Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0420 Transporter Info
Gene Name SLC5A11
Transporter Name Sodium/myo-inositol cotransporter 2
Gene ID
115584
UniProt ID
Q8WWX8

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A11 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Bone marrow; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A11 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A11 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Breast; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A11 gene in coronary artery disease condition [4]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC5A11 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Sodium/myo-inositol cotransporter 2.

        JUNB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A11 gene [5]

TF Protein Name

 Transcription factor JunB Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunB (JUNB) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

        JUND 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A11 gene in coronary artery disease condition [4]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC5A11 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Sodium/myo-inositol cotransporter 2.

       Transcriptional Phenomenon2

 Direct binding to SLC5A11 gene [1]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Bone marrow; Brain; Breast; Cervix; Colon; Coronary artery; Embryo; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A11 gene in coronary artery disease condition [4]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLC5A11 gene in coronary artery disease condition, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A11 gene in prostate cancer condition [6]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC5A11 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/myo-inositol cotransporter 2.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A11 gene in health condition [7]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC5A11 gene in health condition, which leads to an affected expression of the drug transporter Sodium/myo-inositol cotransporter 2.

        PGR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A11 gene in pregnancy condition [8]

TF Protein Name

 Progesterone receptor Transcription Factor Info

Studied Phenotype

 Pregnancy [ICD11: JA00-JA2Z]

Tissue

 Endometrium

Related DT Changes

 Up regulating

Experimental Material

 Suffolk sheep

Detailed Description

 Progesterone receptor (PGR) has been reported to activate the transcription of SLC5A11 gene in pregnancy condition, which leads to an increased expression of the drug transporter Sodium/myo-inositol cotransporter 2.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A11 gene [3]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

        GATA3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A11 gene in breast cancer condition [9]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC5A11 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium/myo-inositol cotransporter 2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A11 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A11 gene in renal cysts condition [10]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC5A11 gene in renal cysts condition, which leads to an increased expression of the drug transporter Sodium/myo-inositol cotransporter 2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A11 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC5A11 gene, which in turn affects the expression or function of the drug transporter Sodium/myo-inositol cotransporter 2.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A11 gene in monocytes [11]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Interferon regulatory factor 1 (IRF1) has been reported to activate the transcription of SLC5A11 gene in monocytes, which leads to an increased expression of the drug transporter Sodium/myo-inositol cotransporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A11 gene in epithelial to mesenchymal transition condition [12]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC5A11 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium/myo-inositol cotransporter 2.

       Transcriptional Phenomenon2

 Binding to SLC5A11 gene in health condition [13]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC5A11 gene in health condition, which leads to an affected expression of the drug transporter Sodium/myo-inositol cotransporter 2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-351. (ID:ENSG00000158865)
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
7 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
8 Select nutrients in the ovine uterine lumen. ii. glucose transporters in the uterus and peri-implantation conceptuses. Biol Reprod. 2009 Jan;80(1):94-104.
9 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
10 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
11 Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes. Gene. 2011;487(1):21-8.
12 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
13 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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