Modelled DT Structure
Method:homology modeling
Template PDB:6JMQ_A
Identity:48.654%
Minimized Score:-1076.859 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0463 | ||||
| Gene Name | SLC7A10 | ||||
| Protein Name | Asc-type amino acid transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | ASC1; Asc-1; HASC-1; SLC7A10; Solute carrier family 7 member 10 | ||||
| DT Family | Amino Acid-Polyamine-Organocation (APC) Family | ||||
| L-type Amino Acid Transporter (LAT) Family | |||||
| Tissue Specificity | Expressed in brain, heart, kidney, liver,lung, pancreas, placenta, and skeletal muscle. | ||||
| Function | This sodium-independent, high affinity transporter mediates the transport of neutral D- and L-amino acids and may play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. | ||||
| Endogenous Substrate(s) | D-amino acids; L-amino acids | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Asc-type amino acid transporter 1 |
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(β) Cell Distribution Level of Asc-type amino acid transporter 1 |
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(γ) Organelle Distribution Level of Asc-type amino acid transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Asc-type amino acid transporter 1 |
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(γ) Transcriptional Regulation of Asc-type amino acid transporter 1 |
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(δ) Epigenetic Regulation of Asc-type amino acid transporter 1 |
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(ε) Exogenous Modulation of Asc-type amino acid transporter 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(δ) Xenobiotics-regulated Structural Variability |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Asc-type amino acid transporter 1 |
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(β) Disease-specific Protein Abundances of Asc-type amino acid transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Amino acids
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Approved | Drug Info | Nutritional deficiency | 5B7Z | [1] |
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Endogenous Metabolites (EMs) Handled by This DT |
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Endogenous Metabolites (EMs) |
Click to Show/Hide the Full List of EMs: 1 EMs in Total | ||||
| EM Name | PubChem CID | Detail | Experimental Material | Ref | |
| Glycine | EM Info | Identified using Slc7a10 knockout mice | [2] | ||
| References | |||||
| 1 | The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC7A10) | ||||
| 2 | The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission. EMBO Rep. 2015 May;16(5):590-8. | ||||
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