Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0446 Transporter Info
Gene Name SLC6A14
Transporter Name Amino acid transporter ATB0+
Gene ID
11254
UniProt ID
Q9UN76

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        ASCL1 

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       Transcriptional Phenomenon1

 Direct binding to SLC6A14 gene [1]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC6A14 gene, which in turn affects the expression or function of the drug transporter Amino acid transporter ATB0+.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        CUX1 

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       Transcriptional Phenomenon1

 Activation of SLC6A14 gene in multiple human cancer types condition [2]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC6A14 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Amino acid transporter ATB0+.

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A14 gene in ovarian cancer condition [3]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC6A14 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Amino acid transporter ATB0+.

      Class3.3: Fork head / winged helix factors

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        E2F1 

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       Transcriptional Phenomenon1

 Binding to SLC6A14 gene in health condition [4]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC6A14 gene in health condition, which leads to an affected expression of the drug transporter Amino acid transporter ATB0+.

        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A14 gene in breast cancer condition [5]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC6A14 gene in breast cancer condition, which leads to an increased expression of the drug transporter Amino acid transporter ATB0+.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A14 gene in health condition [6]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC6A14 gene in health condition, which leads to an affected expression of the drug transporter Amino acid transporter ATB0+.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-461. (ID:ENSG00000268104)
2 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
3 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
4 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
5 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
6 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.

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