Drug Transporter (DT) Information

General Information of DT
DT ID DTD0452
Gene Name SLC6A2
Protein Name Sodium-dependent noradrenaline transporter
Gene ID
6530
UniProt ID
P23975
TCDB ID
2.A.22.1.2
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4XPB_A

Identity:58.333%

Minimized Score:-1509.924 kcal/mol

Detail: Structure Info

Synonyms NET; NET1; Norepinephrine transporter; SLC6A2; Solute carrier family 6 member 2
DT Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Function This transporter is amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Disease(s) Neurogenic shock [ICD-11:MG40.Y]
Endogenous Substrate(s) 1-methyl-4-tetrahydropyridinium; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-dependent noradrenaline transporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-dependent noradrenaline transporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-dependent noradrenaline transporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium-dependent noradrenaline transporter
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium-dependent noradrenaline transporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-dependent noradrenaline transporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-dependent noradrenaline transporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-dependent noradrenaline transporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-dependent noradrenaline transporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-dependent noradrenaline transporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Amphetamine
 Approved Drug Info Attention deficit hyperactivity disorder 6A05 [1]
Norepinephrine
 Approved Drug Info Septic shock 1G41 [2]

Drug-DT Affinity Assessed by Cell Line

 Approved Drug

 Click to Show/Hide the Full List of Drug:           7 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Norepinephrine Approved Drug Info Monkey kidney fibroblast-like cell (COS)1-NET Km =690 microM [3]
Norepinephrine Approved Drug Info Monkey kidney fibroblast-like cell (COS)1-NET Km =690 microM [3]
Norepinephrine Approved Drug Info Monkey kidney fibroblast-like cell (COS)1-NET Km =690 microM [3]
Norepinephrine Approved Drug Info Monkey kidney fibroblast-like cell (COS)1-NET Km =690 microM [3]
Norepinephrine Approved Drug Info Monkey kidney fibroblast-like cell (COS)1-NET Km =690 microM [3]
Norepinephrine Approved Drug Info Monkey kidney fibroblast-like cell (COS)1-NET Km =690 microM [3]
Norepinephrine Approved Drug Info Monkey kidney fibroblast-like cell (COS)1-NET Km =690 microM [3]
References
1 Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci. 2015 Jan;36(1):41-50.
2 Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. J Neurochem. 2006 May;97(4):1044-51.
3 chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. J Biol Chem. 2007 Jun 15;282(24):17837-44.

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