Drug Transporter (DT) Information

General Information of DT
DT ID DTD0043
Gene Name ABCA5
Protein Name ATP-binding cassette sub-family A member 5
Gene ID
23461
UniProt ID
Q8WWZ7
TCDB ID
3.A.1.211.9
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5XJY_A

Identity:31.016%

Minimized Score:-827.556 kcal/mol

Detail: Structure Info

Synonyms ABC13; ABCA5; EST90625; HTC3; KIAA1888
DT Family ATP-Binding Cassette (ABC) Superfamily
Cholesterol/Phospholipid/Retinal (CPR) Flippase Family (ABCA)
Tissue Specificity Ubiquitously expressed. Highly expressed intestis, skeletal muscle, kidney, liver and placenta.
Function This transporter may play a role in the processing of autolysosomes.
Endogenous Substrate(s) Lipids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-binding cassette sub-family A member 5
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-binding cassette sub-family A member 5
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-binding cassette sub-family A member 5
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of ATP-binding cassette sub-family A member 5
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-binding cassette sub-family A member 5
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-binding cassette sub-family A member 5
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-binding cassette sub-family A member 5
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-binding cassette sub-family A member 5
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-binding cassette sub-family A member 5
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Cholesterol
 Phase 2 Drug Info Cone-Rod dystrophy 9B70 [1]
References
1 Mutations in the cholesterol transporter gene ABCA5 are associated with excessive hair overgrowth. PLoS Genet. 2014 May 15;10(5):e1004333.

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