Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0004 Transporter Info
Gene Name	ABCG2
Transporter Name	Breast cancer resistance protein
Gene ID	9429
UniProt ID	Q9UNQ0

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Elacridar inhibits the reaction ABCG2 protein affects the transport of Resveratrol			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCG2 protein results in increased transport of Sulpiride			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Elacridar inhibits the reaction Protons promotes the reaction ABCG2 protein results in increased export of Resveratrol			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Elacridar results in decreased activity of ABCG2 protein			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ESR1 protein promotes the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol affects the expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Estradiol binds to ESR1 protein which results in decreased expression of ABCG2			[239]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCG2 mRNA			[240]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Estradiol inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Estradiol inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Estradiol results in decreased activity of ABCG2 protein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Estradiol results in decreased activity of ABCG2 protein which results in increased uptake of abacavir			[184]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Estradiol results in decreased expression of ABCG2			[239]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Estradiol results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Estradiol results in increased expression of ABCG2 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Estradiol results in increased expression of ABCG2 protein			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Flutamide inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Flutamide inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Fulvestrant affects the reaction Estradiol results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Fulvestrant inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Fulvestrant inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Progesterone inhibits the reaction Estradiol results in increased expression of ABCG2			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Tamoxifen inhibits the reaction Estradiol results in decreased expression of ABCG2			[239]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cyclosporine affects the expression of ABCG2 mRNA			[223]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[224]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclosporine inhibits the reaction ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cyclosporine results in decreased activity of ABCG2 protein			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Cyclosporine results in increased expression of ABCG2 mRNA			[225]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCG2 gene polymorphism affects the transport of Sulfasalazine			[281]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased transport of Sulfasalazine			[281]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dactinomycin inhibits the reaction Sulfasalazine results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sulfasalazine inhibits the reaction Adenosine Triphosphate co-treated with ABCG2 protein results in increased uptake of estrone sulfate			[190]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Sulfasalazine promotes the reaction Cholesterol results in increased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Sulfasalazine results in decreased methylation of ABCG2 promoter			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Sulfasalazine results in decreased methylation of ABCG2 promoter which results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Sulfasalazine results in increased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	yu ping feng san inhibits the reaction Sulfasalazine results in increased activity of ABCG2 protein			[282]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Gefitinib inhibits the reaction ABCG2 protein results in decreased susceptibility to Doxorubicin			[233]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Gefitinib results in decreased activity of EGFR protein which affects the localization of ABCG2 protein			[233]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Gefitinib results in decreased activity of EGFR protein which affects the localization of ABCG2 protein which results in decreased export of Doxorubicin			[233]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Omeprazole inhibits the reaction ABCG2 protein results in increased transport of lucifer yellow			[254]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Omeprazole results in increased expression of ABCG2 mRNA alternative form			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Omeprazole results in increased expression of ABCG2 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pantoprazole inhibits the reaction ABCG2 protein affects the transport of 7-hydroxymethotrexate			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nelfinavir results in decreased activity of ABCG2 protein			[266]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Progesterone affects the expression of ABCG2			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Progesterone inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Progesterone inhibits the reaction Estradiol results in increased expression of ABCG2			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Progesterone results in decreased activity of ABCG2 protein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in decreased susceptibility to Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein results in increased export of Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Dactinomycin inhibits the reaction Daunorubicin results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Daunorubicin results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	enasidenib inhibits the reaction ABCG2 protein results in decreased susceptibility to Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	enasidenib inhibits the reaction ABCG2 protein results in increased export of Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	enasidenib inhibits the reaction ABCG2 protein results in increased export of Daunorubicin which results in increased susceptibility to Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rosuvastatin Calcium results in increased activity of ABCG2 protein			[146]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chlordecone results in decreased activity of ABCG2 protein			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	6-OH-BDE-47 inhibits the reaction ABCG2 protein results in increased export of Prazosin			[158]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased export of Prazosin			[158]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fulvestrant inhibits the reaction Genistein results in decreased expression of ABCG2 protein			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Genistein inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Genistein inhibits the reaction ABCG2 protein results in increased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Genistein promotes the reaction ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Genistein promotes the reaction ABCG2 protein polymorphism results in decreased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Genistein results in decreased expression of ABCG2 mRNA			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Genistein results in decreased expression of ABCG2 protein			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Luteolin affects the activity of ABCG2 protein			[255]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Decitabine affects the expression of ABCG2 mRNA			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Decitabine affects the expression of ABCG2 protein			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Decitabine inhibits the reaction HDAC1 protein binds to ABCG2 promoter			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Decitabine inhibits the reaction SIN3A protein binds to ABCG2 promoter			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Decitabine inhibits the reaction Smoke results in decreased expression of ABCG2 mRNA			[228]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	VHL protein promotes the reaction Decitabine results in increased expression of ABCG2 mRNA			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	VHL protein promotes the reaction Decitabine results in increased expression of ABCG2 protein			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rifampin promotes the reaction Dextran Sulfate results in decreased expression of ABCG2 mRNA			[229]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin promotes the reaction Lipopolysaccharides results in decreased expression of ABCG2 mRNA			[229]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cisplatin co-treated with jinfukang results in increased expression of ABCG2 mRNA			[212]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cisplatin co-treated with Paclitaxel results in increased expression of ABCG2 mRNA			[213]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Cisplatin results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 protein			[214]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ERBB2 results in increased expression of ABCG2 which results in decreased susceptibility to Cisplatin			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	kang-lai-te inhibits the reaction Cisplatin results in increased expression of ABCG2 mRNA			[215]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	kang-lai-te inhibits the reaction Cisplatin results in increased expression of ABCG2 protein			[215]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	NEAT1 protein affects the susceptibility to Cisplatin which affects the expression of ABCG2 protein			[216]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Cisplatin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Proadifen co-treated with Cisplatin results in increased expression of ABCG2 protein			[218]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenobarbital affects the expression of ABCG2 mRNA			[274]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Arsenic Trioxide affects the expression of ABCG2 mRNA			[194]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Arsenic Trioxide results in increased expression of ABCG2 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Arsenic Trioxide results in increased expression of ABCG2 protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	prolinedithiocarbamate inhibits the reaction Arsenic Trioxide results in increased expression of ABCG2 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	prolinedithiocarbamate inhibits the reaction Arsenic Trioxide results in increased expression of ABCG2 protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	TNF protein promotes the reaction Arsenic Trioxide results in increased expression of ABCG2 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	TNF protein promotes the reaction Arsenic Trioxide results in increased expression of ABCG2 protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Digoxin results in decreased activity of ABCG2 protein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCG2 protein results in decreased susceptibility to Imatinib Mesylate			[248]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Imatinib Mesylate results in increased expression of and results in increased activity of ABCG2 protein			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mometasone Furoate inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mometasone Furoate results in increased activity of ABCG2 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ESR1 protein promotes the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Flutamide inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Flutamide inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Fulvestrant inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Fulvestrant inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Testosterone inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Testosterone results in decreased activity of ABCG2 protein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCG2 protein affects the export of Pravastatin			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pravastatin results in increased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Crizotinib results in decreased activity of ABCG2 protein			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Methoxsalen results in decreased activity of ABCG2 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Methoxsalen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Methoxsalen results in increased expression of ABCG2 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Novobiocin inhibits the reaction Methoxsalen results in decreased activity of ABCG2 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Novobiocin inhibits the reaction Methoxsalen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tamoxifen inhibits the reaction Estradiol results in decreased expression of ABCG2			[239]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fulvestrant inhibits the reaction Estriol results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fulvestrant inhibits the reaction Estriol results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCG2 mutant form inhibits the reaction ERBB2 results in decreased susceptibility to Doxorubicin			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein affects the susceptibility to Doxorubicin			[231]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein affects the transport of Doxorubicin			[232]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein results in decreased susceptibility to Doxorubicin			[233]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCG2 protein results in increased export of Doxorubicin			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCG2 results in decreased abundance of and results in decreased susceptibility to Doxorubicin			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	abemaciclib inhibits the reaction ABCG2 protein results in increased export of Doxorubicin			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Dactinomycin inhibits the reaction Doxorubicin results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ERBB2 results in increased expression of ABCG2 which results in decreased susceptibility to Doxorubicin			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Gefitinib inhibits the reaction ABCG2 protein results in decreased susceptibility to Doxorubicin			[233]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Gefitinib results in decreased activity of EGFR protein which affects the localization of ABCG2 protein which results in decreased export of Doxorubicin			[233]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Sunitinib inhibits the reaction ABCG2 results in decreased abundance of and results in decreased susceptibility to Doxorubicin			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Am 580 promotes the reaction Tretinoin results in increased expression of ABCG2 mRNA			[192]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	CD 2608 promotes the reaction Tretinoin results in increased expression of ABCG2 mRNA			[192]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of ABCG2 mRNA			[287]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein inhibits the reaction Folic Acid deficiency results in decreased susceptibility to Mitoxantrone			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased export of Mitoxantrone			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	5-Methoxypsoralen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCG2 mutant form inhibits the reaction ERBB2 results in decreased susceptibility to Mitoxantrone			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCG2 protein affects the export of Mitoxantrone			[239]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCG2 protein affects the susceptibility to Mitoxantrone			[261]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	ABCG2 protein affects the transport of Mitoxantrone			[262]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	ABCG2 protein affects the uptake of Mitoxantrone			[263]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	ABCG2 protein results in decreased abundance of Mitoxantrone			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	ABCG2 protein results in decreased susceptibility to Mitoxantrone			[238]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	ABCG2 protein results in increased susceptibility to Mitoxantrone			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Beclomethasone inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Cadmium Chloride inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[166]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Chlorpromazine inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	chrysin inhibits the reaction ABCG2 protein results in increased secretion of Mitoxantrone			[209]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Clozapine inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Cyclosporine inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[224]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Dactinomycin inhibits the reaction Mitoxantrone results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	desisobutyrylciclesonide inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	ERBB2 results in increased expression of ABCG2 which results in decreased susceptibility to Mitoxantrone			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Erlotinib Hydrochloride inhibits the reaction ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Erlotinib Hydrochloride inhibits the reaction ABCG2 protein results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Folic Acid deficiency results in increased expression of ABCG2 protein which results in decreased susceptibility to Mitoxantrone			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	GSK 1363089 inhibits the reaction ABCG2 protein results in decreased susceptibility to Mitoxantrone			[247]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	GSK 1363089 results in decreased activity of ABCG2 protein which results in decreased export of Mitoxantrone			[247]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Haloperidol inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Lapatinib inhibits the reaction ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Lapatinib inhibits the reaction ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Methoxsalen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Mitoxantrone results in increased expression of ABCG2 mRNA			[264]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Mitoxantrone results in increased expression of ABCG2 protein			[264]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	MLN 8237 affects the activity of ABCG2 protein which affects the export of Mitoxantrone			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Mometasone Furoate inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Novobiocin inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Novobiocin inhibits the reaction Methoxsalen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Novobiocin results in decreased activity of ABCG2 protein which results in decreased export of Mitoxantrone			[247]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Olanzapine inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	oxfendazole inhibits the reaction ABCG2 protein affects the transport of Mitoxantrone			[124]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Paliperidone Palmitate inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Porphyrins inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	Protons promotes the reaction ABCG2 protein results in decreased susceptibility to Mitoxantrone			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	Quetiapine Fumarate inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Risperidone inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	tryptoquivaline inhibits the reaction ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	tryptoquivaline inhibits the reaction ABCG2 protein affects the uptake of Mitoxantrone			[263]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[265]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCG2 gene polymorphism affects the susceptibility to Methotrexate			[256]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 gene SNP affects the susceptibility to Methotrexate			[257]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein affects the transport of Methotrexate			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein affects the transport of Methotrexate analog			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCG2 protein results in decreased susceptibility to Methotrexate			[258]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCG2 protein results in increased export of and results in decreased susceptibility to Methotrexate			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCG2 protein results in increased export of Methotrexate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCG2 protein results in increased transport of Methotrexate			[259]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCG2 results in increased export of Methotrexate			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Erlotinib Hydrochloride inhibits the reaction ABCG2 protein results in increased export of Methotrexate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Erlotinib Hydrochloride inhibits the reaction ABCG2 results in increased export of Methotrexate			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Lapatinib inhibits the reaction ABCG2 protein results in increased export of Methotrexate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Methotrexate inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Methotrexate inhibits the reaction ABCG2 protein results in increased export of Glutathione			[162]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Methotrexate results in increased expression of ABCG2 mRNA			[260]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Methotrexate results in increased expression of ABCG2 protein			[260]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Protons promotes the reaction ABCG2 protein results in increased export of and results in decreased susceptibility to Methotrexate			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	resveratrol-4'-O-glucuronide inhibits the reaction ABCG2 protein results in increased transport of Methotrexate			[259]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Resveratrol analog inhibits the reaction ABCG2 protein results in increased transport of Methotrexate			[259]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Sunitinib inhibits the reaction ABCG2 results in increased export of Methotrexate			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of Methotrexate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein inhibits the reaction Folic Acid deficiency results in decreased susceptibility to Mitoxantrone			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein affects the transport of Folic Acid			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Folic Acid affects the localization of and affects the expression of ABCG2 protein			[243]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Folic Acid deficiency results in increased expression of ABCG2 mRNA			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Folic Acid deficiency results in increased expression of ABCG2 protein			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Folic Acid deficiency results in increased expression of ABCG2 protein which results in decreased susceptibility to Mitoxantrone			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Protons promotes the reaction ABCG2 protein results in increased transport of Folic Acid			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rosiglitazone inhibits the reaction T 0070907 results in decreased expression of ABCG2 mRNA			[175]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rosiglitazone results in increased expression of ABCG2 mRNA			[175]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rosiglitazone results in increased expression of ABCG2 protein			[175]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dexamethasone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCG2 protein affects the export of Topotecan			[239]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein affects the transport of Topotecan			[262]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein results in decreased susceptibility to Topotecan			[238]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein results in increased export of Topotecan			[238]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCG2 protein results in increased susceptibility to Topotecan			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCG2 protein results in increased transport of Topotecan			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCG2 results in decreased susceptibility to Topotecan			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	chrysin results in decreased activity of ABCG2 protein which results in decreased export of Topotecan			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Lapatinib inhibits the reaction ABCG2 protein results in decreased susceptibility to Topotecan			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Protons promotes the reaction ABCG2 protein results in increased transport of Topotecan			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Sunitinib inhibits the reaction ABCG2 results in decreased susceptibility to Topotecan			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Topotecan results in increased expression of ABCG2 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	tryptoquivaline inhibits the reaction ABCG2 protein results in decreased susceptibility to Topotecan			[285]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	tryptoquivaline results in decreased activity of ABCG2 protein which results in decreased export of Topotecan			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Reserpine inhibits the reaction ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Reserpine inhibits the reaction ABCG2 protein results in increased transport of Irinotecan			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin co-treated with Paclitaxel results in increased expression of ABCG2 mRNA			[213]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ERBB2 results in increased expression of ABCG2 which results in decreased susceptibility to Paclitaxel			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Cisplatin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Doxorubicin			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Fluorouracil			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Vincristine			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	AHR protein promotes the reaction 2-tert-butylhydroquinone results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCG2 5' UTR affects the susceptibility to Methylcholanthrene			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	AHR protein affects the reaction Methylcholanthrene results in increased expression of ABCG2 mRNA			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Methylcholanthrene promotes the reaction AHR protein binds to ABCG2 5' UTR			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Corticosterone results in decreased activity of ABCG2 protein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCG2 mRNA			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 gene polymorphism results in decreased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[164]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCG2 protein results in decreased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCG2 protein results in increased secretion of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[165]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCG2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[166]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Beclomethasone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Cadmium Chloride inhibits the reaction ABCG2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[166]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Dexamethasone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Estradiol inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Methylprednisolone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Triamcinolone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Colforsin inhibits the reaction anandamide inhibits the reaction CREB1 protein modified form binds to ABCG2 promoter			[147]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Androstenedione inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Androstenedione results in decreased activity of ABCG2 protein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dichlorodiphenyl Dichloroethylene metabolite results in decreased activity of ABCG2 protein			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Heptachlor results in decreased activity of ABCG2 protein			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chlordan results in decreased activity of ABCG2 protein			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlordan results in increased expression of ABCG2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cholesterol results in increased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sulfasalazine promotes the reaction Cholesterol results in increased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	TAK-875 metabolite results in decreased activity of ABCG2 protein			[148]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	TAK-875 results in decreased activity of ABCG2 protein			[148]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction Ethanol co-treated with Benzo(a)pyrene which results in increased expression of ABCG2 mRNA			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ethanol co-treated with Benzo(a)pyrene results in increased expression of ABCG2 mRNA			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	GW 4064 inhibits the reaction Ethanol results in increased expression of ABCG2 mRNA			[151]
Regulation Mechanism				Transcription Factor Info
1-hydroxypyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite			[157]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite			[157]
Regulation Mechanism				Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether results in decreased activity of ABCG2 protein			[158]
Regulation Mechanism				Transcription Factor Info
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction indolo(3,2-b)carbazole results in increased expression of ABCG2 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction indolo(3,2-b)carbazole results in increased expression of ABCG2 protein			[159]
Regulation Mechanism				Transcription Factor Info
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction ERBB2 results in increased expression of ABCG2 mRNA			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction ERBB2 results in increased expression of ABCG2 protein			[160]
Regulation Mechanism				Transcription Factor Info
2,5,2',5'-tetrachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,5,2',5'-tetrachlorobiphenyl analog results in decreased expression of ABCG2 mRNA			[161]
Regulation Mechanism				Transcription Factor Info
2',5'-dihydroxychalcone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2',5'-dihydroxychalcone promotes the reaction ABCG2 protein results in increased export of Glutathione			[162]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased susceptibility to 2',5'-dihydroxychalcone			[162]
Regulation Mechanism				Transcription Factor Info
2-Acetylaminofluorene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-Acetylaminofluorene results in increased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
2-chloro-5-nitrobenzanilide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-chloro-5-nitrobenzanilide affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with 2-chloro-5-nitrobenzanilide affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide			[167]
Regulation Mechanism				Transcription Factor Info
3,4,5,3',4'-pentachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ABCG2 mRNA			[168]
Regulation Mechanism				Transcription Factor Info
3-(4-methylphenylsulfonyl)-2-propenenitrile	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction ERBB2 results in increased expression of ABCG2 mRNA			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction ERBB2 results in increased expression of ABCG2 protein			[160]
Regulation Mechanism				Transcription Factor Info
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester	19 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite			[157]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester promotes the reaction ABCG2 protein polymorphism results in decreased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein inhibits the reaction Folic Acid deficiency results in decreased susceptibility to Mitoxantrone			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased export of bisbenzimide ethoxide trihydrochloride			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased export of Mitoxantrone			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of benzoylhypaconine			[174]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of hypaconitine			[174]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of mesaconitine			[174]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in increased expression of ABCG2 protein			[175]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	ABCG2 protein affects the reaction 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased transport of pheophorbide a			[176]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	bisphenol A results in decreased activity of ABCG2 protein which results in decreased transport of 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester			[177]
Regulation Mechanism				Transcription Factor Info
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of ABCG2 protein			[178]
Regulation Mechanism				Transcription Factor Info
3-keto-N-aminoethylaminoethylcaproyldihydrocinnamoyl cyclopamine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-keto-N-aminoethylaminoethylcaproyldihydrocinnamoyl cyclopamine results in decreased expression of ABCG2 mRNA			[179]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-keto-N-aminoethylaminoethylcaproyldihydrocinnamoyl cyclopamine results in decreased expression of ABCG2 protein			[179]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
4-iodo-2,5-dimethoxyphenylisopropylamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of ABCG2 protein			[146]
Regulation Mechanism				Transcription Factor Info
4-nonylphenol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-nonylphenol results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fulvestrant affects the reaction 4-nonylphenol results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction ABCG2 protein results in increased uptake of lucifer yellow			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCG2 protein			[156]
Regulation Mechanism				Transcription Factor Info
5-Methoxypsoralen	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-Methoxypsoralen results in decreased activity of ABCG2 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5-Methoxypsoralen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	5-Methoxypsoralen results in increased expression of ABCG2 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Novobiocin inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCG2 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Novobiocin inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
6,2',4'-trimethoxyflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6,2',4'-trimethoxyflavone inhibits the reaction Benzo(a)pyrene results in increased expression of ABCG2 protein			[181]
Regulation Mechanism				Transcription Factor Info
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with NR1I3 protein results in increased expression of ABCG2 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction NR1I3 protein binds to RXRA protein which binds to ABCG2 promoter			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction NR1I3 protein binds to RXRA protein which binds to ABCG2 promoter which results in increased expression of ABCG2 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
6-prenylchrysin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-prenylchrysin results in decreased activity of ABCG2 protein			[4]
Regulation Mechanism				Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ABCG2 mRNA			[182]
Regulation Mechanism				Transcription Factor Info
7-hydroxymethotrexate	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of 7-hydroxymethotrexate			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased export of 7-hydroxymethotrexate			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pantoprazole inhibits the reaction ABCG2 protein affects the transport of 7-hydroxymethotrexate			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Protons promotes the reaction ABCG2 protein results in increased export of 7-hydroxymethotrexate			[183]
