Modelled DT Structure
Method:homology modeling
Template PDB:2XQ2_A
Identity:31.622%
Minimized Score:-979.441 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0423 | ||||
| Gene Name | SLC5A3 | ||||
| Protein Name | Sodium/myo-inositol cotransporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | BCW2; Na(+)/myo-inositol cotransporter; SLC5A3; SMIT; SMIT1; Sodium/myo-inositol transporter 1; Solute carrier family 5 member 3 | ||||
| DT Family | Solute:Sodium Symporter (SSS) Family ; | ||||
| Function | This transporter prevents intracellular accumulation of high concentrations of myo-inositol that result in impairment of cellular function. | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium/myo-inositol cotransporter |
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(β) Cell Distribution Level of Sodium/myo-inositol cotransporter |
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(γ) Organelle Distribution Level of Sodium/myo-inositol cotransporter |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium/myo-inositol cotransporter |
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(γ) Transcriptional Regulation of Sodium/myo-inositol cotransporter |
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(δ) Epigenetic Regulation of Sodium/myo-inositol cotransporter |
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(ε) Exogenous Modulation of Sodium/myo-inositol cotransporter |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(δ) Xenobiotics-regulated Structural Variability |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium/myo-inositol cotransporter |
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(β) Disease-specific Protein Abundances of Sodium/myo-inositol cotransporter |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Clinical Trial Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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MYO-inositol
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Phase 4 | Drug Info | Polycystic ovary syndrome | 5A80.1 | [1] |
| References | |||||
| 1 | Identification of a novel Na+/myo-inositol cotransporter. J Biol Chem. 2002 Sep 20;277(38):35219-24. | ||||
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