| General Information of DT | |||||
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| DT ID | DTD0515 | ||||
| Gene Name | ATP10A | ||||
| Protein Name | Probable phospholipid-transporting ATPase VA | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6LCP_A Identity:39.37% Minimized Score:-1235.898 kcal/mol Detail: Structure Info |
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| Synonyms | ATP10A; ATP10C; ATPVA; ATPVC; ATPase class V type 10A; Aminophospholipid translocase VA; KIAA0566; P4-ATPase flippase complex alpha subunit ATP10A | ||||
| DT Family | P-Type ATPase (P-ATPase) Superfamily ; | ||||
| Tissue Specificity | Widely expressed, with highest levels inkidney, followed by lung, brain, prostate, testis, ovary and smallintestine. | ||||
| Function | This transporter is a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. | ||||
| Endogenous Substrate(s) | Phosphatidylserine | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Probable phospholipid-transporting ATPase VA |
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(β) Cell Distribution Level of Probable phospholipid-transporting ATPase VA |
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(γ) Organelle Distribution Level of Probable phospholipid-transporting ATPase VA |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Probable phospholipid-transporting ATPase VA |
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(γ) Transcriptional Regulation of Probable phospholipid-transporting ATPase VA |
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(δ) Epigenetic Regulation of Probable phospholipid-transporting ATPase VA |
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(ε) Exogenous Modulation of Probable phospholipid-transporting ATPase VA |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Probable phospholipid-transporting ATPase VA |
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(β) Disease-specific Protein Abundances of Probable phospholipid-transporting ATPase VA |
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(γ) Species- and Tissue-specific DT Abundances |
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