Drug Transporter (DT) Information

General Information of DT
DT ID DTD0446
Gene Name SLC6A14
Protein Name Amino acid transporter ATB0+
Gene ID
11254
UniProt ID
Q9UN76
TCDB ID
2.A.22.2.3
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4XPT_A; 4M48_A

Identity:44.154%;43.501%

Minimized Score:-1378.492 kcal/mol

Detail: Structure Info

Synonyms Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); BMIQ11; SLC6A14; Solute carrier family 6 member 14
DT Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Tissue Specificity Levels are highest in adult and fetal lung, intrachea and salivary gland. Lower levels detected in mammarygland, stomach and pituitary gland, and very low levels in colon,uterus, prostate and testis.
Function This transporter mediates the uptake of large amounts of neutral and cationic amino acids (except proline) in a sodium (+)/chlorine (-)-dependent manner.
Endogenous Substrate(s) Neutral and cationic amino acids; Na+; Cl-
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Amino acid transporter ATB0+
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Amino acid transporter ATB0+
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Amino acid transporter ATB0+
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Amino acid transporter ATB0+
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Amino acid transporter ATB0+
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Amino acid transporter ATB0+
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Amino acid transporter ATB0+
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Amino acid transporter ATB0+
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Amino acid transporter ATB0+
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Amino acids
 Approved Drug Info Nutritional deficiency 5B7Z [1]
References
1 Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer. Br J Pharmacol. 2016 Dec;173(23):3292-3306.

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