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Five Aspects of Phenotypic and Regulatory Variability are Provided for Each DT in VARIDT 3.0 (Graphic Illustration) :
α. Microbiota Influence (MBI) of DTs
2,072 MBI data of 145 DTs regulated by 124 microbe species, and the relative abundances of these microbe species across 76 diseases
β. Post-Translational Modification (PTM) of DTs
10,255 PTM data of 418 DTs that were related to 24 PTM types, and graphical illustrations on 9,717 experimentally-validated PTM sites
γ. Transcriptional Regulation (TSR) of DTs
10,610 TSR data of 381 DTs that were regulated by 357 TFs, and the differential expression profiles of these TFs across 59 organs and 106 diseases
δ. Epigenetic Regulation (EGR) of DTs
46,748 EGR data of 287 DTs related to 3 types of EGR
ε. Exogenous Modulation (EGM) of DTs
12,209 EGM data of 419 DTs modulated by 1,717 xenobiotics
Four Aspects of Structural Variability are Provided for Each DT in VARIDT 2.0 (Graphic Illustration) :
α. Mutation-induced Spatial Variations in Folded State (MISVFS)
145 mutation-induced structures originating from 42 DTs
β. Difference among the DT Structures of Human and Model Organisms (DASHMO)
1,622 inter-species structures from 17 species covering 292 DTs
γ. Outward-facing and Inward-facing Conformations (OFAIFC)
118 conformations belonging to 59 DTs
δ. Xenobiotics-driven Alterations in 3D Complex (XEDAIC)
822 xenobiotics-regulated structures of 506 xenobiotics in complex with 57 DTs
Three Aspects of Genenal Variability Data are Provided for Each DT in VARIDT 1.0 (Graphic Illustration) :
α. Epigenetic Regulations and Genetic Polymorphisms of DTs (ERGPDT)
23,947 DNA methylations, 7,225 noncoding RNA regulations, 92 histone modifications and 1,278 genetic polymorphisms of DTs
β. Disease-, Species-, and Tissue-Specific Protein Abundances (DSTSPA)
Differential abundance profiles and downloadable data of 257 DTs in 21,781 patients/healthy individuals of 61 tissues and 108 diseases
Protein abundances of 245 DTs in 67 tissues of Homo sapiens or model organisms (Mus musculus and Rattus norvegicus)
γ. Exogenous Factors Modulating DT Activity (EFMDTA)
1,225 exogenous factors (dietary constituents, small molecular/biological drugs, natural products, etc.) modulating activity of 148 DTs
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