| General Information of DT | |||||
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| DT ID | DTD0524 | ||||
| Gene Name | CACNG3 | ||||
| Protein Name | Voltage-dependent calcium channel gamma-3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:5KK2_E Identity:73.994% Minimized Score:-470.632 kcal/mol Detail: Structure Info |
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| Synonyms | CACNG3; Neuronal voltage-gated calcium channel gamma-3 subunit; TARP gamma-3; Transmembrane AMPAR regulatory protein gamma-3; Voltage-dependent calcium channel gamma-3 subunit | ||||
| DT Family | Ca(+) Channel Auxiliary Subunit Gama1-Gama8 (CCAgama) Family ; | ||||
| Function | This transporter regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-dependent calcium channel gamma-3 |
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(β) Cell Distribution Level of Voltage-dependent calcium channel gamma-3 |
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(γ) Organelle Distribution Level of Voltage-dependent calcium channel gamma-3 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-dependent calcium channel gamma-3 |
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(δ) Epigenetic Regulation of Voltage-dependent calcium channel gamma-3 |
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(ε) Exogenous Modulation of Voltage-dependent calcium channel gamma-3 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-dependent calcium channel gamma-3 |
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(β) Disease-specific Protein Abundances of Voltage-dependent calcium channel gamma-3 |
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(γ) Species- and Tissue-specific DT Abundances |
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