Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0335 Transporter Info
Gene Name SLC38A8
Transporter Name Putative sodium-coupled neutral amino acid transporter 8
Gene ID
146167
UniProt ID
A6NNN8

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A8 gene [1]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC38A8 gene, which in turn affects the expression or function of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A8 gene in melanoma condition [2]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC38A8 gene in melanoma condition, which leads to an increased expression of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A8 gene [3]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC38A8 gene, which in turn affects the expression or function of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A8 gene in hematopoiesis condition [4]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC38A8 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A8 gene [5]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC38A8 gene, which in turn affects the expression or function of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

        CTCFL 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A8 gene [5]

TF Protein Name

 Transcriptional repressor CTCFL Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC38A8 gene, which in turn affects the expression or function of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A8 gene [6]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC38A8 gene, which in turn affects the expression or function of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A8 gene [3]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC38A8 gene, which in turn affects the expression or function of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A8 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC38A8 gene, which in turn affects the expression or function of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A8 gene in health condition [7]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC38A8 gene in health condition, which leads to an affected expression of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A8 gene in prostate cancer condition [8]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC38A8 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A8 gene in human embryonic stem cells (hESCs) condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC38A8 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Putative sodium-coupled neutral amino acid transporter 8.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-378. (ID:ENSG00000166558)
2 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
5 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
6 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
8 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
9 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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