydrolysis of Adenosine Triphosphate			[279]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride promotes the reaction HIF1A protein results in increased expression of ABCB1 mRNA			[458]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	HIPK2 protein inhibits the reaction cobaltous chloride promotes the reaction HIF1A protein results in increased expression of ABCB1 mRNA			[458]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	zinc chloride inhibits the reaction cobaltous chloride results in increased expression of ABCB1 mRNA			[459]
Regulation Mechanism				Transcription Factor Info
Colchicine	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the transport of Colchicine			[460]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to Colchicine			[461]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased export of Colchicine			[461]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Colchicine inhibits the reaction Verapamil analog results in increased activity of ABCB1 protein mutant form			[185]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Colchicine results in increased expression of ABCB1			[462]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Colchicine results in increased expression of ABCB1 mRNA			[463]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	MGMT protein co-treated with ABCB1 protein results in decreased susceptibility to Colchicine			[429]
Regulation Mechanism				Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
costunolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	costunolide results in decreased expression of ABCB1 protein			[464]
Regulation Mechanism				Transcription Factor Info
cucurbitacin I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cucurbitacin I inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
cyazofamid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of cyazofamid			[473]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	cyazofamid affects the reaction ABCB1 protein results in increased uptake of Digoxin			[473]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil inhibits the reaction ABCB1 protein results in increased transport of cyazofamid			[473]
Regulation Mechanism				Transcription Factor Info
Cycloserine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cycloserine inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[328]
Regulation Mechanism				Transcription Factor Info
Cymarine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cymarine inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[411]
Regulation Mechanism				Transcription Factor Info
cyproconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyproconazole results in decreased expression of ABCB1 mRNA			[346]
Regulation Mechanism				Transcription Factor Info
daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
decamethrin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
dehydroandrographolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dehydroandrographolide inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deoxycholic Acid metabolite results in increased expression of ABCB1 mRNA			[207]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
Deoxyglucose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deoxyglucose inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
deoxynivalenol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to deoxynivalenol			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	deoxynivalenol inhibits the reaction valspodar inhibits the reaction ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
desethylamiodarone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	desethylamiodarone inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	desethylamiodarone inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	desethylamiodarone results in decreased activity of ABCB1 protein			[79]
Regulation Mechanism				Transcription Factor Info
desisobutyrylciclesonide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	desisobutyrylciclesonide inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	desisobutyrylciclesonide inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
desloratadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of desloratadine			[434]
Regulation Mechanism				Transcription Factor Info
desmethylazelastine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	desmethylazelastine inhibits the reaction ABCB1 protein results in increased transport of Daunorubicin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	desmethylazelastine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	desmethylazelastine results in decreased activity of ABCB1 protein			[79]
Regulation Mechanism				Transcription Factor Info
diacetyldiphenylurea bisguanylhydrazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diacetyldiphenylurea bisguanylhydrazone inhibits the reaction 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA			[352]
Regulation Mechanism				Transcription Factor Info
diallyl disulfide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diallyl disulfide inhibits the reaction PARK7 protein results in increased expression of ABCB1 mRNA			[497]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	diallyl disulfide results in decreased expression of ABCB1 mRNA			[497]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	diallyl disulfide results in increased expression of ABCB1 mRNA			[302]
Regulation Mechanism				Transcription Factor Info
diallyl trisulfide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diallyl trisulfide results in decreased expression of ABCB1 protein			[498]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	diallyl trisulfide results in increased expression of ABCB1 mRNA			[302]
Regulation Mechanism				Transcription Factor Info
dibenzo(a,l)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dibenzo(a,l)pyrene results in increased expression of ABCB1 mRNA			[400]
Regulation Mechanism				Transcription Factor Info
Dichlororibofuranosylbenzimidazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlororibofuranosylbenzimidazole inhibits the reaction mangiferin results in increased expression of ABCB1 protein			[298]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dichlororibofuranosylbenzimidazole inhibits the reaction sodium arsenite results in increased expression of ABCB1 protein			[417]
Regulation Mechanism				Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of ABCB1 mRNA			[315]
Regulation Mechanism				Transcription Factor Info
Digoxigenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Digoxigenin			[500]
Regulation Mechanism				Transcription Factor Info
dihydromyricetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dihydromyricetin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
dihydroxy-vitamin D3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dihydroxy-vitamin D3 results in decreased susceptibility to Particulate Matter which results in decreased expression of ABCB1 mRNA			[508]
Regulation Mechanism				Transcription Factor Info
dimethomorph	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dimethomorph results in decreased activity of ABCB1 protein			[342]
Regulation Mechanism				Transcription Factor Info
dioscin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dioscin results in decreased expression of ABCB1 mRNA			[509]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dioscin results in decreased expression of ABCB1 protein			[509]
Regulation Mechanism				Transcription Factor Info
Domperidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene SNP affects the susceptibility to Domperidone			[516]
Regulation Mechanism				Transcription Factor Info
doramectin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	doramectin results in decreased expression of ABCB1 mRNA			[517]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	doramectin results in decreased expression of ABCB1 protein			[517]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dorsomorphin inhibits the reaction rubimaillin results in decreased expression of ABCB1 mRNA			[304]
Regulation Mechanism				Transcription Factor Info
efonidipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	efonidipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
emamectin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	emamectin inhibits the reaction ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	emamectin results in decreased activity of ABCB1 protein			[205]
Regulation Mechanism				Transcription Factor Info
Emodin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Emodin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
enasidenib	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	enasidenib inhibits the reaction ABCB1 protein results in decreased susceptibility to Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	enasidenib inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	enasidenib inhibits the reaction ABCB1 protein results in increased export of Daunorubicin which results in increased susceptibility to Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
enkephalin-Leu, Ala(2)-melphalan methyl ester-	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the transport of enkephalin-Leu, Ala(2)-melphalan methyl ester- analog			[552]
Regulation Mechanism				Transcription Factor Info
epigallocatechin gallate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate results in decreased expression of ABCB1 mRNA			[553]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	epigallocatechin gallate results in decreased expression of ABCB1 protein			[554]
Regulation Mechanism				Transcription Factor Info
eriodictyol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to Doxorubicin affects the reaction eriodictyol inhibits the reaction Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	eriodictyol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
Erythrosine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythrosine results in decreased activity of ABCB1 protein			[296]
Regulation Mechanism				Transcription Factor Info
Ethylmaleimide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethylmaleimide results in decreased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
evodiamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	evodiamine inhibits the reaction TNF protein results in increased expression of ABCB1 protein			[560]
Regulation Mechanism				Transcription Factor Info
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibrate inhibits the reaction ABCB1 protein results in increased transport of Vincristine			[561]
Regulation Mechanism				Transcription Factor Info
fenoxycarb	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fenoxycarb inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	fenoxycarb results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
fenvalerate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fenvalerate inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	fenvalerate results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
ferric nitrilotriacetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ferric nitrilotriacetate inhibits the reaction Asbestos, Crocidolite results in increased expression of ABCB1 protein			[384]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ferric nitrilotriacetate inhibits the reaction Razoxane results in increased expression of ABCB1 protein			[384]
Regulation Mechanism				Transcription Factor Info
ferrostatin-1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ferrostatin-1 inhibits the reaction HMOX1 protein results in decreased expression of ABCB1 protein			[547]
Regulation Mechanism				Transcription Factor Info
fexofenadine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene SNP affects the susceptibility to fexofenadine			[563]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Itraconazole promotes the reaction ABCB1 gene SNP affects the susceptibility to fexofenadine			[564]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Plant Extracts promotes the reaction ABCB1 protein results in increased transport of fexofenadine			[484]
Regulation Mechanism				Transcription Factor Info
flavone	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	flavone inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	flavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	flavone promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	flavone results in decreased expression of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	flavone results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
fluorexon	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Beclomethasone inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Carvedilol results in decreased activity of ABCB1 protein which results in increased uptake of fluorexon			[430]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Clotrimazole inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Cyclosporine inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	desisobutyrylciclesonide inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Ketoconazole inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Miconazole inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Mometasone Furoate inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Reserpine inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Troleandomycin inhibits the reaction ABCB1 protein results in increased secretion of fluorexon			[369]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Verapamil inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Verapamil results in decreased activity of ABCB1 protein which results in increased uptake of fluorexon			[430]
Regulation Mechanism				Transcription Factor Info
Fluticasone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased secretion of Fluticasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCB1 protein results in increased secretion of Fluticasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Fluticasone results in increased expression of ABCB1 protein			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Fluticasone			[202]
Regulation Mechanism				Transcription Factor Info
fluxapyroxad	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fluxapyroxad results in decreased expression of ABCB1 mRNA			[346]
Regulation Mechanism				Transcription Factor Info
formononetin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction formononetin results in increased expression of ABCB1 mRNA			[362]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	formononetin affects the activity of ABCB1 protein			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	formononetin inhibits the reaction Epirubicin results in increased expression of ABCB1 mRNA			[362]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	formononetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	formononetin results in increased expression of ABCB1 mRNA			[362]
