Drug Transporter (DT) Information

General Information of DT
DT ID DTD0182
Gene Name SLC25A21
Protein Name Mitochondrial 2-oxodicarboxylate carrier
Gene ID
89874
UniProt ID
Q9BQT8
TCDB ID
2.A.29.2.4
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ODC; ODC1; SLC25A21; Solute carrier family 25 member 21
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Ubiquitous.
Function This transporter mediates C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
Endogenous Substrate(s) 2-Amino adipate; 2-Oxopimelate; Pimelate; Citrate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Mitochondrial 2-oxodicarboxylate carrier
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Mitochondrial 2-oxodicarboxylate carrier
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Mitochondrial 2-oxodicarboxylate carrier
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Mitochondrial 2-oxodicarboxylate carrier
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Mitochondrial 2-oxodicarboxylate carrier
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Mitochondrial 2-oxodicarboxylate carrier
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Mitochondrial 2-oxodicarboxylate carrier
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Mitochondrial 2-oxodicarboxylate carrier
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Mitochondrial 2-oxodicarboxylate carrier
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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