General Information of Drug Transporter (DT)
DT ID DTD0110 Transporter Info
Gene Name SLC16A6
Transporter Name Monocarboxylate transporter 7
Gene ID
9120
UniProt ID
O15403
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Approved Drug

  Sulindac

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Sulindac increases the expression of SLC16A6 [1]

  Fluorouracil

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Fluorouracil inhibits the expression of SLC16A6 [2]

  Zinc Acetate

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Zinc Acetate increases the expression of SLC16A6 [3]

  Copper Sulfate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Copper Sulfate increases the expression of SLC16A6 [4]

  Dasatinib

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dasatinib inhibits the expression of SLC16A6 [5]

  Progesterone

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Progesterone inhibits the expression of SLC16A6 [6]

  Liothyronine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Liothyronine increases the expression of SLC16A6 [7]

  Acetaminophen

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acetaminophen increases the expression of SLC16A6 [8]

  Azathioprine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Azathioprine increases the expression of SLC16A6 [9]

  Zidovudine

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Zidovudine inhibits the expression of SLC16A6 [10]

  Ibuprofen

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Ibuprofen increases the expression of SLC16A6 [11]

  Urethane

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Urethane inhibits the expression of SLC16A6 [12]

  Leflunomide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Leflunomide increases the expression of SLC16A6 [13]

  Doxorubicin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Doxorubicin inhibits the expression of SLC16A6 [14]

  Hydroquinone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Hydroquinone inhibits the expression of SLC16A6 [16]

  Tretinoin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tretinoin increases the expression of SLC16A6 [17]

  Estradiol

           5 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Estradiol inhibits the expression of SLC16A6 [18]

  Cyclosporine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cyclosporine increases the expression of SLC16A6 [19]

  Valproic Acid

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Valproic Acid increases the expression of SLC16A6 [20]

Drug Marketed but not Approved by US FDA

  Rotenone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Rotenone increases the expression of SLC16A6 [15]

Drug in Phase 2 Trial

  Motexafin gadolinium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Motexafin gadolinium increases the expression of SLC16A6 [3]

  Bisphenol A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Bisphenol A increases the expression of SLC16A6 [29]

Drug in Phase 1 Trial

  Quercetin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Quercetin increases the expression of SLC16A6 [18]

  Trichostatin A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Trichostatin A increases the expression of SLC16A6 [25]

  Dihydrotestosterone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dihydrotestosterone increases the expression of SLC16A6 [30]

Drug in Preclinical Test

  (+)-JQ1

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

(+)-JQ1 inhibits the expression of SLC16A6 [35]

Investigative Drug

  Beta-naphthoflavone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Beta-naphthoflavone increases the expression of SLC16A6 [21]

Natural Product

  Particulate Matter

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Particulate Matter increases the expression of SLC16A6 [31]

  Tobacco Smoke Pollution

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tobacco Smoke Pollution increases the expression of SLC16A6 [34]

  Caffeine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Caffeine results in increased phosphorylation of SLC16A6 protein [46]

Regulation Mechanism

Transcription Factor Info

Traditional Medicine

  Jinfukang

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Jinfukang increases the expression of SLC16A6 [28]

Environmental toxicant

  Polychlorinated dibenzodioxin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Polychlorinated dibenzodioxin increases the expression of SLC16A6 [18]

Mycotoxins

  Aflatoxin B1

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Aflatoxin B1 increases the expression of SLC16A6 [32]

Acute Toxic Substance

  Oxyquinoline

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Oxyquinoline inhibits the expression of SLC16A6 [18]

  Formaldehyde

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Formaldehyde inhibits the expression of SLC16A6 [22]

  Thimerosal

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Thimerosal increases the expression of SLC16A6 [27]

  Acrylamide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrylamide increases the expression of SLC16A6 [33]

Carcinogen

  Ethyl Methanesulfonate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Ethyl Methanesulfonate inhibits the expression of SLC16A6 [22]

  Benzo(a)pyrene

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Benzo(a)pyrene increases the expression of SLC16A6 [32]

  Nickel

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Nickel results in increased expression of SLC16A6 mRNA [57]

Regulation Mechanism

Transcription Factor Info

Health and Environmental Toxicant

  1-methyl-4-phenylpyridinium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

1-methyl-4-phenylpyridinium increases the expression of SLC16A6 [24]

  Butyraldehyde

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Butyraldehyde increases the expression of SLC16A6 [26]

Herbicide

  Diuron

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Diuron increases the expression of SLC16A6 [23]

Chemical Compound

  DT Modulation1

Fluorouracil results in increased expression of SLC16A6 mRNA [53]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

