Drug Transporter (DT) Information

General Information of DT
DT ID DTD0403
Gene Name SLC56A1
Protein Name Sideroflexin-1
Gene ID
94081
UniProt ID
Q9H9B4
TCDB ID
2.A.54.1.1
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms SFXN1; SLC56A1; TCC; Sideroflexin 1
DT Family Mitochondrial Tricarboxylate Carrier (MTC) Family ;
Function This transporter is mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway, and it transports both D-serine and L-serine and also transport other amino-acids, such as alanine. It may be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria.
Endogenous Substrate(s) Tricarboxylates
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sideroflexin-1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sideroflexin-1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sideroflexin-1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sideroflexin-1
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Sideroflexin-1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sideroflexin-1
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sideroflexin-1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sideroflexin-1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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