Drug Transporter (DT) Information

General Information of DT
DT ID DTD0195
Gene Name SLC25A33
Protein Name Bone marrow stromal cell mitochondrial carrier protein
Gene ID
84275
UniProt ID
Q9BSK2
TCDB ID
2.A.29.10.7
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms BMSC-MCP; HuBMSC-MCP; PNC1; Protein PNC1; SLC25A33; Solute carrier family 25 member 33
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Expressed in the central nervous system. Alsoexpressed in testis and skeletal muscle. Weakly expressed inheart, liver, kidney, prostate, colon and peripheral bloodleukocytes.
Function This transporter is mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides.
Endogenous Substrate(s) Pyrimidines
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Bone marrow stromal cell mitochondrial carrier protein
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Bone marrow stromal cell mitochondrial carrier protein
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Bone marrow stromal cell mitochondrial carrier protein
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Bone marrow stromal cell mitochondrial carrier protein
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Bone marrow stromal cell mitochondrial carrier protein
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Bone marrow stromal cell mitochondrial carrier protein
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Bone marrow stromal cell mitochondrial carrier protein
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Bone marrow stromal cell mitochondrial carrier protein
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Bone marrow stromal cell mitochondrial carrier protein
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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