Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0234 Transporter Info
Gene Name SLC26A6
Transporter Name Anion exchange transporter
Gene ID
65010
UniProt ID
Q9BXS9
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Estradiol inhibits the reaction SLC26A6 protein results in increased transport of Bicarbonates [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Estradiol inhibits the reaction SLC26A6 protein results in increased transport of Oxalates [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Estradiol results in decreased activity of SLC26A6 protein [18]

Regulation Mechanism

 Transcription Factor Info

  1-Butanol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC26A6 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  1-Methyl-3-isobutylxanthine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC26A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC26A6 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  abrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 abrine results in increased expression of SLC26A6 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  Acrolein

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  alpha-pinene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in increased expression of SLC26A6 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  beta-methylcholine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-methylcholine affects the expression of SLC26A6 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  Bicarbonates

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol inhibits the reaction SLC26A6 protein results in increased transport of Bicarbonates [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 SLC26A6 protein results in increased transport of Bicarbonates [18]

Regulation Mechanism

 Transcription Factor Info

  bisphenol F

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC26A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Dexamethasone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC26A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  FR900359

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 FR900359 results in increased phosphorylation of SLC26A6 protein [19]

Regulation Mechanism

 Transcription Factor Info

  Gasoline

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC26A6 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC26A6 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Gasoline results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC26A6 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  Indomethacin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of SLC26A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  isobutyl alcohol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC26A6 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  methacrylaldehyde

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  Okadaic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Okadaic Acid results in decreased expression of SLC26A6 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  Oxalates

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol inhibits the reaction SLC26A6 protein results in increased transport of Oxalates [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 SLC26A6 protein results in increased transport of Oxalates [18]

Regulation Mechanism

 Transcription Factor Info

  Ozone

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Volatile Organic Compounds co-treated with Ozone results in increased oxidation of SLC26A6 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in decreased expression of SLC26A6 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  Tetrachlorodibenzodioxin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tetrachlorodibenzodioxin results in decreased expression of SLC26A6 mRNA [2]

Regulation Mechanism

 Transcription Factor Info

  Thiram

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Thiram results in decreased expression of SLC26A6 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of SLC26A6 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Estradiol

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol inhibits the expression of SLC26A6 [2]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen increases the expression of SLC26A6 [3]

  Vorinostat

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vorinostat inhibits the expression of SLC26A6 [4]

  Doxorubicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin inhibits the expression of SLC26A6 [5]

  Temozolomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Temozolomide increases the expression of SLC26A6 [6]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of SLC26A6 [7]

Drug in Preclinical Test

  (+)-JQ1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 (+)-JQ1 increases the expression of SLC26A6 [9]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution affects the expression of SLC26A6 [10]

Bacterium

  Helicobacter pylori

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Helicobacter pylori infection inhibits the activity of SLC26A6 [1]

Cell System

 Human duodenal epithelial cells (SCBN)-SLC26A6

Environmental toxicant

  Polychlorinated dibenzodioxin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Polychlorinated dibenzodioxin inhibits the expression of SLC26A6 [2]

Mycotoxins

  Aflatoxin B1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 affects the expression of SLC26A6 [2]

Carcinogen

  Benzo(a)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene inhibits the expression of SLC26A6 [2]

Health and Environmental Toxicant

  Lead

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Lead inhibits the expression of SLC26A6 [8]
References
1 Helicobacter pylori infection downregulates duodenal CFTR and SLC26A6 expressions through TGF signaling pathway. BMC Microbiol. 2018 Aug 17;18(1):87.
2 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
3 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
4 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
5 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
6 Temozolomide induces activation of Wnt/beta-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278.
7 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
8 Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res. 2011 Jan;19(1):1-13.
9 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
10 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
11 Transcriptional response to organic compounds from diverse gasoline and biogasoline fuel emissions in human lung cells. Toxicol In Vitro. 2018;48:329-341.
12 Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles. PLoS One. 2017;12(6):e0179583.
13 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
14 Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
15 Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Commun Biol. 2020;3(1):392.
16 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
17 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352.
18 Estrogen treatment reduced oxalate transporting activity and enhanced migration through the involvement of SLC26A6 in lung cancer cells. Toxicol In Vitro. 2022;82:105373.
19 Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
20 A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
21 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
22 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.

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