Drug Transporter (DT) Information

General Information of DT
DT ID DTD0420
Gene Name SLC5A11
Protein Name Sodium/myo-inositol cotransporter 2
Gene ID
115584
UniProt ID
Q8WWX8
TCDB ID
2.A.21.3.6
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:2XQ2_A

Identity:32.765%

Minimized Score:-1079.765 kcal/mol

Detail: Structure Info

Synonyms KST1; Na(+)/myo-inositol cotransporter 2; RKST1; SGLT6; SLC5A11; SLGTX; SMIT2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; Sodium/myo-inositol transporter 2; Solute carrier family 5 member 11
DT Family Solute:Sodium Symporter (SSS) Family ;
Function This transporter involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/myo-inositol cotransporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/myo-inositol cotransporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/myo-inositol cotransporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(γ) Transcriptional Regulation of Sodium/myo-inositol cotransporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/myo-inositol cotransporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/myo-inositol cotransporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/myo-inositol cotransporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/myo-inositol cotransporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
MYO-inositol
 Phase 4 Drug Info Polycystic ovary syndrome 5A80.1 [1]
References
1 The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8.

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