Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0544 Transporter Info
Gene Name KCNA5
Transporter Name Voltage-gated potassium channel subunit Kv1.5
Gene ID
3741
UniProt ID
P22460

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        JUN 

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       Transcriptional Phenomenon1

 Binding to KCNA5 gene in K562 cells [1]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of KCNA5 gene in K562 cells, which leads to an affected expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

      Class1.2: Basic helix-loop-helix factors

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        HIF1A 

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       Transcriptional Phenomenon1

 Repression of KCNA5 gene in pulmonary arterial hypertension condition [2]

TF Protein Name

 Hypoxia-inducible factor 1-alpha Transcription Factor Info

Studied Phenotype

 Pulmonary arterial hypertension [ICD11: BB01.0]

Tissue

 Lung

Related DT Changes

 Down regulating

Experimental Material

 Sprague-Dawley rats

Detailed Description

 Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to repress the transcription of KCNA5 gene in pulmonary arterial hypertension condition, which leads to a decreased expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

        MYC 

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       Transcriptional Phenomenon1

 Binding to KCNA5 gene in embryonic stem cells condition [3]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of KCNA5 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.3: C2H2 zinc finger factors

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        KLF5 

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       Transcriptional Phenomenon1

 Activation of KCNA5 gene in gastric cancer condition [4]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of KCNA5 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F1 

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       Transcriptional Phenomenon1

 Binding to KCNA5 gene in MCF7 cells [5]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of KCNA5 gene in MCF7 cells, which leads to an affected expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

      Class3.4: Heat shock factors

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        HSF1 

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       Transcriptional Phenomenon1

 Activation of KCNA5 gene in cervical cancer condition [6]

TF Protein Name

 Heat shock factor protein 1 Transcription Factor Info

Studied Phenotype

 Cervical cancer [ICD11: 2C77]

Tissue

 Cervix

Related DT Changes

 Up regulating

Experimental Material

 Human human papillomavirus-related endocervical adenocarcinoma cells (HeLa)

Detailed Description

 Heat shock factor protein 1 (HSF1) has been reported to activate the transcription of KCNA5 gene in cervical cancer condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX2 

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       Transcriptional Phenomenon1

 Activation of KCNA5 gene in prostate cancer condition [7]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of KCNA5 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

      Class6.5: T-Box factors

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        EOMES 

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       Transcriptional Phenomenon1

 Activation of KCNA5 gene in health condition [8]

TF Protein Name

 Eomesodermin homolog Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Eomesodermin homolog (EOMES) has been reported to activate the transcription of KCNA5 gene in health condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Activation of KCNA5 gene in human embryonic stem cells (hESCs) condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of KCNA5 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel subunit Kv1.5.
References
1 c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
2 An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 2006 Jun 6;113(22):2630-41.
3 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
4 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
5 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
6 Functional stabilization of Kv1.5 protein by Hsp70 in mammalian cell lines. Biochem Biophys Res Commun. 2008 Aug 1;372(3):469-74.
7 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
8 Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25(3):238-50.
9 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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