Drug Transporter (DT) Information

General Information of DT
DT ID DTD0281
Gene Name SLC32A1
Protein Name Vesicular inhibitory amino acid transporter
Gene ID
140679
UniProt ID
Q9H598
TCDB ID
2.A.18.5.4
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms GABA and glycine transporter; SLC32A1; Solute carrier family 32 member 1; VGAT; VIAAT; Vesicular GABA transporter; hVIAAT
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Retina. Expressed throughout the horizontalcells or more specifically at the terminals.
Function This transporter is involved in the uptake of GABA and glycine into the synaptic vesicles.
Endogenous Substrate(s) Amino acids; H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Vesicular inhibitory amino acid transporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Vesicular inhibitory amino acid transporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Vesicular inhibitory amino acid transporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Vesicular inhibitory amino acid transporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Vesicular inhibitory amino acid transporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Vesicular inhibitory amino acid transporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Vesicular inhibitory amino acid transporter
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Vesicular inhibitory amino acid transporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Vesicular inhibitory amino acid transporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Gamma-aminobutyric acid
 Phase 1/2 Drug Info Inflammatory bowel disease DD7Z [1]
References
1 Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jul 1;87(1):164-78.

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