Regulation Mechanism				Transcription Factor Info
Fusidic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fusidic Acid inhibits the reaction ABCB1 protein results in increased export of Digoxin			[507]
Regulation Mechanism				Transcription Factor Info
galangin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	galangin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	galangin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	galangin results in increased expression of ABCB1 mRNA			[273]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	galangin results in increased expression of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Verapamil promotes the reaction galangin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
gambogic acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine affects the reaction gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of CASP7 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine affects the reaction gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of PARP1 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of CASP7 protein			[361]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	gambogic acid affects the reaction ABCB1 protein affects the susceptibility to Doxorubicin which affects the cleavage of PARP1 protein			[361]
Regulation Mechanism				Transcription Factor Info
gamma-terpinene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gamma-terpinene inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
geldanamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	geldanamycin inhibits the reaction TNF protein results in increased expression of ABCB1 mRNA			[339]
Regulation Mechanism				Transcription Factor Info
germacrone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein inhibits the reaction germacrone results in increased susceptibility to Doxorubicin			[524]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	germacrone inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[524]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	germacrone inhibits the reaction Doxorubicin results in increased expression of ABCB1 protein			[524]
Regulation Mechanism				Transcription Factor Info
gingerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gingerol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[469]
Regulation Mechanism				Transcription Factor Info
ginkgolic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginkgolic acid affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
ginkgolide A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginkgolide A results in increased expression of ABCB1 mRNA			[179]
Regulation Mechanism				Transcription Factor Info
ginkgolide B	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginkgolide B results in increased expression of ABCB1 mRNA			[179]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NR1I2 protein affects the reaction ginkgolide B results in increased expression of ABCB1 mRNA			[272]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sulforaphane inhibits the reaction ginkgolide B results in increased expression of ABCB1 mRNA			[272]
Regulation Mechanism				Transcription Factor Info
ginsenoside F2	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginsenoside F2 analog inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
glabridin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glabridin affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
glaucine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glaucine results in increased activity of ABCB1 protein			[303]
Regulation Mechanism				Transcription Factor Info
globotriaosylceramide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased chemical synthesis of globotriaosylceramide			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction ABCB1 protein results in increased chemical synthesis of globotriaosylceramide			[480]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoconazole inhibits the reaction ABCB1 protein results in increased chemical synthesis of globotriaosylceramide			[480]
Regulation Mechanism				Transcription Factor Info
Glutathione	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glutathione inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glutathione inhibits the reaction Ethanol results in increased expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glutathione inhibits the reaction Hydrogen Peroxide affects the expression of ABCB1 mRNA			[329]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glutathione inhibits the reaction titanium dioxide results in increased expression of ABCB1 mRNA			[213]
Regulation Mechanism				Transcription Factor Info
glycitein	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glycitein inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	glycitein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	glycitein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
Glycyrrhetinic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhetinic Acid affects the activity of ABCB1 protein which affects the susceptibility to Vinblastine			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycyrrhetinic Acid affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycyrrhetinic Acid inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycyrrhetinic Acid inhibits the reaction Verapamil results in increased activity of ABCB1 protein			[139]
Regulation Mechanism				Transcription Factor Info
GSK 1363089	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK 1363089 inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[536]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GSK 1363089 results in decreased activity of ABCB1 protein			[536]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	GSK 1363089 results in decreased activity of ABCB1 protein which results in decreased export of Rhodamine 123			[536]
Regulation Mechanism				Transcription Factor Info
Guanosine Triphosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased hydrolysis of Guanosine Triphosphate			[279]
Regulation Mechanism				Transcription Factor Info
GW 7647	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 7647 results in increased expression of ABCB1 mRNA			[322]
Regulation Mechanism				Transcription Factor Info
Hexachlorocyclohexane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hexachlorocyclohexane results in increased expression of ABCB1 mRNA			[124]
Regulation Mechanism				Transcription Factor Info
huperzine A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of huperzine A			[549]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCB1 protein results in increased transport of huperzine A			[549]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil inhibits the reaction ABCB1 protein results in increased transport of huperzine A			[549]
Regulation Mechanism				Transcription Factor Info
hydramethylnon	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hydramethylnon binds to ABCB1 protein			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	hydramethylnon inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
hypaconitine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of hypaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of hypaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of hypaconitine			[401]
Regulation Mechanism				Transcription Factor Info
hyperforin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hyperforin inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	hyperforin results in increased expression of ABCB1			[567]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	hyperforin results in increased expression of ABCB1 mRNA			[568]
Regulation Mechanism				Transcription Factor Info
hypericin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hypericin inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	hypericin results in increased expression of ABCB1			[567]
Regulation Mechanism				Transcription Factor Info
indole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indole promotes the reaction NR1I2 protein binds to ABCB1 promoter			[276]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	indole results in increased expression of ABCB1 mRNA			[276]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NR1I2 protein promotes the reaction indole results in increased expression of ABCB1 mRNA			[276]
Regulation Mechanism				Transcription Factor Info
indole-3-carbinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indole-3-carbinol results in decreased expression of ABCB1			[571]
Regulation Mechanism				Transcription Factor Info
indoleacetamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indoleacetamide promotes the reaction NR1I2 protein binds to ABCB1 promoter			[276]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	indoleacetamide results in increased expression of ABCB1 mRNA			[276]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NR1I2 protein promotes the reaction indoleacetamide results in increased expression of ABCB1 mRNA			[276]
Regulation Mechanism				Transcription Factor Info
Irinotecan	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 exon SNP affects the susceptibility to and affects the metabolism of Irinotecan			[572]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 gene polymorphism affects the susceptibility to Irinotecan			[573]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein affects the export of Irinotecan			[574]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein results in decreased susceptibility to Irinotecan			[575]
Regulation Mechanism				Transcription Factor Info
isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein			[506]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein which results in increased uptake of Digoxin			[506]
Regulation Mechanism				Transcription Factor Info
isosafrole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	isosafrole results in increased expression of ABCB1 protein			[75]
Regulation Mechanism				Transcription Factor Info
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vorinostat co-treated with Isotretinoin results in increased expression of ABCB1 mRNA			[576]
Regulation Mechanism				Transcription Factor Info
isovitexin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	isovitexin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	isovitexin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
juniper berry oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	juniper berry oil results in increased expression of ABCB1 mRNA			[319]
Regulation Mechanism				Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	K 7174 results in increased expression of ABCB1 mRNA			[306]
Regulation Mechanism				Transcription Factor Info
kaempferide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	kaempferide inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	kaempferide inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
kaempferol	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of kaempferol			[349]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	kaempferol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	kaempferol inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	kaempferol inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	kaempferol inhibits the reaction ABCB1 protein results in increased secretion of Ritonavir			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	kaempferol results in decreased expression of ABCB1 mRNA			[214]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	kaempferol results in decreased expression of ABCB1 protein			[214]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	kaempferol results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Verapamil co-treated with kaempferol results in decreased expression of ABCB1 mRNA			[214]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Verapamil co-treated with kaempferol results in decreased expression of ABCB1 protein			[214]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Verapamil promotes the reaction kaempferol results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
kenpaullone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	kenpaullone results in increased expression of ABCB1 protein			[289]
Regulation Mechanism				Transcription Factor Info
KN 93	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	KN 93 inhibits the reaction Digoxin results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	KN 93 inhibits the reaction Ouabain results in increased expression of ABCB1 protein			[343]
Regulation Mechanism				Transcription Factor Info
KT 5720	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	KT 5720 results in decreased activity of ABCB1 protein			[488]
Regulation Mechanism				Transcription Factor Info
Lansoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 affects the susceptibility to Lansoprazole			[581]
Regulation Mechanism				Transcription Factor Info
LCL161	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LCL161 binds to and affects the activity of ABCB1 protein			[365]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	LCL161 inhibits the reaction ABCB1 protein results in increased export of Fluorescent Dyes			[365]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	LCL161 inhibits the reaction ABCB1 protein results in increased export of mitotracker green FM			[365]
Regulation Mechanism				Transcription Factor Info
Lomustine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lomustine results in increased expression of ABCB1 protein			[186]
Regulation Mechanism				Transcription Factor Info
macitentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	macitentan results in decreased expression of ABCB1 mRNA			[208]
Regulation Mechanism				Transcription Factor Info
Magnesium	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Calcium inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Copper inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Magnesium results in increased activity of ABCB1 protein which results in increased hydrolysis of Adenosine Triphosphate			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Nickel inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Zinc inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
mangiferin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlororibofuranosylbenzimidazole inhibits the reaction mangiferin results in increased expression of ABCB1 protein			[298]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	mangiferin results in increased expression of ABCB1 mRNA			[298]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	mangiferin results in increased expression of ABCB1 protein			[298]
Regulation Mechanism				Transcription Factor Info
manidipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	manidipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
matairesinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	matairesinol affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
Meloxicam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Meloxicam inhibits the reaction Doxorubicin results in increased activity of ABCB1 protein			[533]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Meloxicam inhibits the reaction Doxorubicin results in increased expression of ABCB1 protein			[533]
Regulation Mechanism				Transcription Factor Info
mepirodipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mepirodipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
mesaconitine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of mesaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine results in decreased activity of ABCB1 protein which results in decreased transport of mesaconitine			[401]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil results in decreased activity of ABCB1 protein which results in decreased transport of mesaconitine			[401]
Regulation Mechanism				Transcription Factor Info
metazachlor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	metazachlor results in increased activity of ABCB1 protein			[122]
Regulation Mechanism				Transcription Factor Info
Methadone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methadone affects the activity of ABCB1 protein			[385]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Methadone results in increased expression of ABCB1 protein			[385]
Regulation Mechanism				Transcription Factor Info
methoxyfenozide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of methoxyfenozide			[590]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	methoxyfenozide inhibits the reaction ABCB1 protein results in increased transport of Quinidine			[590]
Regulation Mechanism				Transcription Factor Info
midostaurin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	midostaurin results in decreased activity of ABCB1 protein			[184]
Regulation Mechanism				Transcription Factor Info
Mifepristone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the reaction Mifepristone results in decreased transport of calcein AM			[415]
Regulation Mechanism				Transcription Factor Info
miltefosine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to miltefosine			[591]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	miltefosine binds to and results in decreased activity of ABCB1 protein			[591]
Regulation Mechanism				Transcription Factor Info
mitotracker green FM	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of mitotracker green FM			[365]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	LCL161 inhibits the reaction ABCB1 protein results in increased export of mitotracker green FM			[365]
Regulation Mechanism				Transcription Factor Info
MLN 8237	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of MLN 8237			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	MLN 8237 affects the activity of ABCB1 protein			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	MLN 8237 affects the activity of ABCB1 protein which affects the export of Daunorubicin			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	zosuquidar trihydrochloride inhibits the reaction ABCB1 protein results in increased transport of MLN 8237			[403]
Regulation Mechanism				Transcription Factor Info
Mometasone Furoate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mometasone Furoate inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[394]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mometasone Furoate inhibits the reaction ABCB1 protein results in increased export of fluorexon			[394]
Regulation Mechanism				Transcription Factor Info
morin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	morin promotes the reaction Quercetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	morin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
moxidectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	moxidectin results in decreased expression of ABCB1 protein			[595]
Regulation Mechanism				Transcription Factor Info
mulberroside A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mulberroside A inhibits the reaction NR1I2 protein results in increased susceptibility to Rifampin which results in increased expression of ABCB1 mRNA			[596]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	mulberroside A inhibits the reaction NR1I2 protein results in increased susceptibility to Rifampin which results in increased expression of ABCB1 protein			[596]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	mulberroside A results in decreased expression of ABCB1 mRNA			[597]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	mulberroside A results in decreased expression of and results in decreased activity of ABCB1 protein			[597]
Regulation Mechanism				Transcription Factor Info
myricetin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	myricetin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	myricetin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	myricetin results in increased expression of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
N-(1-phenylcyclohexyl)-3-ethoxypropanamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-(1-phenylcyclohexyl)-3-ethoxypropanamine results in increased activity of ABCB1 protein			[303]
Regulation Mechanism				Transcription Factor Info
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Colforsin results in increased expression of ABCB1 mRNA			[281]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of ABCB1 protein			[304]
Regulation Mechanism				Transcription Factor Info
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCB1 mRNA			[304]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCB1 protein			[299]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ABCB1 mRNA			[299]
Regulation Mechanism				Transcription Factor Info
N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine			[413]
Regulation Mechanism				Transcription Factor Info
N-acetyl-L-arginine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the transport of N-acetyl-L-arginine			[598]
Regulation Mechanism				Transcription Factor Info
N-acetylsphingosine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-acetylsphingosine results in increased expression of ABCB1			[487]
Regulation Mechanism				Transcription Factor Info
naphthalene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naphthalene results in decreased activity of ABCB1 protein			[290]
Regulation Mechanism				Transcription Factor Info
naphthalenediimide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naphthalenediimide analog results in decreased expression of ABCB1 mRNA			[599]
Regulation Mechanism				Transcription Factor Info
naringenin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringenin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	naringenin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	naringenin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	naringenin results in increased expression of ABCB1 mRNA			[291]
Regulation Mechanism				Transcription Factor Info
naringin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
N-caproylsphingosine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to N-caproylsphingosine			[413]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	valspodar inhibits the reaction ABCB1 protein results in decreased susceptibility to N-caproylsphingosine			[413]
Regulation Mechanism				Transcription Factor Info
nemadectin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nemadectin results in decreased expression of ABCB1 mRNA			[517]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	nemadectin results in decreased expression of ABCB1 protein			[517]
Regulation Mechanism				Transcription Factor Info
Nicardipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicardipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
nilotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the susceptibility to nilotinib			[569]
Regulation Mechanism				Transcription Factor Info
nilvadipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nilvadipine inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[131]
Regulation Mechanism				Transcription Factor Info
nimesulide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nimesulide results in decreased expression of ABCB1 protein			[299]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	nimesulide results in increased expression of ABCB1 mRNA			[299]
Regulation Mechanism				Transcription Factor Info
nivalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nivalenol results in increased expression of ABCB1 protein			[603]
Regulation Mechanism				Transcription Factor Info
N-Methyl-3,4-methylenedioxyamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ABCB1 protein			[282]
Regulation Mechanism				Transcription Factor Info
nobiletin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nobiletin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	nobiletin promotes the reaction ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate			[366]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	nobiletin promotes the reaction ABCB1 protein results in increased import of Daunorubicin			[366]
Regulation Mechanism				Transcription Factor Info
N-oleoylethanolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of N-oleoylethanolamine			[373]
Regulation Mechanism				Transcription Factor Info
norathyriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	norathyriol results in increased expression of ABCB1 protein			[298]
Regulation Mechanism				Transcription Factor Info
Norethindrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Norethindrone results in increased expression of ABCB1 mRNA			[177]
Regulation Mechanism				Transcription Factor Info
Nortriptyline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 exon SNP affects the susceptibility to Nortriptyline			[604]
Regulation Mechanism				Transcription Factor Info
notoginsenoside R1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	notoginsenoside R1 results in increased expression of ABCB1 mRNA			[308]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NR1I2 protein promotes the reaction notoginsenoside R1 results in increased expression of ABCB1 mRNA			[308]
Regulation Mechanism				Transcription Factor Info
NSC73306	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased susceptibility to NSC73306			[605]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tariquidar inhibits the reaction ABCB1 protein results in increased susceptibility to NSC73306			[605]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	valspodar inhibits the reaction ABCB1 protein results in increased susceptibility to NSC73306			[605]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	zosuquidar trihydrochloride analog inhibits the reaction ABCB1 protein results in increased susceptibility to NSC73306			[605]
Regulation Mechanism				Transcription Factor Info
nutlin 3	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the susceptibility to nutlin 3			[606]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	nutlin 3 results in decreased expression of ABCB1 protein			[607]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	PVT1 protein inhibits the reaction nutlin 3 results in decreased expression of ABCB1 protein			[607]
Regulation Mechanism				Transcription Factor Info
NVP-BSK805	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NVP-BSK805 results in decreased activity of ABCB1 protein			[432]
Regulation Mechanism				Transcription Factor Info
oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oltipraz results in increased expression of ABCB1 mRNA			[286]
Regulation Mechanism				Transcription Factor Info
omadacycline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of omadacycline			[609]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased transport of omadacycline			[609]
Regulation Mechanism				Transcription Factor Info
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of ABCB1 mRNA			[284]
Regulation Mechanism				Transcription Factor Info
o,p'-DDT	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	o,p'-DDT results in decreased activity of ABCB1 protein			[128]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	o,p'-DDT results in increased expression of ABCB1 mRNA			[124]
Regulation Mechanism				Transcription Factor Info
ophiobolin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ophiobolin A inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
Oxygen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of ABCB1 mRNA			[610]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Oxygen deficiency results in increased expression of ABCB1 mRNA			[611]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	pyrazolanthrone inhibits the reaction Oxygen deficiency results in increased expression of ABCB1 mRNA			[611]
Regulation Mechanism				Transcription Factor Info
Paliperidone Palmitate	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene polymorphism affects the abundance of Paliperidone Palmitate			[618]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the abundance of Paliperidone Palmitate			[618]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in increased transport of Paliperidone Palmitate			[619]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Paliperidone Palmitate inhibits the reaction ABCB1 protein results in decreased export of Doxorubicin			[218]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Paliperidone Palmitate results in decreased activity of ABCB1 protein			[194]
Regulation Mechanism				Transcription Factor Info
palmidrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of palmidrol			[373]
Regulation Mechanism				Transcription Factor Info
Parathion	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased export of Parathion			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Parathion binds to ABCB1 protein			[437]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Parathion inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[437]
Regulation Mechanism				Transcription Factor Info
parthenolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	parthenolide results in decreased expression of ABCB1 protein			[464]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased activity of ABCB1 protein			[305]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased activity of ABCB1 protein			[305]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanoic acid results in decreased expression of ABCB1 mRNA			[621]
Regulation Mechanism				Transcription Factor Info
phloxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	phloxine results in decreased activity of ABCB1 protein			[296]
Regulation Mechanism				Transcription Factor Info