SLC16A6 protein affects the susceptibility to Fluorouracil [2]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Zinc Acetate co-treated with motexafin gadolinium results in increased expression of SLC16A6 mRNA [3]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Estradiol co-treated with Progesterone results in decreased expression of SLC16A6 mRNA [48]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Progesterone co-treated with Estradiol results in decreased expression of SLC16A6 mRNA [51]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Zidovudine results in increased expression of SLC16A6 mRNA [10]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Estradiol co-treated with Progesterone results in decreased expression of SLC16A6 mRNA [48]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Estradiol co-treated with TGFB1 protein results in decreased expression of SLC16A6 mRNA [49]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

Estradiol results in increased expression of SLC16A6 mRNA [50]

Regulation Mechanism

Transcription Factor Info

  DT Modulation4

Progesterone co-treated with Estradiol results in decreased expression of SLC16A6 mRNA [51]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A6 mRNA [27]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Valproic Acid affects the expression of SLC16A6 mRNA [64]

Regulation Mechanism

Transcription Factor Info

  Pentanal

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Pentanal increases the expression of SLC16A6 [26]

  DT Modulation1

AHR protein affects the reaction Benzo(a)pyrene results in increased expression of SLC16A6 mRNA [42]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Benzo(a)pyrene affects the expression of SLC16A6 mRNA [43]

Regulation Mechanism

Transcription Factor Info

  1-Methyl-4-phenylpyridinium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

1-Methyl-4-phenylpyridinium results in increased expression of SLC16A6 mRNA [24]

Regulation Mechanism

Transcription Factor Info

  2,4,5,2',4',5'-hexachlorobiphenyl

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of SLC16A6 mRNA [36]

Regulation Mechanism

Transcription Factor Info

  3,4-dichloroaniline

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

3,4-dichloroaniline results in increased expression of SLC16A6 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A6 mRNA [27]

Regulation Mechanism

Transcription Factor Info

  7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC16A6 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  8-Bromo Cyclic Adenosine Monophosphate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC16A6 mRNA [38]

Regulation Mechanism

Transcription Factor Info

  Acrolein

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  Aldehydes

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Aldehydes results in increased expression of SLC16A6 mRNA [40]

Regulation Mechanism

Transcription Factor Info

  alpha-pinene

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  Amphotericin B

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Amphotericin B analog results in increased expression of SLC16A6 mRNA [41]

Regulation Mechanism

Transcription Factor Info

  benzo(e)pyrene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

benzo(e)pyrene results in increased methylation of SLC16A6 intron [44]

Regulation Mechanism

Transcription Factor Info

  beta-Naphthoflavone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

beta-Naphthoflavone results in increased expression of SLC16A6 mRNA [21]

Regulation Mechanism

Transcription Factor Info

  bisphenol A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol A results in increased expression of SLC16A6 mRNA [29]

Regulation Mechanism

Transcription Factor Info

  butyraldehyde

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

butyraldehyde results in increased expression of SLC16A6 mRNA [26]

Regulation Mechanism

Transcription Factor Info

  Cadmium Chloride

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cadmium Chloride results in decreased expression of SLC16A6 mRNA [45]

Regulation Mechanism

Transcription Factor Info

  CGP 52608

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

CGP 52608 promotes the reaction RORA protein binds to SLC16A6 gene [47]

Regulation Mechanism

Transcription Factor Info

  dorsomorphin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A6 mRNA [27]

Regulation Mechanism

Transcription Factor Info

  Etoposide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

SLC16A6 protein affects the susceptibility to Etoposide [52]

Regulation Mechanism

Transcription Factor Info

  FR900359

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

FR900359 results in decreased phosphorylation of SLC16A6 protein [54]

Regulation Mechanism

Transcription Factor Info

  hydroquinone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

hydroquinone results in decreased expression of SLC16A6 mRNA [16]

Regulation Mechanism

Transcription Factor Info

  licochalcone B

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

licochalcone B results in decreased expression of SLC16A6 mRNA [55]

Regulation Mechanism

Transcription Factor Info

  methacrylaldehyde

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  Methapyrilene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Methapyrilene results in increased methylation of SLC16A6 intron [44]

Regulation Mechanism

Transcription Factor Info

  Methylcholanthrene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Methylcholanthrene promotes the reaction AHR protein binds to SLC16A6 promoter [56]

Regulation Mechanism

Transcription Factor Info

  methylmercuric chloride

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

methylmercuric chloride results in increased expression of SLC16A6 mRNA [20]

Regulation Mechanism

Transcription Factor Info

  Methyl Methanesulfonate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Methyl Methanesulfonate results in decreased expression of SLC16A6 mRNA [22]

Regulation Mechanism

Transcription Factor Info

  Mitomycin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

SLC16A6 protein affects the susceptibility to Mitomycin [52]

Regulation Mechanism

Transcription Factor Info

  Mitoxantrone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

SLC16A6 protein affects the susceptibility to Mitoxantrone [52]

