Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0648 Transporter Info
Gene Name	ATP7A
Transporter Name	Copper-transporting ATPase 1
Gene ID	538
UniProt ID	Q04656

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of ATP7A gene		[24]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of ATP7A intron		[25]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Oxaliplatin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxaliplatin increases the expression of ATP7A		[1]
Paclitaxel	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paclitaxel increases the expression of ATP7A		[2]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of ATP7A		[3]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of ATP7A		[4]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of ATP7A		[5]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ATP7A		[6]
Drug in Phase 2 Trial
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 inhibits the expression of ATP7A		[14]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of ATP7A		[17]
Drug in Phase 1 Trial
Tetradecanoylphorbol Acetate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetradecanoylphorbol Acetate increases the expression of ATP7A		[7]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of ATP7A		[8]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of ATP7A		[16]
Investigative Drug
Pyrrolidine dithiocarbamic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pyrrolidine dithiocarbamic acid inhibits the expression of ATP7A		[12]
Milchsaure	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Milchsaure inhibits the expression of ATP7A		[18]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of ATP7A		[19]
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in increased expression of ATP7A mRNA		[68]
Regulation Mechanism			Transcription Factor Info
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang inhibits the expression of ATP7A		[15]
Acute Toxic Substance
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the expression of ATP7A		[11]
Paraquat	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paraquat increases the expression of ATP7A		[20]
Carcinogen
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of ATP7A		[10]
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of ATP7A		[13]
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Atrazine inhibits the expression of ATP7A		[9]
DT Modulation1	ATP7A protein promotes the reaction Paraquat results in increased chemical synthesis of Hydrogen Peroxide		[62]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7A protein results in increased susceptibility to Paraquat		[62]
Regulation Mechanism			Transcription Factor Info
Chemical Compound
DT Modulation1	ATP7A protein affects the susceptibility to Oxaliplatin		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7A protein results in decreased susceptibility to Oxaliplatin		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	MIR495 mRNA results in decreased expression of ATP7A protein which results in increased susceptibility to Oxaliplatin		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ATP7A protein results in decreased susceptibility to Paclitaxel		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid results in increased methylation of ATP7A gene		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ATP7A protein promotes the reaction Tetradecanoylphorbol Acetate results in increased expression of FLT1 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetradecanoylphorbol Acetate results in increased expression of ATP7A protein which results in increased export of Copper		[7]
Regulation Mechanism			Transcription Factor Info
Cupric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cupric oxide increases the expression of ATP7A		[3]
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ATP7A mRNA		[21]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of ATP7A mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Adenosine Triphosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper co-treated with Adenosine Triphosphate results in increased phosphorylation of ATP7A protein		[23]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of ATP7A mRNA		[26]
Regulation Mechanism			Transcription Factor Info
bathocuproine sulfonate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bathocuproine sulfonate inhibits the reaction ATP7A protein results in increased activity of TYR protein		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	cupric chloride inhibits the reaction bathocuproine sulfonate inhibits the reaction ATP7A protein results in increased activity of TYR protein		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Penicillamine co-treated with bathocuproine sulfonate promotes the reaction CLU protein binds to ATP7A protein		[28]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of ATP7A promoter		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of ATP7A exon		[29]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene affects the methylation of ATP7A intron		[25]
Regulation Mechanism			Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased expression of ATP7A mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Brefeldin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Brefeldin A inhibits the reaction ATP7A protein affects the localization of Doxorubicin		[30]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of ATP7A mRNA		[13]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of ATP7A mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Carboplatin	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein promotes the reaction ANXA4 protein results in decreased susceptibility to Carboplatin		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Carboplatin affects the localization of ATP7A protein		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	MIR495 mRNA results in decreased expression of ATP7A protein which results in increased susceptibility to Carboplatin		[33]
