Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0242 Transporter Info
Gene Name	SLC27A5
Transporter Name	Bile acid-CoA ligase
Gene ID	10998
UniProt ID	Q9Y2P5

Post-Translational Modification of This DT
Overview ofSLC27A5 Modification Sites with Functional and Structural Information
Sequence	M G V R Q Q L A L L L L L L L L L W G L G Q P V W P V A V A L T L R W L L G D P T C C V L L G L A M L A R P W L G P W V P H G L S L A A A A L A L T L L P A R L P P G L R W L P A D V I F L A K I L H L G L K I R G C L S R Q P P D T F V D A F E R R A R A Q P G R A L L V W T G P G A G S V T F G E L D A R A C Q A A W A L K A E L G D P A S L C A G E P T A L L V L A S Q A V P A L C M W L G L A K L G C P T A W I N P H G R G M P L A H S V L S S G A R V L V V D P D L R E S L E E I L P K L Q A E N I R C F Y L S H T S P T P G V G A L G A A L D A A P S H P V P A D L R A G I T W R S P A L F I Y T S G T T G L P K P A I L T H E R V L Q M S K M L S L S G A T A D D V V Y T V L P L Y H V M G L V V G I L G C L D L G A T C V L A P K F S T S C F W D D C R Q H G V T V I L Y V G E L L R Y L C N I P Q Q P E D R T H T V R L A M G N G L R A D V W E T F Q Q R F G P I R I W E V Y G S T E G N M G L V N Y V G R C G A L G K M S C L L R M L S P F E L V Q F D M E A A E P V R D N Q G F C I P V G L G E P G L L L T K V V S Q Q P F V G Y R G P R E L S E R K L V R N V R Q S G D V Y Y N T G D V L A M D R E G F L Y F R D R L G D T F R W K G E N V S T H E V E G V L S Q V D F L Q Q V N V Y G V C V P G C E G K V G M A A V Q L A P G Q T F D G E K L Y Q H V R A W L P A Y A T P H F I R I Q D A M E V T S T F K L M K T R L V R E G F N V G I V V D P L F V L D N R A Q S F R P L T A E M Y Q A V C E G T W R L
PTM type	X-Acetylation X-Phosphorylation X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A5			[1], [2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	241
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC27A5 Lysine 241 has the potential to affect its expression or activity.
Phosphorylation
Serine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A5			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	365
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A5 Serine 365 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC27A5			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	501
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A5 Serine 501 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC27A5			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	515
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A5 Serine 515 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A5			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	554
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A5 Threonine 554 has the potential to affect its expression or activity.

References
1	Regulation of cellular metabolism by protein lysine acetylation. Science. 2010 Feb 19;327(5968):1000-4.
2	Global-scale profiling of differential expressed lysine acetylated proteins in colorectal cancer tumors and paired liver metastases. J Proteomics. 2016 Jun 16;142:24-32.
3	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.
4	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
5	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
6	Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics. J Proteome Res. 2017 Feb 3;16(2):852-861.

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Detail Information of Post-Translational Modifications

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