Regulation Mechanism				Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction anandamide results in decreased expression of ABCG2 mRNA			[147]
Regulation Mechanism				Transcription Factor Info
abacavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol results in decreased activity of ABCG2 protein which results in increased uptake of abacavir			[184]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCG2 protein which results in increased uptake of abacavir			[184]
Regulation Mechanism				Transcription Factor Info
abemaciclib	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abemaciclib inhibits the reaction ABCG2 protein results in increased export of Doxorubicin			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	abemaciclib inhibits the reaction ABCG2 protein results in increased export of Rhodamine 123			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	abemaciclib results in decreased activity of ABCG2 protein			[72]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of ABCG2 mRNA			[185]
Regulation Mechanism				Transcription Factor Info
Acyclovir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of Acyclovir			[188]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tryptoquivaline inhibits the reaction ABCG2 protein affects the transport of Acyclovir			[188]
Regulation Mechanism				Transcription Factor Info
Adenosine Triphosphate	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Adenosine Triphosphate co-treated with ABCG2 protein results in increased uptake of estrone sulfate			[190]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Lapatinib promotes the reaction ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sulfasalazine inhibits the reaction Adenosine Triphosphate co-treated with ABCG2 protein results in increased uptake of estrone sulfate			[190]
Regulation Mechanism				Transcription Factor Info
albendazole sulfoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of albendazole sulfoxide			[124]
Regulation Mechanism				Transcription Factor Info
AM 251	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction AM 251 results in increased expression of ABCG2 protein			[143]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4'-methoxy-1-naphthylfenoterol inhibits the reaction AM 251 results in increased expression of ABCG2 protein			[143]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	AM 251 results in increased expression of ABCG2 protein			[143]
Regulation Mechanism				Transcription Factor Info
Am 580	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Am 580 promotes the reaction Tretinoin results in increased expression of ABCG2 mRNA			[192]
Regulation Mechanism				Transcription Factor Info
ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate results in increased expression of ABCG2 mRNA			[193]
Regulation Mechanism				Transcription Factor Info
anandamide	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction anandamide results in decreased expression of ABCG2 mRNA			[147]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	anandamide affects the reaction O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	anandamide inhibits the reaction CREB1 protein modified form binds to ABCG2 promoter			[147]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	anandamide results in decreased expression of ABCG2 mRNA			[147]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	anandamide results in decreased expression of ABCG2 protein			[147]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Colforsin inhibits the reaction anandamide inhibits the reaction CREB1 protein modified form binds to ABCG2 promoter			[147]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	iodopravadoline inhibits the reaction anandamide results in decreased expression of ABCG2 mRNA			[147]
Regulation Mechanism				Transcription Factor Info
Asbestos, Amosite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Amosite results in increased methylation of ABCG2 promoter			[195]
Regulation Mechanism				Transcription Factor Info
Atazanavir Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
azaspiracid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azaspiracid results in increased expression of ABCG2 mRNA			[144]
Regulation Mechanism				Transcription Factor Info
azidoprazosin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azidoprazosin binds to ABCG2 protein			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Lapatinib inhibits the reaction azidoprazosin binds to ABCG2 protein			[189]
Regulation Mechanism				Transcription Factor Info
Beclomethasone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beclomethasone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Beclomethasone inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Beclomethasone results in increased activity of ABCG2 protein			[62]
Regulation Mechanism				Transcription Factor Info
Benzo(a)pyrene	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction Ethanol co-treated with Benzo(a)pyrene which results in increased expression of ABCG2 mRNA			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	6,2',4'-trimethoxyflavone inhibits the reaction Benzo(a)pyrene results in increased expression of ABCG2 protein			[181]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Benzo(a)pyrene results in decreased methylation of ABCG2 5' UTR			[198]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Benzo(a)pyrene results in increased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Benzo(a)pyrene results in increased expression of ABCG2 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Benzo(a)pyrene results in increased expression of ABCG2 protein			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	benzo(k)fluoranthene promotes the reaction ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Ethanol co-treated with Benzo(a)pyrene results in increased expression of ABCG2 mRNA			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	indolo(3,2-b)carbazole promotes the reaction ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction Benzo(a)pyrene results in increased expression of ABCG2 protein			[181]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	oltipraz promotes the reaction ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
benzo(k)fluoranthene	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AHR protein promotes the reaction benzo(k)fluoranthene results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	benzo(k)fluoranthene promotes the reaction ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	benzo(k)fluoranthene results in increased expression of ABCG2 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	benzo(k)fluoranthene results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	benzo(k)fluoranthene results in increased expression of and results in increased activity of ABCG2 protein			[159]
Regulation Mechanism				Transcription Factor Info
benzoylhypaconine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of benzoylhypaconine			[174]
Regulation Mechanism				Transcription Factor Info
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction indolo(3,2-b)carbazole results in increased expression of ABCG2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in increased expression of ABCG2 mRNA			[132]
Regulation Mechanism				Transcription Factor Info
bisbenzimide ethoxide trihydrochloride	23 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased export of bisbenzimide ethoxide trihydrochloride			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	bisphenol A results in decreased activity of ABCG2 protein which results in decreased transport of bisbenzimide ethoxide trihydrochloride			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Cimetidine inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Cyclosporine inhibits the reaction ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	danofloxacin inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Genistein inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Genistein promotes the reaction ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Methotrexate inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	MLN 8237 affects the activity of ABCG2 protein which affects the export of bisbenzimide ethoxide trihydrochloride			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	MYC protein results in increased expression of ABCG2 protein which results in increased export of bisbenzimide ethoxide trihydrochloride			[199]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Nitrofurantoin inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Porphyrins inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Reserpine inhibits the reaction ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Tobacco Smoke Pollution inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	verlukast inhibits the reaction ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
bisphenol A	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased transport of bisphenol A			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in decreased activity of ABCG2 protein			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in decreased activity of ABCG2 protein which results in decreased transport of 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in decreased activity of ABCG2 protein which results in decreased transport of bisbenzimide ethoxide trihydrochloride			[177]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	bisphenol A results in decreased expression of ABCG2 mRNA			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	bisphenol A results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Fulvestrant affects the reaction bisphenol A results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Fulvestrant inhibits the reaction bisphenol A results in decreased expression of ABCG2 mRNA			[201]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Fulvestrant inhibits the reaction bisphenol A results in decreased expression of ABCG2 protein			[201]
Regulation Mechanism				Transcription Factor Info
butylbenzyl phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butylbenzyl phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein inhibits the reaction Cadmium Chloride results in increased expression of MT1A protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein inhibits the reaction Cadmium Chloride results in increased expression of MT2A protein			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cadmium Chloride inhibits the reaction ABCG2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[166]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Cadmium Chloride inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[166]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Cadmium Chloride results in decreased activity of ABCG2 protein			[166]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCG2 mRNA			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Cadmium Chloride results in increased expression of ABCG2 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
Carboplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carboplatin results in decreased expression of ABCG2 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Carboplatin results in decreased expression of ABCG2 protein			[71]
Regulation Mechanism				Transcription Factor Info
CD 2608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CD 2608 promotes the reaction Tretinoin results in increased expression of ABCG2 mRNA			[192]
Regulation Mechanism				Transcription Factor Info
cerivastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the export of cerivastatin			[205]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
Chlorpromazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
chrysin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chrysin inhibits the reaction ABCG2 protein results in increased secretion of Mitoxantrone			[209]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	chrysin inhibits the reaction ABCG2 protein results in increased transport of Nitrofurantoin			[209]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	chrysin results in decreased activity of ABCG2 protein			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	chrysin results in decreased activity of ABCG2 protein which results in decreased export of Topotecan			[210]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	chrysin results in decreased expression of ABCG2 mRNA			[211]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	chrysin results in increased expression of ABCG2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	chrysin results in increased expression of ABCG2 protein			[210]
Regulation Mechanism				Transcription Factor Info
Cimetidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of Cimetidine			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
Clozapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of ABCG2 mRNA			[219]
Regulation Mechanism				Transcription Factor Info
Cromolyn Sodium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cromolyn Sodium results in increased expression of ABCG2 protein			[220]
Regulation Mechanism				Transcription Factor Info
cyazofamid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased uptake of cyazofamid			[190]
Regulation Mechanism				Transcription Factor Info
Cyclophosphamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the susceptibility to Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide			[222]
Regulation Mechanism				Transcription Factor Info
dabrafenib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dabrafenib results in increased expression of ABCG2 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
Dactinomycin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin inhibits the reaction Daunorubicin results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dactinomycin inhibits the reaction Doxorubicin results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dactinomycin inhibits the reaction Mitoxantrone results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Dactinomycin inhibits the reaction SHH protein alternative form results in increased expression of ABCG2 protein			[179]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Dactinomycin inhibits the reaction Sulfasalazine results in increased expression of ABCG2 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
danofloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	danofloxacin inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
danusertib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in decreased susceptibility to danusertib			[226]
Regulation Mechanism				Transcription Factor Info
decamethrin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
desisobutyrylciclesonide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	desisobutyrylciclesonide inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	desisobutyrylciclesonide results in increased activity of ABCG2 protein			[62]
Regulation Mechanism				Transcription Factor Info
Dextran Sulfate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextran Sulfate results in decreased expression of ABCG2 mRNA			[229]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dextran Sulfate results in decreased expression of ABCG2 protein			[229]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rifampin promotes the reaction Dextran Sulfate results in decreased expression of ABCG2 mRNA			[229]
Regulation Mechanism				Transcription Factor Info
dibenzoylmethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dibenzoylmethane results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
Dibutyl Phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dibutyl Phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
diclofensine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diclofensine affects the activity of ABCG2 protein			[146]
Regulation Mechanism				Transcription Factor Info
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
diethyl phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diethyl phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
Dimethylnitrosamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dimethylnitrosamine results in increased expression of ABCG2 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
dimethyl phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate results in increased expression of ABCG2 mRNA			[202]
Regulation Mechanism				Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Docetaxel results in decreased susceptibility to Docetaxel which results in decreased expression of ABCG2 mRNA			[230]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
enasidenib	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	enasidenib inhibits the reaction ABCG2 protein results in decreased susceptibility to Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	enasidenib inhibits the reaction ABCG2 protein results in increased export of Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	enasidenib inhibits the reaction ABCG2 protein results in increased export of Daunorubicin which results in increased susceptibility to Daunorubicin			[169]
Regulation Mechanism				Transcription Factor Info
epigallocatechin gallate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate results in decreased activity of ABCG2 protein			[236]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	epigallocatechin gallate results in increased expression of ABCG2 mRNA			[237]
Regulation Mechanism				Transcription Factor Info
Epirubicin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the susceptibility to Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide			[222]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in decreased susceptibility to Epirubicin			[238]
Regulation Mechanism				Transcription Factor Info
Erlotinib Hydrochloride	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erlotinib Hydrochloride inhibits the reaction ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Erlotinib Hydrochloride inhibits the reaction ABCG2 protein results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Erlotinib Hydrochloride inhibits the reaction ABCG2 protein results in increased export of Methotrexate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Erlotinib Hydrochloride inhibits the reaction ABCG2 results in increased export of Methotrexate			[234]
Regulation Mechanism				Transcription Factor Info
