Drug Transporter (DT) Information

General Information of DT
DT ID DTD0242
Gene Name SLC27A5
Protein Name Bile acid-CoA ligase
Gene ID
10998
UniProt ID
Q9Y2P5
TCDB ID
4.C.1.1.13
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ACSB; ACSVL6; BA-CoA ligase; BACS; BAL; Very long-chain acyl-CoA synthetase homolog 2; Cholate--CoA ligase; FACVL3; FATP-5; FATP5; Fatty acid transport protein 5; Fatty-acid-coenzyme A ligase, very long-chain 3; SLC27A5; Solute carrier family 27 member 5; VLACS-related; VLACSR; VLCS-H2; VLCSH2; Bile acyl-CoA synthetase; Very long-chain acyl-CoA synthetase-related protein
DT Family Fatty Acid Transporter (FAT) Family ;
Tissue Specificity Predominantly expressed in liver.
Function This acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters.
Endogenous Substrate(s) Fatty acids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Bile acid-CoA ligase
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Bile acid-CoA ligase
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Bile acid-CoA ligase
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Bile acid-CoA ligase
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Bile acid-CoA ligase
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Bile acid-CoA ligase
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Bile acid-CoA ligase
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Bile acid-CoA ligase
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Bile acid-CoA ligase
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.