Drug Transporter (DT) Information

General Information of DT
DT ID DTD0335
Gene Name SLC38A8
Protein Name Putative sodium-coupled neutral amino acid transporter 8
Gene ID
146167
UniProt ID
A6NNN8
TCDB ID
2.A.18.6.12
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms FVH2; SLC38A8; Solute carrier family 38 member 8
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Expressed in fetal and adult brain, and spinalcord. In the brain, it is localized in the cell body and axon ofthe majority of neuronal cells and in a subset of glial cells.Found throughout the neuronal retina, with higher expressionlevels in the inner and outer plexiform layers and thephotoreceptor layer. Very weak expression is also present in thekidneys, thymus, and testes.
Function This transporter is putative sodium-dependent amino acid/proton antiporter.
Endogenous Substrate(s) Amino acids; Proton
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Putative sodium-coupled neutral amino acid transporter 8
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Putative sodium-coupled neutral amino acid transporter 8
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Putative sodium-coupled neutral amino acid transporter 8
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Putative sodium-coupled neutral amino acid transporter 8
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Putative sodium-coupled neutral amino acid transporter 8
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Putative sodium-coupled neutral amino acid transporter 8
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Putative sodium-coupled neutral amino acid transporter 8
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Putative sodium-coupled neutral amino acid transporter 8
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Putative sodium-coupled neutral amino acid transporter 8
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-glutamic acid
 Approved Drug Info Schizophrenia 6A20 [1]
References
1 Structural modeling of a novel SLC38A8 mutation that causes foveal hypoplasia. Mol Genet Genomic Med. 2017 Feb 26;5(3):202-209.

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