estrone sulfate	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the export of estrone sulfate			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein affects the transport of estrone sulfate			[241]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein results in increased export of estrone sulfate			[242]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein results in increased uptake of estrone sulfate			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Adenosine Triphosphate co-treated with ABCG2 protein results in increased uptake of estrone sulfate			[190]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Androstenedione inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Estradiol inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	hippuric acid inhibits the reaction ABCG2 protein results in increased export of estrone sulfate			[242]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Indican inhibits the reaction ABCG2 protein results in increased export of estrone sulfate			[242]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Kynurenic Acid inhibits the reaction ABCG2 protein results in increased export of estrone sulfate			[242]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Progesterone inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Risperidone inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Sulfasalazine inhibits the reaction Adenosine Triphosphate co-treated with ABCG2 protein results in increased uptake of estrone sulfate			[190]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Testosterone inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
Etoposide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 mutant form inhibits the reaction ERBB2 results in decreased susceptibility to Etoposide			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ERBB2 results in increased expression of ABCG2 which results in decreased susceptibility to Etoposide			[160]
Regulation Mechanism				Transcription Factor Info
finrozole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 co-treated with finrozole results in decreased expression of ABCG2 protein			[136]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Aflatoxin B1 co-treated with finrozole results in increased expression of ABCG2 mRNA			[136]
Regulation Mechanism				Transcription Factor Info
flavone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	flavone results in increased expression of ABCG2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	flavone results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
Fluorouracil	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 mutant form inhibits the reaction ERBB2 results in decreased susceptibility to Fluorouracil			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein affects the susceptibility to Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide			[222]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ERBB2 results in increased expression of ABCG2 which results in decreased susceptibility to Fluorouracil			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Fluorouracil			[217]
Regulation Mechanism				Transcription Factor Info
Flutamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flutamide inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Flutamide inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 affects the susceptibility to Fulvestrant			[244]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fulvestrant affects the reaction 4-nonylphenol results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Fulvestrant affects the reaction bisphenol A results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Fulvestrant affects the reaction Estradiol results in decreased expression of ABCG2 protein			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Fulvestrant inhibits the reaction bisphenol A results in decreased expression of ABCG2 mRNA			[201]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Fulvestrant inhibits the reaction bisphenol A results in decreased expression of ABCG2 protein			[201]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Fulvestrant inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Fulvestrant inhibits the reaction Estradiol co-treated with Testosterone results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Fulvestrant inhibits the reaction Estriol results in increased expression of ABCG2 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Fulvestrant inhibits the reaction Estriol results in increased expression of ABCG2 protein			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Fulvestrant inhibits the reaction Genistein results in decreased expression of ABCG2 protein			[170]
Regulation Mechanism				Transcription Factor Info
ginsenoside Re	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased transport of ginsenoside Re			[245]
Regulation Mechanism				Transcription Factor Info
ginsenoside Rg1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased transport of ginsenoside Rg1			[245]
Regulation Mechanism				Transcription Factor Info
ginsenoside Rg3	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginsenoside Rg3 results in decreased expression of ABCG2 mRNA			[149]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	XMU-MP-1 inhibits the reaction ginsenoside Rg3 results in decreased expression of ABCG2 mRNA			[149]
Regulation Mechanism				Transcription Factor Info
Glutathione	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2',5'-dihydroxychalcone promotes the reaction ABCG2 protein results in increased export of Glutathione			[162]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased export of Glutathione			[162]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Methotrexate inhibits the reaction ABCG2 protein results in increased export of Glutathione			[162]
Regulation Mechanism				Transcription Factor Info
Glyburide	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCG2 protein results in increased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester promotes the reaction ABCG2 protein polymorphism results in decreased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein polymorphism results in decreased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein results in increased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Genistein inhibits the reaction ABCG2 protein results in increased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Genistein promotes the reaction ABCG2 protein polymorphism results in decreased export of Glyburide			[170]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
Glycyrrhetinic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhetinic Acid inhibits the reaction ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide			[246]
Regulation Mechanism				Transcription Factor Info
GSK 1363089	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK 1363089 inhibits the reaction ABCG2 protein results in decreased susceptibility to Mitoxantrone			[247]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GSK 1363089 results in decreased activity of ABCG2 protein			[247]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	GSK 1363089 results in decreased activity of ABCG2 protein which results in decreased export of Mitoxantrone			[247]
Regulation Mechanism				Transcription Factor Info
GW 4064	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 4064 inhibits the reaction Ethanol results in increased expression of ABCG2 mRNA			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GW 4064 results in decreased expression of ABCG2 mRNA			[151]
Regulation Mechanism				Transcription Factor Info
Haloperidol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Haloperidol inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
Hexachlorocyclohexane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hexachlorocyclohexane results in increased expression of ABCG2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
hippuric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hippuric acid inhibits the reaction ABCG2 protein results in increased export of estrone sulfate			[242]
Regulation Mechanism				Transcription Factor Info
hypaconitine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of hypaconitine			[174]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased transport of hypaconitine			[174]
Regulation Mechanism				Transcription Factor Info
Indican	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indican inhibits the reaction ABCG2 protein results in increased export of estrone sulfate			[242]
Regulation Mechanism				Transcription Factor Info
indole-3-carbinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indole-3-carbinol results in increased expression of ABCG2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
indolo(3,2-b)carbazole	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction indolo(3,2-b)carbazole results in increased expression of ABCG2 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction indolo(3,2-b)carbazole results in increased expression of ABCG2 protein			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction indolo(3,2-b)carbazole results in increased expression of ABCG2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	indolo(3,2-b)carbazole promotes the reaction ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	indolo(3,2-b)carbazole results in increased expression of ABCG2 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	indolo(3,2-b)carbazole results in increased expression of and results in increased activity of ABCG2 protein			[159]
Regulation Mechanism				Transcription Factor Info
iodopravadoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	iodopravadoline inhibits the reaction anandamide results in decreased expression of ABCG2 mRNA			[147]
Regulation Mechanism				Transcription Factor Info
Irinotecan	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 affects the susceptibility to Irinotecan			[249]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 gene polymorphism affects the susceptibility to and affects the metabolism of Irinotecan			[250]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 mRNA results in increased susceptibility to Irinotecan			[251]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCG2 protein affects the export of Irinotecan			[252]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCG2 protein affects the metabolism of Irinotecan			[250]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCG2 protein results in decreased susceptibility to Irinotecan			[238]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCG2 protein results in increased susceptibility to Irinotecan			[227]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCG2 protein results in increased transport of Irinotecan			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ABCG2 results in decreased susceptibility to Irinotecan			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Porphyrins inhibits the reaction ABCG2 protein results in decreased susceptibility to Irinotecan			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Reserpine inhibits the reaction ABCG2 protein results in increased transport of Irinotecan			[104]
Regulation Mechanism				Transcription Factor Info
isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCG2 protein			[184]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCG2 protein which results in increased uptake of abacavir			[184]
Regulation Mechanism				Transcription Factor Info
Kynurenic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kynurenic Acid inhibits the reaction ABCG2 protein results in increased export of estrone sulfate			[242]
Regulation Mechanism				Transcription Factor Info
Lapatinib	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lapatinib inhibits the reaction ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Lapatinib inhibits the reaction ABCG2 protein results in decreased susceptibility to Topotecan			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Lapatinib inhibits the reaction ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Lapatinib inhibits the reaction ABCG2 protein results in increased export of Methotrexate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Lapatinib inhibits the reaction ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Lapatinib inhibits the reaction azidoprazosin binds to ABCG2 protein			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Lapatinib promotes the reaction ABCG2 protein results in increased hydrolysis of Adenosine Triphosphate			[189]
Regulation Mechanism				Transcription Factor Info
ledipasvir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ledipasvir binds to ABCG2 protein			[253]
Regulation Mechanism				Transcription Factor Info
lucifer yellow	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction ABCG2 protein results in increased uptake of lucifer yellow			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased transport of lucifer yellow			[254]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCG2 protein results in increased uptake of lucifer yellow			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Novobiocin inhibits the reaction ABCG2 protein results in increased uptake of lucifer yellow			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Omeprazole inhibits the reaction ABCG2 protein results in increased transport of lucifer yellow			[254]
Regulation Mechanism				Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of ABCG2 mRNA			[140]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
mesaconitine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein which results in decreased transport of mesaconitine			[174]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased transport of mesaconitine			[174]
Regulation Mechanism				Transcription Factor Info
methotrexate-alpha glutamate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Protons promotes the reaction ABCG2 protein results in increased export of methotrexate-alpha glutamate			[183]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in decreased susceptibility to methylmercuric chloride			[139]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	methylmercuric chloride results in decreased expression of ABCG2 mRNA			[139]
Regulation Mechanism				Transcription Factor Info
Methylprednisolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methylprednisolone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
Mifepristone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the reaction Mifepristone results in decreased transport of pheophorbide a			[176]
Regulation Mechanism				Transcription Factor Info
mitragynine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mitragynine affects the activity of ABCG2 protein			[146]
Regulation Mechanism				Transcription Factor Info
MLN 8237	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MLN 8237 affects the activity of ABCG2 protein			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	MLN 8237 affects the activity of ABCG2 protein which affects the export of bisbenzimide ethoxide trihydrochloride			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	MLN 8237 affects the activity of ABCG2 protein which affects the export of Mitoxantrone			[173]
Regulation Mechanism				Transcription Factor Info
monoisoamyl-2,3-dimercaptosuccinate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of ABCG2 mRNA			[131]
Regulation Mechanism				Transcription Factor Info
moxidectin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased export of moxidectin			[265]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of moxidectin			[265]
Regulation Mechanism				Transcription Factor Info
Naproxen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen affects the activity of ABCG2 protein			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Naproxen affects the expression of ABCG2 protein			[127]
Regulation Mechanism				Transcription Factor Info
NCX 4040	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NCX 4040 results in increased expression of ABCG2 mRNA			[133]
Regulation Mechanism				Transcription Factor Info
nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
nilotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the susceptibility to nilotinib			[248]
Regulation Mechanism				Transcription Factor Info
nimesulide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nimesulide results in decreased activity of ABCG2 protein			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	nimesulide results in decreased expression of ABCG2 protein			[127]
Regulation Mechanism				Transcription Factor Info
Nitrofurantoin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of Nitrofurantoin			[267]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased transport of Nitrofurantoin			[209]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	chrysin inhibits the reaction ABCG2 protein results in increased transport of Nitrofurantoin			[209]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Nitrofurantoin inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[163]
Regulation Mechanism				Transcription Factor Info
notoginsenoside R1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased transport of notoginsenoside R1			[245]
Regulation Mechanism				Transcription Factor Info
Novobiocin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Novobiocin inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCG2 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Novobiocin inhibits the reaction 5-Methoxypsoralen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Novobiocin inhibits the reaction ABCG2 protein results in increased uptake of lucifer yellow			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Novobiocin inhibits the reaction Methoxsalen results in decreased activity of ABCG2 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Novobiocin inhibits the reaction Methoxsalen results in decreased activity of ABCG2 protein which results in decreased export of and results in increased abundance of Mitoxantrone			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Novobiocin results in decreased activity of ABCG2 protein			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Novobiocin results in decreased activity of ABCG2 protein which results in decreased export of Mitoxantrone			[247]
Regulation Mechanism				Transcription Factor Info
Olanzapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olanzapine inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
oleoylethanolamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oleoylethanolamide affects the reaction O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
oltipraz	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oltipraz promotes the reaction ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	oltipraz results in increased activity of ABCG2 protein			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	oltipraz results in increased expression of ABCG2 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	anandamide affects the reaction O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	oleoylethanolamide affects the reaction O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of ABCG2 mRNA			[269]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of ABCG2 protein			[152]
