Drug Transporter (DT) Information

General Information of DT
DT ID DTD0234
Gene Name SLC26A6
Protein Name Anion exchange transporter
Gene ID
65010
UniProt ID
Q9BXS9
TCDB ID
2.A.53.2.7
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6RTC_A

Identity:39.535%

Minimized Score:-1342.667 kcal/mol

Detail: Structure Info

Synonyms Pendrin-L1; Pendrin-like protein 1; SLC26A6; Solute carrier family 26 member 6
DT Family Sulfate Permease (SULP) Family ;
Tissue Specificity Ubiquitous. Highest levels in kidney andpancreas. Lower expression in heart, skeletal muscle, liver andplacenta. Also found in lung and brain. Isoform 4 is ubiquitouslyexpressed. Isoform 6 is expressed in heart, brain, placenta, lung,liver, kidney, pancreas, spleen, thymus, prostate, testis andovary. Isoform 5 is expressed weakly in placenta, lung, liver andpancreas.
Function This transporter mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. And it acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate.
Endogenous Substrate(s) Cl-; Hydrogen sulfate; Hydroxide; Formate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Anion exchange transporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Anion exchange transporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Anion exchange transporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Anion exchange transporter
Microbiota Influence (MBI)

(β) Post-translational Modification of Anion exchange transporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Anion exchange transporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Anion exchange transporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Anion exchange transporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Anion exchange transporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Anion exchange transporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Bicarbonate
 Phase 3 Drug Info Metabolic acidosis 5C73 [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:         10 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Citrate
311
EM Info Identified using slc26a6 null mice [2]
Glycolate
757
EM Info Identified using slc26a6 null mice [2]
Hippuric acid
464
EM Info Identified using slc26a6 null mice [2]
M-hydroxyphenylpropionylsulfate
132990973
EM Info Identified using slc26a6 null mice [2]
Methylamine
6329
EM Info Identified using slc26a6 null mice [2]
Myo-inositol
892
EM Info Identified using slc26a6 null mice [2]
Oxalate
71081
EM Info Identified using slc26a6 null mice [2]
Taurine
1123
EM Info Identified using slc26a6 null mice [2]
Trimethylamine
1146
EM Info Identified using slc26a6 null mice [2]
Trimethylamine-N-oxide
1145
EM Info Identified using slc26a6 null mice [2]
References
1 Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005 Jul 20;24(14):2499-511.
2 Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model. J Proteome Res. 2012 Sep 7;11(9):4425-35.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.