Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0447 Transporter Info
Gene Name SLC6A15
Transporter Name Sodium-dependent neutral amino acid transporter B(0)AT2
Gene ID
55117
UniProt ID
Q9H2J7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CREB1 

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       Transcriptional Phenomenon1

 Direct binding to SLC6A15 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Embryo; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC6A15 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

      Class1.2: Basic helix-loop-helix factors

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        MITF 

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       Transcriptional Phenomenon1

 Activation of SLC6A15 gene in melanoma condition [2]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC6A15 gene in melanoma condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

        MYC 

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       Transcriptional Phenomenon1

 Repression of SLC6A15 gene in medulloblastoma condition [3]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC6A15 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

      Class1.3: Basic helix-span-helix factors

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        TFAP2A 

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       Transcriptional Phenomenon1

 Binding to SLC6A15 gene in MCF7 cells [4]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC6A15 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Direct binding to SLC6A15 gene [5]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC6A15 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

      Class2.3: C2H2 zinc finger factors

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        KLF4 

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       Transcriptional Phenomenon1

 Direct binding to SLC6A15 gene [6]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin; Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC6A15 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC6A15 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC6A15 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        FOXA2 

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       Transcriptional Phenomenon1

 Direct binding to SLC6A15 gene [7]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC6A15 gene, which in turn affects the expression or function of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP53 

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       Transcriptional Phenomenon1

 Direct binding to SLC6A15 gene in HFKS condition [8]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC6A15 gene in HFKS condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC6A15 gene in epithelial to mesenchymal transition condition [9]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC6A15 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

      Class6.4: Runt domain factors

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        RUNX2 

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       Transcriptional Phenomenon1

 Activation of SLC6A15 gene in prostate cancer condition [10]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC6A15 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A15 gene in HaCaT keratinocytes condition [11]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC6A15 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A15 gene in epithelial ovarian cancer condition [12]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC6A15 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Sodium-dependent neutral amino acid transporter B(0)AT2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-159. (ID:ENSG00000072041)
2 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
3 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
4 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
8 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
9 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
10 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
11 Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.
12 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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