Drug Transporter (DT) Information

General Information of DT
DT ID DTD0351
Gene Name SLC3A1
Protein Name Neutral and basic amino acid transport protein rBAT
Gene ID
6519
UniProt ID
Q07837
TCDB ID
8.A.9.1.2
3D Structure

Crystal Structure

Crystallisation Method:EM

PDB ID:6LI9

Corresponding Chain:A/C

Sequence Length:2-685

Detail: Struture Info

Synonyms ATR1; CSNU1; D2h; NBAT; RBAT; SLC3A1; Solute carrier family 3 member 1; b(0),+-type amino acid transport protein
DT Family rBAT Transport Accessory Protein (rBAT) Family ;
Tissue Specificity Expressed in the brush border membrane in thekidney (at protein level). Predominantly expressed in the kidney,small intestine and pancreas. Weakly expressed in liver.
Function This transporter mediates the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Involved in the high-affinity reabsorption of cystine in the kidney tubule.
Endogenous Substrate(s) Cystine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Neutral and basic amino acid transport protein rBAT
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Neutral and basic amino acid transport protein rBAT
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Neutral and basic amino acid transport protein rBAT
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Neutral and basic amino acid transport protein rBAT
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Neutral and basic amino acid transport protein rBAT
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Neutral and basic amino acid transport protein rBAT
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Neutral and basic amino acid transport protein rBAT
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Neutral and basic amino acid transport protein rBAT
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Neutral and basic amino acid transport protein rBAT
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Amino acids
 Approved Drug Info Nutritional deficiency 5B7Z [1]
References
1 Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts. Biometals. 2019 Jan 30.

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