General Information of Drug Transporter (DT)
DT ID	DTD0452 Transporter Info
Gene Name	SLC6A2
Transporter Name	Sodium-dependent noradrenaline transporter
Gene ID	6530
UniProt ID	P23975
Modelled Structures of This DT
Click to Save PDB File in TXT Format
Detail Information of Structural Model
Method	Homology modeling
Template PDB	4XPB_A		Identity	58.333%
Performance	Minimized Score	-1509.924 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	High
Ramachandran Plot
	Click to Save Ramachandran Plot in PNG Format
	Ramz Z Score	-1.15 ±0.33
	Residues in Favored Region	535	Ramachandran favored	97.45%
	Number of Outliers	1	Ramachandran outliers	0.18%
Local Quality
	Click to Save Local Quality Plot in PNG Format
	QMEANBrane Score		0.82
AlphaFold Protein Structure Database	P23975 Click to jump to the details page
SWISS-MODEL Database	P23975 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8HFE	EM	2.5 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
8HFF	EM	2.86 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
8HFG	EM	3 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
8HFI	EM	2.5 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
8HFL	EM	3 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
8I3V	EM	2.85 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
8WGR	EM	2.75 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
8WGX	EM	3.47 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
	Click to Save PDB File in TXT Format
Corresponding chain	A
Sequence Length	617		Mutation	No
References
1	Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature. 2024;632(8026):921-929.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.