phosalone	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon promotes the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diazinon promotes the reaction phosalone results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Endosulfan inhibits the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Endosulfan inhibits the reaction phosalone results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	phosalone co-treated with Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	phosalone co-treated with Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	phosalone inhibits the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	phosalone inhibits the reaction Endosulfan results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	phosalone inhibits the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	phosalone inhibits the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	phosalone results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	propiconazole inhibits the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	propiconazole inhibits the reaction phosalone results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
Phosphatidylcholines	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the export of Phosphatidylcholines			[625]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein affects the transport of Phosphatidylcholines			[626]
Regulation Mechanism				Transcription Factor Info
phyllodulcin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	phyllodulcin affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
PI103	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PI103 results in decreased expression of ABCB1 mRNA			[627]
Regulation Mechanism				Transcription Factor Info
pimecrolimus	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pimecrolimus inhibits the reaction Rifampin results in increased expression of ABCB1 mRNA			[317]
Regulation Mechanism				Transcription Factor Info
pinostrobin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to pinostrobin			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pinostrobin inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	pinostrobin inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	pinostrobin inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	pinostrobin results in decreased activity of ABCB1 protein			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	pinostrobin results in decreased activity of ABCB1 protein which results in decreased export of calcein AM			[418]
Regulation Mechanism				Transcription Factor Info
piperine	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction piperine results in increased expression of ABCB1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ketoconazole inhibits the reaction NR1I2 protein promotes the reaction piperine results in increased expression of ABCB1 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NR1I2 protein promotes the reaction piperine results in increased expression of ABCB1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NR1I2 protein promotes the reaction piperine results in increased expression of ABCB1 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	piperine analog results in decreased expression of ABCB1 protein			[628]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	piperine results in increased expression of ABCB1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	piperine results in increased expression of ABCB1 protein			[68]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in increased expression of ABCB1 mRNA			[629]
Regulation Mechanism				Transcription Factor Info
pitavastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the transport of pitavastatin			[630]
Regulation Mechanism				Transcription Factor Info
plastochromanol 8	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	plastochromanol 8 results in increased expression of ABCB1			[187]
Regulation Mechanism				Transcription Factor Info
Pravastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Pravastatin			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased transport of Pravastatin analog			[53]
Regulation Mechanism				Transcription Factor Info
Prazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the transport of Prazosin			[53]
Regulation Mechanism				Transcription Factor Info
propiconazole	20 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diazinon promotes the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Endosulfan promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Endosulfan promotes the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	phosalone inhibits the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	phosalone inhibits the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	propiconazole inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[556]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	propiconazole inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[556]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	propiconazole inhibits the reaction phosalone inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	propiconazole inhibits the reaction phosalone results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	propiconazole metabolite affects the reaction ABCB1 protein results in increased transport of quinidinium			[556]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	propiconazole promotes the reaction Endosulfan inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	propiconazole promotes the reaction Endosulfan results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	propiconazole promotes the reaction Verapamil inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	propiconazole promotes the reaction Verapamil results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	propiconazole results in increased expression of ABCB1 mRNA			[292]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Verapamil promotes the reaction propiconazole inhibits the reaction ABCB1 protein results in increased transport of calcein AM			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Verapamil promotes the reaction propiconazole results in decreased activity of ABCB1 protein			[129]
Regulation Mechanism				Transcription Factor Info
Propranolol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Propranolol results in increased expression of ABCB1 mRNA			[631]
Regulation Mechanism				Transcription Factor Info
Proscillaridin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Proscillaridin			[500]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Proscillaridin inhibits the reaction ABCB1 protein results in increased transport of quinidinium			[411]
Regulation Mechanism				Transcription Factor Info
protoapigenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	protoapigenone analog results in decreased expression of ABCB1 protein			[632]
Regulation Mechanism				Transcription Factor Info
psorospermin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	psorospermin inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[542]
Regulation Mechanism				Transcription Factor Info
puerarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	puerarin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
Puromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Puromycin			[295]
Regulation Mechanism				Transcription Factor Info
pyrazolanthrone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrazolanthrone inhibits the reaction MAP3K1 protein results in increased expression of ABCB1 mRNA			[611]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pyrazolanthrone inhibits the reaction Oxygen deficiency results in increased expression of ABCB1 mRNA			[611]
Regulation Mechanism				Transcription Factor Info
quercitrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quercitrin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
Quetiapine Fumarate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quetiapine Fumarate results in decreased activity of ABCB1 protein			[194]
Regulation Mechanism				Transcription Factor Info
Quinacrine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Quinacrine			[550]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCB1 protein results in increased transport of Quinacrine			[550]
Regulation Mechanism				Transcription Factor Info
Razoxane	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ferric nitrilotriacetate inhibits the reaction Razoxane results in increased expression of ABCB1 protein			[384]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Razoxane results in increased expression of ABCB1 protein			[384]
Regulation Mechanism				Transcription Factor Info
rescinnamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rescinnamine results in increased expression of ABCB1 mRNA			[256]
Regulation Mechanism				Transcription Factor Info
Rhodamine 123	38 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-methylquercetin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-methylquercetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	5,7-dimethoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	5,7-dimethoxyflavone inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	5-hydroxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	5-methoxyflavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	5-oxo-hexahydroquinoline analog inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[640]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCB1 protein results in increased export of Rhodamine 123			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	abemaciclib inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	baicalein inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	baicalein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	betulin inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[402]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	biochanin A inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	biochanin A promotes the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	CEP 33779 inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[431]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	daidzein inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	flavone inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	formononetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Genistein promotes the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	glycitein promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	GSK 1363089 results in decreased activity of ABCB1 protein which results in decreased export of Rhodamine 123			[536]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	isovitexin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	kaempferol inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	myricetin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	naringenin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	naringin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Quercetin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Quercetin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	quercitrin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Rutin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	tangeretin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	tangeretin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	taxifolin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Verapamil inhibits the reaction ABCB1 protein results in increased export of Rhodamine 123			[640]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Verapamil results in decreased activity of ABCB1 protein which results in decreased export of Rhodamine 123			[536]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased export of Rhodamine 123			[403]
Regulation Mechanism				Transcription Factor Info
rhodioloside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rhodioloside affects the reaction ABCB1 protein results in increased transport of Digoxin			[340]
Regulation Mechanism				Transcription Factor Info
Rifabutin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifabutin results in increased expression of ABCB1 mRNA			[183]
Regulation Mechanism				Transcription Factor Info
Ro 21-5104	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ro 21-5104 results in increased expression of ABCB1 mRNA			[307]
Regulation Mechanism				Transcription Factor Info
romidepsin	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein binds to and affects the export of romidepsin			[645]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to romidepsin			[375]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	romidepsin promotes the reaction Tretinoin results in increased expression of ABCB1 mRNA			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	romidepsin results in increased acetylation of ABCB1 promoter			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	romidepsin results in increased expression of ABCB1 mRNA			[646]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	romidepsin results in increased expression of ABCB1 protein			[645]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Tretinoin co-treated with romidepsin results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Tretinoin co-treated with romidepsin results in increased expression of ABCB1 protein			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Tretinoin promotes the reaction romidepsin results in increased acetylation of ABCB1 promoter			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	valspodar inhibits the reaction Tretinoin co-treated with romidepsin results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
Rose Bengal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rose Bengal results in decreased activity of ABCB1 protein			[296]
Regulation Mechanism				Transcription Factor Info
rosemary oil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rosemary oil results in increased expression of ABCB1 mRNA			[319]
Regulation Mechanism				Transcription Factor Info
rostafuroxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LSS gene polymorphism co-treated with HSD3B1 gene polymorphism co-treated with ABCB1 gene polymorphism co-treated with ADD1 gene polymorphism co-treated with ADD3 gene polymorphism affects the susceptibility to rostafuroxin			[647]
Regulation Mechanism				Transcription Factor Info
rubimaillin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dorsomorphin inhibits the reaction rubimaillin results in decreased expression of ABCB1 mRNA			[304]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rubimaillin inhibits the reaction RELA protein results in increased expression of ABCB1 protein			[304]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	rubimaillin results in decreased expression of ABCB1 mRNA			[304]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	rubimaillin results in decreased expression of ABCB1 protein			[304]
Regulation Mechanism				Transcription Factor Info
schaftoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	schaftoside inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
sciadopitysin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sciadopitysin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sciadopitysin results in decreased activity of ABCB1 protein			[320]
Regulation Mechanism				Transcription Factor Info
secomilbemycin D	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	secomilbemycin D results in decreased expression of ABCB1 protein			[595]
Regulation Mechanism				Transcription Factor Info
sepantronium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to sepantronium			[365]
Regulation Mechanism				Transcription Factor Info
sesamin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sesamin affects the activity of ABCB1 protein which results in increased abundance of Daunorubicin			[139]
Regulation Mechanism				Transcription Factor Info
Sesquiterpenes	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sesquiterpenes analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Daunorubicin			[149]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sesquiterpenes analog inhibits the reaction ABCB1 protein results in decreased susceptibility to Vinblastine			[149]
Regulation Mechanism				Transcription Factor Info
Silybin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silybin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
sinensetin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sinensetin analog inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sinensetin analog results in decreased activity of ABCB1 protein			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sinensetin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	sinensetin results in decreased activity of ABCB1 protein			[320]
Regulation Mechanism				Transcription Factor Info
S-methyl N,N-diethylthiocarbamate sulfone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-methyl N,N-diethylthiocarbamate sulfone results in decreased activity of ABCB1 protein			[192]
Regulation Mechanism				Transcription Factor Info
S-methyl N,N-diethylthiolcarbamate sulfoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-methyl N,N-diethylthiolcarbamate sulfoxide results in decreased activity of ABCB1 protein			[192]
Regulation Mechanism				Transcription Factor Info
SNX 2112	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SNX 2112 results in decreased expression of and results in decreased activity of ABCB1 protein			[651]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin inhibits the reaction sodium arsenite results in increased expression of ABCB1 mRNA			[278]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dichlororibofuranosylbenzimidazole inhibits the reaction sodium arsenite results in increased expression of ABCB1 protein			[417]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite affects the expression of ABCB1 mRNA			[652]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	sodium arsenite promotes the reaction ABCB1 protein results in increased secretion of calcein AM			[417]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	sodium arsenite results in increased expression of ABCB1 mRNA			[278]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	sodium arsenite results in increased expression of ABCB1 protein			[417]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	sodium arsenite results in increased expression of ABCB1 protein which results in decreased susceptibility to Vinblastine			[278]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Verapamil binds to and results in decreased activity of ABCB1 protein inhibits the reaction sodium arsenite promotes the reaction ABCB1 protein results in increased secretion of calcein AM			[417]
Regulation Mechanism				Transcription Factor Info
Sodium Azide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Azide co-treated with Iodoacetates inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[481]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Azide inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
Sorafenib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SNHG1 protein affects the susceptibility to Sorafenib which affects the expression of ABCB1 protein			[653]
Regulation Mechanism				Transcription Factor Info
Sotalol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Sotalol			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	valspodar inhibits the reaction ABCB1 protein results in increased transport of Sotalol			[404]
Regulation Mechanism				Transcription Factor Info
SR 12813	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SR 12813 results in increased activity of NR1I2 protein which results in increased expression of ABCB1 mRNA			[654]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SR 12813 results in increased expression of ABCB1 mRNA			[654]
Regulation Mechanism				Transcription Factor Info
Stavudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Stavudine results in increased expression of ABCB1 mRNA			[655]
Regulation Mechanism				Transcription Factor Info
Strophanthidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Strophanthidin			[500]
Regulation Mechanism				Transcription Factor Info
Succimer	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Succimer co-treated with Magnetite Nanoparticles results in increased expression of ABCB1 mRNA			[656]
Regulation Mechanism				Transcription Factor Info
sulconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulconazole results in increased expression of ABCB1 mRNA			[593]
Regulation Mechanism				Transcription Factor Info
sulfinosine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulfinosine co-treated with Curcumin results in decreased expression of ABCB1 mRNA			[472]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sulfinosine results in decreased expression of ABCB1 mRNA			[472]
Regulation Mechanism				Transcription Factor Info
sulforaphane	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulforaphane inhibits the reaction ginkgolide B results in increased expression of ABCB1 mRNA			[272]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sulforaphane results in decreased expression of ABCB1 mRNA			[272]
Regulation Mechanism				Transcription Factor Info
Sulpiride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of Sulpiride			[657]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Verapamil inhibits the reaction ABCB1 protein results in increased transport of Sulpiride			[657]
Regulation Mechanism				Transcription Factor Info
tamarixetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tamarixetin results in increased expression of ABCB1 mRNA			[273]
Regulation Mechanism				Transcription Factor Info
tangeretin	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tangeretin inhibits the reaction ABCB1 protein results in decreased uptake of Daunorubicin			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tangeretin inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tangeretin inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	tangeretin inhibits the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	tangeretin results in decreased activity of ABCB1 protein			[320]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	tangeretin results in decreased expression of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	tangeretin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Verapamil inhibits the reaction tangeretin results in increased activity of ABCB1 protein			[327]
Regulation Mechanism				Transcription Factor Info
tariquidar	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tariquidar inhibits the reaction ABCB1 protein results in increased susceptibility to NSC73306			[605]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tariquidar inhibits the reaction ABCB1 protein results in increased transport of Fentanyl			[562]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tariquidar results in decreased activity of ABCB1 protein			[661]
Regulation Mechanism				Transcription Factor Info
Tartrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB1 mRNA			[388]
Regulation Mechanism				Transcription Factor Info
taxane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	taxane analog affects the activity of ABCB1 protein			[662]
Regulation Mechanism				Transcription Factor Info
taxifolin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	taxifolin promotes the reaction Elacridar inhibits the reaction ABCB1 protein results in decreased uptake of Rhodamine 123			[327]
Regulation Mechanism				Transcription Factor Info
tebufenozide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of tebufenozide			[590]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tebufenozide inhibits the reaction ABCB1 protein results in increased transport of Quinidine			[590]
Regulation Mechanism				Transcription Factor Info
Technetium Tc 99m Sestamibi	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene polymorphism affects the export of Technetium Tc 99m Sestamibi			[663]
Regulation Mechanism				Transcription Factor Info
tectochrysin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in decreased susceptibility to tectochrysin			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tectochrysin inhibits the reaction ABCB1 protein results in decreased susceptibility to Docetaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tectochrysin inhibits the reaction ABCB1 protein results in decreased susceptibility to Paclitaxel			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	tectochrysin inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	tectochrysin results in decreased activity of ABCB1 protein			[418]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	tectochrysin results in decreased activity of ABCB1 protein which results in decreased export of calcein AM			[418]
Regulation Mechanism				Transcription Factor Info
Temozolomide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 mRNA			[438]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCB1 protein			[438]
Regulation Mechanism				Transcription Factor Info
terameprocol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	terameprocol inhibits the reaction Doxorubicin results in increased expression of ABCB1 mRNA			[535]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	terameprocol inhibits the reaction SP1 protein results in increased expression of ABCB1 mRNA			[535]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	terameprocol results in decreased expression of ABCB1 mRNA			[535]
Regulation Mechanism				Transcription Factor Info
terpinolene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	terpinolene inhibits the reaction ABCB1 protein results in increased uptake of Digoxin			[356]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A results in decreased activity of ABCB1 protein			[305]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in increased expression of ABCB1 mRNA			[286]
Regulation Mechanism				Transcription Factor Info
Tetradecanoylphorbol Acetate	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in decreased susceptibility to Doxorubicin affects the reaction 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB1 protein results in decreased susceptibility to Doxorubicin affects the reaction eriodictyol inhibits the reaction Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	eriodictyol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	kaempferol inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Quercetin inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	withaferin A inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
tetrandrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrandrine results in decreased expression of ABCB1			[664]
Regulation Mechanism				Transcription Factor Info
Thiabendazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiabendazole results in decreased expression of ABCB1 mRNA			[346]
Regulation Mechanism				Transcription Factor Info
thiazolyl blue	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	thiazolyl blue results in decreased activity of ABCB1 protein			[665]
Regulation Mechanism				Transcription Factor Info
tipifarnib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 gene SNP affects the susceptibility to tipifarnib			[666]
Regulation Mechanism				Transcription Factor Info
titanium dioxide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glutathione inhibits the reaction titanium dioxide results in increased expression of ABCB1 mRNA			[213]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ketoconazole inhibits the reaction titanium dioxide results in increased expression of ABCB1 mRNA			[213]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	titanium dioxide results in increased expression of ABCB1 mRNA			[213]
Regulation Mechanism				Transcription Factor Info
tocophersolan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methoxy poly(ethylene glycol-co-epsilon-caprolactone) co-treated with tocophersolan co-treated with Resveratrol results in decreased expression of ABCB1 protein			[639]
Regulation Mechanism				Transcription Factor Info
tocotrienol, alpha	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tocotrienol, alpha results in increased expression of ABCB1			[187]
Regulation Mechanism				Transcription Factor Info
tocotrienol, beta	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tocotrienol, beta results in increased expression of ABCB1			[187]
Regulation Mechanism				Transcription Factor Info
tocotrienol, delta	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tocotrienol, delta results in increased expression of ABCB1			[187]
Regulation Mechanism				Transcription Factor Info
traumatic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the transport of traumatic acid			[598]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Verapamil inhibits the reaction ABCB1 protein affects the transport of traumatic acid			[598]
Regulation Mechanism				Transcription Factor Info
triadimefon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triadimefon results in increased expression of ABCB1 mRNA			[292]
Regulation Mechanism				Transcription Factor Info
trichostatin A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine co-treated with trichostatin A affects the methylation of ABCB1 gene which affects the expression of ABCB1 mRNA			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Decitabine promotes the reaction trichostatin A results in increased expression of ABCB1 mRNA			[334]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	trichostatin A affects the methylation of ABCB1 gene which affects the expression of ABCB1 mRNA			[483]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	trichostatin A results in increased expression of ABCB1 mRNA			[667]
Regulation Mechanism				Transcription Factor Info