Regulation Mechanism

Transcription Factor Info

  motexafin gadolinium

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

motexafin gadolinium results in increased expression of SLC16A6 mRNA [3]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Zinc Acetate co-treated with motexafin gadolinium results in increased expression of SLC16A6 mRNA [3]

Regulation Mechanism

Transcription Factor Info

  N-Nitrosopyrrolidine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

N-Nitrosopyrrolidine results in increased expression of SLC16A6 mRNA [32]

Regulation Mechanism

Transcription Factor Info

  Okadaic Acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Okadaic Acid results in increased expression of SLC16A6 mRNA [58]

Regulation Mechanism

Transcription Factor Info

  Oxygen

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Oxygen deficiency results in increased expression of SLC16A6 mRNA [11]

Regulation Mechanism

Transcription Factor Info

  Ozone

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

Volatile Organic Compounds co-treated with Ozone results in decreased expression of SLC16A6 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  pentanal

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

pentanal results in increased expression of SLC16A6 mRNA [26]

Regulation Mechanism

Transcription Factor Info

  perfluorooctanoic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

perfluorooctanoic acid results in increased expression of SLC16A6 protein [59]

Regulation Mechanism

Transcription Factor Info

  propionaldehyde

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

propionaldehyde results in increased expression of SLC16A6 mRNA [26]

Regulation Mechanism

Transcription Factor Info

  Silicon Dioxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Silicon Dioxide analog results in increased expression of SLC16A6 mRNA [60]

Regulation Mechanism

Transcription Factor Info

  S-Nitrosoglutathione

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

S-Nitrosoglutathione results in increased expression of SLC16A6 mRNA [61]

Regulation Mechanism

Transcription Factor Info

  Tetrachlorodibenzodioxin

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tetrachlorodibenzodioxin affects the expression of SLC16A6 mRNA [62]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Tetrachlorodibenzodioxin results in increased expression of SLC16A6 mRNA [42]

Regulation Mechanism

Transcription Factor Info

  trichostatin A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

trichostatin A results in increased expression of SLC16A6 mRNA [25]

Regulation Mechanism

Transcription Factor Info

  Triiodothyronine

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction Triiodothyronine results in increased expression of SLC16A6 mRNA [7]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Triiodothyronine results in increased expression of SLC16A6 mRNA [7]

Regulation Mechanism

Transcription Factor Info

  tris(2-butoxyethyl) phosphate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tris(2-butoxyethyl) phosphate affects the expression of SLC16A6 mRNA [63]

Regulation Mechanism

Transcription Factor Info
References
1 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
2 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12.
3 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
4 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
5 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
6 Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
7 Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
8 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
9 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
10 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
11 Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
12 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
13 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
14 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
15 Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone. Arch Toxicol. 2018 Aug;92(8):2587-2606.
16 Keratinocyte-derived IL-36 Gamma plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
17 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
18 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
19 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
20 Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
21 Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene Human Immunity and Metabolic Syndrome 9k. Toxicol In Vitro. 2010 Feb;24(1):85-91.
22 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
23 Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches. Toxicology. 2013 Dec 15;314(2-3):238-46.
24 Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death Dis. 2014 May 8;5(5):e1222.
25 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
26 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
27 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
28 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
29 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
30 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
31 Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles. BMC Genomics. 2018 Apr 27;19(1):302.
32 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
33 Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids. Food Chem Toxicol. 2020 Oct;144:111643.
34 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
35 Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
36 PCB congener specific oxidative stress response by microarray analysis using human liver cell line. Environ Int. 2010;36(8):907-17.
37 Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line. Genomics. 2009;93(4):332-42.
38 The bone marrow-derived human mesenchymal stem cell: potential progenitor of the endometrial stromal fibroblast. Biol Reprod. 2010;82(6):1076-87.
39 Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Commun Biol. 2020;3(1):392.
40 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
41 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017;27(7):537-543.
42 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
43 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
44 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
45 Gene expression and pathway analysis of human hepatocellular carcinoma cells treated with cadmium. Toxicol Appl Pharmacol. 2015;288(3):399-408.
46 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
47 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
48 Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands. Endocrinology. 2010;151(9):4515-26.
49 Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160.
50 17 beta-Estradiol Activates HSF1 via MAPK Signaling in ER alpha-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533.
51 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
52 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006;118(7):1699-712.
53 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
54 Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
55 Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2. Food Chem Toxicol. 2021;150:112096.
56 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci. 2010;117(1):90-100.
57 Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol. 2015;135(3):712-20.
58 A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
59 High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver. Arch Toxicol. 2017;91(1):247-258.
60 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
61 Transcriptome analysis in various cell lines exposed to nitric oxide. J Toxicol Sci. 2024;49(6):281-288.
62 Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2012 May;127(1):199-215.
63 Toxicogenomics of the flame retardant tris (2-butoxyethyl) phosphate in HepG2 cells using RNA-seq. Toxicol In Vitro. 2018;46:178-188.
64 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.

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