Regulation Mechanism				Transcription Factor Info
o,p'-DDT	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	o,p'-DDT results in decreased activity of ABCG2 protein			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	o,p'-DDT results in increased expression of ABCG2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
oxfendazole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of oxfendazole			[124]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	oxfendazole inhibits the reaction ABCG2 protein affects the transport of Mitoxantrone			[124]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	oxfendazole results in decreased activity of ABCG2 protein			[124]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in increased expression of ABCG2 protein			[270]
Regulation Mechanism				Transcription Factor Info
Paliperidone Palmitate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paliperidone Palmitate inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid results in decreased expression of ABCG2 mRNA			[271]
Regulation Mechanism				Transcription Factor Info
Panobinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of ABCG2 mRNA			[140]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased activity of ABCG2 protein			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctane sulfonic acid results in increased expression of ABCG2 mRNA			[272]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased transport of perfluorooctanoic acid			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanoic acid results in decreased activity of ABCG2 protein			[273]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	perfluorooctanoic acid results in increased expression of ABCG2 mRNA			[193]
Regulation Mechanism				Transcription Factor Info
pheophorbide a	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the reaction 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased transport of pheophorbide a			[176]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein affects the reaction Mifepristone results in decreased transport of pheophorbide a			[176]
Regulation Mechanism				Transcription Factor Info
pibrentasvir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pibrentasvir binds to ABCG2 protein			[253]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in increased expression of ABCG2 mRNA			[275]
Regulation Mechanism				Transcription Factor Info
pitavastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the transport of pitavastatin			[32]
Regulation Mechanism				Transcription Factor Info
Potassium Dichromate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Potassium Dichromate results in increased expression of ABCG2 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
Proadifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Proadifen co-treated with Cisplatin results in increased expression of ABCG2 protein			[218]
Regulation Mechanism				Transcription Factor Info
prolinedithiocarbamate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	prolinedithiocarbamate inhibits the reaction Arsenic Trioxide results in increased expression of ABCG2 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	prolinedithiocarbamate inhibits the reaction Arsenic Trioxide results in increased expression of ABCG2 protein			[59]
Regulation Mechanism				Transcription Factor Info
protoapigenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	protoapigenone analog results in decreased expression of ABCG2 protein			[276]
Regulation Mechanism				Transcription Factor Info
Quetiapine Fumarate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quetiapine Fumarate inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
resmethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	resmethrin results in decreased activity of ABCG2 protein			[40]
Regulation Mechanism				Transcription Factor Info
resveratrol-4'-O-glucuronide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased transport of resveratrol-4'-O-glucuronide			[259]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	resveratrol-4'-O-glucuronide inhibits the reaction ABCG2 protein results in increased transport of Methotrexate			[259]
Regulation Mechanism				Transcription Factor Info
Rhodamine 123	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased export of Rhodamine 123			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	abemaciclib inhibits the reaction ABCG2 protein results in increased export of Rhodamine 123			[72]
Regulation Mechanism				Transcription Factor Info
Risperidone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Risperidone inhibits the reaction ABCG2 protein results in increased transport of Mitoxantrone			[171]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Risperidone inhibits the reaction ABCG2 protein results in increased uptake of estrone sulfate			[171]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of ABCG2 mRNA			[278]
Regulation Mechanism				Transcription Factor Info
Silymarin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AHR protein promotes the reaction Silymarin results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silymarin results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the expression of ABCG2 mRNA			[279]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite affects the splicing of ABCG2 mRNA			[280]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in decreased expression of ABCG2 mRNA			[131]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	sodium arsenite results in increased expression of ABCG2 mRNA			[280]
Regulation Mechanism				Transcription Factor Info
Sulfapyridine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 gene polymorphism affects the transport of Sulfapyridine			[281]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased transport of Sulfapyridine			[281]
Regulation Mechanism				Transcription Factor Info
sulindac sulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulindac sulfide results in increased expression of ABCG2 mRNA			[125]
Regulation Mechanism				Transcription Factor Info
Sulpiride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein results in increased transport of Sulpiride			[235]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar inhibits the reaction ABCG2 protein results in increased transport of Sulpiride			[235]
Regulation Mechanism				Transcription Factor Info
Sunitinib	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the reaction ABCG2 results in decreased abundance of and results in decreased susceptibility to Doxorubicin			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sunitinib inhibits the reaction ABCG2 results in decreased susceptibility to Topotecan			[234]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sunitinib inhibits the reaction ABCG2 results in increased export of Methotrexate			[234]
Regulation Mechanism				Transcription Factor Info
T 0070907	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the reaction T 0070907 results in decreased expression of ABCG2 mRNA			[175]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	T 0070907 results in decreased expression of ABCG2 mRNA			[175]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	T 0070907 results in decreased expression of ABCG2 protein			[175]
Regulation Mechanism				Transcription Factor Info
Tartrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCG2 mRNA			[196]
Regulation Mechanism				Transcription Factor Info
taxane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	taxane analog affects the activity of ABCG2 protein			[283]
Regulation Mechanism				Transcription Factor Info
tectochrysin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tectochrysin results in decreased activity of ABCG2 protein			[4]
Regulation Mechanism				Transcription Factor Info
Temozolomide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A results in decreased activity of ABCG2 protein			[138]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction Tetrachlorodibenzodioxin results in increased expression of ABCG2 mRNA			[284]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCG2 mRNA			[240]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in increased expression of ABCG2			[165]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tetrachlorodibenzodioxin results in increased expression of ABCG2 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tetrachlorodibenzodioxin results in increased expression of ABCG2 protein			[159]
Regulation Mechanism				Transcription Factor Info
Triamcinolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triamcinolone inhibits the reaction ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine			[61]
Regulation Mechanism				Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCG2 mRNA			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of ABCG2 mRNA			[286]
Regulation Mechanism				Transcription Factor Info
tryptoquivaline	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tryptoquivaline inhibits the reaction ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tryptoquivaline inhibits the reaction ABCG2 protein affects the transport of Acyclovir			[188]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tryptoquivaline inhibits the reaction ABCG2 protein affects the uptake of Mitoxantrone			[263]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	tryptoquivaline inhibits the reaction ABCG2 protein results in decreased susceptibility to Topotecan			[285]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of Methotrexate			[189]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of Mitoxantrone			[265]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	tryptoquivaline inhibits the reaction ABCG2 protein results in increased export of moxidectin			[265]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	tryptoquivaline results in decreased activity of ABCG2 protein			[241]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	tryptoquivaline results in decreased activity of ABCG2 protein which results in decreased export of Topotecan			[210]
Regulation Mechanism				Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanadates results in increased expression of ABCG2 mRNA			[288]
Regulation Mechanism				Transcription Factor Info
venetoclax	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	venetoclax binds to ABCG2 protein			[253]
Regulation Mechanism				Transcription Factor Info
verlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	verlukast inhibits the reaction ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride			[104]
Regulation Mechanism				Transcription Factor Info
Vincristine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel results in decreased expression of ABCG2 which results in decreased susceptibility to Vincristine			[217]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Vincristine results in decreased susceptibility to Vincristine which results in increased expression of ABCG2 mRNA			[230]
Regulation Mechanism				Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of ABCG2 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
Warfarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 SNP affects the susceptibility to Warfarin			[289]
Regulation Mechanism				Transcription Factor Info
XMU-MP-1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	XMU-MP-1 inhibits the reaction ginsenoside Rg3 results in decreased expression of ABCG2 mRNA			[149]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	XMU-MP-1 results in increased expression of ABCG2 mRNA			[149]
Regulation Mechanism				Transcription Factor Info
zearalenol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zearalenol results in decreased expression of ABCG2 mRNA			[290]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	zearalenol results in decreased expression of ABCG2 protein			[290]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	zearalenol results in increased expression of ABCG2 mRNA			[290]
Regulation Mechanism				Transcription Factor Info
Herbicide
DT Modulation1	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Estradiol	23 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the transportation of Topotecan by ABCG2			[5]
Affected Drug/Substrate	Topotecan	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-BCRP
DT Modulation2	Estradiol induces the activity of ABCG2			[10], [11], [12]
Imatinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imatinib induces the activity of ABCG2			[8], [9]
DT Modulation2	Imatinib inhibits the activity of ABCG2			[8], [9]
Cyclosporine	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the transportation of ATPase by ABCG2 (Ki = 0.5 microM)			[13]
Affected Drug/Substrate	ATPase	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
DT Modulation2	Cyclosporine inhibits the activity of ABCG2			[28]
Sulfasalazine	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfasalazine inhibits the transportation of Estrone sulfate by ABCG2 (IC50 = 0.73 microM)			[14]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Oocytes-BCRP
DT Modulation2	Sulfasalazine inhibits the activity of ABCG2			[25]
Gefitinib	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gefitinib inhibits the transportation of Hoechst 33342 by ABCG2 (IC50 = 0.4 microM)			[15]
Affected Drug/Substrate	Hoechst 33342	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
DT Modulation2	Gefitinib inhibits the activity of ABCG2			[27]
Omeprazole	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the transportation of Methotrexate by ABCG2 (IC50 = 10-50 microM)			[16]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
DT Modulation2	Omeprazole inhibits the activity of ABCG2			[20]
Pantoprazole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pantoprazole inhibits the transportation of Methotrexate by ABCG2 (IC50 = 10 microM)			[16]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
DT Modulation2	Pantoprazole inhibits the activity of ABCG2			[16], [20]
Lopinavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lopinavir inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 7.66 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
DT Modulation2	Lopinavir inhibits the activity of ABCG2			[17]
Nelfinavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nelfinavir inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 13.5 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
DT Modulation2	Nelfinavir inhibits the activity of ABCG2			[26]
Hesperetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hesperetin inhibits the transportation of mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
DT Modulation2	Hesperetin inhibits the transportation of SN-38 by ABCG2			[19]
Affected Drug/Substrate	SN-38	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-BCRP
Etravirine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etravirine inhibits the activity of ABCG2			[21], [22]
Progesterone	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone induces the activity of ABCG2			[23], [24]
DT Modulation2	Progesterone inhibits the activity of ABCG2			[24]
Itraconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of ABCG2			[29], [30]
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of ABCG2			[30]
Daunorubicin	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daunorubicin inhibits the transportation of Estrone sulfate by ABCG2 (IC50 = 59 microM)			[31]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Mouse lymphoma (P388) cells-BCRP
Atorvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the transportation of Estrone sulfate by ABCG2 (Ki = 14.3 microM)			[32]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Cerivastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cerivastatin inhibits the transportation of Estrone sulfate by ABCG2 (Ki = 18.1 microM)			[32]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Fluvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvastatin inhibits the transportation of Estrone sulfate by ABCG2 (Ki = 5.43 microM)			[32]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Pitavastatin calcium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pitavastatin calcium inhibits the transportation of Estrone sulfate by ABCG2 (Ki = 2.92 microM)			[32]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Rosuvastatin Calcium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosuvastatin inhibits the transportation of Estrone sulfate by ABCG2 (Ki = 15.4 microM)			[32]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Simvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the transportation of Estrone sulfate by ABCG2 (Ki = 18 microM)			[32]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Erlotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erlotinib inhibits the transportation of Estrone sulfate by ABCG2 (IC50 = 0.13 microM; Ki = 0.15 microM)			[33]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Myelogenous leukemia cell line (K562)-BCRP
Atovaquone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atovaquone inhibits the transportation of Estrone sulphate by ABCG2 (IC50 = 0.23 microM)			[34]
Affected Drug/Substrate	Estrone sulphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Anidulafungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Anidulafungin inhibits the transportation of Fluorescent protein by ABCG2 (IC50 = 7 microM)			[35]
Affected Drug/Substrate	Fluorescent protein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Nilotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nilotinib inhibits the transportation of Methotrexate by ABCG2 (Ki = 0.69 microM)			[38]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Abacavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Abacavir inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 385 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Amprenavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amprenavir inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 181 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Atazanavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atazanavir inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 69.1 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Delavirdine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Delavirdine inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 18.7 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Efavirenz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Efavirenz inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 20.6 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Saquinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Saquinavir inhibits the transportation of Pheophorbide A by ABCG2 (IC50 = 27.4 microM)			[17]
