Drug Transporter (DT) Information

General Information of DT
DT ID DTD0094
Gene Name SLC13A4
Protein Name Na(+)/sulfate cotransporter SUT-1
Gene ID
26266
UniProt ID
Q9UKG4
TCDB ID
2.A.47.1.14
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5XH7_A; 5UL7_A; 5ULD_A

Identity:36.364%;32.231%;29.003%

Minimized Score:-623.229 kcal/mol

Detail: Structure Info

Synonyms NaS2; SLC13A4; SUT-1; SUT1; Solute carrier family 13 member 4
DT Family Divalent Anion:Na(+) Symporter (DASS) Family ;
Tissue Specificity Highly expressed in placenta and testis withintermediate levels in brain and lower levels in heart, thymus andliver.
Function This sodium/sulfate cotransporter mediates the reabsorption of sulfate in the high endothelial venules (HEV).
Endogenous Substrate(s) Na+; Selenate; Thiosulfate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Na(+)/sulfate cotransporter SUT-1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Na(+)/sulfate cotransporter SUT-1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Na(+)/sulfate cotransporter SUT-1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Na(+)/sulfate cotransporter SUT-1
Microbiota Influence (MBI)

(β) Post-translational Modification of Na(+)/sulfate cotransporter SUT-1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Na(+)/sulfate cotransporter SUT-1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Na(+)/sulfate cotransporter SUT-1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Na(+)/sulfate cotransporter SUT-1
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Na(+)/sulfate cotransporter SUT-1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Na(+)/sulfate cotransporter SUT-1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           7 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Sulfate Investigative Drug Info Xenopus oocytes-SUT1 Km =0.38 microM [1]
Sulfate Investigative Drug Info Xenopus oocytes-SUT1 Km =0.38 microM [1]
Sulfate Investigative Drug Info Xenopus oocytes-SUT1 Km =0.38 microM [1]
Sulfate Investigative Drug Info Xenopus oocytes-SUT1 Km =0.38 microM [1]
Sulfate Investigative Drug Info Xenopus oocytes-SUT1 Km =0.38 microM [1]
Sulfate Investigative Drug Info Xenopus oocytes-SUT1 Km =0.38 microM [1]
Sulfate Investigative Drug Info Xenopus oocytes-SUT1 Km =0.38 microM [1]
References
1 SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312.

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