Regulation Mechanism			Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chromium hexavalent ion results in decreased expression of ATP7A mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Cisplatin	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATOX1 protein binds to Cisplatin promotes the reaction ATP7A protein binds to and results in increased metabolism of Cisplatin		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7A mutant form results in increased susceptibility to Cisplatin		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ATP7A protein affects the susceptibility to Cisplatin		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	ATP7A protein inhibits the reaction MIR495 mRNA results in increased uptake of and results in increased susceptibility to Cisplatin		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	ATP7A protein promotes the reaction ANXA4 protein results in decreased susceptibility to Cisplatin		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	ATP7A protein results in decreased susceptibility to Cisplatin		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Cisplatin affects the localization of ATP7A protein		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Cisplatin results in decreased expression of ATP7A mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	MIR495 mRNA results in decreased expression of ATP7A protein which results in increased susceptibility to Cisplatin		[33]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of ATP7A mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Copper	27 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	AP1S1 gene mutant form inhibits the reaction Copper affects the localization of ATP7A protein		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ARF1 mutant form inhibits the reaction ATP7A gene mutant form results in decreased export of and results in increased abundance of Copper		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ATP7A gene mutant form affects the reaction STX5 mutant form results in decreased uptake of Copper		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	ATP7A gene mutant form results in decreased abundance of Copper		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	ATP7A gene mutant form results in decreased export of and results in increased abundance of Copper		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	ATP7A gene mutant form results in increased abundance of Copper		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	ATP7A protein affects the metabolism of Copper		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	ATP7A protein affects the oxidation of SCO1 protein which affects the abundance of Copper		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	ATP7A protein affects the transport of Copper		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	ATP7A protein binds to Copper		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	ATP7A protein mutant form results in decreased abundance of Copper		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	ATP7A protein results in decreased abundance of Copper		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	ATP7A protein results in decreased susceptibility to cupric chloride results in increased abundance of Copper		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	ATP7A protein results in decreased uptake of cupric chloride results in increased abundance of Copper		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	ATP7A protein results in increased export of Copper		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation16	ATP7A protein results in increased transport of Copper		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation17	COMMD1 protein results in increased activity of ATP7A protein mutant form which results in increased transport of Copper		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation18	Copper affects the localization of ATP7A protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation19	Copper binds to and affects the folding of ATP7A protein		[53]
Regulation Mechanism			Transcription Factor Info
DT Modulation20	Copper binds to ATP7A protein		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation21	Copper binds to ATP7A protein which results in decreased oxidation of Copper		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation22	Copper co-treated with Adenosine Triphosphate results in increased phosphorylation of ATP7A protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation23	Copper results in increased phosphorylation of and affects the localization of ATP7A protein		[56]
Regulation Mechanism			Transcription Factor Info
DT Modulation24	Copper results in increased phosphorylation of and results in increased activity of ATP7A protein		[57]
Regulation Mechanism			Transcription Factor Info
DT Modulation25	Estrogens promotes the reaction ATP7A protein affects the transport of Copper		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation26	NSC 689534 binds to Copper which results in increased expression of ATP7A mRNA		[58]
Regulation Mechanism			Transcription Factor Info
DT Modulation27	Tetradecanoylphorbol Acetate results in increased expression of ATP7A protein which results in increased export of Copper		[7]
Regulation Mechanism			Transcription Factor Info
cupric chloride	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein results in decreased susceptibility to cupric chloride results in increased abundance of Copper		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7A protein results in decreased uptake of cupric chloride results in increased abundance of Copper		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ATP7A protein results in increased transport of cupric chloride		[57]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	cupric chloride inhibits the reaction bathocuproine sulfonate inhibits the reaction ATP7A protein results in increased activity of TYR protein		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	cupric chloride promotes the reaction CLU protein binds to ATP7A protein		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	cupric chloride results in decreased glutathionylation of ATP7A protein		[59]
Regulation Mechanism			Transcription Factor Info
cupric oxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric oxide analog results in increased expression of ATP7A mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	cupric oxide analog results in increased expression of ATP7A protein		[3]
Regulation Mechanism			Transcription Factor Info
Diamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diamide promotes the reaction CLU protein binds to ATP7A protein		[28]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of ATP7A mRNA		[60]
Regulation Mechanism			Transcription Factor Info
