Drug Transporter (DT) Information

General Information of DT
DT ID DTD0648
Gene Name ATP7A
Protein Name Copper-transporting ATPase 1
Gene ID
538
UniProt ID
Q04656
TCDB ID
3.A.3.5.6
3D Structure

Crystal Structure

Crystallisation Method:NMR

PDB ID:2KMV

Corresponding Chain:A

Sequence Length:1051-1231

Detail: Struture Info

Synonyms ATP7A; Copper pump 1; Menkes disease-associated protein; MC1; MNK
DT Family P-Type ATPase (P-ATPase) Superfamily ;
Tissue Specificity Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines.
Function This transporter may supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Copper-transporting ATPase 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Copper-transporting ATPase 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Copper-transporting ATPase 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Copper-transporting ATPase 1
Microbiota Influence (MBI)

(β) Post-translational Modification of Copper-transporting ATPase 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Copper-transporting ATPase 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Copper-transporting ATPase 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Copper-transporting ATPase 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Copper-transporting ATPase 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Copper-transporting ATPase 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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