Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0163 Transporter Info
Gene Name	SLC24A2
Transporter Name	Sodium/potassium/calcium exchanger 2
Gene ID	25769
UniProt ID	Q9UI40

Post-Translational Modification of This DT
Overview ofSLC24A2 Modification Sites with Functional and Structural Information
Sequence	M D L Q Q S T T I T S L E K W C L D E S L S G C R R H Y S V K K K L K L I R V L G L F M G L V A I S T V S F S I S A F S E T D T Q S T G E A S V V S G P R V A Q G Y H Q R T L L D L N D K I L D Y T P Q P P L S K E G E S E N S T D H A Q G D Y P K D I F S L E E R R K G A I I L H V I G M I Y M F I A L A I V C D E F F V P S L T V I T E K L G I S D D V A G A T F M A A G G S A P E L F T S L I G V F I A H S N V G I G T I V G S A V F N I L F V I G M C A L F S R E I L N L T W W P L F R D V S F Y I V D L I M L I I F F L D N V I M W W E S L L L L T A Y F C Y V V F M K F N V Q V E K W V K Q M I N R N K V V K V T A P E A Q A K P S A A R D K D E P T L P A K P R L Q R G G S S A S L H N S L M R N S I F Q L M I H T L D P L A E E L G S Y G K L K Y Y D T M T E E G R F R E K A S I L H K I A K K K C H V D E N E R Q N G A A N H V E K I E L P N S T S T D V E M T P S S D A S E P V Q N G N L S H N I E G A E A Q T A D E E E D Q P L S L A W P S E T R K Q V T F L I V F P I V F P L W I T L P D V R K P S S R K F F P I T F F G S I T W I A V F S Y L M V W W A H Q V G E T I G I S E E I M G L T I L A A G T S I P D L I T S V I V A R K G L G D M A V S S S V G S N I F D I T V G L P L P W L L Y T V I H R F Q P V A V S S N G L F C A I V L L F I M L L F V I L S I A L C K W R M N K I L G F I M F G L Y F V F L V V S V L L E D R I L T C P V S I
PTM type	X-N-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	111
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC24A2 Asparagine 111 has the potential to affect its expression or activity.
Phosphorylation
Serine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	6
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 6 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC24A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	11
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 11 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC24A2			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	126
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 126 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC24A2			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	333
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 333 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC24A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	334
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 334 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC24A2			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	336
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 336 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC24A2			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	340
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 340 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC24A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Serine 384 has the potential to affect its expression or activity.
Threonine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A2			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	7
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Threonine 7 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC24A2			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	8
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Threonine 8 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC24A2			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Threonine 10 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC24A2			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A2 Threonine 372 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A2			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	310
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC24A2 Lysine 310 has the potential to affect its expression or activity.

References
1	Topology of the retinal cone NCKX2 Na/Ca-K exchanger. Biochemistry. 2003 Mar 4;42(8):2485-91.
2	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins. Proteomics. 2015 Jan;15(2-3):508-519.
5	Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome. Proteomics. 2015 Jan;15(2-3):500-7.
6	Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov;14(11):1166-72.
7	Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography. J Proteome Res. 2008 Oct;7(10):4215-24.
8	Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease. Proteomics. 2018 Oct;18(20):e1800108.

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Detail Information of Post-Translational Modifications

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