Dithiothreitol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dithiothreitol inhibits the reaction Ethylmaleimide results in increased glutathionylation of ATP7A protein		[59]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ATP7A mRNA		[21]
Regulation Mechanism			Transcription Factor Info
Doxorubicin	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein affects the localization of Doxorubicin		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7A protein results in decreased susceptibility to Doxorubicin		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ATP7A protein results in increased export of Doxorubicin		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Brefeldin A inhibits the reaction ATP7A protein affects the localization of Doxorubicin		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Monensin inhibits the reaction ATP7A protein affects the localization of Doxorubicin		[30]
Regulation Mechanism			Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in decreased expression of ATP7A mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ATP7A mRNA		[21]
Regulation Mechanism			Transcription Factor Info
Estrogens	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estrogens promotes the reaction ATP7A protein affects the transport of Copper		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estrogens results in increased activity of ATP7A protein		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estrogens results in increased expression of and affects the localization of ATP7A protein		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Estrogens results in increased expression of ATP7A mRNA		[46]
Regulation Mechanism			Transcription Factor Info
Ethylmaleimide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dithiothreitol inhibits the reaction Ethylmaleimide results in increased glutathionylation of ATP7A protein		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ethylmaleimide results in increased glutathionylation of ATP7A protein		[59]
Regulation Mechanism			Transcription Factor Info
Etoposide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein results in decreased susceptibility to Etoposide		[30]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 affects the phosphorylation of ATP7A protein		[61]
Regulation Mechanism			Transcription Factor Info
Hydrogen Peroxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein promotes the reaction Paraquat results in increased chemical synthesis of Hydrogen Peroxide		[62]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Hydrogen Peroxide promotes the reaction CLU protein binds to ATP7A protein		[28]
Regulation Mechanism			Transcription Factor Info
Irinotecan	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein results in decreased susceptibility to Irinotecan		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ATP7A protein results in increased export of Irinotecan		[30]
Regulation Mechanism			Transcription Factor Info
Lactic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lactic Acid results in decreased expression of ATP7A mRNA		[18]
Regulation Mechanism			Transcription Factor Info
Melanins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	TYR protein co-treated with ATP7A protein results in increased abundance of Melanins		[27]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene affects the methylation of ATP7A intron		[25]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of ATP7A mRNA		[63]
Regulation Mechanism			Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in increased expression of ATP7A mRNA		[10]
Regulation Mechanism			Transcription Factor Info
Mitoxantrone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein results in decreased susceptibility to Mitoxantrone		[30]
Regulation Mechanism			Transcription Factor Info
Monensin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Monensin inhibits the reaction ATP7A protein affects the localization of Doxorubicin		[30]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in increased expression of ATP7A mRNA		[58]
Regulation Mechanism			Transcription Factor Info
Omeprazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the reaction ATP7A protein results in increased activity of TYR protein		[64]
Regulation Mechanism			Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in increased expression of ATP7A mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid results in increased phosphorylation of ATP7A protein		[66]
Regulation Mechanism			Transcription Factor Info
Penicillamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Penicillamine co-treated with bathocuproine sulfonate promotes the reaction CLU protein binds to ATP7A protein		[28]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) results in decreased expression of ATP7A mRNA		[67]
Regulation Mechanism			Transcription Factor Info
pyrrolidine dithiocarbamic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pyrrolidine dithiocarbamic acid results in decreased expression of ATP7A		[12]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of ATP7A mRNA		[69]
Regulation Mechanism			Transcription Factor Info
Silver	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver binds to ATP7A protein		[53]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased expression of ATP7A mRNA		[31]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of ATP7A mRNA		[16]
Regulation Mechanism			Transcription Factor Info
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ATP7A protein results in decreased susceptibility to Vincristine		[30]
Regulation Mechanism			Transcription Factor Info

References
1	Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells. Int J Oncol. 2006 Jul;29(1):225-35.
2	Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68.
3	Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells. J Trace Elem Med Biol. 2014 Jul;28(3):344-50.
4	Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
5	Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
6	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
7	Copper egress is induced by PMA in human THP-1 monocytic cell line. Biometals. 2009 Jun;22(3):531-9.
8	Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
9	Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
10	Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
11	Using expression profiling to understand the effects of chronic cadmium exposure on MCF-7 breast cancer cells. PLoS One. 2013 Dec 20;8(12):e84646.
