Drug Transporter (DT) Information

General Information of DT
DT ID DTD0419
Gene Name SLC5A10
Protein Name Sodium/glucose cotransporter 5
Gene ID
125206
UniProt ID
A0PJK1
TCDB ID
2.A.21.3.15
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:2XQ2_A

Identity:32.421%

Minimized Score:-1030.89 kcal/mol

Detail: Structure Info

Synonyms Na(+)/glucose cotransporter 5; SGLT-5; SGLT5; SLC5A10; Solute carrier family 5 member 10
DT Family Solute:Sodium Symporter (SSS) Family ;
Tissue Specificity Seems to be exclusively expressed in kidney.
Function This transporter mediataes the transport of mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/glucose cotransporter 5
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/glucose cotransporter 5
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/glucose cotransporter 5
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/glucose cotransporter 5
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/glucose cotransporter 5
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/glucose cotransporter 5
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/glucose cotransporter 5
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/glucose cotransporter 5
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/glucose cotransporter 5
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
2-Deoxyglucose
 Phase 1/2 Drug Info Cancer 2A00-2F9Z [1]
References
1 The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8.

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