| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0544 | ||||
| Gene Name | KCNA5 | ||||
| Protein Name | Voltage-gated potassium channel subunit Kv1.5 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:2A79_B Identity:77.108% Minimized Score:-870.23 kcal/mol Detail: Structure Info |
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| Synonyms | HPCN1; Voltage-gated potassium channel HK2; Potassium voltage-gated channel subfamily A member 5 | ||||
| DT Family | Voltage-gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Pancreatic islets and insulinoma. | ||||
| Function | This transporter is voltage-gated potassium channel, which mediates transmembrane potassium transport in excitable membranes. And forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated potassium channel subunit Kv1.5 |
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(β) Cell Distribution Level of Voltage-gated potassium channel subunit Kv1.5 |
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(γ) Organelle Distribution Level of Voltage-gated potassium channel subunit Kv1.5 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-gated potassium channel subunit Kv1.5 |
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(γ) Transcriptional Regulation of Voltage-gated potassium channel subunit Kv1.5 |
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(δ) Epigenetic Regulation of Voltage-gated potassium channel subunit Kv1.5 |
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(ε) Exogenous Modulation of Voltage-gated potassium channel subunit Kv1.5 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated potassium channel subunit Kv1.5 |
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(β) Disease-specific Protein Abundances of Voltage-gated potassium channel subunit Kv1.5 |
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(γ) Species- and Tissue-specific DT Abundances |
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