| General Information of DT | |||||
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| DT ID | DTD0478 | ||||
| Gene Name | SLC8A2 | ||||
| Protein Name | Sodium/calcium exchanger 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:3US9_A Identity:56.25% Minimized Score:-679.471 kcal/mol Detail: Structure Info |
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| Synonyms | KIAA1087; NCX2; Na(+)/Ca(2+)-exchange protein 2; SLC8A2; Solute carrier family 8 member 2 | ||||
| DT Family | Ca(2+):Cation Antiporter (CACA) Family ; | ||||
| Function | This transporter mediates the exchange of calcium ions and sodium ions on cell membrane, which is helpful for the regulation of cytoplasmic calcium ion water and calcium ion-dependent cell processes. | ||||
| Endogenous Substrate(s) | Ca2+; Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium/calcium exchanger 2 |
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(β) Cell Distribution Level of Sodium/calcium exchanger 2 |
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(γ) Organelle Distribution Level of Sodium/calcium exchanger 2 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium/calcium exchanger 2 |
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(γ) Transcriptional Regulation of Sodium/calcium exchanger 2 |
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(δ) Epigenetic Regulation of Sodium/calcium exchanger 2 |
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(ε) Exogenous Modulation of Sodium/calcium exchanger 2 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium/calcium exchanger 2 |
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(β) Disease-specific Protein Abundances of Sodium/calcium exchanger 2 |
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(γ) Species- and Tissue-specific DT Abundances |
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