Drug Transporter (DT) Information

General Information of DT
DT ID DTD0462
Gene Name SLC7A1
Protein Name High affinity cationic amino acid transporter 1
Gene ID
6541
UniProt ID
P30825
TCDB ID
2.A.3.3.9
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6F34_A

Identity:37.701%

Minimized Score:-974.834 kcal/mol

Detail: Structure Info

Synonyms ATRC1; CAT-1; CAT1; ERR; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; HCAT1; REC1L; SLC7A1; Solute carrier family 7 member 1; System Y+ basic amino acid transporter
DT Family Amino Acid-Polyamine-Organocation (APC) Family
Cationic Amino Acid Transporter (CAT) Family
Tissue Specificity Ubiquitous.
Function This transporter is high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
Endogenous Substrate(s) Arginine; Lysine; Ornithine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of High affinity cationic amino acid transporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of High affinity cationic amino acid transporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of High affinity cationic amino acid transporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of High affinity cationic amino acid transporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of High affinity cationic amino acid transporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of High affinity cationic amino acid transporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of High affinity cationic amino acid transporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of High affinity cationic amino acid transporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of High affinity cationic amino acid transporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Amino acids
 Approved Drug Info Nutritional deficiency 5B7Z [1]
References
1 The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC7A1)

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