Drug Transporter (DT) Information

General Information of DT
DT ID DTD0435
Gene Name SLC63A2
Protein Name Protein spinster homolog 2
Gene ID
124976
UniProt ID
Q8IVW8
TCDB ID
2.A.1.49.6
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms SPNS2; Spinster homolog 2
DT Family Major Facilitator Superfamily (MFS)
Endosomal Spinster (Spinster) Family
Function This transporter mediates the transport of sphingosine 1-phosphate (S1P) in the extraembryonic yolk syncytial layer (YSL), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function.
Endogenous Substrate(s) Dehydroshpingosine-1-P
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Protein spinster homolog 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Protein spinster homolog 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Protein spinster homolog 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Protein spinster homolog 2
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Protein spinster homolog 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Protein spinster homolog 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Protein spinster homolog 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Protein spinster homolog 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sphingosine-1-phosphate
 Phase 1 Drug Info Acne vulgaris ED80 [1]
References
1 The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC63A2)

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