Affected Drug/Substrate	Pheophorbide A	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Permethrin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Permethrin inhibits the transportation of Sulfasalazine by ABCG2 (IC50 = 7 microM)			[40]
Affected Drug/Substrate	Sulfasalazine	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
Dolutegravir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dolutegravir inhibits the transportation of Cimetidine by ABCG2			[44]
Affected Drug/Substrate	Cimetidine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Linagliptin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linagliptin inhibits the transportation of Estrone sulfate by ABCG2			[45]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Prazosin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prazosin inhibits the transportation of Estrone sulfate by ABCG2			[45]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Quercetin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Simeprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simeprevir inhibits the transportation of Digoxin by ABCG2			[48]
Affected Drug/Substrate	Digoxin	Modulation Type	Inhibition
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the activity of ABCG2			[50]
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Decitabine	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine inhibits DNA methyltransferase, which then enhances Novobiocin's transportation via downregulating the hypermethylation in ABCG2's promoter			[53]
Affected Drug/Substrate	Novobiocin	Modulation Type	Inducer
Cell System	Human small cell lung cancer cells (PC-6)
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine increases the expression of ABCG2			[54]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human liver samples
Rifampin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of ABCG2			[55]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatocytes
Cisplatin	12 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of ABCG2			[56]
Regulation Mechanism	via enhancement of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	human colorectal adenocarcinoma cells (LS174T)
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide increases the expression of ABCG2			[57]
Regulation Mechanism	via enhancement of Endothelial PAS domain-containing protein 1 (EPAS1)			Transcription Factor Info
Cell System	Human cardiac side population cells
Phenobarbital	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital increases the expression of ABCG2			[58]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 3 (NR1I3)			Transcription Factor Info
Cell System	Human hepatocytes
Arsenic Trioxide	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of ABCG2			[59]
Regulation Mechanism	via enhancement of Nuclear factor NF-kappa-B p105 subunit (NFKB1)			Transcription Factor Info
Cell System	Human lung adenocarcinoma cells (A549)
Troglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone increases the expression of ABCG2			[60]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (Caco-2)
Digoxin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Digoxin inhibits the activity of ABCG2			[61]
Imatinib Mesylate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imatinib Mesylate increases the expression of ABCG2			[9]
Mometasone Furoate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mometasone Furoate increases the activity of ABCG2			[62]
Estrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone increases the expression of ABCG2			[12]
Celecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the expression of ABCG2			[64]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of ABCG2			[65]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of ABCG2			[66]
Testosterone	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the activity of ABCG2			[67]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of ABCG2			[68]
Lindane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lindane increases the expression of ABCG2			[37]
Ciprofloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ciprofloxacin increases the expression of ABCG2			[69]
Pravastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin increases the activity of ABCG2			[70]
Chloroquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the expression of ABCG2			[71]
Abemaciclib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Abemaciclib inhibits the activity of ABCG2			[72]
Crizotinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Crizotinib inhibits the activity of ABCG2			[73]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of ABCG2			[74]
Methoxsalen	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methoxsalen inhibits the activity of ABCG2			[75]
Tamoxifen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen increases the expression of ABCG2			[76]
Dabrafenib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dabrafenib increases the expression of ABCG2			[78]
Doxorubicin	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin increases the expression of ABCG2			[79]
Tretinoin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of ABCG2			[80]
Acetaminophen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ABCG2			[81]
DT Modulation2	Acetaminophen results in decreased expression of and results in decreased activity of ABCG2 protein			[186]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetaminophen results in increased expression of ABCG2 protein			[187]
Regulation Mechanism				Transcription Factor Info
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ABCG2			[82]
Dacomitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dacomitinib inhibits the activity of ABCG2			[83]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Leflunomide inhibits the activity of ABCG2			[84]
Doxycycline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxycycline induces the activity of ABCG2			[85]
Mitoxantrone	54 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitoxantrone inhibits the activity of ABCG2			[18], [86]
Telaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telaprevir induces the activity of ABCG2			[87]
Osimertinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Osimertinib inhibits the activity of ABCG2			[88]
Methotrexate	22 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the activity of ABCG2			[42]
Folic Acid	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Folic acid induces the activity of ABCG2			[89], [90]
Rosiglitazone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone induces the activity of ABCG2			[8], [91], [92]
Dexamethasone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone induces the activity of ABCG2			[93]
Topotecan	15 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Topotecan induces the activity of ABCG2			[94], [95]
Nicardipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicardipine inhibits the activity of ABCG2			[96], [97]
Sirolimus	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sirolimus inhibits the activity of ABCG2			[98]
Tacrolimus	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tacrolimus inhibits the activity of ABCG2			[98]
Oxycodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxycodone induces the activity of ABCG2			[99]
Ritonavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the activity of ABCG2			[100]
Dipyridamole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the activity of ABCG2			[101], [102]
Propafenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propafenone inhibits the activity of ABCG2			[103]
Reserpine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Reserpine inhibits the activity of ABCG2			[104], [105], [106]
Toremifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Toremifene inhibits the activity of ABCG2			[107]
Plicamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plicamycin inhibits the activity of ABCG2			[108]
Insulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Insulin induces the activity of ABCG2			[109]
Nimodipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nimodipine inhibits the activity of ABCG2			[110]
Glecaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glecaprevir inhibits the activity of ABCG2			[111]
Tolcapone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolcapone inhibits the activity of ABCG2			[112]
Selexipag	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selexipag inhibits the activity of ABCG2			[113]
Eetuximab	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eetuximab inhibits the activity of ABCG2			[114]
Oxytetracycline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxytetracycline induces the activity of ABCG2			[115]
Febuxostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Febuxostat inhibits the activity of ABCG2			[116]
Micafungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Micafungin inhibits the activity of ABCG2			[35]
Clofibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clofibrate induces the activity of ABCG2			[117]
Venlafaxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Venlafaxine induces the activity of ABCG2			[118]
Paclitaxel	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel increases the expression of ABCG2			[119]
Regulation Mechanism	via enhancement of Signal transducer and activator of transcription 3 (STAT3)			Transcription Factor Info
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inducer
Cell System	Human doxorubicin-resistant epithelial ovarian cancer cells (A2780-R)
Drug Marketed but not Approved by US FDA
Catechin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Catechin inhibits the expression of ABCG2			[63]
Estriol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estriol increases the expression of ABCG2			[11]
Drug in Phase 4 Trial
Glafenine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glafenine inhibits the activity of ABCG2			[155]
Drug in Phase 2/3 Trial
Butyric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyric Acid increases the expression of ABCG2			[77]
Drug in Phase 3 Trial
Curcumin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin inhibits the transportation of Mitoxantrone by ABCG2			[1]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
DT Modulation2	Curcumin inhibits the transportation of Pheophorbide by ABCG2			[1]
Affected Drug/Substrate	Pheophorbide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
DT Modulation3	Curcumin inhibits the transportation of Resveratrol-3-O-glucuronide by ABCG2			[2]
Affected Drug/Substrate	Resveratrol-3-O-glucuronide	Modulation Type	Inhibition
Cell System	Model organism in vivo (mouse)
DT Modulation4	Curcumin inhibits the transportation of Sulfasalazine by ABCG2			[3]
Affected Drug/Substrate	Sulfasalazine	Modulation Type	Inhibition
Cell System	Model organism in vivo (mouse)
Corticosterone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Corticosterone inhibits the activity of ABCG2			[61]
Resveratrol	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the expression of ABCG2			[134]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan increases the expression of ABCG2			[145]
Drug in Phase 2 Trial
SN-38	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SN-38 inhibits the transportation of Estrone sulfate by ABCG2 (IC50 = 1.6 microM)			[31]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Mouse lymphoma (P388) cells-BCRP
Genistein	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of ABCG2			[122]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human fetal liver samples
Sulindac sulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac sulfide increases the expression of ABCG2			[125]
Colforsin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin increases the expression of ABCG2			[130]
Ethanol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol increases the expression of ABCG2			[151]
Drug in Phase 1 Trial
Naringenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringenin inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Oxfendazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxfendazole inhibits the activity of ABCG2			[124]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of ABCG2			[131]
HSDB-3466	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	HSDB-3466 inhibits the activity of ABCG2			[75]
TAK-875	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TAK-875 inhibits the activity of ABCG2			[148]
Q-100154	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Q-100154 inhibits the expression of ABCG2			[149]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of ABCG2			[140]
Drug in Preclinical Test
Oleic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oleic Acid increases the expression of ABCG2			[135]
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of ABCG2			[141]
Anandamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Anandamide inhibits the expression of ABCG2			[147]
Discontinued Drug
Elacridar	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Elacridar inhibits the transportation of Mitoxantrone by ABCG2 (IC50 = 0.31 microM)			[4]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
DT Modulation2	Elacridar inhibits the transportation of Estrone sulfate by ABCG2			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-BCRP
DT Modulation3	Elacridar inhibits the transportation of Mitoxantrone by ABCG2			[7]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Tariquidar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tariquidar inhibits the transportation of Calcein AM by ABCG2			[49]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Investigative Drug
Coumestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol inhibits the transportation of Methotrexate by ABCG2 (IC50 = 0.063 microM)			[42]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daidzein inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Kaempferol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kaempferol inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Morin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Morin inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
GW9662	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW9662 inhibits the expression of ABCG2			[60]
Regulation Mechanism	via the inhibition of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	Sprague-Dawley rats
Desisobutyryl-ciclesonide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desisobutyryl-ciclesonide increases the activity of ABCG2			[62]
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone increases the expression of ABCG2			[132]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of ABCG2			[140]
N-nonylphenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-nonylphenol inhibits the expression of ABCG2			[142]
Chloropyrifos oxon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloropyrifos oxon increases the expression of ABCG2			[152]
Rutin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rutin inhibits the activity of ABCG2			[42]
Patented Pharmaceutical Agent
AM-251	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AM-251 increases the expression of ABCG2			[143]
GW-4064	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW-4064 inhibits the expression of ABCG2			[151]
Drug Withdrawn
Nimesulide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nimesulide inhibits the expression of ABCG2			[127]
Natural Product
DT Modulation1	AHR protein promotes the reaction Curcumin results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Curcumin results in decreased expression of ABCG2 mRNA			[221]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Curcumin results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
Pyrethroids	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrethroids inhibits the transportation of Fmitremorgin C by ABCG2 (IC50 = 42.5 microM)			[36]
Affected Drug/Substrate	Fmitremorgin C	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Tetramethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethrin inhibits the transportation of Fmitremorgin C by ABCG2 (IC50 = 72.5 microM)			[36]
Affected Drug/Substrate	Fmitremorgin C	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Chlordecone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlordecone inhibits the transportation of Hoechst 33342 by ABCG2 (IC50 = 90.4 microM)			[37]
Affected Drug/Substrate	Hoechst 33342	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Endosulfan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the transportation of Hoechst 33342 by ABCG2 (IC50 = 24.8 microM)			[37]
Affected Drug/Substrate	Hoechst 33342	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BCRP
Isoflavones	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoflavones inhibits the transportation of Mitoxantrone by ABCG2 in a non-competitive manner (IC50 = 8.8 microM)			[39]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Resmethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resmethrin inhibits the transportation of Sulfasalazine by ABCG2 (IC50 = 5.6 microM)			[40]
Affected Drug/Substrate	Sulfasalazine	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 1860 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Chlormequate chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlormequate chloride inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 1260 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Chlorpyrifos	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 285 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Chlorpyrifos-methyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos-methyl inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 31 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Diflufenican	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diflufenican inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 13 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Dimethoate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dimethoate inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 22 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Dimethomorph	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dimethomorph inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 26 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Dithianon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dithianon inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 202 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Epoxiconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epoxiconazole inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 455 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Glyphosate	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glyphosate inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 148 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Enilconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imazalil inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 109 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Ioxynil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ioxynil inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 540 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Methiocarb	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methiocarb inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 440 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Rimsulfuron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rimsulfuron inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 12 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Thiacloprid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiacloprid inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 396 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Tolclofos-methyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolclofos-methyl inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 17 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
