Drug Transporter (DT) Information

General Information of DT
DT ID DTD0375
Gene Name SLC48A1
Protein Name Heme transporter HRG1
Gene ID
55652
UniProt ID
Q6P1K1
TCDB ID
2.A.110.1.1
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms HRG-1; HRG1; Heme-responsive gene 1 protein homolog; SLC48A1; Solute carrier family 48 member 1; hHRG-1
DT Family Heme Transporter, Heme-Responsive Gene Protein (HRG) Family ;
Tissue Specificity Highly expressed in the brain, kidney, heartand skeletal muscle. Moderately expressed in the liver, lung,placenta and small intestine.
Function This heme transporter regulates intracellular heme availability through the endosomal or lysosomal compartment.
Endogenous Substrate(s) Heme
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Heme transporter HRG1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Heme transporter HRG1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Heme transporter HRG1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Heme transporter HRG1
Microbiota Influence (MBI)

(β) Post-translational Modification of Heme transporter HRG1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Heme transporter HRG1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Heme transporter HRG1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Heme transporter HRG1
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Heme transporter HRG1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Heme transporter HRG1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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