| General Information of DT | |||||
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| DT ID | DTD0400 | ||||
| Gene Name | SLC55A1 | ||||
| Protein Name | Mitochondrial proton/calcium exchanger protein | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:3SKQ_A Identity:39.487% Minimized Score:-545.51 kcal/mol Detail: Structure Info |
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| Synonyms | LETM1; Leucine zipper-EF-hand-containing transmembrane protein 1; SLC55A1 | ||||
| DT Family | Mitochondrial Inner membrane k(+)/h(+) and ca(2+)/h(+) Exchanger (LETM1) Family ; | ||||
| Function | This transporter is mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. | ||||
| Endogenous Substrate(s) | Ca2+; Mn2+; Gd3+; La3+; Sr2+; Ba2+; Mg2+; K+; Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Mitochondrial proton/calcium exchanger protein |
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(β) Cell Distribution Level of Mitochondrial proton/calcium exchanger protein |
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(γ) Organelle Distribution Level of Mitochondrial proton/calcium exchanger protein |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Mitochondrial proton/calcium exchanger protein |
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(δ) Epigenetic Regulation of Mitochondrial proton/calcium exchanger protein |
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(ε) Exogenous Modulation of Mitochondrial proton/calcium exchanger protein |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Mitochondrial proton/calcium exchanger protein |
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(β) Disease-specific Protein Abundances of Mitochondrial proton/calcium exchanger protein |
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(γ) Species- and Tissue-specific DT Abundances |
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