Berry anthocyanins	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Berry anthocyanins inhibits the activity of ABCG2 (IC50 = 7.8 microM)			[43]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
DT Modulation1	AHR protein promotes the reaction Quercetin results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quercetin affects the expression of ABCG2 mRNA			[277]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quercetin results in decreased expression of ABCG2 mRNA			[128]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Quercetin results in decreased expression of ABCG2 protein			[128]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Quercetin results in increased expression of ABCG2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Quercetin results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
Cigarette smoke condensate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate induces the transportation of Hoechst 33342 by ABCG2			[46]
Affected Drug/Substrate	Hoechst 33342	Modulation Type	Inducer
Cell System	Human hepatoma HepaRG cells-BCRP
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Luteolin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Luteolin inhibits the transportation of Mitoxantrone by ABCG2			[18]
Affected Drug/Substrate	Mitoxantrone	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Cinnamic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cinnamic acid inhibits the transportation of Rosuvastatin by ABCG2 in a competitive manner			[47]
Affected Drug/Substrate	Rosuvastatin	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-BCRP
Gallic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gallic acid inhibits the transportation of Rosuvastatin by ABCG2 in a competitive manner			[47]
Affected Drug/Substrate	Rosuvastatin	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-BCRP
Piperine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piperine inhibits the transportation of Rosuvastatin by ABCG2 in a competitive manner			[47]
Affected Drug/Substrate	Rosuvastatin	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-BCRP
Tripterine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celastrol inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Chrysoeriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chrysoeriol inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Ellagic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ellagic acid inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Laricitrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Laricitrin inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Limonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Limonin inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Oleanolic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oleanolic acid inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Propyl gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propyl gallate inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Sinapic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sinapic acid inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Tamarixetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamarixetin inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Tricetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tricetin inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Tricetin 3',4',5'-trimethylether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tricetin 3',4',5'-trimethylether inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Ursolic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ursolic acid inhibits the activity of ABCG2			[51]
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Black cohosh extract (1mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Black cohosh extract (1mg/ml) inhibits the activity of ABCG2			[42]
Cell System	Mammalian cells expressing human wild-type BCRP
Gymnema sylvestre extract (1mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gymnema sylvestre extract (1mg/ml) inhibits the activity of ABCG2			[42]
Cell System	Mammalian cells expressing human wild-type BCRP
Passion flower extract (1mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Passion flower extract (1mg/ml) inhibits the activity of ABCG2			[42]
Cell System	Mammalian cells expressing human wild-type BCRP
Rutin extract (1mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rutin extract (1mg/ml) inhibits the activity of ABCG2			[42]
Cell System	Mammalian cells expressing human wild-type BCRP
Soybean extract (1mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Soybean extract (1mg/ml) inhibits the activity of ABCG2 (IC50 = 16.5 microM)			[42]
Cell System	Mammalian cells expressing human wild-type BCRP
Tetrahydrocurcumin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrahydrocurcumin inhibits the activity of ABCG2			[52]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BCRP
Flavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flavone increases the expression of ABCG2			[63]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (Caco-2)
Chrysin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chrysin increases the expression of ABCG2			[63]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (Caco-2)
6-bromoindirubin-3'-oxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-bromoindirubin-3'-oxime increases the expression of ABCG2			[128]
DT Modulation1	ABCG2 protein affects the transport of Resveratrol			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein results in increased transport of Resveratrol metabolite			[259]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	AHR protein promotes the reaction Resveratrol results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Elacridar inhibits the reaction ABCG2 protein affects the transport of Resveratrol			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Elacridar inhibits the reaction Protons promotes the reaction ABCG2 protein results in increased export of Resveratrol			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Protons promotes the reaction ABCG2 protein results in increased export of Resveratrol			[183]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Resveratrol analog inhibits the reaction ABCG2 protein results in increased transport of Methotrexate			[259]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Resveratrol results in increased expression of ABCG2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Resveratrol results in increased expression of ABCG2 protein			[63]
Regulation Mechanism				Transcription Factor Info
Vitallium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitallium inhibits the expression of ABCG2			[137]
Cholesterol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholesterol increases the activity of ABCG2			[70]
Mitragynine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitragynine affects the activity of ABCG2			[146]
Indolo(3,2-b)carbazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indolo(3,2-b)carbazole increases the expression of ABCG2			[63]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of ABCG2			[153]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of ABCG2			[154]
Oroxylin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oroxylin A inhibits the activity of ABCG2 (IC50 = 0.477 microM)			[156]
Cell System	Human embryonic kidney 293 cells (HEK293)-ABCG2
Plant Extract
Ginkgo biloba extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgo biloba extract increases the expression of ABCG2			[8]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (LS174T)
Environmental toxicant
o,p'-dichlorodiphenyltrichloroethane (DDT)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	O,p'-DDT inhibits the transportation of Sulfasalazine by ABCG2 (IC50 = 10.4 microM)			[40]
Affected Drug/Substrate	Sulfasalazine	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
p,p'-dichlorodiphenyldichloroethane (DDE)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p,p'-DDE inhibits the transportation of Sulfasalazine by ABCG2 (IC50 = 4 microM)			[40]
Affected Drug/Substrate	Sulfasalazine	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
p,p'-dichlorodiphenyltrichloroethane (DDT)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p,p'-DDT inhibits the transportation of Sulfasalazine by ABCG2 (IC50 = 5 microM)			[40]
Affected Drug/Substrate	Sulfasalazine	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
p,p'-tetrachlorodiphenylethane (DDD)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p,p'-DDD inhibits the transportation of Sulfasalazine by ABCG2 (IC50 = 3 microM)			[40]
Affected Drug/Substrate	Sulfasalazine	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BCRP
Carbendazim	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbendazim inhibits the transportation of WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) by ABCG2 (IC50 = 525 microM)			[41]
Affected Drug/Substrate	WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate)	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-BCRP
2-tert-butylhydroquinone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-tert-butylhydroquinone increases the expression of ABCG2			[120]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of ABCG2			[123]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human colon carcinoma cells (HCT 116)
NCX-4040	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NCX-4040 increases the expression of ABCG2			[133]
Dichlorodiphenyl Dichloroethylene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene inhibits the activity of ABCG2			[40]
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A inhibits the activity of ABCG2			[138]
Mycotoxins
Aflatoxin B1	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of ABCG2			[136]
DT Modulation2	Aflatoxin B1 affects the expression of ABCG2 protein			[191]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 co-treated with finrozole results in decreased expression of ABCG2 protein			[136]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Aflatoxin B1 co-treated with finrozole results in increased expression of ABCG2 mRNA			[136]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Aflatoxin B1 results in increased expression of ABCG2 mRNA			[136]
Regulation Mechanism				Transcription Factor Info
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG2 protein affects the susceptibility to ochratoxin A			[268]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCG2 protein affects the transport of ochratoxin A			[268]
Regulation Mechanism				Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of ABCG2 mRNA			[130]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Cadmium	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of ABCG2			[126]
Mercury	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mercury increases the expression of ABCG2			[126]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	15 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the expression of ABCG2			[129]
Mercuric Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mercuric Chloride increases the expression of ABCG2			[139]
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid increases the expression of ABCG2			[150]
Carcinogen
Methylcholanthrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methylcholanthrene increases the expression of ABCG2			[121]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human placental trophoblast cells (TR-S)
DT Modulation1	ABCG2 protein inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCG2 mRNA			[204]
Regulation Mechanism				Transcription Factor Info
Dimethyl nitrosamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dimethyl nitrosamine increases the expression of ABCG2			[126]
2-acetylaminofluorene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-acetylaminofluorene increases the activity of ABCG2			[70]
Chromium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chromium results in increased expression of ABCG2 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
Pesticide/Insecticide
DT Modulation1	Permethrin results in decreased activity of ABCG2 protein			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chlorpyrifos co-treated with 2-chloro-5-nitrobenzanilide affects the expression of ABCG2 mRNA			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Cisplatin which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Fluorouracil which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCG2 protein			[206]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Chlorpyrifos results in increased expression of ABCG2 mRNA			[207]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Chlorpyrifos results in increased expression of ABCG2 protein			[208]
Regulation Mechanism				Transcription Factor Info
Dieldrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dieldrin increases the expression of ABCG2			[37]
Heptachlor	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Heptachlor inhibits the activity of ABCG2			[37]
DDT	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DDT metabolite results in decreased activity of ABCG2 protein			[40]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
DT Modulation1	Endosulfan results in decreased activity of ABCG2 protein			[37]
Regulation Mechanism				Transcription Factor Info
Androstenedione	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Androstenedione inhibits the activity of ABCG2			[67]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the activity of ABCG2			[138]
Chlordan	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlordan inhibits the activity of ABCG2			[37]
Azaspiracid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azaspiracid increases the expression of ABCG2			[144]

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129	ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):210-7.
130	Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo). Toxicology. 2009 Sep 19;263(2-3):100-7.
131	Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies. Biochem Pharmacol. 2009 Nov 15;78(10):1340-9.
132	Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene Human Immunity and Metabolic Syndrome 9k. Toxicol In Vitro. 2010 Feb;24(1):85-91.
133	Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells. Biochem Pharmacol. 2010 Jun 15;79(12):1759-71.
134	Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One. 2011 Jan 31;6(1):e16530.
135	Oleic acid decreases BCRP mediated efflux of mitoxantrone in Caco-2 cell monolayers. Food Chem Toxicol. 2012 Oct;50(10):3635-45.
136	The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells. Toxicol Lett. 2013 Apr 26;218(3):200-6.
137	Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells. J R Soc Interface. 2013 Jul 3;10(86):20130428.
138	Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro. Toxicol Sci. 2013 Dec;136(2):382-91.
139	Comparative toxicogenomic responses of mercuric and methyl-mercury. BMC Genomics. 2013 Oct 11;14:698.
140	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
141	CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
142	The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures. Mol Cell Endocrinol. 2016 Jul 5;429:41-9.
143	Selective GPR55 antagonism reduces chemoresistance in cancer cells. Pharmacol Res. 2016 Sep;111:757-766.
144	Whole genome mRNA transcriptomics analysis reveals different modes of action of the diarrheic shellfish poisons okadaic acid and dinophysis toxin-1 versus azaspiracid-1 in Caco-2 cells. Toxicol In Vitro. 2018 Feb;46:102-112.
145	Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells. Onco Targets Ther. 2018 May 18;11:2945-2954.
146	Inhibition and stimulation of the human breast cancer resistance protein as in vitro predictor of drug-drug interactions of drugs of abuse. Arch Toxicol. 2018 Sep;92(9):2875-2884.
147	Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol Res. 2019 Mar;141:331-342.
148	Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites. J Biochem Mol Toxicol. 2019 Aug;33(8):e22345.
149	Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells. Environ Toxicol. 2020 Jun;35(6):643-651.
150	Comparison of long-term versus short-term effects of okadaic acid on the apoptotic status of human HepaRG cells. Chem Biol Interact. 2020 Feb 1;317:108937.
151	Prenatal ethanol exposure increases maternal bile acids through placental transport pathway. Toxicology. 2021 Jun 30;458:152848.
152	Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells. Toxicol In Vitro. 2022 Feb;78:105268.
153	The mechanisms for lung cancer risk of PM2.5 : Induction of epithelial-mesenchymal transition and cancer stem cell properties in human non-small cell lung cancer cells. Environ Toxicol. 2017 Nov;32(11):2341-2351.
154	Assessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarette smoke on gingival organotypic cultures. Food Chem Toxicol. 2019 Mar;125:252-270.
155	ABCG2-dependent dye exclusion activity and clonal potential in epithelial cells continuously growing for 1 month from limbal explants. Invest Ophthalmol Vis Sci. 2011 Jun 17;52(7):4330-7.
156	Interactions between Oroxylin A with the solute carrier transporters and ATP-binding cassette transporters: Drug transporters profile for this flavonoid. Chem Biol Interact. 2020 Jun 1;324:109097.
157	Polycyclic aromatic hydrocarbons in food--efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells. Food Chem Toxicol. 2013;62:797-804.
158	Inhibition of the Human ABC Efflux Transporters P-gp and BCRP by the BDE-47 Hydroxylated Metabolite 6-OH-BDE-47: Considerations for Human Exposure. Toxicol Sci. 2017;155(1):270-282.
159	Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis. 2005 Oct;26(10):1754-63.
