Drug Transporter (DT) Information

General Information of DT
DT ID DTD0163
Gene Name SLC24A2
Protein Name Sodium/potassium/calcium exchanger 2
Gene ID
25769
UniProt ID
Q9UI40
TCDB ID
2.A.19.4.11
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms NCKX2; Na(+)/K(+)/Ca(2+)-exchange protein 2; Retinal cone Na-Ca+K exchanger; SLC24A2; Solute carrier family 24 member 2
DT Family Ca(2+):Cation Antiporter (CACA) Family ;
Function This transporter mediates the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants.
Endogenous Substrate(s) Ca2+; K+; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/potassium/calcium exchanger 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/potassium/calcium exchanger 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/potassium/calcium exchanger 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/potassium/calcium exchanger 2
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Sodium/potassium/calcium exchanger 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/potassium/calcium exchanger 2
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/potassium/calcium exchanger 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/potassium/calcium exchanger 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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