| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0447 | ||||
| Gene Name | SLC6A15 | ||||
| Protein Name | Sodium-dependent neutral amino acid transporter B(0)AT2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6M17_A Identity:42.81% Minimized Score:-1392.005 kcal/mol Detail: Structure Info |
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| Synonyms | Sodium- and chloride-dependent neurotransmitter transporter NTT73; Sodium-coupled branched-chain amino-acid transporter 1; Solute carrier family 6 member 15; Transporter v7-3; SLC6A15; B0AT2; NTT73; SBAT1 | ||||
| DT Family | Neurotransmitter:Sodium Symporter (NSS) Family ; | ||||
| Tissue Specificity | Almost exclusively expressed in the brain. | ||||
| Function | This transporter is a sodium-dependent neutral amino acid transporter. And it exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. | ||||
| Endogenous Substrate(s) | Na+, Neutral amino acids | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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(β) Cell Distribution Level of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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(γ) Organelle Distribution Level of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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(γ) Transcriptional Regulation of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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(δ) Epigenetic Regulation of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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(ε) Exogenous Modulation of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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(β) Disease-specific Protein Abundances of Sodium-dependent neutral amino acid transporter B(0)AT2 |
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(γ) Species- and Tissue-specific DT Abundances |
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