trimethoxybenzoylyohimbine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trimethoxybenzoylyohimbine results in increased expression of ABCB1 mRNA			[256]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of ABCB1 mRNA			[668]
Regulation Mechanism				Transcription Factor Info
trospium chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of trospium chloride			[669]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	valspodar inhibits the reaction ABCB1 protein results in increased transport of trospium chloride			[669]
Regulation Mechanism				Transcription Factor Info
tryptanthrine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tryptanthrine binds to ABCB1 promoter			[670]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tryptanthrine results in decreased expression of ABCB1 mRNA			[670]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tryptanthrine results in decreased expression of ABCB1 protein			[670]
Regulation Mechanism				Transcription Factor Info
tryptoquivaline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tryptoquivaline inhibits the reaction ABCB1 protein results in increased export of Doxorubicin			[364]
Regulation Mechanism				Transcription Factor Info
U 0126	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	U 0126 results in decreased expression of ABCB1 mRNA			[671]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	U 0126 results in decreased expression of ABCB1 protein			[671]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	U 0126 results in increased expression of ABCB1 mRNA			[672]
Regulation Mechanism				Transcription Factor Info
Ursolic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein inhibits the reaction Ursolic Acid results in increased susceptibility to Doxorubicin			[525]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ursolic Acid results in decreased expression of ABCB1 mRNA			[525]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ursolic Acid results in decreased expression of ABCB1 protein			[525]
Regulation Mechanism				Transcription Factor Info
valspodar	27 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deoxynivalenol inhibits the reaction valspodar inhibits the reaction ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	valspodar affects the activity of ABCB1 protein			[676]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	valspodar inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	valspodar inhibits the reaction ABCB1 protein results in decreased susceptibility to N-caproylsphingosine			[413]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	valspodar inhibits the reaction ABCB1 protein results in decreased uptake of Doxorubicin			[479]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	valspodar inhibits the reaction ABCB1 protein results in increased export of calcein AM			[416]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	valspodar inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[494]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	valspodar inhibits the reaction ABCB1 protein results in increased export of Diazinon			[482]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	valspodar inhibits the reaction ABCB1 protein results in increased export of Paraquat			[620]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Aldosterone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Beclomethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Dexamethasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Fluticasone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Hydrocortisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Methylprednisolone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	valspodar inhibits the reaction ABCB1 protein results in increased secretion of Prednisone			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	valspodar inhibits the reaction ABCB1 protein results in increased susceptibility to NSC73306			[605]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	valspodar inhibits the reaction ABCB1 protein results in increased transport of Bisoprolol			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	valspodar inhibits the reaction ABCB1 protein results in increased transport of Carvedilol			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	valspodar inhibits the reaction ABCB1 protein results in increased transport of Digoxin			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	valspodar inhibits the reaction ABCB1 protein results in increased transport of Sotalol			[404]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	valspodar inhibits the reaction ABCB1 protein results in increased transport of trospium chloride			[669]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	valspodar inhibits the reaction Tretinoin co-treated with romidepsin results in increased expression of ABCB1 mRNA which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	valspodar results in decreased activity of ABCB1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	valspodar results in decreased activity of ABCB1 protein which results in decreased transport of Digoxin			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	valspodar results in decreased activity of ABCB1 protein which results in decreased transport of Xanthenes			[413]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	valspodar results in decreased activity of ABCB1 protein which results in increased susceptibility to Paclitaxel			[483]
Regulation Mechanism				Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanadates results in decreased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
veliparib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased transport of veliparib			[677]
Regulation Mechanism				Transcription Factor Info
venetoclax	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	venetoclax inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein			[350]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	venetoclax inhibits the reaction Daunorubicin results in increased expression of ABCB1 protein which results in decreased export of Daunorubicin			[350]
Regulation Mechanism				Transcription Factor Info
verlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	verlukast results in decreased activity of ABCB1 protein			[561]
Regulation Mechanism				Transcription Factor Info
Vitamin B 12	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin B 12 inhibits the reaction Methotrexate results in increased expression of ABCB1 mRNA			[589]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Vitamin B 12 results in decreased expression of ABCB1 mRNA			[589]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Vitamin B 12 results in decreased expression of ABCB1 protein			[589]
Regulation Mechanism				Transcription Factor Info
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vorinostat co-treated with Isotretinoin results in increased expression of ABCB1 mRNA			[576]
Regulation Mechanism				Transcription Factor Info
Warfarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 polymorphism affects the susceptibility to Warfarin			[683]
Regulation Mechanism				Transcription Factor Info
withaferin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	withaferin A inhibits the reaction ABCB1 protein results in decreased susceptibility to Doxorubicin promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA			[351]
Regulation Mechanism				Transcription Factor Info
Xanthenes	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein results in increased export of Xanthenes			[422]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB1 protein results in increased transport of Xanthenes			[413]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Calcium deficiency inhibits the reaction ABCB1 protein results in increased export of Xanthenes			[422]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	valspodar results in decreased activity of ABCB1 protein which results in decreased transport of Xanthenes			[413]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Xanthenes results in decreased activity of ABCB1 protein			[684]
Regulation Mechanism				Transcription Factor Info
Zinc	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc inhibits the reaction Magnesium results in increased activity of ABCB1 protein			[279]
Regulation Mechanism				Transcription Factor Info
zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chloride inhibits the reaction cobaltous chloride results in increased expression of ABCB1 mRNA			[459]
Regulation Mechanism				Transcription Factor Info
zosuquidar trihydrochloride	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB1 protein affects the reaction zosuquidar trihydrochloride results in decreased transport of calcein AM			[415]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	zosuquidar trihydrochloride analog inhibits the reaction ABCB1 protein results in increased susceptibility to NSC73306			[605]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	zosuquidar trihydrochloride inhibits the reaction ABCB1 protein results in decreased susceptibility to Vincristine			[682]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	zosuquidar trihydrochloride inhibits the reaction ABCB1 protein results in increased export of Daunorubicin			[493]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	zosuquidar trihydrochloride inhibits the reaction ABCB1 protein results in increased transport of MLN 8237			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein			[609]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased export of bisbenzimide ethoxide trihydrochloride			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased export of Daunorubicin			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased export of Rhodamine 123			[403]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased transport of N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide			[540]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	zosuquidar trihydrochloride results in decreased activity of ABCB1 protein which results in decreased transport of omadacycline			[609]
Regulation Mechanism				Transcription Factor Info

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450	Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cytokine. 2011;56(2):365-75.
451	Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-B pathway and regulating transporter mediated drug efflux. J Ethnopharmacol. 2021;264:113388.
452	Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2ells. Chem Biol Interact. 2019;297:130-140.
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454	Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli fructus. Toxicol Appl Pharmacol. 2005;209(2):167-73.
455	Besides CYP2C192, the variant allele CYP2C93 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation. Pharmacogenet Genomics. 2010;20(1):18-25.
456	Genetic causes of clopidogrel nonresponsiveness: which ones really count?. Pharmacotherapy. 2010;30(3):265-74.
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464	Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness. Biomed Pharmacother. 2023;167:115413.
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466	Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem Pharmacol. 2004;68(10):2043-52.
467	Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines. Toxicol Appl Pharmacol. 2016;305:216-233.
468	Chemosensitizing effects of synthetic curcumin analogs on human multi-drug resistance leukemic cells. Chem Biol Interact. 2016;244:140-8.
469	Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. Drug Metab Dispos. 2008;36(7):1283-90.
470	Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells. Arch Pharm Res. 2006;29(10):866-73.
471	Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways. Int J Pharm. 2008;358(1-2):224-9.
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474	RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clin Cancer Res. 2003;9(2):827-36.
475	Different evolution of trough and dose levels during the first year after transplantation for tacrolimus versus cyclosporine. Transplant Proc. 2005;37(5):2051-3.
476	Cyclosporine and sirolimus interaction in a kidney transplant patient. Transplant Proc. 2005;37(5):2317-9.
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479	Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J Pharmacol Exp Ther. 2008;324(1):95-102.
480	Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. J Biol Chem. 2004;279(9):7867-76.
481	Different effects of metabolic inhibitors and cyclosporin A on daunorubicin transport in leukemia cells from patients with AML. Leuk Res. 2003;27(2):183-91.
482	Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein. Toxicol Lett. 2006;161(3):200-9.
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485	Cylindrospermopsin effects on protein profile of HepG2 cells. Toxicol Mech Methods. 2016;26(7):554-563.
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488	Establishment and characterization of new cellular lymphoma model expressing transgenic human MDR1. Leuk Res. 2005;29(4):407-14.
489	Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR). Mol Pharm. 2009;6(6):1816-25.
490	Subcellular daunorubicin distribution and its relation to multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R. World J Gastroenterol. 2002;8(4):644-9.
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493	Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3 and ATP-binding cassette transporters. Arch Toxicol. 2022 Dec;96(12):3265-3277.
494	A patient with adrenocortical carcinoma: characterization of its biological activity and drug resistance profile. Clin Cancer Res. 1997;3(3):389-94.
495	Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone. Eur J Pharmacol. 2005;528(1-3):27-36.
496	Tacrolimus, a calcineurin inhibitor, overcomes treatment unresponsiveness mediated by P-glycoprotein on lymphocytes in refractory rheumatoid arthritis. J Rheumatol. 2010;37(3):512-20.
497	Diallyl disulfide antagonizes DJ-1 mediated proliferation, epithelial-mesenchymal transition, and chemoresistance in gastric cancer cells. Environ Toxicol. 2024;39(8):4105-4119.
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499	Multi drug resistance-1 (MDR1) expression in response to chronic diazinon exposure: an in vitro study on Caco-2 cells. Bull Environ Contam Toxicol. 2011;86(1):105-9.
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502	Human intestinal P-glycoprotein activity estimated by the model substrate digoxin. Scand J Clin Lab Invest. 2007;67(2):123-34.
503	Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005;57(6):759-64.
504	No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract. Planta Med. 2005;71(4):331-7.
505	P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil. Pharmacol Res. 1999;40(4):301-6.
506	Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters. J Ocul Pharmacol Ther. 2015;31(4):248-55.
