Drug Transporter (DT) Information

General Information of DT
DT ID DTD0395
Gene Name SLC52A3
Protein Name Riboflavin transporter 2
Gene ID
113278
UniProt ID
Q9NQ40
TCDB ID
2.A.125.1.2
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms BVVLS; BVVLS1; C20orf54; RFT2; RFVT3; SLC52A3; Solute carrier family 52, riboflavin transporter, member 3; bA371L19.1; hRFT2
DT Family Eukaryotic Riboflavin Transporter (E-RFT) Family ;
Tissue Specificity Predominantly expressed in testis. Highlyexpressed in small intestine and prostate.
Function This transporter is for riboflavin. Riboflavin transport is Na(+)-independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions.
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Riboflavin transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Riboflavin transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Riboflavin transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Riboflavin transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Riboflavin transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Riboflavin transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Riboflavin transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Riboflavin transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Riboflavin transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Riboflavin
 Approved Drug Info Acne vulgaris ED80 [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           3 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Flavin adenine dinucleotide
643975
EM Info Identified using SLC52A3-knockdown drosophila melanogaster [2]
Flavin mononucleotide
643976
EM Info Identified using SLC52A3-knockdown drosophila melanogaster [2]
Riboflavin
493570
EM Info Identified using SLC52A3-knockdown drosophila melanogaster [2]
References
1 An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188.
2 Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. Brain. 2017 Nov 1;140(11):2820-2837.

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