12	Cytotoxic effects of pyrrolidine dithiocarbamate in small-cell lung cancer cells, alone and in combination with cisplatin. Int J Oncol. 2014 Oct;45(4):1749-59.
13	Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
14	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
15	Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
16	A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302.
17	Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
18	Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
19	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
20	CD34+ derived macrophage and dendritic cells display differential responses to paraquat. Toxicol In Vitro. 2021 Sep;75:105198.
21	Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
22	Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
23	Comparative features of copper ATPases ATP7A and ATP7B heterologously expressed in COS-1 cells. Biochemistry. 2010;49(46):10006-12.
24	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
25	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
26	Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
27	The Menkes copper transporter is required for the activation of tyrosinase. Hum Mol Genet. 2000;9(19):2845-51.
28	Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B. J Biol Chem. 2011;286(12):10073-83.
29	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
30	Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007;67(10):4860-8.
31	High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
32	Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A. Int J Cancer. 2014;134(8):1796-809.
33	miR-495 enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A). J Cell Biochem. 2014 Jul;115(7):1234-42.
34	Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis. Toxicol Lett. 2019;305:40-50.
35	Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification. Biochem J. 2013 Aug 15;454(1):147-56.
36	Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC). J Transl Med. 2012;10:21.
37	Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil. Br J Cancer. 2007;97(3):334-44.
38	The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction. Chem Biol Interact. 2024;393:110943.
39	Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS One. 2014;9(3):e90544.
40	MEDNIK syndrome: a novel defect of copper metabolism treatable by zinc acetate therapy. Brain. 2013;136(Pt 3):872-81.
41	The ADP-ribosylation factor 1 (Arf1) is involved in regulating copper uptake. Int J Biochem Cell Biol. 2011;43(1):146-53.
42	Syntaxin 5 is required for copper homeostasis in Drosophila and mammals. PLoS One. 2010;5(12):e14303.
43	Downregulation of myelination, energy, and translational genes in Menkes disease brain. Mol Genet Metab. 2005;85(4):291-300.
44	Atp7a determines a hierarchy of copper metabolism essential for notochord development. Cell Metab. 2006;4(2):155-62.
45	COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux. Mol Biol Cell. 2013;24(6):683-91.
46	Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells. Biochem J. 2007;402(2):241-50.
47	Lumenal loop M672-P707 of the Menkes protein (ATP7A) transfers copper to peptidylglycine monooxygenase. J Am Chem Soc. 2012;134(25):10458-68.
48	Identification of four novel mutations in classical Menkes disease and successful prenatal DNA diagnosis. Mol Genet Metab. 2001;73(1):86-90.
49	Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. J Biol Chem. 2004;279(19):20378-86.
50	Functional analyses of copper transporter genes in the human liver cell line HepG2. Toxicol In Vitro. 2020;66:104856.
51	Alteration of copper physiology in mice overexpressing the human Menkes protein ATP7A. Am J Physiol Regul Integr Comp Physiol. 2006;290(5):R1460-7.
52	The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. Cell Mol Life Sci. 2012;69(1):149-63.
53	Stoichiometry of complex formation between Copper(I) and the N-terminal domain of the Menkes protein. Biochemistry. 2000;39(23):6857-63.
54	Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein. J Biol Chem. 2006 Sep 29;281(39):29141-7.
55	The lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites. J Biol Chem. 2011;286(30):26585-94.
56	Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase. Int J Biochem Cell Biol. 2009;41(12):2403-12.
57	Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A). Biochem J. 2007;401(2):569-79.
58	A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.
59	Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B. J Biol Chem. 2010;285(35):27111-27121.
60	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
61	Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
62	A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nat Chem Biol. 2017;13(12):1274-1279.
63	Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
64	Omeprazole, a gastric proton pump inhibitor, inhibits melanogenesis by blocking ATP7A trafficking. J Invest Dermatol. 2015;135(3):834-841.
65	Mechanistic basis of a combination D-penicillamine and platinum drugs synergistically inhibits tumor growth in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo. Biochem Pharmacol. 2015;95(1):28-37.
66	Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448.
67	Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.
68	One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
69	High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Exogenous Modulation

Visitor Map

Correspondence