| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0110 | ||||
| Gene Name | SLC16A6 | ||||
| Protein Name | Monocarboxylate transporter 7 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:7BP3_A Identity:32.143% Minimized Score:-1011.198 kcal/mol Detail: Structure Info |
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| Synonyms | SLC16A6; MCT7; Solute carrier family 16 member 6 | ||||
| DT Family | Major Facilitator Superfamily (MFS) | ||||
| Monocarboxylate Transporter (MCT) Family | |||||
| Function | This transporter is proton-linked monocarboxylate transporter,and it catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. | ||||
| Endogenous Substrate(s) | Monocarboxylates | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Monocarboxylate transporter 7 |
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(β) Cell Distribution Level of Monocarboxylate transporter 7 |
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(γ) Organelle Distribution Level of Monocarboxylate transporter 7 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Monocarboxylate transporter 7 |
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(γ) Transcriptional Regulation of Monocarboxylate transporter 7 |
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(δ) Epigenetic Regulation of Monocarboxylate transporter 7 |
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(ε) Exogenous Modulation of Monocarboxylate transporter 7 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Monocarboxylate transporter 7 |
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(β) Disease-specific Protein Abundances of Monocarboxylate transporter 7 |
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(γ) Species- and Tissue-specific DT Abundances |
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