Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0281 Transporter Info
Gene Name SLC32A1
Transporter Name Vesicular inhibitory amino acid transporter
Gene ID
140679
UniProt ID
Q9H598

Transcriptional Regulation of This DT (TSR)

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC32A1 gene in prostate cancer condition [1]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC32A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Vesicular inhibitory amino acid transporter.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Binding to SLC32A1 gene in hematopoiesis condition [2]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC32A1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Vesicular inhibitory amino acid transporter.

       Transcriptional Phenomenon2

 Binding to SLC32A1 gene in megakaryocytes condition [3]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC32A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Vesicular inhibitory amino acid transporter.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC32A1 gene in hematopoiesis condition [2]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC32A1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Vesicular inhibitory amino acid transporter.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC32A1 gene in erythroleukemia condition [4]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC32A1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Vesicular inhibitory amino acid transporter.

        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC32A1 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC32A1 gene, which in turn affects the expression or function of the drug transporter Vesicular inhibitory amino acid transporter.

        SALL4 

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       Transcriptional Phenomenon1

 Binding to SLC32A1 gene in health condition [6]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to bind to the transcription of SLC32A1 gene in health condition, which leads to an affected expression of the drug transporter Vesicular inhibitory amino acid transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        CDX2 

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       Transcriptional Phenomenon1

 Direct binding to SLC32A1 gene in health condition [7]

TF Protein Name

 Homeobox protein CDX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein CDX-2 (CDX2) has been reported to bind to the transcription of SLC32A1 gene in health condition, which leads to an affected expression of the drug transporter Vesicular inhibitory amino acid transporter.

        HNF1B 

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       Transcriptional Phenomenon1

 Activation of SLC32A1 gene in renal cysts condition [8]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC32A1 gene in renal cysts condition, which leads to an increased expression of the drug transporter Vesicular inhibitory amino acid transporter.

      Class3.3: Fork head / winged helix factors

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        E2F6 

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       Transcriptional Phenomenon1

 Direct binding to SLC32A1 gene [9]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC32A1 gene, which in turn affects the expression or function of the drug transporter Vesicular inhibitory amino acid transporter.

      Class3.5: Tryptophan cluster factors

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        GABPA 

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       Transcriptional Phenomenon1

 Direct binding to SLC32A1 gene [10]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC32A1 gene, which in turn affects the expression or function of the drug transporter Vesicular inhibitory amino acid transporter.
References
1 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
2 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
3 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
4 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
7 Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2). J Biol Chem. 2010;285(33):25115-25.
8 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
9 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-188. (ID:ENSG00000101438)
10 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.

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