507	The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy. Drug Metab Dispos. 2016;44(5):692-9.
508	Vitamin D Counteracts an IL-23-Dependent IL-17A(+)IFN-g(+) Response Driven by Urban Particulate Matter. Am J Respir Cell Mol Biol. 2017;57(3):355-366.
509	Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):146-54.
510	Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism. J Natl Cancer Inst. 2000;92(11):898-902.
511	Genetic Variations of Drug Transporters Can Influence on Drug Response in Patients Treated with Docetaxel Chemotherapy. Cancer Res Treat. 2015;47(3):509-17.
512	Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int J Cancer. 2004;111(4):617-26.
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514	Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance. Cancer Genet Cytogenet. 2007;173(1):1-9.
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516	Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. Dig Dis Sci. 2011;56(1):115-24.
517	Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin. J Pharm Pharmacol. 2010;62(3):393-9.
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521	Doxorubicin decreases paraquat accumulation and toxicity in Caco-2 cells. Toxicol Lett. 2013;217(1):34-41.
522	Therapeutic efficacy and bone marrow protection of the mdr1 gene and over-dose chemotherapy with doxorubicin for rabbits with VX2 hepatocarcinoma. Hepatobiliary Pancreat Dis Int. 2006;5(4):545-51.
523	Mitochondrial localization and activity of P-glycoprotein in doxorubicin-resistant K562 cells. Biochem Pharmacol. 2006;71(8):1162-74.
524	Germacrone reverses adriamycin resistance in human chronic myelogenous leukemia K562/ADM cells by suppressing MDR1 gene/P-glycoprotein expression. Chem Biol Interact. 2018;288:32-37.
525	Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus. Environ Toxicol. 2021 Feb;36(2):267-275.
526	Major contribution of the multidrug transporter P-glycoprotein to reduced susceptibility of poly(ADP-ribose) polymerase-1 knock-out cells to doxorubicin action. J Cell Biochem. 2005;95(5):1012-28.
527	Reversal of p-glycoprotein-mediated multidrug resistance by CJX1, an amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. Life Sci. 2005;77(18):2221-32.
528	Gene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance. Oncogene. 2001;20(11):1300-6.
529	Overcoming multidrug resistance in human carcinoma cells by an antisense oligodeoxynucleotide--doxorubicin conjugate in vitro and in vivo. Mol Pharm. 2008;5(4):579-87.
530	Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett. 2009;279(1):74-83.
531	Interleukin-6 contributes to chemoresistance in MDA-MB-231 cells via targeting HIF-1a. J Biochem Mol Toxicol. 2018;32(3):e22039.
532	Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells. Mol Med Rep. 2015;11(1):341-8.
533	Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemic HL-60 cells. J Pharmacol Exp Ther. 2005;312(1):346-54.
534	Quantification of the expression of multidrug resistance-related genes in human tumour cell lines grown with free doxorubicin or doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres. Anticancer Res. 2004;24(6):3781-8.
535	Reversal of multidrug resistance by two nordihydroguaiaretic acid derivatives, M4N and maltose-M3N, and their use in combination with doxorubicin or paclitaxel. Cancer Chemother Pharmacol. 2006;58(5):640-53.
536	Foretinib, a c-MET receptor tyrosine kinase inhibitor, tackles multidrug resistance in cancer cells by inhibiting ABCB1 and ABCG2 transporters. Toxicol Appl Pharmacol. 2024;484:116866.
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538	Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J Biol Chem. 2009 Jan 30;284(5):2657-2671.
539	Loperamide potentiates doxorubicin sensitivity in triple-negative breast cancer cells by targeting MDR1 and JNK and suppressing mTOR and Bcl-2: In vitro and molecular docking study. J Biochem Mol Toxicol. 2022;36(1):e22938.
540	The inhibitory and combinative mechanism of HZ08 with P-glycoprotein expressed on the membrane of Caco-2 cell line. Toxicol Appl Pharmacol. 2014;274(2):232-9.
541	Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient: pluronic P85. Mol Pharm. 2006;3(2):113-23.
542	Efficacy and cost of cardiac monitoring in patients receiving doxorubicin. Cancer. 1982;50(1):32-41.
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544	Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression. BMC Cancer. 2008;8:327.
545	Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin. Biochim Biophys Acta. 2014;1840(1):615-25.
546	Resveratrol reverses multidrug resistance in human breast cancer doxorubicin-resistant cells. Exp Ther Med. 2014;7(6):1611-1616.
547	Myoglobin improves doxycycline sensitivity in pancreatic cancer through promoting heme oxygenase-1-mediated ferroptosis. Environ Toxicol. 2024;39(4):2166-2181.
548	Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941. Drug Metab Dispos. 2010;38(9):1422-6.
549	Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice. Food Chem Toxicol. 2017;107(Pt A):68-73.
550	Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006;34(7):1136-44.
551	Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56.
552	Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE. Pharm Res. 2002;19(6):787-93.
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554	(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine. 2010;17(5):356-62.
555	Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23.
556	P-glycoprotein inhibition by the agricultural pesticide propiconazole and its hydroxylated metabolites: Implications for pesticide-drug interactions. Toxicol Lett. 2015;232(1):37-45.
557	Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo). Toxicology. 2009 Sep 19;263(2-3):100-7.
558	Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia. Blood. 2004 Jan 1;103(1):67-72.
559	Everolimus pharmacokinetics and its exposure-toxicity relationship in patients with thyroid cancer. Cancer Chemother Pharmacol. 2016;78(1):63-71.
560	Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. J Biol Chem. 2005;280(17):17203-12.
561	Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport. Xenobiotica. 2005 Jul;35(7):737-53.
562	P-Glycoprotein on Blood-Brain Barrier Plays a Vital Role in Fentanyl Brain Exposure and Respiratory Toxicity in Rats. Toxicol Sci. 2018;164(1):353-362.
563	A variant 2677A allele of the MDR1 gene affects fexofenadine disposition. Clin Pharmacol Ther. 2004;76(5):418-27.
564	Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clin Pharmacol Ther. 2005 Aug;78(2):191-201.
565	Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line. J Gastroenterol. 2006;41(12):1149-57.
566	Effects of endocrine disruptors on genes associated with 17beta-estradiol metabolism and excretion. Steroids. 2008 Nov;73(12):1242-51.
567	Potential for interaction of kava and St. John's wort with drugs. J Ethnopharmacol. 2005;100(1-2):108-13.
568	No activation of human pregnane X receptor by hyperforin-related phloroglucinols. J Pharmacol Exp Ther. 2014;348(3):393-400.
569	Reversal of ABCB1 mediated efflux by imatinib and nilotinib in cells expressing various transporter levels. Chem Biol Interact. 2017;273:171-179.
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571	Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle. 2005;4(9):1201-15.
572	Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. Br J Clin Pharmacol. 2005;59(4):415-24.
573	Irinotecan pathway genotype analysis to predict pharmacokinetics. Clin Cancer Res. 2003;9(9):3246-53.
574	Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. Br J Cancer. 2005;92(2):259-64.
575	A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor. J Pharmacol Exp Ther. 2006;319(1):82-104.
576	Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
577	Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005;27(3):322-33.
578	Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event. Am J Trop Med Hyg. 2010;83(1):28-32.
579	Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans? BMC Med Genet. 2010 Jul 14;11:111.
580	Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene. 2007;26(2):258-68.
581	Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects. Eur J Clin Pharmacol. 2009;65(6):593-600.
582	Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb. Environ Res. 2015;138:224-32.
583	Mebendazole, an antiparasitic drug, inhibits drug transporters expression in preclinical model of gastric peritoneal carcinomatosis. Toxicol In Vitro. 2017 Sep;43:87-91.
584	Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study. Environ Int. 2016;94:224-229.
585	Genetic Polymorphisms in Multispecific Transporters Mitigate Mercury Nephrotoxicity in an Artisanal and Small-Scale Gold Mining Community in Colombia. Toxicol Sci. 2020;178(2):338-346.
586	The effect of 3435C>T MDR1 gene polymorphism on rheumatoid arthritis treatment with disease-modifying antirheumatic drugs. Eur J Clin Pharmacol. 2006;62(11):933-7.
587	Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol. 2008 Apr;35(4):572-9.
588	Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. Cancer. 2012 Apr 01;118(7):1856-67.
589	Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells. Cell Physiol Biochem. 2007;20(6):967-76.
590	In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines. Toxicol Appl Pharmacol. 2016;298:40-7.
591	MDR1 causes resistance to the antitumour drug miltefosine. Br J Cancer. 2001;84(10):1405-11.
592	A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical carcinoma: continuous infusion doxorubicin, vincristine, and etoposide with daily mitotane as a P-glycoprotein antagonist. Cancer. 2002;94(9):2333-43.
593	Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019;93(8):2247-2264.
594	Life-threatening adverse events following therapeutic opioid administration in adults: is pharmacogenetic analysis useful?. Pain Res Manag. 2013;18(3):133-6.
595	Reversal effects of two new milbemycin compounds on multidrug resistance in MCF-7/adr cells in vitro. Eur J Pharmacol. 2011;659(2-3):108-13.
596	Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells. J Biochem Mol Toxicol. 2017;31(5).
597	Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B. Chem Biol Interact. 2014;213:44-50.
598	Identification of a substrate of the renal tubular transporters for detecting drug-induced early acute kidney injury. Toxicol Sci. 2024;201(2):190-205.
