| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0531 | ||||
| Gene Name | KCNH7 | ||||
| Protein Name | Voltage-gated potassium channel Kv11.3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:5VA2_A Identity:83.992% Minimized Score:-1177.376 kcal/mol Detail: Structure Info |
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| Synonyms | ERG-3; ERG3; Eag-related protein 3; Ether-a-go-go-related gene potassium channel 3; Ether-a-go-go-related protein 3; HERG3; KCNH7; Kv11.3; Potassium voltage-gated channel subfamily H member 7; hERG-3; Voltage-gated potassium channel subunit Kv11.3 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Expressed in prolactin-secreting adenomas. | ||||
| Function | This transporter is a pore-forming (alpha) subunit of voltage-gated potassium channel and may be modulated by cAMP and subunit assembly. | ||||
| Endogenous Substrate(s) | Potassium ions | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated potassium channel Kv11.3 |
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(β) Cell Distribution Level of Voltage-gated potassium channel Kv11.3 |
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(γ) Organelle Distribution Level of Voltage-gated potassium channel Kv11.3 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-gated potassium channel Kv11.3 |
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(δ) Epigenetic Regulation of Voltage-gated potassium channel Kv11.3 |
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(ε) Exogenous Modulation of Voltage-gated potassium channel Kv11.3 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated potassium channel Kv11.3 |
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(β) Disease-specific Protein Abundances of Voltage-gated potassium channel Kv11.3 |
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(γ) Species- and Tissue-specific DT Abundances |
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