160	Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells. Acta Biochim Biophys Sin (Shanghai). 2011;43(8):647-53.
161	Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes. Toxicol In Vitro. 2023;89:105568.
162	Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem. 2010 May 28;285(22):16582-7.
163	The ABCG2 efflux transporter from rabbit placenta: Cloning and functional characterization. Placenta. 2016;38:8-15.
164	Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival. BJU Int. 2008 Dec;102(11):1694-9.
165	Fungicide prochloraz and environmental pollutant dioxin induce the ABCG2 transporter in bovine mammary epithelial cells by the arylhydrocarbon receptor signaling pathway. Toxicol Sci. 2013 Feb;131(2):491-501.
166	Cadmium inhibits ABCG2 transporter function in BeWo choriocarcinoma cells and MCF-7 cells overexpressing ABCG2. Placenta. 2012;33(10):859-65.
167	Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci. 2009;108(2):492-500.
168	Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126. Arch Toxicol. 2018;92(8):2533-2547.
169	Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3 and ATP-binding cassette transporters. Arch Toxicol. 2022 Dec;96(12):3265-3277.
170	Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter. J Pharmacol Exp Ther. 2016 Apr;357(1):103-13.
171	Antipsychotic drugs inhibit the function of breast cancer resistance protein. Basic Clin Pharmacol Toxicol. 2008 Oct;103(4):336-41.
172	Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells. Int J Cancer. 2008;123(7):1712-20.
173	Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter. Toxicol Appl Pharmacol. 2022;434:115823.
174	The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett. 2013;216(2-3):86-99.
175	Regulation of the placental BCRP transporter by PPAR gamma. J Biochem Mol Toxicol. 2017;31(5).
176	Mifepristone potentiates etoposide toxicity in Hep G2 cells by modulating drug transport. Toxicol In Vitro. 2019;54:33-40.
177	Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP). Int J Mol Sci. 2021;22(11).
178	Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines. Toxicol In Vitro. 2019 Feb;54:10-22.
179	ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Oncogene. 2011;30(49):4874-86.
180	Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
181	Ah receptor antagonism represses head and neck tumor cell aggressive phenotype. Mol Cancer Res. 2012;10(10):1369-79.
182	Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Carcinogenesis. 2010;31(6):1149-57.
183	The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
184	Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters. J Ocul Pharmacol Ther. 2015;31(4):248-55.
185	Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
186	The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis. Toxicol Appl Pharmacol. 2014;277(1):77-85.
187	Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases. Drug Metab Dispos. 2007 Oct;35(10):1963-9.
188	Acyclovir is a substrate for the human breast cancer resistance protein (BCRP/ABCG2): implications for renal tubular transport and acyclovir-induced nephrotoxicity. Can J Physiol Pharmacol. 2011;89(9):675-80.
189	Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res. 2008;68(19):7905-14.
190	Interactions between cyazofamid and human drug transporters. J Biochem Mol Toxicol. 2020;34(4):e22459.
191	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
192	All-trans retinoic acid enhances the transport of phase II metabolites of benzo[a]pyrene by inducing the Breast Cancer Resistance Protein expression in Caco-2 cells. Toxicol Lett. 2010;197(2):151-5.
193	A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells. Front Toxicol. 2022;4:881347.
194	In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53.
195	Global and gene-specific DNA methylation effects of different asbestos fibres on human bronchial epithelial cells. Environ Int. 2018;115:301-311.
196	Testing in vitro tools for the prediction of cholestatic liver injury induced by non-pharmaceutical chemicals. Food Chem Toxicol. 2021;152:112165.
197	Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure. Cell Biol Toxicol. 2023;39(2):371-390.
198	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
199	C-myc amplification altered the gene expression of ABC- and SLC-transporters in human breast epithelial cells. Mol Pharm. 2009;6(2):627-33.
200	A new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP/ABCG2). Chem Biol Interact. 2022;351:109718.
201	Maternal exposure to bisphenol A induces fetal growth restriction via upregulating the expression of estrogen receptors. Chemosphere. 2022 Jan;287(Pt 3):132244.
202	Associations of environmental phthalate exposure with male steroid hormone synthesis and metabolism: An integrated epidemiology and toxicology study. J Hazard Mater. 2022;436:129213.
203	Placental BCRP transporter reduces cadmium accumulation and toxicity in immortalized human trophoblasts. Reprod Toxicol. 2023;121:108466.
204	Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes. Toxicology. 2022;470:153153.
205	Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005;314(3):1059-67.
206	Chronic exposure of human glioblastoma tumors to low concentrations of a pesticide mixture induced multidrug resistance against chemotherapy agents. Ecotoxicol Environ Saf. 2020;202:110940.
207	Chlorpyrifos modifies the expression of genes involved in human placental function. Reprod Toxicol. 2012;33(3):331-8.
208	Impact of chlorpyrifos on human villous trophoblasts and chorionic villi. Toxicol Appl Pharmacol. 2017 Aug 15;329:26-39.
209	Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos. 2007 Feb;35(2):268-74.
210	Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters. Biochem Pharmacol. 2010 Aug 15;80(4):471-9.
211	Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact. 2010 Dec 5;188(3):659-67.
212	Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
213	Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3. Acta Biochim Biophys Sin (Shanghai). 2010;42(9):593-602.
214	Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma. J Oral Pathol Med. 2011;40(8):621-8.
215	Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-B pathway and regulating transporter mediated drug efflux. J Ethnopharmacol. 2021;264:113388.
216	NEAT1 contributes to the CSC-like traits of A549/CDDP cells via activating Wnt signaling pathway. Chem Biol Interact. 2018;296:154-161.
217	FaDu cell characteristics induced by multidrug resistance. Oncol Rep. 2011 Nov;26(5):1189-95.
218	Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin. Toxicol Lett. 2016 Jan 22;243:56-66.
219	Alterations of histone modifications by cobalt compounds. Carcinogenesis. 2009;30(7):1243-51.
220	Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology. 2023;483:153387.
221	Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZ. Environ Toxicol. 2021;36(6):1135-1142.
222	RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clin Cancer Res. 2003;9(2):827-36.
223	Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells. Toxicol Sci. 2014;141(1):244-53.
224	Novel tetrahydroisoquinolin-ethyl-phenylamine based multidrug resistance inhibitors with broad-spectrum modulating properties. Cancer Chemother Pharmacol. 2007;59(1):61-9.
225	Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
226	Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro. PLoS One. 2011;6(4):e19164.
227	Aberrant promoter methylation of the ABCG2 gene in renal carcinoma. Mol Cell Biol. 2006 Nov;26(22):8572-85.
228	Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B. Toxicol In Vitro. 2011;25(2):446-53.
229	Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions. Toxicol Lett. 2024;394:57-65.
230	L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18.
231	Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes. Br J Cancer. 2008 May 6;98(9):1515-24.
232	Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
233	Gefitinib inhibition of drug resistance to doxorubicin by inactivating ABCG2 in thyroid cancer cell lines. Arch Otolaryngol Head Neck Surg. 2007;133(10):1022-7.
234	Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett. 2009;279(1):74-83.
235	Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol. 2017 Dec;91(12):3873-3884.
236	(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine. 2010;17(5):356-62.
237	[Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU]. Ai Zheng. 2008 Oct;27(10):1056-64.
238	Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Res. 1999;59(23):5938-46.
239	Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2. Cancer Res. 2005;65(2):596-604.
240	Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
241	Culture period-dependent change of function and expression of ATP-binding cassette transporters in Caco-2 cells. Drug Metab Dispos. 2009;37(9):1956-62.
242	Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations. PLoS One. 2011;6(4):e18438.
243	Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation. Mol Pharmacol. 2005;67(4):1349-59.
244	Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013;109(10):2751-62.
245	Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3. Br J Pharmacol. 2015;172(4):1059-73.
246	Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport. Drug Metab Dispos. 2008 Jul;36(7):1206-11.
247	Foretinib, a c-MET receptor tyrosine kinase inhibitor, tackles multidrug resistance in cancer cells by inhibiting ABCB1 and ABCG2 transporters. Toxicol Appl Pharmacol. 2024;484:116866.
248	Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 in human leukemia cells. Chem Biol Interact. 2014;219:203-10.
249	Role of ABCG2 as a biomarker for predicting resistance to CPT-11/SN-38 in lung cancer. Cancer Sci. 2006;97(3):192-8.
250	Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. Br J Clin Pharmacol. 2005;59(4):415-24.
251	Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int J Cancer. 2004;111(4):617-26.
252	Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. Br J Cancer. 2005;92(2):259-64.
253	Prospective Drug Candidates as Human Multidrug Transporter ABCG2 Inhibitors: an In Silico Drug Discovery Study. Cell Biochem Biophys. 2021;79(2):189-200.
254	Human MRP2 exports MC-LR but not the glutathione conjugate. Chem Biol Interact. 2019;311:108761.
255	Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Arch Biochem Biophys. 2010;498(2):111-8.
256	Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis. Am J Hematol. 2011;86(1):98-101.
257	Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis. J Invest Dermatol. 2008 Aug;128(8):1925-9.
258	Functional expression and characterization in Xenopus laevis oocytes of the ABCG2 transporter derived from A549 human lung adenocarcinoma cells. Oncol Rep. 2012;27(2):499-503.
259	Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Mol Pharmacol. 2009;75(4):876-85.
260	Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
261	Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells. Toxicol In Vitro. 2014 Oct;28(7):1259-73.
262	Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2). Cancer Chemother Pharmacol. 2005;56(4):344-50.
263	Expression and function of ABCB1 and ABCG2 in human placental tissue. Drug Metab Dispos. 2005;33(4):524-9.
264	Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93.
265	In vitro and in vivo interaction of moxidectin with BCRP/ABCG2. Chem Biol Interact. 2009;180(1):106-12.
266	Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. Pharmacogenet Genomics. 2005;15(9):599-608.
267	The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin. Mol Pharmacol. 2005 May;67(5):1758-64.
268	Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1. Toxicol Appl Pharmacol. 2017;329:18-25.
269	The role of efflux transporters in cytotoxicity and intracellular concentration of chlorpyrifos and chlorpyrifos oxon in human cell lines. Toxicol In Vitro. 2024;101:105942.
270	Hypoxia influences stem cell-like properties in multidrug resistant K562 leukemic cells. Blood Cells Mol Dis. 2013;51(3):177-84.
271	Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte-Like Cells Derived From Human-Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip. J Appl Toxicol. 2025;45(3):460-471.
272	Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells. Arch Toxicol. 2020 Sep;94(9):3137-3155.
273	Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid. Toxicology. 2013;306:108-13.
274	Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75.
275	Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009;4(8):e6796.
276	The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy. Toxicol Appl Pharmacol. 2020;402:115129.
277	Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
278	Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. Mol Pharm. 2013;10(8):3242-52.
279	Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. Environ Health Perspect. 2010;118(1):108-15.
280	Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns. BMC Genomics. 2015 Mar 19;16(1):212.
281	Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 (BCRP) gene polymorphisms in humans. Clin Pharmacol Ther. 2008 Jul;84(1):95-103.
282	The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells. Front Pharmacol. 2021;12:678126.
283	Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents. J Med Chem. 2005;48(6):2218-28.
284	The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines. Mol Carcinog. 2014 Oct;53(10):765-76.
285	CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function. Biochem Pharmacol. 2014;91(2):144-56.
286	From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
287	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
288	Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.
289	Association between ABCG2 and ABCB1 genes and warfarin stability: a case-control study. Thromb Res. 2014;134(6):1359-62.
290	In vitro toxicological effects of estrogenic mycotoxins on human placental cells: structure activity relationships. Toxicol Appl Pharmacol. 2012;259(3):366-75.

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