Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0531 Transporter Info | ||||
| Gene Name | KCNH7 | ||||
| Protein Name | Voltage-gated potassium channel Kv11.3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs17716942 | ||||
| Site of GPD | chr2:162404181 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>C | ||||
| Minor Allele Frequency | C=0.0505/253 (Global) | ||||
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 4 Drugs in Total | ||||
| Etanercept | N.A. | Myotonic Disorders | Genotype CC is not associated with response to etanercept in people with Psoriasis as compared to genotype TT. | [ 1] | |
| Adalimumab | N.A. | Myotonic Disorders | Genotype CC is not associated with response to adalimumab in people with Psoriasis as compared to genotype TT. | [ 1] | |
| Ustekinumab | N.A. | Myotonic Disorders | Genotype CC is not associated with response to ustekinumab in people with Psoriasis as compared to genotype TT. | [ 1] | |
| Ustekinumab | N.A. | Psoriasis | Irrelevant to the drug response in patients (compare with genotype TT) | [ 1] | |
| References | |||||
| 1 | Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis. Br J Dermatol. 2017 May;176(5):1288-1296. | ||||
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