Drug Transporter (DT) Information

General Information of DT
DT ID DTD0265
Gene Name SLC2A7
Protein Name Glucose transporter type 7
Gene ID
155184
UniProt ID
Q6PXP3
TCDB ID
2.A.1.1.37
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4YB9_D

Identity:59.657%

Minimized Score:-1194.435 kcal/mol

Detail: Structure Info

Synonyms GLUT-7; GLUT7; SLC2A7; Solute carrier family 2, facilitated glucose transporter member 7
DT Family Major Facilitator Superfamily (MFS)
Sugar Porter (SP) Family
Tissue Specificity Expressed in small intestine and colon. Weaklyexpressed in testis and prostate.
Function This high-affinity transporter is for glucose and fructose.
Endogenous Substrate(s) Glucose
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Glucose transporter type 7
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Glucose transporter type 7
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Glucose transporter type 7
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Glucose transporter type 7
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Glucose transporter type 7
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Glucose transporter type 7
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Glucose transporter type 7
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Glucose transporter type 7
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Glucose transporter type 7
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Fructose
 Approved Drug Info Emesis MD90 [1]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
2-Deoxyglucose
 Phase 1/2 Drug Info Cancer 2A00-2F9Z [1]

Drug-DT Affinity Assessed by Cell Line

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:         15 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
2-Deoxyglucose Phase 1/2 Drug Info Xenopus oocytes-GLUT7 Km =300 microM [1]
References
1 Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128.

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