Drug Transporter (DT) Information

General Information of DT
DT ID DTD0241
Gene Name SLC27A4
Protein Name Long-chain fatty acid transport protein 4
Gene ID
10999
UniProt ID
Q6P1M0
TCDB ID
4.C.1.1.10
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ACSVL4; FATP-4; FATP4; Fatty acid transport protein 4; IPS; SLC27A4; Solute carrier family 27 member 4
DT Family Fatty Acid Transporter (FAT) Family ;
Tissue Specificity Expressed at highest levels in brain, testis,colon and kidney. Expressed at medium levels in heart and liver,small intestine and stomach. Expressed at low levels in peripheralleukocytes, bone marrow, skeletal muscle and aorta. Expressed inadipose tissue.
Function This transporter mediates the transport of long chain fatty acids (LFCA) through plasma membrane. It seems to be the main fatty acid transporter in small intestinal cells. It plays a role in the formation of epidermal barrier. Essential for fat absorption in early embryo.
Endogenous Substrate(s) Fatty acids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Long-chain fatty acid transport protein 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Long-chain fatty acid transport protein 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Long-chain fatty acid transport protein 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Long-chain fatty acid transport protein 4
Microbiota Influence (MBI)

(β) Post-translational Modification of Long-chain fatty acid transport protein 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Long-chain fatty acid transport protein 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Long-chain fatty acid transport protein 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Long-chain fatty acid transport protein 4
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Long-chain fatty acid transport protein 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Long-chain fatty acid transport protein 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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