Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0241 Transporter Info
Gene Name	SLC27A4
Transporter Name	Long-chain fatty acid transport protein 4
Gene ID	10999
UniProt ID	Q6P1M0

Post-Translational Modification of This DT
Overview ofSLC27A4 Modification Sites with Functional and Structural Information
Sequence	M L L G A S L V G V L L F S K L V L K L P W T Q V G F S L L F L Y L G S G G W R F I R V F I K T I R R D I F G G L V L L K V K A K V R Q C L Q E R R T V P I L F A S T V R R H P D K T A L I F E G T D T H W T F R Q L D E Y S S S V A N F L Q A R G L A S G D V A A I F M E N R N E F V G L W L G M A K L G V E A A L I N T N L R R D A L L H C L T T S R A R A L V F G S E M A S A I C E V H A S L D P S L S L F C S G S W E P G A V P P S T E H L D P L L K D A P K H L P S C P D K G F T D K L F Y I Y T S G T T G L P K A A I V V H S R Y Y R M A A L V Y Y G F R M R P N D I V Y D C L P L Y H S A G N I V G I G Q C L L H G M T V V I R K K F S A S R F W D D C I K Y N C T I V Q Y I G E L C R Y L L N Q P P R E A E N Q H Q V R M A L G N G L R Q S I W T N F S S R F H I P Q V A E F Y G A T E C N C S L G N F D S Q V G A C G F N S R I L S F V Y P I R L V R V N E D T M E L I R G P D G V C I P C Q P G E P G Q L V G R I I Q K D P L R R F D G Y L N Q G A N N K K I A K D V F K K G D Q A Y L T G D V L V M D E L G Y L Y F R D R T G D T F R W K G E N V S T T E V E G T L S R L L D M A D V A V Y G V E V P G T E G R A G M A A V A S P T G N C D L E R F A Q V L E K E L P L Y A R P I F L R L L P E L H K T G T Y K F Q K T E L R K E G F D P A I V K D P L F Y L D A Q K G R Y V P L D Q E A Y S R I Q A G E E K L
PTM type	X-Acetylation X-Malonylation X-Oxidation X-Phosphorylation X-Phosphorylation X-S-nitrosylation X-Sulfoxidation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A4			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	471
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC27A4 Lysine 471 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC27A4			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	603
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC27A4 Lysine 603 has the potential to affect its expression or activity.
Malonylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A4			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	454
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at SLC27A4 Lysine 454 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC27A4			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	471
Experimental Method	Co-Immunoprecipitation
Detailed Description	Malonylation at SLC27A4 Lysine 471 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A4			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	323
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC27A4 Cystine 323 has the potential to affect its expression or activity.
Phosphorylation
Serine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A4			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	14
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Serine 14 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC27A4			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	82
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Serine 82 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Serine 373 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC27A4			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	411
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Serine 411 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC27A4			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	555
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Serine 555 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A4			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	83
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Threonine 83 has the potential to affect its expression or activity.
Tyrosine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	243
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Tyrosine 243 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	245
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Tyrosine 245 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC27A4			[8], [11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	414
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Tyrosine 414 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC27A4			[12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A4 Tyrosine 463 has the potential to affect its expression or activity.
S-nitrosylation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A4			[13]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	338
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at SLC27A4 Cystine 338 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC27A4			[13]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	560
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at SLC27A4 Cystine 560 has the potential to affect its expression or activity.
Sulfoxidation
Methionine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A4			[14]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	426
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at SLC27A4 Methionine 426 has the potential to affect its expression or activity.
Ubiquitination
Lysine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	90
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 90 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	90
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 90 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	475
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 475 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	571
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 571 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	571
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 571 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	595
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 595 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	595
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 595 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	598
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 598 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	598
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 598 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC27A4			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	622
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A4 Lysine 622 has the potential to affect its expression or activity.

References
1	Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Mol Cell. 2015 Sep 3;59(5):867-81.
2	Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. Mol Cell Proteomics. 2015 Nov;14(11):3056-71.
3	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
4	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
5	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
6	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
7	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
8	Phosphoproteomic and Functional Analyses Reveal Sperm-specific Protein Changes Downstream of Kappa Opioid Receptor in Human Spermatozoa. Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S118-S131.
9	Offline pentafluorophenyl (PFP)-RP prefractionation as an alternative to high-pH RP for comprehensive LC-MS/MS proteomics and phosphoproteomics. Anal Bioanal Chem. 2017 Jul;409(19):4615-4625.
10	Protein kinase C-alpha interaction with F0F1-ATPase promotes F0F1-ATPase activity and reduces energy deficits in injured renal cells. J Biol Chem. 2015 Mar 13;290(11):7054-66.
11	Deep Phosphotyrosine Proteomics by Optimization of Phosphotyrosine Enrichment and MS/MS Parameters. J Proteome Res. 2017 Feb 3;16(2):1077-1086.
12	Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat Chem Biol. 2016 Nov;12(11):959-966.
13	Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique. Nat Commun. 2019 May 16;10(1):2195.
14	Redox proteomics of protein-bound methionine oxidation. Mol Cell Proteomics. 2011 May;10(5):M110.006866.
15	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
16	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Post-Translational Modifications

Visitor Map

Correspondence