599	Downregulation of c-Myc and p21 expression and induction of S phase arrest by naphthalene diimide derivative in gastric adenocarcinoma cells. Chem Biol Interact. 2019;304:106-123.
600	Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line. Pharm Res. 2008 Sep;25(9):1991-2001.
601	Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. Pharmacogenet Genomics. 2005;15(9):599-608.
602	Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol. 2015;135(3):712-20.
603	Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins. Arch Toxicol. 2025;99(2):701-715.
604	A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics J. 2002;2(3):191-6.
605	Synthesis and structure-activity evaluation of isatin-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein. J Med Chem. 2011;54(16):5878-89.
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607	LncRNA PVT1 contributes to invasion and doxorubicin resistance of bladder cancer cells through promoting MDM2 expression and AURKB-mediated p53 ubiquitination. Environ Toxicol. 2022;37(6):1495-1508.
608	Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier. Toxicol Lett. 2014;225(2):311-7.
609	Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline. Xenobiotica. 2017;47(8):682-696.
610	Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer. 2009;45(16):2882-92.
611	c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia. Cancer Res. 2004;64(24):9057-61.
612	Inhibition of the Human ABC Efflux Transporters P-gp and BCRP by the BDE-47 Hydroxylated Metabolite 6-OH-BDE-47: Considerations for Human Exposure. Toxicol Sci. 2017;155(1):270-282.
613	Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1. J Clin Pharmacol. 2005;45(6):674-82.
614	Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia. Eur J Cancer. 2006 Nov;42(17):2893-6.
615	cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006;96(1):17-39.
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617	Threshold for antiproliferative and proapoptotic activity of ttaxol in HepG2 cells expressing human CYP3A4: effect of P-glycoprotein transporters. Pharmacology. 2003;69(3):142-9.
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620	MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells. Toxicol Sci. 2014;141(2):475-83.
621	An assessment of serum-dependent impacts on intracellular accumulation and genomic response of per- and polyfluoroalkyl substances in a placental trophoblast model. Environ Toxicol. 2020 Dec;35(12):1395-1405.
622	Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75.
623	Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. Pediatr Neurol. 1999;21(4):731-4.
624	CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics. 2005 Nov;15(11):779-86.
625	Functional and histochemical analysis of MDR3 P-glycoprotein in a tetracycline-controlled gene expression system. Eur J Med Res. 2000 Dec 29;5(12):517-22.
626	Role of multidrug resistance 3 deficiency in pediatric and adult liver disease: one gene for three diseases. Semin Liver Dis. 2001;21(4):551-62.
627	PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells. PLoS One. 2012;7(12):e52898.
628	Piperine analog PGP-41 treatment overcomes paclitaxel resistance in NCI/ADR-RES ovarian cells by inhibition of MDR1. Chem Biol Interact. 2023;381:110569.
629	Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009;4(8):e6796.
630	Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin. Mol Pharmacol. 2005 Sep;68(3):800-7.
631	Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?. Biochem Pharmacol. 2004;68(4):783-90.
632	The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy. Toxicol Appl Pharmacol. 2020;402:115129.
633	Flavonoid quercetin, but not apigenin or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants. Neoplasma. 2005;52(4):273-9.
634	The synergistic reversal effect of multidrug resistance by quercetin and hyperthermia in doxorubicin-resistant human myelogenous leukemia cells. Int J Hyperthermia. 2008;24(2):151-9.
635	Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins. Br J Pharmacol. 2002;135(7):1685-94.
636	The role of P-glycoprotein in the bioactivation of raloxifene. Drug Metab Dispos. 2006;34(12):2073-8.
637	Demonstration of the activity of P-glycoprotein by a semi-automated fluorometric method. Anticancer Res. 2009;29(6):2173-7.
638	Trans-resveratrol induces a potential anti-lipogenic effect in lipopolysaccharide-stimulated enterocytes. Cell Mol Biol (Noisy-le-grand). 2015;61(8):9-16.
639	mPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Expert Opin Drug Deliv. 2015;12(3):361-73.
640	5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells. Toxicol Appl Pharmacol. 2019;362:136-149.
641	Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells. Pharmacol Res. 2010;62(5):426-31.
642	Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity. J Med Chem. 2011;54(1):401-5.
643	Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients. Pharmacogenomics. 2006;7(7):987-93.
644	Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions. Pharmacogenomics J. 2010 Oct;10(5):418-30.
645	Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1. J Pharmacol Exp Ther. 2005;313(1):268-76.
646	Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines. J Pharmacol Exp Ther. 2005;314(1):467-75.
647	Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies. Sci Transl Med. 2010;2(59):59ra87.
648	MRP (ABCC) transporters-mediated efflux of anti-HIV drugs, saquinavir and zidovudine, from human endothelial cells. Exp Biol Med (Maywood). 2008;233(9):1149-60.
649	The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. Clin Pharmacol Ther. 2005 Nov;78(5):551-8.
650	Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy. Am J Transplant. 2005 Mar;5(3):595-603.
651	The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-B and disruption of mitochondria-dependent pathways. Chem Biol Interact. 2013;205(1):1-10.
652	Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer. Arch Toxicol. 2021 Jul;95(7):2351-2365.
653	SNHG1, interacting with SND1, contributes to sorafenib resistance of liver cancer cells by increasing m6A-mediated SLC7A11 expression and promoting aerobic glycolysis. Environ Toxicol. 2024;39(3):1269-1282.
654	Regulation of drug resistance by human pregnane X receptor in breast cancer. Cancer Biol Ther. 2009 Jul;8(13):1265-72.
655	Longitudinal effects of thymidine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells. J Antimicrob Chemother. 2008;61(5):1048-52.
656	DMSA-Coated Iron Oxide Nanoparticles Greatly Affect the Expression of Genes Coding Cysteine-Rich Proteins by Their DMSA Coating. Chem Res Toxicol. 2015;28(10):1961-74.
657	Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol. 2017 Dec;91(12):3873-3884.
658	Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation. 2002;74(4):571-2.
659	Initial dosage adjustment for oral administration of tacrolimus using the intestinal MDR1 level in living-donor liver transplant recipients. Transplant Proc. 2005;37(4):1728-9.
660	Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats. J Pharm Sci. 2002;91(3):719-29.
661	Modulation of drug resistance transporters as a strategy for treating myelodysplastic syndrome. Best Pract Res Clin Haematol. 2004;17(4):641-51.
662	Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents. J Med Chem. 2005;48(6):2218-28.
663	Relationship of hepatic functional imaging to irinotecan pharmacokinetics and genetic parameters of drug elimination. J Clin Oncol. 2006;24(26):4228-35.
664	[Effect of tetrandrine combined with daunorubicin on expressions of P21 and P-gp in K562/A02 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Oct;17(5):1179-82.
665	Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity. Eur J Pharm Sci. 2004;23(2):181-8.
666	Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients. Invest New Drugs. 2004 Aug;22(3):285-9.
667	From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
668	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
669	Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
670	Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells. Biochem Biophys Res Commun. 2007;358(1):79-84.
671	Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line. World J Gastroenterol. 2004;10(23):3522-7.
672	U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol. 2014;88(12):2243-59.
673	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
674	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
675	Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010;117(2):155-64.
676	Cyclosporin A is a broad-spectrum multidrug resistance modulator. Clin Cancer Res. 2005;11(6):2320-6.
677	Disposition and drug-drug interaction potential of veliparib (ABT-888), a novel and potent inhibitor of poly(ADP-ribose) polymerase. Drug Metab Dispos. 2011;39(7):1161-9.
678	Expression and function of ABCB1 and ABCG2 in human placental tissue. Drug Metab Dispos. 2005;33(4):524-9.
679	The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells. Front Pharmacol. 2021;12:678126.
680	Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. Cancer Chemother Pharmacol. 2005;56(2):173-81.
681	Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma. Int J Cancer. 2005;115(1):155-63.
682	Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5. J Med Chem. 2011;54(6):1576-86.
683	Is there a role for MDR1, EPHX1 and protein Z gene variants in modulation of warfarin dosage? a study on a cohort of the Egyptian population. Mol Diagn Ther. 2014;18(1):73-83.
684	Inhibition of human CYP3A4, UGT1A6, and P-glycoprotein with halogenated xanthene food dyes and prevention by superoxide dismutase. J Toxicol Environ Health A. 2008;71(19):1307-13.
685	(-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-kappaB/miR-155-5p/MDR1 Pathway. J Agric Food Chem. 2019 Mar 6;67(9):2510-2518.
686	Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1. Sci Rep. 2016 Jun 22;6:28403.
687	Novel application of rhein and its prodrug diacerein for reversing cancer-related multidrug resistance through the dual inhibition of P-glycoprotein efflux and STAT3-mediated P-glycoprotein expression. Biomed Pharmacother. 2022 Jun;150:112995.
688	Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-kappaB signaling and suppressing cAMP-responsive element transcriptional activity. Tumour Biol. 2015 Dec;36(12):9499-510.
689	Tetrandrine prevents multidrug resistance in the osteosarcoma cell line, U-2OS, by preventing Pgp overexpression through the inhibition of NF-kappaB signaling. Int J Mol Med. 2017 Apr;39(4):993-1000.
690	COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. Carcinogenesis. 2011 May;32(5):667-75.

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