| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0255 | ||||
| Gene Name | SLC2A13 | ||||
| Protein Name | Proton myo-inositol cotransporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:4LDS_A Identity:34.08% Minimized Score:-921.08 kcal/mol Detail: Structure Info |
||||
| Synonyms | H(+)-myo-inositol cotransporter; H(+)-myo-inositol symporter; Hmit; SLC2A13; Solute carrier family 2 member 13 | ||||
| DT Family | Major Facilitator Superfamily (MFS) | ||||
| Sugar Porter (SP) Family | |||||
| Tissue Specificity | Predominantly expressed in the brain. | ||||
| Function | This is a H(+)-myo-inositol cotransporter. Its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and NRF2 pathway. | ||||
| Endogenous Substrate(s) | Myoinositol; H+; Inositol | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Proton myo-inositol cotransporter |
|||||
|
(β) Cell Distribution Level of Proton myo-inositol cotransporter |
|||||
|
(γ) Organelle Distribution Level of Proton myo-inositol cotransporter |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(β) Post-translational Modification of Proton myo-inositol cotransporter |
|||||
|
(γ) Transcriptional Regulation of Proton myo-inositol cotransporter |
|||||
|
(δ) Epigenetic Regulation of Proton myo-inositol cotransporter |
|||||
|
(ε) Exogenous Modulation of Proton myo-inositol cotransporter |
|||||
|
Structural Variability Data of This DT |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
(γ) Outward/inward-facing Conformation |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Proton myo-inositol cotransporter |
|||||
|
(β) Disease-specific Protein Abundances of Proton myo-inositol cotransporter |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.